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P23573

- CDC2C_DROME

UniProt

P23573 - CDC2C_DROME

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Protein
Cell division control protein 2 cognate
Gene
cdc2c, CG10498
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Like cdc2, could play a key role in the control of the eukaryotic cell cycle.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371ATP By similarity
Active sitei130 – 1301Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 229ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC
  3. cyclin-dependent protein serine/threonine kinase activity Source: FlyBase
  4. protein binding Source: IntAct
  5. protein serine/threonine kinase activity Source: FlyBase
Complete GO annotation...

GO - Biological processi

  1. G1/S transition of mitotic cell cycle Source: FlyBase
  2. G2/M transition of mitotic cell cycle Source: FlyBase
  3. JAK-STAT cascade Source: FlyBase
  4. cellular process Source: FlyBase
  5. mitotic nuclear division Source: UniProtKB-KW
  6. protein phosphorylation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22. 1994.
ReactomeiREACT_104865. G2 Phase.
REACT_180258. Factors involved in megakaryocyte development and platelet production.
REACT_180658. G0 and Early G1.
REACT_182058. Senescence-Associated Secretory Phenotype (SASP).
REACT_209977. Activation of the pre-replicative complex.
REACT_211248. CDK-mediated phosphorylation and removal of Cdc6.
REACT_218568. Activation of ATR in response to replication stress.
REACT_218589. Orc1 removal from chromatin.
REACT_224351. Regulation of APC/C activators between G1/S and early anaphase.
SignaLinkiP23573.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 2 cognate (EC:2.7.11.22, EC:2.7.11.23)
Gene namesi
Name:cdc2c
ORF Names:CG10498
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0004107. cdc2c.

Subcellular locationi

GO - Cellular componenti

  1. microtubule associated complex Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Cell division control protein 2 cognate
PRO_0000085744Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181Phosphothreonine By similarity
Modified residuei19 – 191Phosphotyrosine By similarity
Modified residuei162 – 1621Phosphotyrosine1 Publication
Modified residuei163 – 1631Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP23573.
PRIDEiP23573.

Expressioni

Gene expression databases

BgeeiP23573.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CycJQ241595EBI-95916,EBI-455799
CycKQ961D15EBI-95916,EBI-130995
dapP916543EBI-95916,EBI-868936

Protein-protein interaction databases

BioGridi67428. 50 interactions.
DIPiDIP-648N.
IntActiP23573. 73 interactions.
MINTiMINT-1509625.

Structurei

3D structure databases

ProteinModelPortaliP23573.
SMRiP23573. Positions 5-290.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 287280Protein kinase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00720000108415.
InParanoidiP23573.
KOiK02206.
OMAiAHELIMS.
OrthoDBiEOG7966H8.
PhylomeDBiP23573.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23573-1 [UniParc]FASTAAdd to Basket

« Hide

MTTILDNFQR AEKIGEGTYG IVYKARSNST GQDVALKKIR LEGETEGVPS    50
TAIREISLLK NLKHPNVVQL FDVVISGNNL YMIFEYLNMD LKKLMDKKKD 100
VFTPQLIKSY MHQILDAVGF CHTNRILHRD LKPQNLLVDT AGKIKLADFG 150
LARAFNVPMR AYTHEVVTLW YRAPEILLGT KFYSTGVDIW SLGCIFSEMI 200
MRRSLFPGDS EIDQLYRIFR TLSTPDETNW PGVTQLPDFK TKFPRWEGTN 250
MPQPITEHEA HELIMSMLCY DPNLRISAKD ALQHAYFRNV QHVDHVALPV 300
DPNAGSASRL TRLV 314
Length:314
Mass (Da):35,888
Last modified:November 1, 1991 - v1
Checksum:i576A88767F9D35C0
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271S → T1 Publication
Sequence conflicti119 – 1191G → A1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X57486 mRNA. Translation: CAA40724.1.
AE014297 Genomic DNA. Translation: AAN14363.1.
AY051671 mRNA. Translation: AAK93095.1.
PIRiE46036.
RefSeqiNP_001163666.1. NM_001170195.2.
NP_524420.1. NM_079696.6.
NP_732544.1. NM_169916.3.
UniGeneiDm.2392.

Genome annotation databases

EnsemblMetazoaiFBtr0083921; FBpp0083329; FBgn0004107.
FBtr0083922; FBpp0083330; FBgn0004107.
FBtr0300447; FBpp0289675; FBgn0004107.
GeneIDi42453.
KEGGidme:Dmel_CG10498.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X57486 mRNA. Translation: CAA40724.1 .
AE014297 Genomic DNA. Translation: AAN14363.1 .
AY051671 mRNA. Translation: AAK93095.1 .
PIRi E46036.
RefSeqi NP_001163666.1. NM_001170195.2.
NP_524420.1. NM_079696.6.
NP_732544.1. NM_169916.3.
UniGenei Dm.2392.

3D structure databases

ProteinModelPortali P23573.
SMRi P23573. Positions 5-290.
ModBasei Search...

Protein-protein interaction databases

BioGridi 67428. 50 interactions.
DIPi DIP-648N.
IntActi P23573. 73 interactions.
MINTi MINT-1509625.

Proteomic databases

PaxDbi P23573.
PRIDEi P23573.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0083921 ; FBpp0083329 ; FBgn0004107 .
FBtr0083922 ; FBpp0083330 ; FBgn0004107 .
FBtr0300447 ; FBpp0289675 ; FBgn0004107 .
GeneIDi 42453.
KEGGi dme:Dmel_CG10498.

Organism-specific databases

CTDi 42453.
FlyBasei FBgn0004107. cdc2c.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00720000108415.
InParanoidi P23573.
KOi K02206.
OMAi AHELIMS.
OrthoDBi EOG7966H8.
PhylomeDBi P23573.

Enzyme and pathway databases

BRENDAi 2.7.11.22. 1994.
Reactomei REACT_104865. G2 Phase.
REACT_180258. Factors involved in megakaryocyte development and platelet production.
REACT_180658. G0 and Early G1.
REACT_182058. Senescence-Associated Secretory Phenotype (SASP).
REACT_209977. Activation of the pre-replicative complex.
REACT_211248. CDK-mediated phosphorylation and removal of Cdc6.
REACT_218568. Activation of ATR in response to replication stress.
REACT_218589. Orc1 removal from chromatin.
REACT_224351. Regulation of APC/C activators between G1/S and early anaphase.
SignaLinki P23573.

Miscellaneous databases

GenomeRNAii 42453.
NextBioi 828859.

Gene expression databases

Bgeei P23573.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Drosophila cdc2 homologs: a functional homolog is coexpressed with a cognate variant."
    Lehner C.F., O'Farrell P.H.
    EMBO J. 9:3573-3581(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Oregon-R.
    Tissue: Embryo.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.
  5. "Primary structure, expression, and signal-dependent tyrosine phosphorylation of a Drosophila homolog of extracellular signal-regulated kinase."
    Biggs W.H. III, Zipursky S.L.
    Proc. Natl. Acad. Sci. U.S.A. 89:6295-6299(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 21-167.
    Tissue: Imaginal disk.
  6. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-162 AND THR-163, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiCDC2C_DROME
AccessioniPrimary (citable) accession number: P23573
Secondary accession number(s): Q0KI40, Q9TXB2, Q9VDJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: September 3, 2014
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi