Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tumor necrosis factor ligand superfamily member 4

Gene

TNFSF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.

GO - Molecular functioni

  1. receptor binding Source: ProtInc
  2. tumor necrosis factor receptor superfamily binding Source: BHF-UCL

GO - Biological processi

  1. acute inflammatory response Source: BHF-UCL
  2. CD4-positive, alpha-beta T cell costimulation Source: Ensembl
  3. cellular response to lipopolysaccharide Source: BHF-UCL
  4. cellular response to nitrogen dioxide Source: Ensembl
  5. cellular response to prostaglandin E stimulus Source: BHF-UCL
  6. chemokine (C-C motif) ligand 11 production Source: BHF-UCL
  7. cholesterol metabolic process Source: Ensembl
  8. defense response to nematode Source: BHF-UCL
  9. immune response Source: InterPro
  10. memory T cell activation Source: BHF-UCL
  11. negative regulation of cytokine secretion Source: Ensembl
  12. negative regulation of interferon-gamma production Source: BHF-UCL
  13. negative regulation of interleukin-17 production Source: BHF-UCL
  14. negative regulation of regulatory T cell differentiation Source: BHF-UCL
  15. negative regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  16. negative regulation of T-helper 1 cell differentiation Source: BHF-UCL
  17. negative regulation of transcription, DNA-templated Source: BHF-UCL
  18. positive regulation of activated T cell proliferation Source: Ensembl
  19. positive regulation of alpha-beta T cell proliferation Source: BHF-UCL
  20. positive regulation of B cell activation Source: BHF-UCL
  21. positive regulation of CD4-positive, alpha-beta T cell costimulation Source: BHF-UCL
  22. positive regulation of CD4-positive, alpha-beta T cell differentiation Source: BHF-UCL
  23. positive regulation of cell proliferation Source: ProtInc
  24. positive regulation of immunoglobulin mediated immune response Source: BHF-UCL
  25. positive regulation of immunoglobulin secretion Source: BHF-UCL
  26. positive regulation of inflammatory response Source: BHF-UCL
  27. positive regulation of interferon-gamma production Source: BHF-UCL
  28. positive regulation of interleukin-10 production Source: BHF-UCL
  29. positive regulation of interleukin-12 production Source: BHF-UCL
  30. positive regulation of interleukin-13 production Source: BHF-UCL
  31. positive regulation of interleukin-2 production Source: Ensembl
  32. positive regulation of interleukin-4-dependent isotype switching to IgE isotypes Source: BHF-UCL
  33. positive regulation of interleukin-4 production Source: BHF-UCL
  34. positive regulation of interleukin-6 production Source: BHF-UCL
  35. positive regulation of memory T cell activation Source: Ensembl
  36. positive regulation of memory T cell differentiation Source: BHF-UCL
  37. positive regulation of T cell cytokine production Source: BHF-UCL
  38. positive regulation of T-helper 2 cell activation Source: Ensembl
  39. positive regulation of T-helper 2 cell differentiation Source: BHF-UCL
  40. positive regulation of type 2 immune response Source: BHF-UCL
  41. regulation of adaptive immune response Source: BHF-UCL
  42. regulation of inflammatory response Source: BHF-UCL
  43. response to nitrogen dioxide Source: BHF-UCL
  44. response to virus Source: BHF-UCL
  45. signal transduction Source: ProtInc
  46. T cell proliferation Source: Ensembl
  47. T-helper 2 cell activation Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 4
Alternative name(s):
Glycoprotein Gp34
OX40 ligand
Short name:
OX40L
TAX transcriptionally-activated glycoprotein 1
CD_antigen: CD252
Gene namesi
Name:TNFSF4
Synonyms:TXGP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:11934. TNFSF4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei24 – 5027Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini51 – 183133ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: BHF-UCL
  2. extracellular space Source: BHF-UCL
  3. integral component of plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Systemic lupus erythematosus1 Publication

Disease susceptibility is associated with variations affecting the gene represented in this entry. The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T-cell-APC interaction and the functional consequences of T-cell activation, thereby destabilizing peripheral tolerance.

