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P23569

- CHSY_PUEML

UniProt

P23569 - CHSY_PUEML

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Protein

Chalcone synthase

Gene

CHS

Organism
Pueraria montana var. lobata (Kudzu vine) (Pueraria lobata)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei164 – 1641PROSITE-ProRule annotation

GO - Molecular functioni

  1. naringenin-chalcone synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. flavonoid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase
Gene namesi
Name:CHS
OrganismiPueraria montana var. lobata (Kudzu vine) (Pueraria lobata)
Taxonomic identifieri3893 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaePueraria

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Chalcone synthasePRO_0000216043Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP23569.
SMRiP23569. Positions 3-389.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23569-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MVSVAEIRQA QRAEGPATIL AIGTANPPNC VDQSTYPDYY FRITNSEHMT
60 70 80 90 100
ELKEKFQRMC DKSMIKKRYM YLTEEILKEN PNMCAYMAPS LDARQDMVVV
110 120 130 140 150
EVPKLGKEAA TKAIKEWGQP KSKITHLIFC TTSGVDMPGA DYQLTKQLGL
160 170 180 190 200
RPYVKRYMMY QQGCFAGGTV LRLAKDLAEN NKGARVLVVC SEITAVTFRG
210 220 230 240 250
PSDTHLDSLV GQALFGDGAA AVIVGSDPIP QVEKPLYELV WTAQTIAPDS
260 270 280 290 300
EGAIDGHLRE VGLTFHLLKD VPGIVSKNID KALFEAFNPL NISDYNSIFW
310 320 330 340 350
IAHPGGPAIL DQVEQKLGLK PEKMKATRDV LSDYGNMSSA CVLFILDEMR
360 370 380
RKSAENGLKT TGEGLEWGVL FGFGPGLTIE TVVLRSVAI
Length:389
Mass (Da):42,832
Last modified:November 1, 1991 - v1
Checksum:i438F6DC77A37F5DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10223 mRNA. Translation: BAA01075.1.
D63855 Genomic DNA. Translation: BAA09918.1.
PIRiJQ0911. SYFJCP.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10223 mRNA. Translation: BAA01075.1 .
D63855 Genomic DNA. Translation: BAA09918.1 .
PIRi JQ0911. SYFJCP.

3D structure databases

ProteinModelPortali P23569.
SMRi P23569. Positions 3-389.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00154 .

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000451. PKS_III. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation, sequence and bacterial expression of a cDNA for chalcone synthase from the cultured cells of Pueraria lobata."
    Nakajima O., Akiyama T., Hakamatsuka T., Shibuya M., Noguchi H., Ebizuka Y., Sankawa U.
    Chem. Pharm. Bull. 39:1911-1913(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "cDNA and genomic DNA clonings of chalcone synthase from Pueraria lobata."
    Nakajima O., Shibuya M., Hakamatsuka T., Noguchi H., Ebizuka Y., Sankawa U.
    Biol. Pharm. Bull. 19:71-76(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-59.

Entry informationi

Entry nameiCHSY_PUEML
AccessioniPrimary (citable) accession number: P23569
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: November 26, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3