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Protein

Alpha-internexin

Gene

Ina

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges (By similarity).By similarity

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD
  • structural molecule activity Source: InterPro

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • nervous system development Source: UniProtKB-KW
  • tissue regeneration Source: RGD

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-internexin
Short name:
Alpha-Inx
Gene namesi
Name:Ina
Synonyms:Inexa
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2911 Ina

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000637851 – 505Alpha-internexinAdd BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei72PhosphoserineBy similarity1
Modified residuei219PhosphoserineBy similarity1
Modified residuei290N6-acetyllysineBy similarity1
Modified residuei335PhosphoserineCombined sources1
Modified residuei474PhosphoserineCombined sources1
Modified residuei502PhosphoserineBy similarity1

Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP23565
PRIDEiP23565

2D gel databases

World-2DPAGEi0004:P23565

PTM databases

iPTMnetiP23565
PhosphoSitePlusiP23565

Expressioni

Developmental stagei

Levels of this protein reach a maximum at embryonic day 16 and decline into adulthood.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NsmfQ9EPI65EBI-6899875,EBI-6899705

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

BioGridi246662, 3 interactors
IntActiP23565, 4 interactors
MINTiP23565
STRINGi10116.ENSRNOP00000027417

Structurei

3D structure databases

ProteinModelPortaliP23565
SMRiP23565
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 407IF rodPROSITE-ProRule annotationAdd BLAST314

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 87HeadAdd BLAST87
Regioni88 – 129Coil 1AAdd BLAST42
Regioni130 – 142Linker 1Add BLAST13
Regioni143 – 238Coil 1BAdd BLAST96
Regioni239 – 262Linker 2Add BLAST24
Regioni263 – 408Coil 2Add BLAST146
Regioni409 – 505TailAdd BLAST97

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi449 – 458Poly-Glu10

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGME Eukaryota
ENOG410XPTM LUCA
HOGENOMiHOG000230977
HOVERGENiHBG013015
InParanoidiP23565
PhylomeDBiP23565

Family and domain databases

InterProiView protein in InterPro
IPR027703 Alpha-Inx
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR006821 Intermed_filament_DNA-bd
PANTHERiPTHR23239 PTHR23239, 1 hit
PTHR23239:SF132 PTHR23239:SF132, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF04732 Filament_head, 1 hit
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

P23565-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFGSEHYLC SASSYRKVFG DGSRLSARLS GPGASGSFRS QSLSRSNVAS
60 70 80 90 100
TAACSSASSL GLGLAYRRLP ASDGLDLSQA AARTNEYKII RTNEKEQLQG
110 120 130 140 150
LNDRFAVFIE KVHQLETQNR ALEAELAALR QRHAEPSRVG ELFQRELREL
160 170 180 190 200
RAQLEEASSA RAQALLERDG LAEEVQRLRA RCEEESRGRE GAERALKAQQ
210 220 230 240 250
RDVDGATLAR LDLEKKVESL LDELAFVRQV HDEEVAELLA TLQASSQAAA
260 270 280 290 300
EVDVAVAKPD LTSALREIRA QYESLAAKNL QSAEEWYKSK FANLNEQAAR
310 320 330 340 350
STEAIRASRE EIHEYRRQLQ ARTIEIEGLR GANESLERQI LELEERHSAE
360 370 380 390 400
VAGYQDSIGQ LESDLRNTKS EMARHLREYQ DLLNVKMALD IEIAAYRKLL
410 420 430 440 450
EGEETRFSTS GLSISGLNPL PNPSYLLPPR ILSSTTSKVS SAGLSLKKEE
460 470 480 490 500
EEEEEEEEGA SKEVTKKTSK VGESFEETLE ETVVSTKKTE KSTIEEITTS

SSQKM
Length:505
Mass (Da):56,115
Last modified:October 1, 1996 - v2
Checksum:i287E548F0DA4D818
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152 – 153AQ → GE in CAA36264 (PubMed:2311576).Curated2
Sequence conflicti239 – 242Missing AA sequence (PubMed:2311576).Curated4
Sequence conflicti458Missing AA sequence (PubMed:2311576).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52017 mRNA Translation: CAA36264.1
M73049 Genomic DNA Translation: AAA41444.1
PIRiA41023
UniGeneiRn.88941

Genome annotation databases

UCSCiRGD:2911 rat

Similar proteinsi

Entry informationi

Entry nameiAINX_RAT
AccessioniPrimary (citable) accession number: P23565
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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