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P23569

- CHSY_PUEML

UniProt

P23569 - CHSY_PUEML

Protein

Chalcone synthase

Gene

CHS

Organism
Pueraria montana var. lobata (Kudzu vine) (Pueraria lobata)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Nov 1991)
      Previous versions | rss
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    Functioni

    The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

    Catalytic activityi

    3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei164 – 1641PROSITE-ProRule annotation

    GO - Molecular functioni

    1. naringenin-chalcone synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. flavonoid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Flavonoid biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00154.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chalcone synthase (EC:2.3.1.74)
    Alternative name(s):
    Naringenin-chalcone synthase
    Gene namesi
    Name:CHS
    OrganismiPueraria montana var. lobata (Kudzu vine) (Pueraria lobata)
    Taxonomic identifieri3893 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaePueraria

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 389389Chalcone synthasePRO_0000216043Add
    BLAST

    Proteomic databases

    ProMEXiP23569.

    Structurei

    3D structure databases

    ProteinModelPortaliP23569.
    SMRiP23569. Positions 3-389.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the chalcone/stilbene synthases family.Curated

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    InterProiIPR012328. Chalcone/stilbene_synth_C.
    IPR018088. Chalcone/stilbene_synthase_AS.
    IPR001099. Chalcone/stilbene_synthase_N.
    IPR011141. Polyketide_synthase_type-III.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF02797. Chal_sti_synt_C. 1 hit.
    PF00195. Chal_sti_synt_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000451. PKS_III. 1 hit.
    SUPFAMiSSF53901. SSF53901. 2 hits.
    PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P23569-1 [UniParc]FASTAAdd to Basket

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    MVSVAEIRQA QRAEGPATIL AIGTANPPNC VDQSTYPDYY FRITNSEHMT    50
    ELKEKFQRMC DKSMIKKRYM YLTEEILKEN PNMCAYMAPS LDARQDMVVV 100
    EVPKLGKEAA TKAIKEWGQP KSKITHLIFC TTSGVDMPGA DYQLTKQLGL 150
    RPYVKRYMMY QQGCFAGGTV LRLAKDLAEN NKGARVLVVC SEITAVTFRG 200
    PSDTHLDSLV GQALFGDGAA AVIVGSDPIP QVEKPLYELV WTAQTIAPDS 250
    EGAIDGHLRE VGLTFHLLKD VPGIVSKNID KALFEAFNPL NISDYNSIFW 300
    IAHPGGPAIL DQVEQKLGLK PEKMKATRDV LSDYGNMSSA CVLFILDEMR 350
    RKSAENGLKT TGEGLEWGVL FGFGPGLTIE TVVLRSVAI 389
    Length:389
    Mass (Da):42,832
    Last modified:November 1, 1991 - v1
    Checksum:i438F6DC77A37F5DE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10223 mRNA. Translation: BAA01075.1.
    D63855 Genomic DNA. Translation: BAA09918.1.
    PIRiJQ0911. SYFJCP.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10223 mRNA. Translation: BAA01075.1 .
    D63855 Genomic DNA. Translation: BAA09918.1 .
    PIRi JQ0911. SYFJCP.

    3D structure databases

    ProteinModelPortali P23569.
    SMRi P23569. Positions 3-389.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    ProMEXi P23569.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00154 .

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    InterProi IPR012328. Chalcone/stilbene_synth_C.
    IPR018088. Chalcone/stilbene_synthase_AS.
    IPR001099. Chalcone/stilbene_synthase_N.
    IPR011141. Polyketide_synthase_type-III.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF02797. Chal_sti_synt_C. 1 hit.
    PF00195. Chal_sti_synt_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000451. PKS_III. 1 hit.
    SUPFAMi SSF53901. SSF53901. 2 hits.
    PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation, sequence and bacterial expression of a cDNA for chalcone synthase from the cultured cells of Pueraria lobata."
      Nakajima O., Akiyama T., Hakamatsuka T., Shibuya M., Noguchi H., Ebizuka Y., Sankawa U.
      Chem. Pharm. Bull. 39:1911-1913(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "cDNA and genomic DNA clonings of chalcone synthase from Pueraria lobata."
      Nakajima O., Shibuya M., Hakamatsuka T., Noguchi H., Ebizuka Y., Sankawa U.
      Biol. Pharm. Bull. 19:71-76(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-59.

    Entry informationi

    Entry nameiCHSY_PUEML
    AccessioniPrimary (citable) accession number: P23569
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: November 1, 1991
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3