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Protein

Gamma-aminobutyric acid receptor subunit gamma-1

Gene

Gabrg1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

GO - Molecular functioni

  • chloride channel activity Source: UniProtKB-KW
  • extracellular ligand-gated ion channel activity Source: InterPro
  • GABA-A receptor activity Source: RGD
  • GABA receptor binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit gamma-1
Alternative name(s):
GABA(A) receptor subunit gamma-1
Gene namesi
Name:Gabrg1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi621732. Gabrg1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini36 – 272ExtracellularCuratedAdd BLAST237
Transmembranei273 – 294HelicalCuratedAdd BLAST22
Transmembranei299 – 320HelicalCuratedAdd BLAST22
Transmembranei332 – 354HelicalCuratedAdd BLAST23
Topological domaini355 – 444CytoplasmicCuratedAdd BLAST90
Transmembranei445 – 465HelicalCuratedAdd BLAST21

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • chloride channel complex Source: UniProtKB-KW
  • GABA-A receptor complex Source: GO_Central
  • membrane Source: RGD
  • postsynaptic membrane Source: UniProtKB-SubCell
  • receptor complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL296.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000000047536 – 465Gamma-aminobutyric acid receptor subunit gamma-1Add BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...)Sequence analysis1
Glycosylationi127N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi188 ↔ 202By similarity
Glycosylationi245N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

May be palmitoylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP23574.
PRIDEiP23574.

Expressioni

Gene expression databases

BgeeiENSRNOG00000002360.
GenevisibleiP23574. RN.

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.

GO - Molecular functioni

  • GABA receptor binding Source: RGD

Protein-protein interaction databases

BioGridi250833. 1 interactor.
STRINGi10116.ENSRNOP00000003240.

Chemistry databases

BindingDBiP23574.

Structurei

3D structure databases

ProteinModelPortaliP23574.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3642. Eukaryota.
ENOG410XNQG. LUCA.
GeneTreeiENSGT00760000119010.
HOGENOMiHOG000231337.
HOVERGENiHBG051707.
InParanoidiP23574.
KOiK05186.
OMAiVRLMFLL.
OrthoDBiEOG091G0805.
PhylomeDBiP23574.
TreeFamiTF315453.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR005438. GABBAg1_rcpt.
IPR005437. GABBAg_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01620. GABAARGAMMA.
PR01621. GABAARGAMMA1.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23574-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSGKVFLFS PSLLWSQTRG VRLIFLLLTL HLGNCIDKAD DEDDEDLTMN
60 70 80 90 100
KTWVLAPKIH EGDITQILNS LLQGYDNKLR PDIGVRPTVI ETDVYVNSIG
110 120 130 140 150
PVDPINMEYT IDIIFAQTWF DSRLKFNSTM KVLMLNSNMV GKIWIPDTFF
160 170 180 190 200
RNSRKSDAHW ITTPNRLLRI WSDGRVLYTL RLTINAECYL QLHNFPMDEH
210 220 230 240 250
SCPLEFSSYG YPKNEIEYKW KKPSVEVADP KYWRLYQFAF VGLRNSTEIS
260 270 280 290 300
HTISGDYIIM TIFFDLSRRM GYFTIQTYIP CILTVVLSWV SFWINKDAVP
310 320 330 340 350
ARTSLGITTV LTMTTLSTIA RKSLPKVSYV TAMDLFVSVC FIFVFAALME
360 370 380 390 400
YGTLHYFTSN NKGKTTRDRK LKSKTSVSPG LHAGSTLIPM NNISMPQGED
410 420 430 440 450
DYGYQCLEGK DCATFFCCFE DCRTGSWREG RIHIRIAKID SYSRIFFPTA
460
FALFNLVYWV GYLYL
Length:465
Mass (Da):53,551
Last modified:November 1, 1991 - v1
Checksum:i7EC2CE8FBF04663B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57514 mRNA. Translation: CAA40739.1.
PIRiS12056.
RefSeqiNP_542153.1. NM_080586.1.
UniGeneiRn.10366.

Genome annotation databases

EnsembliENSRNOT00000003240; ENSRNOP00000003240; ENSRNOG00000002360.
GeneIDi140674.
KEGGirno:140674.
UCSCiRGD:621732. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57514 mRNA. Translation: CAA40739.1.
PIRiS12056.
RefSeqiNP_542153.1. NM_080586.1.
UniGeneiRn.10366.

3D structure databases

ProteinModelPortaliP23574.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250833. 1 interactor.
STRINGi10116.ENSRNOP00000003240.

Chemistry databases

BindingDBiP23574.
ChEMBLiCHEMBL296.

Proteomic databases

PaxDbiP23574.
PRIDEiP23574.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003240; ENSRNOP00000003240; ENSRNOG00000002360.
GeneIDi140674.
KEGGirno:140674.
UCSCiRGD:621732. rat.

Organism-specific databases

CTDi2565.
RGDi621732. Gabrg1.

Phylogenomic databases

eggNOGiKOG3642. Eukaryota.
ENOG410XNQG. LUCA.
GeneTreeiENSGT00760000119010.
HOGENOMiHOG000231337.
HOVERGENiHBG051707.
InParanoidiP23574.
KOiK05186.
OMAiVRLMFLL.
OrthoDBiEOG091G0805.
PhylomeDBiP23574.
TreeFamiTF315453.

Miscellaneous databases

PROiP23574.

Gene expression databases

BgeeiENSRNOG00000002360.
GenevisibleiP23574. RN.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR005438. GABBAg1_rcpt.
IPR005437. GABBAg_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01620. GABAARGAMMA.
PR01621. GABAARGAMMA1.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBRG1_RAT
AccessioniPrimary (citable) accession number: P23574
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: October 5, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This subunit carries the benzodiazepine binding site.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.