Reviewed, UniProtKB/Swiss-Prot P23524 (GLXK2_ECOLI)

Names and origin

Protein names

Recommended name:
    Glycerate kinase 2
    EC=2.7.1.31

Gene names

Name:	garK
Synonyms:	yhaD
Ordered Locus Names:	b3124, JW3093

Organism

Escherichia coli (strain K12) [Complete proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	ATP + (R)-glycerate = ADP + 3-phospho-(R)-glycerate.
Sequence similarities	Belongs to the glycerate kinase type-1 family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	organic acid phosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glycerate kinase activity Inferred from electronic annotation. Source: EC protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
rsgA	P39286	1	EBI-562100,EBI-562672

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 381	381	Glycerate kinase 2		PRO_0000071532

Sequences

	Sequence		Length	Mass (Da)
	P23524-1 [UniParc]. Last modified December 15, 1998. Version 2. Checksum: 0A048E2E5F9FBE32	FASTA	381	39,104
	10 20 30 40 50 60 MKIVIAPDSY KESLSASEVA QAIEKGFREI FPDAQYVSVP VADGGEGTVE AMIAATQGAE 70 80 90 100 110 120 RHAWVTGPLG EKVNASWGIS GDGKTAFIEM AAASGLELVP AEKRDPLVTT SRGTGELILQ 130 140 150 160 170 180 ALESGATNII IGIGGSATND GGAGMVQALG AKLCDANGNE IGFGGGSLNT LNDIDISGLD 190 200 210 220 230 240 PRLKDCVIRV ACDVTNPLVG DNGASRIFGP QKGASEAMIV ELDNNLSHYA EVIKKALHVD 250 260 270 280 290 300 VKDVPGAGAA GGMGAALMAF LGAELKSGIE IVTTALNLEE HIHDCTLVIT GEGRIDSQSI 310 320 330 340 350 360 HGKVPIGVAN VAKKYHKPVI GIAGSLTDDV GVVHQHGIDA VFSVLTSIGT LDEAFRGAYD 370 380 NICRASRNIA ATLAIGMRNA G

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Precise mapping of the rnpB gene encoding the RNA component of RNase P in Escherichia coli K-12." Komine Y., Inokuchi H. J. Bacteriol. 173:1813-1816(1991) [PubMed: 1705543] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D90212 Genomic DNA. Translation: BAA14239.1. Different initiation. U18997 Genomic DNA. Translation: AAA57927.1. Different initiation. U00096 Genomic DNA. Translation: AAC76158.2. AP009048 Genomic DNA. Translation: BAE77171.1. Different initiation.
PIR	JQ0614.
RefSeq	AP_003670.1. NP_417593.4.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:28063N.
IntAct	P23524. 7 interactions.
Genome annotation databases
GeneID	947632.
GenomeReviews	Gene locus JW3093 in contig AP009048_GR. Gene locus b3124 in contig U00096_GR.
KEGG	ecj:JW3093. eco:b3124.
Organism-specific databases
EchoBASE	EB1162.
EcoGene	EG11175. garK.
CMR	Search...
Phylogenomic databases
HOGENOM	P23524.
OMA	P23524. TVDAIRH.
Enzyme and pathway databases
BioCyc	EcoCyc:GKI-MON. MetaCyc:GKI-MON.
Family and domain databases
InterPro	IPR018193. Glyc_kinase_flavodox-like-dom. IPR004381. Glycerate_kinase. [Graphical view]
Gene3D	G3DSA:3.90.1510.10. Glyc_kinase. 1 hit.
PANTHER	PTHR21599. Glyc_kinase. 1 hit.
Pfam	PF02595. Gly_kinase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00045. Glyc_kinase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GLXK2_ECOLI

Accession

Primary (citable) accession number: P23524
Secondary accession number(s): Q2M985

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	December 15, 1998
Last modified:	June 16, 2009
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)