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Protein

Oligodendrocyte-myelin glycoprotein

Gene

OMG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-193634. Axonal growth inhibition (RHOA activation).
SIGNORiP23515.

Names & Taxonomyi

Protein namesi
Recommended name:
Oligodendrocyte-myelin glycoprotein
Gene namesi
Name:OMG
Synonyms:OMGP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:8135. OMG.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31922.

Polymorphism and mutation databases

BioMutaiOMG.
DMDMi129122.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 PublicationAdd
BLAST
Chaini25 – 417393Oligodendrocyte-myelin glycoproteinPRO_0000021888Add
BLAST
Propeptidei418 – 44023Removed in mature formSequence analysisPRO_0000021889Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi45 – 451N-linked (GlcNAc...)Sequence analysis
Glycosylationi61 – 611N-linked (GlcNAc...)Sequence analysis
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence analysis
Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence analysis
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence analysis
Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence analysis
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence analysis
Glycosylationi234 – 2341N-linked (GlcNAc...)Sequence analysis
Glycosylationi364 – 3641N-linked (GlcNAc...)Sequence analysis
Glycosylationi389 – 3891N-linked (GlcNAc...)Sequence analysis
Lipidationi417 – 4171GPI-anchor amidated serineSequence analysis
Glycosylationi425 – 4251N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

O-glycosylated in its Ser/Thr-rich repeat domain.Curated

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiP23515.
MaxQBiP23515.
PaxDbiP23515.
PeptideAtlasiP23515.
PRIDEiP23515.
TopDownProteomicsiP23515.

PTM databases

iPTMnetiP23515.
PhosphoSiteiP23515.

Expressioni

Tissue specificityi

Oligodendrocytes and myelin of the central nervous system.

Gene expression databases

BgeeiP23515.
CleanExiHS_OMG.
GenevisibleiP23515. HS.

Organism-specific databases

HPAiHPA008206.
HPA012693.

Interactioni

Subunit structurei

Binds to RTN4R.By similarity

Protein-protein interaction databases

BioGridi111022. 1 interaction.
STRINGi9606.ENSP00000247271.

Structurei

3D structure databases

ProteinModelPortaliP23515.
SMRiP23515. Positions 30-284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 5531LRRNTAdd
BLAST
Repeati56 – 7722LRR 1Add
BLAST
Repeati79 – 10022LRR 2Add
BLAST
Repeati101 – 12121LRR 3Add
BLAST
Repeati124 – 14522LRR 4Add
BLAST
Repeati147 – 16822LRR 5Add
BLAST
Repeati169 – 18921LRR 6Add
BLAST
Repeati192 – 21322LRR 7Add
BLAST
Repeati216 – 23924LRR 8Add
BLAST
Repeati229 – 27042Ser/Thr-richAdd
BLAST
Repeati271 – 29222Ser/Thr-richAdd
BLAST
Repeati293 – 33543Ser/Thr-richAdd
BLAST
Repeati336 – 37742Ser/Thr-richAdd
BLAST
Repeati378 – 41639Ser/Thr-richAdd
BLAST

Sequence similaritiesi

Contains 8 LRR (leucine-rich) repeats.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00780000122040.
HOGENOMiHOG000115267.
HOVERGENiHBG007868.
InParanoidiP23515.
KOiK16666.
OMAiATLTIHL.
OrthoDBiEOG7MD4QG.
PhylomeDBiP23515.
TreeFamiTF335688.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 5 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23515-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYQILKMSL CLFILLFLTP GILCICPLQC ICTERHRHVD CSGRNLSTLP
60 70 80 90 100
SGLQENIIHL NLSYNHFTDL HNQLTQYTNL RTLDISNNRL ESLPAHLPRS
110 120 130 140 150
LWNMSAANNN IKLLDKSDTA YQWNLKYLDV SKNMLEKVVL IKNTLRSLEV
160 170 180 190 200
LNLSSNKLWT VPTNMPSKLH IVDLSNNSLT QILPGTLINL TNLTHLYLHN
210 220 230 240 250
NKFTFIPDQS FDQLFQLQEI TLYNNRWSCD HKQNITYLLK WMMETKAHVI
260 270 280 290 300
GTPCSTQISS LKEHNMYPTP SGFTSSLFTV SGMQTVDTIN SLSVVTQPKV
310 320 330 340 350
TKIPKQYRTK ETTFGATLSK DTTFTSTDKA FVPYPEDTST ETINSHEAAA
360 370 380 390 400
ATLTIHLQDG MVTNTSLTSS TKSSPTPMTL SITSGMPNNF SEMPQQSTTL
410 420 430 440
NLWREETTTN VKTPLPSVAN AWKVNASFLL LLNVVVMLAV
Length:440
Mass (Da):49,608
Last modified:May 1, 1992 - v2
Checksum:i762FD0E8905EA050
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti21 – 211G → D.
Corresponds to variant rs11080149 [ dbSNP | Ensembl ].
VAR_051252
Natural varianti435 – 4351V → A.
Corresponds to variant rs16972169 [ dbSNP | Ensembl ].
VAR_051253

