##gff-version 3
P23508	UniProtKB	Chain	1	829	.	.	.	ID=PRO_0000079333;Note=Colorectal mutant cancer protein	
P23508	UniProtKB	Region	114	139	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P23508	UniProtKB	Region	282	320	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P23508	UniProtKB	Region	672	700	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P23508	UniProtKB	Motif	766	782	.	.	.	Note=Nuclear localization signal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24824780;Dbxref=PMID:24824780	
P23508	UniProtKB	Motif	826	829	.	.	.	Note=PDZ-binding	
P23508	UniProtKB	Compositional bias	114	130	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P23508	UniProtKB	Modified residue	828	828	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22480440;Dbxref=PMID:22480440	
P23508	UniProtKB	Alternative sequence	1	19	.	.	.	ID=VSP_037660;Note=In isoform 2. MNSGVAMKYGNDSSAELSE->MMAAAAAAAAGSSSSGGGGGGSGSSSSSSDTSSTGEEERMRRLFQTCDGDGDGYISRNDLLMVCRQLNMEESVAEIMNQLGADENGKISFQDFTRCRMQLVREIRKEEVDLSAKSDNSCTKKLRDRIASWPTSSDNSLGALSAARESWEYDSGARDLQSPDVQSQSALQKLLEYGGSSLHQQAALHKLLTQSPHIGNSVGGSYLELANT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039	
P23508	UniProtKB	Natural variant	142	142	.	.	.	ID=VAR_079267;Note=E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27932480;Dbxref=dbSNP:rs185322500,PMID:27932480	
P23508	UniProtKB	Natural variant	190	190	.	.	.	ID=VAR_050905;Note=K->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:1848370;Dbxref=dbSNP:rs6594681,PMID:14702039,PMID:15489334,PMID:1848370	
P23508	UniProtKB	Natural variant	267	267	.	.	.	ID=VAR_005141;Note=In a colorectal cancer sample. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1651563;Dbxref=PMID:1651563	
P23508	UniProtKB	Natural variant	486	486	.	.	.	ID=VAR_005142;Note=In a colorectal cancer sample. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1651563;Dbxref=dbSNP:rs35269015,PMID:1651563	
P23508	UniProtKB	Natural variant	490	490	.	.	.	ID=VAR_005143;Note=In a colorectal cancer sample. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1651563;Dbxref=dbSNP:rs760495893,PMID:1651563	
P23508	UniProtKB	Natural variant	506	506	.	.	.	ID=VAR_005144;Note=In colorectal cancer samples%3B somatic mutation%3B decreased binding to CCAR2%3B significant decrease in its ability to induce the relocalization of CCAR2 to the cytoplasm%3B loss of its ability to repress the beta-catenin pathway%3B loss of its ability to induce the SIRT1-mediated deacetylation of beta-catenin. R->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1651563,ECO:0000269|PubMed:1848370,ECO:0000269|PubMed:24824780;Dbxref=dbSNP:rs121917732,PMID:1651563,PMID:1848370,PMID:24824780	
P23508	UniProtKB	Natural variant	698	698	.	.	.	ID=VAR_005145;Note=In colorectal cancer samples%3B somatic mutation. A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1651563,ECO:0000269|PubMed:1848370;Dbxref=dbSNP:rs121917731,PMID:1651563,PMID:1848370	
P23508	UniProtKB	Natural variant	751	751	.	.	.	ID=VAR_033753;Note=S->C;Dbxref=dbSNP:rs17313892	
P23508	UniProtKB	Mutagenesis	828	828	.	.	.	Note=Reduced binding to SCRIB. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22480440;Dbxref=PMID:22480440	
P23508	UniProtKB	Mutagenesis	828	828	.	.	.	Note=Higher membrane localization%2C reduced formation of lamellipodia%2C accumulation of MYH10 at the cell cortex. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22480440;Dbxref=PMID:22480440	
P23508	UniProtKB	Sequence conflict	353	353	.	.	.	Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P23508	UniProtKB	Beta strand	825	829	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6MTU	
P23508	UniProtKB	Sequence conflict	25	25	.	.	.	Note=S->GSSSG;Ontology_term=ECO:0000305;evidence=ECO:0000305