Reviewed, UniProtKB/Swiss-Prot P23508 (CRCM_HUMAN)

Names and origin

Protein names

Recommended name:
    Colorectal mutant cancer protein
      Short name=Protein MCC

Gene names

Name:

MCC

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	829 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Candidate for the putative colorectal tumor suppressor gene located at 5q21.
Tissue specificity	Expressed in a variety of tissues.
Involvement in disease	Is probably involved in early stages of colorectal neoplasia in both sporadic and familial tumors.
Sequence similarities	Belongs to the MCC family.

Ontologies

Keywords
Biological process	Cell cycle
Coding sequence diversity	Polymorphism
Disease	Disease mutation
Molecular function	Anti-oncogene
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of cell cycle Inferred from electronic annotation. Source: UniProtKB-KW signal transduction Ref.1 Traceable author statement. Source: ProtInc
Molecular function	protein binding Inferred from physical interaction. Source: IntAct receptor activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CBR1	P16152	1	EBI-307531,EBI-351348
CCNA1	P78396	1	EBI-307531,EBI-375065
CLTC	Q00610	1	EBI-307531,EBI-354967
CSNK1D	P48730	1	EBI-307531,EBI-751621
CSNK1E	P49674	1	EBI-307531,EBI-749343
DFFA	O00273	1	EBI-307531,EBI-727171
EIF3A	Q14152	1	EBI-307531,EBI-366617
EPRS	P07814	1	EBI-307531,EBI-355315
EZR	P15311	1	EBI-307531,EBI-1056902
HPRT1	P00492	1	EBI-307531,EBI-748210
KRT18	P05783	1	EBI-307531,EBI-297888
LTA4H	P09960	1	EBI-307531,EBI-721089
MARS	P56192	1	EBI-307531,EBI-355848
MTHFD1	P11586	1	EBI-307531,EBI-709638
MYH10	P35580	1	EBI-307531,EBI-351758
NFKBIB	Q15653	1	EBI-307531,EBI-352889
PAICS	P22234	1	EBI-307531,EBI-712261
PDCD10	Q9BUL8	1	EBI-307531,EBI-740195
PFAS	O15067	1	EBI-307531,EBI-1052653
PFKP	Q01813	1	EBI-307531,EBI-359022
PPP2R1A	P30153	1	EBI-307531,EBI-302388
PSMD2	Q13200	1	EBI-307531,EBI-357648
PSME3	P61289	1	EBI-307531,EBI-355546
SNRNP200	O75643	1	EBI-307531,EBI-1045395
STK24	Q5T5B3	1	EBI-307531,EBI-1054809
STRN	O43815	1	EBI-307531,EBI-1046642
STRN3	Q13033	1	EBI-307531,EBI-1053857
STRN4	Q9NRL3	1	EBI-307531,EBI-717245
TARS	P26639	1	EBI-307531,EBI-1042683
TPM3	P06753	1	EBI-307531,EBI-355607
VCP	Q5VYM0	1	EBI-307531,EBI-1046421
VDAC1	P21796	1	EBI-307531,EBI-354158
VHL	P40337	1	EBI-307531,EBI-301246
VPS35	Q96QK1	1	EBI-307531,EBI-1054634

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 829	829	Colorectal mutant cancer protein		PRO_0000079333
Natural variations
	Natural variant	190	1	R → K: dbSNP rs6594681.		VAR_050905
	Natural variant	267	1	R → L in colorectal cancer. Ref.3		VAR_005141
	Natural variant	486	1	P → L in colorectal cancer. dbSNP rs35269015. Ref.3		VAR_005142
	Natural variant	490	1	S → L in colorectal cancer. Ref.3		VAR_005143
	Natural variant	506	1	R → Q in colorectal cancer. Ref.3		VAR_005144
	Natural variant	698	1	A → V in colorectal cancer. Ref.3		VAR_005145
	Natural variant	751	1	S → C: dbSNP rs17313892.		VAR_033753

