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Protein

Apolipoprotein E

Gene

APOE

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding
Biological processLipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein E
Short name:
Apo-E
Gene namesi
Name:APOE
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chylomicron, HDL, Secreted, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000000198519 – 298Apolipoprotein EAdd BLAST280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei137Methionine sulfoxideBy similarity1
Modified residuei141PhosphoserineBy similarity1
Glycosylationi291O-linked (GalNAc...) threonineBy similarity1
Glycosylationi292O-linked (GalNAc...) serineBy similarity1

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Glycoprotein, Oxidation, Phosphoprotein

Expressioni

Tissue specificityi

Secreted in plasma.

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000006519.

Structurei

3D structure databases

ProteinModelPortaliP23529.
SMRiP23529.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati74 – 951Add BLAST22
Repeati96 – 1172Add BLAST22
Repeati118 – 1393Add BLAST22
Repeati140 – 1614Add BLAST22
Repeati162 – 1835Add BLAST22
Repeati184 – 2046Add BLAST21
Repeati205 – 2227Add BLAST18
Repeati223 – 2448Add BLAST22

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni74 – 2448 X 22 AA approximate tandem repeatsAdd BLAST171
Regioni152 – 162LDL receptor bindingBy similarityAdd BLAST11
Regioni156 – 159Heparin-bindingBy similarity4
Regioni218 – 225Heparin-bindingBy similarity8

Sequence similaritiesi

Belongs to the apolipoprotein A1/A4/E family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IVK0. Eukaryota.
ENOG4111MYC. LUCA.
HOGENOMiHOG000034006.
HOVERGENiHBG010582.
InParanoidiP23529.

Family and domain databases

InterProiView protein in InterPro
IPR000074. ApoA_E.
PfamiView protein in Pfam
PF01442. Apolipoprotein. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23529-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLWAALVV TLLAGCRADV EPEVEVREPA VWQSGQPWEL ALSRFWDYLR
60 70 80 90 100
WVQTLSDQVQ EELLSNQVTQ ELTLLIEDTM KEVKAYKAEL EKELGPVAED
110 120 130 140 150
TKARLAKELQ AAQARLGADM EEVRNRLSQY RSEVQAMLGQ SSEELRARLT
160 170 180 190 200
SHPRKMKRRL QRDIDELQKR MAVYKAGAQE GAERGVSAIR ERLGSLIEQG
210 220 230 240 250
RLQALASQPL QERAQAWGEQ MRGRLEKVGS QARDRLEEVR EQMEEVRVKV
260 270 280 290
EEQAEAFQAR LKSWFEPMME DMRRQWAELI QKVQVAVGAS TSAPSQEP
Length:298
Mass (Da):34,211
Last modified:November 1, 1991 - v1
Checksum:i2B74C1A7F59FD70B
GO

Sequence databases

PIRiS12635.

Similar proteinsi

Entry informationi

Entry nameiAPOE_CAVPO
AccessioniPrimary (citable) accession number: P23529
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: May 10, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families