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Protein

Oligodendrocyte-myelin glycoprotein

Gene

OMG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126861-MONOMER.
ReactomeiR-HSA-193634. Axonal growth inhibition (RHOA activation).
SIGNORiP23515.

Names & Taxonomyi

Protein namesi
Recommended name:
Oligodendrocyte-myelin glycoprotein
Gene namesi
Name:OMG
Synonyms:OMGP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:8135. OMG.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4974.
OpenTargetsiENSG00000126861.
PharmGKBiPA31922.

Polymorphism and mutation databases

BioMutaiOMG.
DMDMi129122.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000002188825 – 417Oligodendrocyte-myelin glycoproteinAdd BLAST393
PropeptideiPRO_0000021889418 – 440Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...)Sequence analysis1
Glycosylationi61N-linked (GlcNAc...)Sequence analysis1
Glycosylationi103N-linked (GlcNAc...)Sequence analysis1
Glycosylationi152N-linked (GlcNAc...)Sequence analysis1
Glycosylationi176N-linked (GlcNAc...)Sequence analysis1
Glycosylationi189N-linked (GlcNAc...)Sequence analysis1
Glycosylationi192N-linked (GlcNAc...)Sequence analysis1
Glycosylationi234N-linked (GlcNAc...)Sequence analysis1
Glycosylationi364N-linked (GlcNAc...)Sequence analysis1
Glycosylationi389N-linked (GlcNAc...)Sequence analysis1
Lipidationi417GPI-anchor amidated serineSequence analysis1
Glycosylationi425N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

O-glycosylated in its Ser/Thr-rich repeat domain.Curated

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiP23515.
PaxDbiP23515.
PeptideAtlasiP23515.
PRIDEiP23515.
TopDownProteomicsiP23515.

PTM databases

iPTMnetiP23515.
PhosphoSitePlusiP23515.

Expressioni

Tissue specificityi

Oligodendrocytes and myelin of the central nervous system.

Gene expression databases

BgeeiENSG00000126861.
CleanExiHS_OMG.
GenevisibleiP23515. HS.

Organism-specific databases

HPAiHPA008206.
HPA012693.

Interactioni

Subunit structurei

Binds to RTN4R.By similarity

Protein-protein interaction databases

BioGridi111022. 1 interactor.
STRINGi9606.ENSP00000247271.

Structurei

3D structure databases

ProteinModelPortaliP23515.
SMRiP23515.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 55LRRNTAdd BLAST31
Repeati56 – 77LRR 1Add BLAST22
Repeati79 – 100LRR 2Add BLAST22
Repeati101 – 121LRR 3Add BLAST21
Repeati124 – 145LRR 4Add BLAST22
Repeati147 – 168LRR 5Add BLAST22
Repeati169 – 189LRR 6Add BLAST21
Repeati192 – 213LRR 7Add BLAST22
Repeati216 – 239LRR 8Add BLAST24
Repeati229 – 270Ser/Thr-richAdd BLAST42
Repeati271 – 292Ser/Thr-richAdd BLAST22
Repeati293 – 335Ser/Thr-richAdd BLAST43
Repeati336 – 377Ser/Thr-richAdd BLAST42
Repeati378 – 416Ser/Thr-richAdd BLAST39

Sequence similaritiesi

Contains 8 LRR (leucine-rich) repeats.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00780000122040.
HOGENOMiHOG000115267.
HOVERGENiHBG007868.
InParanoidiP23515.
KOiK16666.
OMAiATLTIHL.
OrthoDBiEOG091G08JZ.
PhylomeDBiP23515.
TreeFamiTF335688.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 5 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23515-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYQILKMSL CLFILLFLTP GILCICPLQC ICTERHRHVD CSGRNLSTLP
60 70 80 90 100
SGLQENIIHL NLSYNHFTDL HNQLTQYTNL RTLDISNNRL ESLPAHLPRS
110 120 130 140 150
LWNMSAANNN IKLLDKSDTA YQWNLKYLDV SKNMLEKVVL IKNTLRSLEV
160 170 180 190 200
LNLSSNKLWT VPTNMPSKLH IVDLSNNSLT QILPGTLINL TNLTHLYLHN
210 220 230 240 250
NKFTFIPDQS FDQLFQLQEI TLYNNRWSCD HKQNITYLLK WMMETKAHVI
260 270 280 290 300
GTPCSTQISS LKEHNMYPTP SGFTSSLFTV SGMQTVDTIN SLSVVTQPKV
310 320 330 340 350
TKIPKQYRTK ETTFGATLSK DTTFTSTDKA FVPYPEDTST ETINSHEAAA
360 370 380 390 400
ATLTIHLQDG MVTNTSLTSS TKSSPTPMTL SITSGMPNNF SEMPQQSTTL
410 420 430 440
NLWREETTTN VKTPLPSVAN AWKVNASFLL LLNVVVMLAV
Length:440
Mass (Da):49,608
Last modified:May 1, 1992 - v2
Checksum:i762FD0E8905EA050
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05125221G → D.Corresponds to variant rs11080149dbSNPEnsembl.1
Natural variantiVAR_051253435V → A.Corresponds to variant rs16972169dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63623 mRNA. Translation: AAA59970.1. Sequence problems.
X57436 Genomic DNA. Translation: CAA40684.1.
X51694 mRNA. Translation: CAA35991.1. Sequence problems.
CH471147 Genomic DNA. Translation: EAW80279.1.
CH471147 Genomic DNA. Translation: EAW80280.1.
BC018050 mRNA. Translation: AAH18050.1.
CCDSiCCDS11265.1.
PIRiA36688. A39613.
RefSeqiNP_002535.3. NM_002544.4.
UniGeneiHs.113874.

Genome annotation databases

EnsembliENST00000247271; ENSP00000247271; ENSG00000126861.
GeneIDi4974.
KEGGihsa:4974.
UCSCiuc002hgj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63623 mRNA. Translation: AAA59970.1. Sequence problems.
X57436 Genomic DNA. Translation: CAA40684.1.
X51694 mRNA. Translation: CAA35991.1. Sequence problems.
CH471147 Genomic DNA. Translation: EAW80279.1.
CH471147 Genomic DNA. Translation: EAW80280.1.
BC018050 mRNA. Translation: AAH18050.1.
CCDSiCCDS11265.1.
PIRiA36688. A39613.
RefSeqiNP_002535.3. NM_002544.4.
UniGeneiHs.113874.

3D structure databases

ProteinModelPortaliP23515.
SMRiP23515.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111022. 1 interactor.
STRINGi9606.ENSP00000247271.

PTM databases

iPTMnetiP23515.
PhosphoSitePlusiP23515.

Polymorphism and mutation databases

BioMutaiOMG.
DMDMi129122.

Proteomic databases

MaxQBiP23515.
PaxDbiP23515.
PeptideAtlasiP23515.
PRIDEiP23515.
TopDownProteomicsiP23515.

Protocols and materials databases

DNASUi4974.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000247271; ENSP00000247271; ENSG00000126861.
GeneIDi4974.
KEGGihsa:4974.
UCSCiuc002hgj.4. human.

Organism-specific databases

CTDi4974.
DisGeNETi4974.
GeneCardsiOMG.
HGNCiHGNC:8135. OMG.
HPAiHPA008206.
HPA012693.
MIMi164345. gene.
neXtProtiNX_P23515.
OpenTargetsiENSG00000126861.
PharmGKBiPA31922.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00780000122040.
HOGENOMiHOG000115267.
HOVERGENiHBG007868.
InParanoidiP23515.
KOiK16666.
OMAiATLTIHL.
OrthoDBiEOG091G08JZ.
PhylomeDBiP23515.
TreeFamiTF335688.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126861-MONOMER.
ReactomeiR-HSA-193634. Axonal growth inhibition (RHOA activation).
SIGNORiP23515.

Miscellaneous databases

GeneWikiiOMG_(gene).
GenomeRNAii4974.
PROiP23515.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126861.
CleanExiHS_OMG.
GenevisibleiP23515. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 5 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOMGP_HUMAN
AccessioniPrimary (citable) accession number: P23515
Secondary accession number(s): E1P659
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: May 1, 1992
Last modified: November 2, 2016
This is version 160 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Do not confuse oligodendrocyte-myelin glycoprotein (OMG) with myelin-oligodendrocyte glycoprotein (MOG).Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.