Sequences

	Sequence		Length	Mass (Da)
	P23508-1 [UniParc]. Last modified November 1, 1991. Version 1. Checksum: 5D45225FD91CA18F	FASTA	829	93,055
	10 20 30 40 50 60 MNSGVAMKYG NDSSAELSEL HSAALASLKG DIVELNKRLQ QTERERDLLE KKLAKAQCEQ 70 80 90 100 110 120 SHLMREHEDV QERTTLRYEE RITELHSVIA ELNKKIDRLQ GTTIREEDEY SELRSELSQS 130 140 150 160 170 180 QHEVNEDSRS MDQDQTSVSI PENQSTMVTA DMDNCSDLNS ELQRVLTGLE NVVCGRKKSS 190 200 210 220 230 240 CSLSVAEVDR HIEQLTTASE HCDLAIKTVE EIEGVLGRDL YPNLAEERSR WEKELAGLRE 250 260 270 280 290 300 ENESLTAMLC SKEEELNRTK ATMNAIREER DRLRRRVREL QTRLQSVQAT GPSSPGRLTS 310 320 330 340 350 360 TNRPINPSTG ELSTSSSSND IPIAKIAERV KLSKTRSESS SSDRPVLGSE ISSIGVSSSV 370 380 390 400 410 420 AEHLAHSLQD CSNIQEIFQT LYSHGSAISE SKIREFEVET ERLNSRIEHL KSQNDLLTIT 430 440 450 460 470 480 LEECKSNAER MSMLVGKYES NATALRLALQ YSEQCIEAYE LLLALAESEQ SLILGQFRAA 490 500 510 520 530 540 GVGSSPGDQS GDENITQMLK RAHDCRKTAE NAAKALLMKL DGSCGGAFAV AGCSVQPWES 550 560 570 580 590 600 LSSNSHTSTT SSTASSCDTE FTKEDEQRLK DYIQQLKNDR AAVKLTMLEL ESIHIDPLSY 610 620 630 640 650 660 DVKPRGDSQR LDLENAVLMQ ELMAMKEEMA ELKAQLYLLE KEKKALELKL STREAQEQAY 670 680 690 700 710 720 LVHIEHLKSE VEEQKEQRMR SLSSTSSGSK DKPGKECADA ASPALSLAEL RTTCSENELA 730 740 750 760 770 780 AEFTNAIRRE KKLKARVQEL VSALERLTKS SEIRHQQSAE FVNDLKRANS NLVAAYEKAK 790 800 810 820 KKHQNKLKKL ESQMMAMVER HETQVRMLKQ RIALLEEENS RPHTNETSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers." Kinzler K.W., Nilbert M.C., Vogelstein B., Bryan T.M., Levy D.B., Smith K.J., Preisinger A.C., Hamilton S.R., Hedge P., Markham A., Carlson M., Joslyn G., Groden J., White R., Miki Y., Miyoshi Y., Nishisho I., Nakamura Y. Science 251:1366-1370(1991) [PubMed: 1848370] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle.
[3]	"Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients." Nishisho I., Nakamura Y., Miyoshi Y., Miki Y., Ando H., Horii A., Koyama K., Utsunomiya J., Baba S., Hedge P., Markham A., Krush A.J., Petersen G.M., Hamilton S.R., Nilbert M.C., Levy D.B., Bryan T.M., Preisinger A.C. , Smith K.J., Su L.-K., Kinzler K.W., Vogelstein B. Science 253:665-669(1991) [PubMed: 1651563] [Abstract] Cited for: VARIANTS COLORECTAL CANCER LEU-267; LEU-486; L-490; GLN-506 AND VAL-698.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M62397 mRNA. Translation: AAA52069.1. BC009279 mRNA. Translation: AAH09279.1. BC018919 mRNA. Translation: AAH18919.1.
IPI	IPI00011957.
PIR	A33166. A38434.
RefSeq	NP_002378.1.
UniGene	Hs.593171
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:27599N.
IntAct	P23508. 235 interactions.
PTM databases
PhosphoSite	P23508.
Proteomic databases
PRIDE	P23508.
Genome annotation databases
Ensembl	ENSG00000171444. Homo sapiens. [Contig view]
GeneID	4163.
Organism-specific databases
GeneCards	GC05M112388.
HGNC	HGNC:6935. MCC.
MIM	159350. gene.
PharmGKB	PA30679.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P23508.
Gene expression databases
ArrayExpress	P23508.
Bgee	P23508.
CleanEx	HS_MCC.
GermOnline	ENSG00000171444. Homo sapiens.
Family and domain databases
InterPro	IPR019536. USH1C-bd_PDZ_domain. [Graphical view]
Pfam	PF10506. MCC-bdg_PDZ. 3 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	16402.
SOURCE	Search...

Entry information

Entry name

CRCM_HUMAN

Accession

Primary (citable) accession number: P23508

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	November 1, 1991
Last modified:	June 16, 2009
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)