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P23568

- EFTU_MYCPN

UniProt

P23568 - EFTU_MYCPN

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Protein
Elongation factor Tu
Gene
tuf, MPN_665, MP177
Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 268GTP By similarity
Nucleotide bindingi81 – 855GTP By similarity
Nucleotide bindingi136 – 1394GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. GTPase activity Source: InterPro
  3. translation elongation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-711-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor Tu
Short name:
EF-Tu
Gene namesi
Name:tuf
Ordered Locus Names:MPN_665
ORF Names:MP177
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Elongation factor TuUniRule annotation
PRO_0000091350Add
BLAST

Proteomic databases

PaxDbiP23568.

PTM databases

PhosSiteiP10111004.

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

IntActiP23568. 21 interactions.
STRINGi272634.MPN665.

Structurei

3D structure databases

ProteinModelPortaliP23568.
SMRiP23568. Positions 2-393.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 204195tr-type G
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 268G1 By similarity
Regioni60 – 645G2 By similarity
Regioni81 – 844G3 By similarity
Regioni136 – 1394G4 By similarity
Regioni174 – 1763G5 By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0050.
KOiK02358.
OMAiERKPHIN.
OrthoDBiEOG6R5C6X.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23568-1 [UniParc]FASTAAdd to Basket

« Hide

MAREKFDRSK PHVNVGTIGH IDHGKTTLTA AICTVLAKEG KSAATRYDQI    50
DKAPEEKARG ITINSAHVEY SSDKRHYAHV DCPGHADYIK NMITGAAQMD 100
GAILVVSATD SVMPQTREHI LLARQVGVPR MVVFLNKCDI ATDEEVQELV 150
AEEVRDLLTS YGFDGKNTPI IYGSALKALE GDPKWEAKIH DLMNAVDEWI 200
PTPEREVDKP FLLAIEDTMT ITGRGTVVTG RVERGELKVG QEIEIVGLRP 250
IRKAVVTGIE MFKKELDSAM AGDNAGVLLR GVDRKEVERG QVLAKPGSIK 300
PHKKFKAEIY ALKKEEGGRH TGFLNGYRPQ FYFRTTDVTG SISLPENTEM 350
VLPGDNTSIT VELIAPIACE KGSKFSIREG GRTVGAGSVT EVLE 394
Length:394
Mass (Da):43,149
Last modified:November 1, 1997 - v2
Checksum:i32818DA027954BD8
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 132HV → QL in CAA39292. 1 Publication
Sequence conflicti65 – 651S → I in CAA39292. 1 Publication
Sequence conflicti122 – 1221L → V in CAA39292. 1 Publication
Sequence conflicti136 – 1361N → F in CAA39292. 1 Publication
Sequence conflicti198 – 20912EWIPT…REVDK → DGFQLLNVKWTN in CAA39292. 1 Publication
Add
BLAST
Sequence conflicti265 – 2651E → V in CAA39292. 1 Publication
Sequence conflicti360 – 3601T → S in CAA39292. 1 Publication
Sequence conflicti391 – 3944EVLE → KCLNSESRILSWLC in CAA39292. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55768 Genomic DNA. Translation: CAA39292.1.
U00089 Genomic DNA. Translation: AAB95825.1.
PIRiS73503.
RefSeqiNP_110354.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB95825; AAB95825; MPN_665.
GeneIDi877030.
KEGGimpn:MPN665.
PATRICi20022815. VBIMycPne110_0730.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55768 Genomic DNA. Translation: CAA39292.1 .
U00089 Genomic DNA. Translation: AAB95825.1 .
PIRi S73503.
RefSeqi NP_110354.1. NC_000912.1.

3D structure databases

ProteinModelPortali P23568.
SMRi P23568. Positions 2-393.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P23568. 21 interactions.
STRINGi 272634.MPN665.

PTM databases

PhosSitei P10111004.

Proteomic databases

PaxDbi P23568.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB95825 ; AAB95825 ; MPN_665 .
GeneIDi 877030.
KEGGi mpn:MPN665.
PATRICi 20022815. VBIMycPne110_0730.

Phylogenomic databases

eggNOGi COG0050.
KOi K02358.
OMAi ERKPHIN.
OrthoDBi EOG6R5C6X.

Enzyme and pathway databases

BioCyci MPNE272634:GJ6Z-711-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00118_B. EF_Tu_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view ]
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence and codon usage of the elongation factor Tu(EF-Tu) gene from Mycoplasma pneumoniae."
    Yogev D., Sela S., Bercovier H., Razin S.
    Mol. Microbiol. 4:1303-1310(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiEFTU_MYCPN
AccessioniPrimary (citable) accession number: P23568
Secondary accession number(s): P75126
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi