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P23568 (EFTU_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Elongation factor Tu
Short name=EF-Tu
Gene names
Name:tuf
Ordered Locus Names:MPN_665
ORF Names:MP177
OrganismMycoplasma pneumoniae (strain ATCC 29342 / M129) [Reference proteome] [HAMAP]
Taxonomic identifier272634 [NCBI]
Taxonomic lineageBacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma ›

Protein attributes

Sequence length394 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis By similarity. HAMAP-Rule MF_00118_B

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Molecular functionElongation factor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processGTP catabolic process

Inferred from electronic annotation. Source: GOC

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: HAMAP

GTPase activity

Inferred from electronic annotation. Source: InterPro

translation elongation factor activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 394394Elongation factor Tu HAMAP-Rule MF_00118_B
PRO_0000091350

Regions

Nucleotide binding19 – 268GTP By similarity
Nucleotide binding81 – 855GTP By similarity
Nucleotide binding136 – 1394GTP By similarity

Experimental info

Sequence conflict12 – 132HV → QL in CAA39292. Ref.1
Sequence conflict651S → I in CAA39292. Ref.1
Sequence conflict1221L → V in CAA39292. Ref.1
Sequence conflict1361N → F in CAA39292. Ref.1
Sequence conflict198 – 20912EWIPT…REVDK → DGFQLLNVKWTN in CAA39292. Ref.1
Sequence conflict2651E → V in CAA39292. Ref.1
Sequence conflict3601T → S in CAA39292. Ref.1
Sequence conflict391 – 3944EVLE → KCLNSESRILSWLC in CAA39292. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P23568 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 32818DA027954BD8

FASTA39443,149
        10         20         30         40         50         60 
MAREKFDRSK PHVNVGTIGH IDHGKTTLTA AICTVLAKEG KSAATRYDQI DKAPEEKARG 

        70         80         90        100        110        120 
ITINSAHVEY SSDKRHYAHV DCPGHADYIK NMITGAAQMD GAILVVSATD SVMPQTREHI 

       130        140        150        160        170        180 
LLARQVGVPR MVVFLNKCDI ATDEEVQELV AEEVRDLLTS YGFDGKNTPI IYGSALKALE 

       190        200        210        220        230        240 
GDPKWEAKIH DLMNAVDEWI PTPEREVDKP FLLAIEDTMT ITGRGTVVTG RVERGELKVG 

       250        260        270        280        290        300 
QEIEIVGLRP IRKAVVTGIE MFKKELDSAM AGDNAGVLLR GVDRKEVERG QVLAKPGSIK 

       310        320        330        340        350        360 
PHKKFKAEIY ALKKEEGGRH TGFLNGYRPQ FYFRTTDVTG SISLPENTEM VLPGDNTSIT 

       370        380        390 
VELIAPIACE KGSKFSIREG GRTVGAGSVT EVLE

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence and codon usage of the elongation factor Tu(EF-Tu) gene from Mycoplasma pneumoniae."
Yogev D., Sela S., Bercovier H., Razin S.
Mol. Microbiol. 4:1303-1310(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29342 / M129.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X55768 Genomic DNA. Translation: CAA39292.1.
U00089 Genomic DNA. Translation: AAB95825.1.
PIRS73503.
RefSeqNP_110354.1. NC_000912.1.

3D structure databases

ProteinModelPortalP23568.
SMRP23568. Positions 2-393.
ModBaseSearch...

Protein-protein interaction databases

IntActP23568. 21 interactions.
STRING272634.MPN665.

PTM databases

PhosSiteP10111004.

Proteomic databases

PaxDbP23568.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB95825; AAB95825; MPN_665.
GeneID877030.
KEGGmpn:MPN665.
PATRIC20022815. VBIMycPne110_0730.

Phylogenomic databases

eggNOGCOG0050.
KOK02358.
OMAANQMECA.
ProtClustDBPRK12736.

Enzyme and pathway databases

BioCycMPNE272634:GJ6Z-711-MONOMER.

Family and domain databases

HAMAPMF_00118_B. EF_Tu_B.
InterProIPR000795. EF_GTP-bd_dom.
IPR005225. Small_GTP-bd_dom.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
IPR009000. Transl_elong_init/rib_B-barrel.
[Graphical view]
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSPR00315. ELONGATNFCT.
SUPFAMSSF50465. Elong_init_C. 1 hit.
SSF50447. Translat_factor. 1 hit.
TIGRFAMsTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameEFTU_MYCPN
AccessionPrimary (citable) accession number: P23568
Secondary accession number(s): P75126
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1997
Last modified: May 1, 2013
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Mycoplasma pneumoniae

Mycoplasma pneumoniae (strain M129): entries and gene names

SIMILARITY comments

Index of protein domains and families

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