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Protein

Endoglucanase B

Gene

celB

Organism
Paenibacillus lautus (Bacillus lautus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei177 – 1771Proton donorBy similarity
Active sitei299 – 2991NucleophileBy similarity

GO - Molecular functioni

  1. cellulase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Protein family/group databases

CAZyiCBM46. Carbohydrate-Binding Module Family 46.
GH5. Glycoside Hydrolase Family 5.

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase B (EC:3.2.1.4)
Alternative name(s):
Cellulase B
Endo-1,4-beta-glucanase B
Short name:
EG-B
Gene namesi
Name:celB
OrganismiPaenibacillus lautus (Bacillus lautus)
Taxonomic identifieri1401 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Add
BLAST
Chaini31 – 566536Endoglucanase BPRO_0000007835Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP23550.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR005102. Carbo-bd_X2.
IPR001547. Glyco_hydro_5.
IPR018087. Glyco_hydro_5_CS.
IPR016282. Glyco_hydro_5_endoGlcnase_B.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view]
PfamiPF03442. CBM_X2. 1 hit.
PF00150. Cellulase. 1 hit.
[Graphical view]
PIRSFiPIRSF001043. Endoglucanase_B. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00659. GLYCOSYL_HYDROL_F5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23550-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKRRSSKVI LSLAIVVALL AAVEPNAALA AAPPSAMQSY VEAMQPGWNL
60 70 80 90 100
GNSLDAVGAD ETLARGNPRI TKELIQNIAA QGYKSIRIPV TWDSHIGAAP
110 120 130 140 150
NYQIEAAYLN RVQEVVQWAL DANLYVMINV HHDSWLWISK MESQHDQVLA
160 170 180 190 200
RYNAIWTQIA NKFKNSPSKL MFESVNEPRF TDGGTTDEAK QQKMLDELNV
210 220 230 240 250
SFFNIVRNSG GQNATRPLVL STLEASPTQE RMTALYNTMT KLNDKNLIAT
260 270 280 290 300
VHFYGFWPFS VNIAGYTKFD AETQNDIITT FDNVYNTFVA KGIPVVVGEY
310 320 330 340 350
GLLGFDKNTG VIEQGEKLKF FEFFAQYVKQ KSISTMLWDN GQHFNRTSFK
360 370 380 390 400
WSDPDLFNMI KASWTGRSST ASSDLIHVKQ GTAVKDTSVQ LNLNGNTLTS
410 420 430 440 450
LSVNGTTLKS GTDYTLNSSR LTFKASQLTK LTSLGKLGVN ATIVTKFNRG
460 470 480 490 500
ADWKFNVVLY NTPKLSSTTG TTSSFAIPTA FNGDQLATME AVYVNGGNAG
510 520 530 540 550
PHNWTSFKEF ETTFSPAYSE GKIKLQQAFF NEVNDTTVTL KFQFWSGEIV
560
NYTIKKSGST VTGTAS
Length:566
Mass (Da):62,622
Last modified:November 1, 1991 - v1
Checksum:i6426C8D8E29022C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33762 Genomic DNA. Translation: AAA22408.1.
PIRiJH0218.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33762 Genomic DNA. Translation: AAA22408.1.
PIRiJH0218.

3D structure databases

ProteinModelPortaliP23550.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiCBM46. Carbohydrate-Binding Module Family 46.
GH5. Glycoside Hydrolase Family 5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR005102. Carbo-bd_X2.
IPR001547. Glyco_hydro_5.
IPR018087. Glyco_hydro_5_CS.
IPR016282. Glyco_hydro_5_endoGlcnase_B.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view]
PfamiPF03442. CBM_X2. 1 hit.
PF00150. Cellulase. 1 hit.
[Graphical view]
PIRSFiPIRSF001043. Endoglucanase_B. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00659. GLYCOSYL_HYDROL_F5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Multiple endo-beta-1,4-glucanase-encoding genes from Bacillus lautus PL236 and characterization of the celB gene."
    Joergensen P.L., Hansen C.K.
    Gene 93:55-60(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: PL236.

Entry informationi

Entry nameiGUNB_PAELA
AccessioniPrimary (citable) accession number: P23550
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: October 1, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.