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P23568

- EFTU_MYCPN

UniProt

P23568 - EFTU_MYCPN

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Protein

Elongation factor Tu

Gene

tuf

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 268GTPUniRule annotation
Nucleotide bindingi81 – 855GTPUniRule annotation
Nucleotide bindingi136 – 1394GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-HAMAP
  3. translation elongation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-711-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor TuUniRule annotation
Short name:
EF-TuUniRule annotation
Gene namesi
Name:tufUniRule annotation
Ordered Locus Names:MPN_665
ORF Names:MP177
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Elongation factor TuPRO_0000091350Add
BLAST

Proteomic databases

PaxDbiP23568.

PTM databases

PhosSiteiP10111004.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

IntActiP23568. 21 interactions.
STRINGi272634.MPN665.

Structurei

3D structure databases

ProteinModelPortaliP23568.
SMRiP23568. Positions 2-393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 204195tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 268G1By similarity
Regioni60 – 645G2By similarity
Regioni81 – 844G3By similarity
Regioni136 – 1394G4By similarity
Regioni174 – 1763G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0050.
KOiK02358.
OMAiERKPHIN.
OrthoDBiEOG6R5C6X.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23568-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAREKFDRSK PHVNVGTIGH IDHGKTTLTA AICTVLAKEG KSAATRYDQI
60 70 80 90 100
DKAPEEKARG ITINSAHVEY SSDKRHYAHV DCPGHADYIK NMITGAAQMD
110 120 130 140 150
GAILVVSATD SVMPQTREHI LLARQVGVPR MVVFLNKCDI ATDEEVQELV
160 170 180 190 200
AEEVRDLLTS YGFDGKNTPI IYGSALKALE GDPKWEAKIH DLMNAVDEWI
210 220 230 240 250
PTPEREVDKP FLLAIEDTMT ITGRGTVVTG RVERGELKVG QEIEIVGLRP
260 270 280 290 300
IRKAVVTGIE MFKKELDSAM AGDNAGVLLR GVDRKEVERG QVLAKPGSIK
310 320 330 340 350
PHKKFKAEIY ALKKEEGGRH TGFLNGYRPQ FYFRTTDVTG SISLPENTEM
360 370 380 390
VLPGDNTSIT VELIAPIACE KGSKFSIREG GRTVGAGSVT EVLE
Length:394
Mass (Da):43,149
Last modified:November 1, 1997 - v2
Checksum:i32818DA027954BD8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 132HV → QL in CAA39292. (PubMed:2126326)Curated
Sequence conflicti65 – 651S → I in CAA39292. (PubMed:2126326)Curated
Sequence conflicti122 – 1221L → V in CAA39292. (PubMed:2126326)Curated
Sequence conflicti136 – 1361N → F in CAA39292. (PubMed:2126326)Curated
Sequence conflicti198 – 20912EWIPT…REVDK → DGFQLLNVKWTN in CAA39292. (PubMed:2126326)CuratedAdd
BLAST
Sequence conflicti265 – 2651E → V in CAA39292. (PubMed:2126326)Curated
Sequence conflicti360 – 3601T → S in CAA39292. (PubMed:2126326)Curated
Sequence conflicti391 – 3944EVLE → KCLNSESRILSWLC in CAA39292. (PubMed:2126326)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55768 Genomic DNA. Translation: CAA39292.1.
U00089 Genomic DNA. Translation: AAB95825.1.
PIRiS73503.
RefSeqiNP_110354.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB95825; AAB95825; MPN_665.
GeneIDi877030.
KEGGimpn:MPN665.
PATRICi20022815. VBIMycPne110_0730.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55768 Genomic DNA. Translation: CAA39292.1 .
U00089 Genomic DNA. Translation: AAB95825.1 .
PIRi S73503.
RefSeqi NP_110354.1. NC_000912.1.

3D structure databases

ProteinModelPortali P23568.
SMRi P23568. Positions 2-393.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P23568. 21 interactions.
STRINGi 272634.MPN665.

PTM databases

PhosSitei P10111004.

Proteomic databases

PaxDbi P23568.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB95825 ; AAB95825 ; MPN_665 .
GeneIDi 877030.
KEGGi mpn:MPN665.
PATRICi 20022815. VBIMycPne110_0730.

Phylogenomic databases

eggNOGi COG0050.
KOi K02358.
OMAi ERKPHIN.
OrthoDBi EOG6R5C6X.

Enzyme and pathway databases

BioCyci MPNE272634:GJ6Z-711-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00118_B. EF_Tu_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view ]
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence and codon usage of the elongation factor Tu(EF-Tu) gene from Mycoplasma pneumoniae."
    Yogev D., Sela S., Bercovier H., Razin S.
    Mol. Microbiol. 4:1303-1310(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiEFTU_MYCPN
AccessioniPrimary (citable) accession number: P23568
Secondary accession number(s): P75126
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3