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63623 mRNA. Translation: AAA59970.1. Sequence problems.
X57436 Genomic DNA. Translation: CAA40684.1.
X51694 mRNA. Translation: CAA35991.1. Sequence problems.
CH471147 Genomic DNA. Translation: EAW80279.1.
CH471147 Genomic DNA. Translation: EAW80280.1.
BC018050 mRNA. Translation: AAH18050.1.
CCDSiCCDS11265.1.
PIRiA36688. A39613.
RefSeqiNP_002535.3. NM_002544.4.
UniGeneiHs.113874.

Genome annotation databases

EnsembliENST00000247271; ENSP00000247271; ENSG00000126861.
GeneIDi4974.
KEGGihsa:4974.
UCSCiuc002hgj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63623 mRNA. Translation: AAA59970.1. Sequence problems.
X57436 Genomic DNA. Translation: CAA40684.1.
X51694 mRNA. Translation: CAA35991.1. Sequence problems.
CH471147 Genomic DNA. Translation: EAW80279.1.
CH471147 Genomic DNA. Translation: EAW80280.1.
BC018050 mRNA. Translation: AAH18050.1.
CCDSiCCDS11265.1.
PIRiA36688. A39613.
RefSeqiNP_002535.3. NM_002544.4.
UniGeneiHs.113874.

3D structure databases

ProteinModelPortaliP23515.
SMRiP23515. Positions 30-284.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111022. 1 interaction.
STRINGi9606.ENSP00000247271.

PTM databases

iPTMnetiP23515.
PhosphoSiteiP23515.

Polymorphism and mutation databases

BioMutaiOMG.
DMDMi129122.

Proteomic databases

EPDiP23515.
MaxQBiP23515.
PaxDbiP23515.
PeptideAtlasiP23515.
PRIDEiP23515.
TopDownProteomicsiP23515.

Protocols and materials databases

DNASUi4974.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000247271; ENSP00000247271; ENSG00000126861.
GeneIDi4974.
KEGGihsa:4974.
UCSCiuc002hgj.4. human.

Organism-specific databases

CTDi4974.
GeneCardsiOMG.
HGNCiHGNC:8135. OMG.
HPAiHPA008206.
HPA012693.
MIMi164345. gene.
neXtProtiNX_P23515.
PharmGKBiPA31922.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00780000122040.
HOGENOMiHOG000115267.
HOVERGENiHBG007868.
InParanoidiP23515.
KOiK16666.
OMAiATLTIHL.
OrthoDBiEOG7MD4QG.
PhylomeDBiP23515.
TreeFamiTF335688.

Enzyme and pathway databases

ReactomeiR-HSA-193634. Axonal growth inhibition (RHOA activation).
SIGNORiP23515.

Miscellaneous databases

GeneWikiiOMG_(gene).
GenomeRNAii4974.
PROiP23515.
SOURCEiSearch...

Gene expression databases

BgeeiP23515.
CleanExiHS_OMG.
GenevisibleiP23515. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 5 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The gene encoding the oligodendrocyte-myelin glycoprotein is embedded within the neurofibromatosis type 1 gene."
    Viskochil D., Cawthon R.M., O'Connell P., Xu G., Stevens J., Culver M., Carey J., White R.
    Mol. Cell. Biol. 11:906-912(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The oligodendrocyte-myelin glycoprotein belongs to a distinct family of proteins and contains the HNK-1 carbohydrate."
    Mikol D.D., Gulcher J., Stefansson K.
    J. Cell Biol. 110:471-479(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Structure and chromosomal localization of the gene for the oligodendrocyte-myelin glycoprotein."
    Mikol D.D., Alexakos M.J., Bayley C.A., Lemons R.S., le Beau M.M., Stefansson K.
    J. Cell Biol. 111:2673-2679(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "A phosphatidylinositol-linked peanut agglutinin-binding glycoprotein in central nervous system myelin and on oligodendrocytes."
    Mikol D.D., Stefansson K.
    J. Cell Biol. 106:1273-1279(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-52.

Entry informationi

Entry nameiOMGP_HUMAN
AccessioniPrimary (citable) accession number: P23515
Secondary accession number(s): E1P659
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: May 1, 1992
Last modified: July 6, 2016
This is version 157 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Do not confuse oligodendrocyte-myelin glycoprotein (OMG) with myelin-oligodendrocyte glycoprotein (MOG).Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.