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Protein

Elongation factor Tu

Gene

tuf

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 26GTPUniRule annotation8
Nucleotide bindingi81 – 85GTPUniRule annotation5
Nucleotide bindingi136 – 139GTPUniRule annotation4

GO - Molecular functioni

  • fibronectin binding Source: CAFA
  • GTPase activity Source: InterPro
  • GTP binding Source: UniProtKB-KW
  • translation elongation factor activity Source: UniProtKB-KW

GO - Biological processi

  • interaction with host via substance in symbiont cell outer membrane Source: CAFA

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMPNE272634:G1GJ3-1066-MONOMER

Protein family/group databases

MoonProtiP23568

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor TuUniRule annotation
Short name:
EF-TuUniRule annotation
Gene namesi
Name:tufUniRule annotation
Ordered Locus Names:MPN_665
ORF Names:MP177
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000808 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

  • cytosol Source: AgBase
  • external side of plasma membrane Source: CAFA
  • membrane Source: AgBase

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000913501 – 394Elongation factor TuAdd BLAST394

Proteomic databases

PRIDEiP23568

Interactioni

Subunit structurei

Monomer.UniRule annotation

Binary interactionsi

WithEntry#Exp.IntActNotes
FN1P027512EBI-2259072,EBI-1220319From Homo sapiens.

GO - Molecular functioni

  • fibronectin binding Source: CAFA

Protein-protein interaction databases

IntActiP23568, 22 interactors

Structurei

3D structure databases

ProteinModelPortaliP23568
SMRiP23568
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 204tr-type GAdd BLAST195

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni19 – 26G1By similarity8
Regioni60 – 64G2By similarity5
Regioni81 – 84G3By similarity4
Regioni136 – 139G4By similarity4
Regioni174 – 176G5By similarity3

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

Phylogenomic databases

KOiK02358
OMAiYGHIDCP

Family and domain databases

CDDicd03697 EFTU_II, 1 hit
HAMAPiMF_00118_B EF_Tu_B, 1 hit
InterProiView protein in InterPro
IPR004161 EFTu-like_2
IPR033720 EFTU_2
IPR031157 G_TR_CS
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR000795 TF_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR009001 Transl_elong_EF1A/Init_IF2_C
IPR004541 Transl_elong_EFTu/EF1A_bac/org
IPR004160 Transl_elong_EFTu/EF1A_C
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
PF03144 GTP_EFTU_D2, 1 hit
PF03143 GTP_EFTU_D3, 1 hit
PRINTSiPR00315 ELONGATNFCT
SUPFAMiSSF50447 SSF50447, 1 hit
SSF50465 SSF50465, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00485 EF-Tu, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS00301 G_TR_1, 1 hit
PS51722 G_TR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P23568-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAREKFDRSK PHVNVGTIGH IDHGKTTLTA AICTVLAKEG KSAATRYDQI
60 70 80 90 100
DKAPEEKARG ITINSAHVEY SSDKRHYAHV DCPGHADYIK NMITGAAQMD
110 120 130 140 150
GAILVVSATD SVMPQTREHI LLARQVGVPR MVVFLNKCDI ATDEEVQELV
160 170 180 190 200
AEEVRDLLTS YGFDGKNTPI IYGSALKALE GDPKWEAKIH DLMNAVDEWI
210 220 230 240 250
PTPEREVDKP FLLAIEDTMT ITGRGTVVTG RVERGELKVG QEIEIVGLRP
260 270 280 290 300
IRKAVVTGIE MFKKELDSAM AGDNAGVLLR GVDRKEVERG QVLAKPGSIK
310 320 330 340 350
PHKKFKAEIY ALKKEEGGRH TGFLNGYRPQ FYFRTTDVTG SISLPENTEM
360 370 380 390
VLPGDNTSIT VELIAPIACE KGSKFSIREG GRTVGAGSVT EVLE
Length:394
Mass (Da):43,149
Last modified:November 1, 1997 - v2
Checksum:i32818DA027954BD8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12 – 13HV → QL in CAA39292 (PubMed:2126326).Curated2
Sequence conflicti65S → I in CAA39292 (PubMed:2126326).Curated1
Sequence conflicti122L → V in CAA39292 (PubMed:2126326).Curated1
Sequence conflicti136N → F in CAA39292 (PubMed:2126326).Curated1
Sequence conflicti198 – 209EWIPT…REVDK → DGFQLLNVKWTN in CAA39292 (PubMed:2126326).CuratedAdd BLAST12
Sequence conflicti265E → V in CAA39292 (PubMed:2126326).Curated1
Sequence conflicti360T → S in CAA39292 (PubMed:2126326).Curated1
Sequence conflicti391 – 394EVLE → KCLNSESRILSWLC in CAA39292 (PubMed:2126326).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55768 Genomic DNA Translation: CAA39292.1
U00089 Genomic DNA Translation: AAB95825.1
PIRiS73503
RefSeqiNP_110354.1, NC_000912.1
WP_010875022.1, NC_000912.1

Genome annotation databases

EnsemblBacteriaiAAB95825; AAB95825; MPN_665
GeneIDi877030
KEGGimpn:MPN665
PATRICifig|272634.6.peg.730

Similar proteinsi

Entry informationi

Entry nameiEFTU_MYCPN
AccessioniPrimary (citable) accession number: P23568
Secondary accession number(s): P75126
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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