Disease descriptionA chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

See also OMIM:152700

Keywords - Diseasei

Systemic lupus erythematosus

Organism-specific databases

MIMi152700. phenotype.
Orphaneti2073. Narcolepsy-cataplexy.
536. Systemic lupus erythematosus.
PharmGKBiPA36625.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 183183Tumor necrosis factor ligand superfamily member 4PRO_0000185493Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 1811 Publication
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi152 – 1521N-linked (GlcNAc...)1 Publication
Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP23510.
PRIDEiP23510.

PTM databases

PhosphoSiteiP23510.

Expressioni

Inductioni

By HTLV-1 transactivator p40-Tax.

Gene expression databases

BgeeiP23510.
CleanExiHS_TNFSF4.
ExpressionAtlasiP23510. baseline and differential.
GenevestigatoriP23510.

Organism-specific databases

HPAiHPA059579.

Interactioni

Subunit structurei

Homotrimer.1 Publication

Protein-protein interaction databases

DIPiDIP-3023N.
STRINGi9606.ENSP00000281834.

Structurei

Secondary structure

1
183
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi61 – 7010Combined sources
Turni71 – 733Combined sources
Beta strandi74 – 785Combined sources
Beta strandi92 – 943Combined sources
Beta strandi99 – 12022Combined sources
Beta strandi126 – 14318Combined sources
Beta strandi148 – 1558Combined sources
Beta strandi165 – 17410Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HEVX-ray2.41F51-183[»]
ProteinModelPortaliP23510.
SMRiP23510. Positions 58-183.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23510.

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47572.
GeneTreeiENSGT00390000015127.
HOGENOMiHOG000076309.
HOVERGENiHBG056457.
InParanoidiP23510.
KOiK05469.
OMAiMEGVQPL.
PhylomeDBiP23510.
TreeFamiTF336384.

Family and domain databases

InterProiIPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P23510-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERVQPLEEN VGNAARPRFE RNKLLLVASV IQGLGLLLCF TYICLHFSAL
60 70 80 90 100
QVSHRYPRIQ SIKVQFTEYK KEKGFILTSQ KEDEIMKVQN NSVIINCDGF
110 120 130 140 150
YLISLKGYFS QEVNISLHYQ KDEEPLFQLK KVRSVNSLMV ASLTYKDKVY
160 170 180
LNVTTDNTSL DDFHVNGGEL ILIHQNPGEF CVL
Length:183
Mass (Da):21,050
Last modified:November 1, 1991 - v1
Checksum:i0D5604AD29D529CF
GO
Isoform 2 (identifier: P23510-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-51: MERVQPLEENVGNAARPRFERNKLLLVASVIQGLGLLLCFTYICLHFSALQ → M

Show »
Length:133
Mass (Da):15,427
Checksum:i27AF148E6E528C8F
GO

Sequence cautioni

The sequence CAA18438.2 differs from that shown. Reason: Erroneous gene model prediction. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5151MERVQ…FSALQ → M in isoform 2. 2 PublicationsVSP_056288Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90224 mRNA. Translation: BAA14259.1.
X79929 mRNA. Translation: CAA56284.1.
AK297932 mRNA. Translation: BAG60249.1.
AL022310 Genomic DNA. Translation: CAA18438.2. Sequence problems.
AL022310 Genomic DNA. Translation: CAI20416.1.
CH471067 Genomic DNA. Translation: EAW90938.1.
BC041663 mRNA. Translation: AAH41663.1.
AB042988 Genomic DNA. Translation: BAB18304.1.
CCDSiCCDS1306.1. [P23510-1]
CCDS72985.1. [P23510-2]
PIRiA39680.
RefSeqiNP_001284491.1. NM_001297562.1. [P23510-2]
NP_003317.1. NM_003326.4. [P23510-1]
UniGeneiHs.181097.

