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P23565 (AINX_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alpha-internexin
Short name=Alpha-Inx
Gene names
Name:Ina
Synonyms:Inexa
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length505 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges By similarity.

Developmental stage

Levels of this protein reach a maximum at embryonic day 16 and decline into adulthood.

Post-translational modification

O-glycosylated By similarity.

Sequence similarities

Belongs to the intermediate filament family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 505505Alpha-internexin
PRO_0000063785

Regions

Region1 – 8787Head
Region88 – 408321Rod
Region88 – 12942Coil 1A
Region130 – 14213Linker 1
Region143 – 23896Coil 1B
Region239 – 26224Linker 2
Region263 – 408146Coil 2
Region409 – 50597Tail
Compositional bias449 – 45810Poly-Glu

Amino acid modifications

Modified residue721Phosphoserine By similarity
Modified residue2901N6-acetyllysine By similarity
Modified residue3351Phosphoserine By similarity
Modified residue5021Phosphoserine By similarity

Experimental info

Sequence conflict152 – 1532AQ → GE in CAA36264. Ref.1
Sequence conflict239 – 2424Missing AA sequence Ref.1
Sequence conflict4581Missing AA sequence Ref.1

Sequences

Sequence LengthMass (Da)Tools
P23565 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: 287E548F0DA4D818

FASTA50556,115
        10         20         30         40         50         60 
MSFGSEHYLC SASSYRKVFG DGSRLSARLS GPGASGSFRS QSLSRSNVAS TAACSSASSL 

        70         80         90        100        110        120 
GLGLAYRRLP ASDGLDLSQA AARTNEYKII RTNEKEQLQG LNDRFAVFIE KVHQLETQNR 

       130        140        150        160        170        180 
ALEAELAALR QRHAEPSRVG ELFQRELREL RAQLEEASSA RAQALLERDG LAEEVQRLRA 

       190        200        210        220        230        240 
RCEEESRGRE GAERALKAQQ RDVDGATLAR LDLEKKVESL LDELAFVRQV HDEEVAELLA 

       250        260        270        280        290        300 
TLQASSQAAA EVDVAVAKPD LTSALREIRA QYESLAAKNL QSAEEWYKSK FANLNEQAAR 

       310        320        330        340        350        360 
STEAIRASRE EIHEYRRQLQ ARTIEIEGLR GANESLERQI LELEERHSAE VAGYQDSIGQ 

       370        380        390        400        410        420 
LESDLRNTKS EMARHLREYQ DLLNVKMALD IEIAAYRKLL EGEETRFSTS GLSISGLNPL 

       430        440        450        460        470        480 
PNPSYLLPPR ILSSTTSKVS SAGLSLKKEE EEEEEEEEGA SKEVTKKTSK VGESFEETLE 

       490        500 
ETVVSTKKTE KSTIEEITTS SSQKM

« Hide

References

[1]"The predicted amino acid sequence of alpha-internexin is that of a novel neuronal intermediate filament protein."
Fliegner K.-H., Ching G.Y., Liem R.K.H.
EMBO J. 9:749-755(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Tissue: Brain.
[2]"Structure of the gene for the neuronal intermediate filament protein alpha-internexin and functional analysis of its promoter."
Ching G.Y., Liem R.K.H.
J. Biol. Chem. 266:19459-19468(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]Lubec G., Afjehi-Sadat L., Chen W.-Q., Kang S.U.
Submitted (JUL-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 46-83; 92-104; 121-130; 152-161; 216-228; 270-278; 291-300; 323-330; 339-366; 387-397; 399-430 AND 439-447, MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Brain, Hippocampus and Spinal cord.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X52017 mRNA. Translation: CAA36264.1.
M73049 Genomic DNA. Translation: AAA41444.1.
IPIIPI00211936.
PIRA41023.
RefSeqNP_062001.1. NM_019128.4.
UniGeneRn.88941.

3D structure databases

ProteinModelPortalP23565.
SMRP23565. Positions 92-129, 325-402.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-4589517.
STRING10116.ENSRNOP00000027417.

PTM databases

PhosphoSiteP23565.

2D gel databases

World-2DPAGE0004:P23565.

Proteomic databases

PaxDbP23565.
PRIDEP23565.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID24503.
KEGGrno:24503.
UCSCRGD:2911. rat.

Organism-specific databases

CTD9118.
RGD2911. Ina.

Phylogenomic databases

eggNOGNOG149366.
HOGENOMHOG000230977.
HOVERGENHBG013015.
InParanoidP23565.
KOK07608.
OrthoDBEOG4R5031.

Gene expression databases

GenevestigatorP23565.
GermOnlineENSRNOG00000020248. Rattus norvegicus.

Family and domain databases

InterProIPR016044. F.
IPR001664. IF.
IPR006821. Intermed_filament_DNA-bd.
IPR018039. Intermediate_filament_CS.
[Graphical view]
PANTHERPTHR23239. PTHR23239. 1 hit.
PfamPF00038. Filament. 1 hit.
PF04732. Filament_head. 1 hit.
[Graphical view]
PROSITEPS00226. IF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio603511.

Entry information

Entry nameAINX_RAT
AccessionPrimary (citable) accession number: P23565
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: October 1, 1996
Last modified: April 3, 2013
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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