Genome annotation databases

EnsembliENST00000281834; ENSP00000281834; ENSG00000117586. [P23510-1]
ENST00000367718; ENSP00000356691; ENSG00000117586. [P23510-2]
GeneIDi7292.
KEGGihsa:7292.
UCSCiuc001giv.3. human.
uc001giw.3. human. [P23510-1]

Polymorphism databases

DMDMi121540.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90224 mRNA. Translation: BAA14259.1.
X79929 mRNA. Translation: CAA56284.1.
AK297932 mRNA. Translation: BAG60249.1.
AL022310 Genomic DNA. Translation: CAA18438.2. Sequence problems.
AL022310 Genomic DNA. Translation: CAI20416.1.
CH471067 Genomic DNA. Translation: EAW90938.1.
BC041663 mRNA. Translation: AAH41663.1.
AB042988 Genomic DNA. Translation: BAB18304.1.
CCDSiCCDS1306.1. [P23510-1]
CCDS72985.1. [P23510-2]
PIRiA39680.
RefSeqiNP_001284491.1. NM_001297562.1. [P23510-2]
NP_003317.1. NM_003326.4. [P23510-1]
UniGeneiHs.181097.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HEVX-ray2.41F51-183[»]
ProteinModelPortaliP23510.
SMRiP23510. Positions 58-183.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3023N.
STRINGi9606.ENSP00000281834.

PTM databases

PhosphoSiteiP23510.

Polymorphism databases

DMDMi121540.

Proteomic databases

PaxDbiP23510.
PRIDEiP23510.

Protocols and materials databases

DNASUi7292.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281834; ENSP00000281834; ENSG00000117586. [P23510-1]
ENST00000367718; ENSP00000356691; ENSG00000117586. [P23510-2]
GeneIDi7292.
KEGGihsa:7292.
UCSCiuc001giv.3. human.
uc001giw.3. human. [P23510-1]

Organism-specific databases

CTDi7292.
GeneCardsiGC01M173152.
HGNCiHGNC:11934. TNFSF4.
HPAiHPA059579.
MIMi152700. phenotype.
603594. gene.
neXtProtiNX_P23510.
Orphaneti2073. Narcolepsy-cataplexy.
536. Systemic lupus erythematosus.
PharmGKBiPA36625.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG47572.
GeneTreeiENSGT00390000015127.
HOGENOMiHOG000076309.
HOVERGENiHBG056457.
InParanoidiP23510.
KOiK05469.
OMAiMEGVQPL.
PhylomeDBiP23510.
TreeFamiTF336384.

Miscellaneous databases

ChiTaRSiTNFSF4. human.
EvolutionaryTraceiP23510.
GenomeRNAii7292.
NextBioi28511.
PROiP23510.
SOURCEiSearch...

Gene expression databases

BgeeiP23510.
CleanExiHS_TNFSF4.
ExpressionAtlasiP23510. baseline and differential.
GenevestigatoriP23510.

Family and domain databases

InterProiIPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a novel glycoprotein, gp34, that is specifically induced by the human T-cell leukemia virus type I transactivator p40tax."
    Miura S., Ohtani K., Numata N., Niki M., Ohbo K., Ina Y., Gojobori T., Tanaka Y., Tozawa H., Nakamura M., Sugamura K.
    Mol. Cell. Biol. 11:1313-1325(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor."
    Godfrey W.R., Fagnoni F.F., Harara M.A., Buck D., Engleman E.G.
    J. Exp. Med. 180:757-762(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  7. "New variations in human OX40 ligand (CD134L) gene."
    Hikami K., Tsuchiya N., Tokunaga K.
    Genes Immun. 1:521-522(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-67.
  8. "Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34."
    Baum P.R., Gayle R.B. III, Ramsdell F., Srinivasan S., Sorensen R.A., Watson M.L., Seldin M.F., Baker E., Sutherland G.R., Clifford K.N., Alderson M.R., Goodwin R.G., Fanslow W.C.
    EMBO J. 13:3992-4001(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  9. "Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus."
    Cunninghame Graham D.S., Graham R.R., Manku H., Wong A.K., Whittaker J.C., Gaffney P.M., Moser K.L., Rioux J.D., Altshuler D., Behrens T.W., Vyse T.J.
    Nat. Genet. 40:83-89(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO SLE.
  10. "The crystal structure of the costimulatory OX40-OX40L complex."
    Compaan D.M., Hymowitz S.G.
    Structure 14:1321-1330(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.41 ANGSTROMS) OF 48-183 IN COMPLEX WITH TNFRSF4, SUBUNIT, DISULFIDE BOND, GLYCOSYLATION AT ASN-152.

Entry informationi

Entry nameiTNFL4_HUMAN
AccessioniPrimary (citable) accession number: P23510
Secondary accession number(s): Q5JZA5, Q8IV74, Q9HCN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: January 7, 2015
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.