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Protein

Dihydrosphingosine 1-phosphate phosphatase YSR3

Gene

YSR3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Dihydrosphingosine 1-phosphate phosphatase required for efficient ceramide synthesis from exogenous sphingoid bases. Involved in endocytosis and calcium-mediated signaling.5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei161Proton donorBy similarity1
Active sitei211NucleophileBy similarity1
Sitei215Stabilizes the active site histidine for nucleophilic attackBy similarity1

GO - Molecular functioni

  • sphingosine-1-phosphate phosphatase activity Source: SGD

GO - Biological processi

  • phospholipid dephosphorylation Source: SGD
  • sphingolipid biosynthetic process Source: SGD

Keywordsi

Molecular functionHydrolase
Biological processLipid metabolism, Sphingolipid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:YKR053C-MONOMER
YEAST:YKR053C-MONOMER
ReactomeiR-SCE-1660661 Sphingolipid de novo biosynthesis

Chemistry databases

SwissLipidsiSLP:000000933

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrosphingosine 1-phosphate phosphatase YSR3 (EC:3.1.3.-)
Alternative name(s):
Long-chain base protein 2
Sphingolipid resistance protein 3
Gene namesi
Name:YSR3
Synonyms:LBP2
Ordered Locus Names:YKR053C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKR053C
SGDiS000001761 YSR3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 86LumenalBy similarityAdd BLAST86
Transmembranei87 – 107Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini108 – 113CytoplasmicBy similarity6
Transmembranei114 – 134Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini135 – 154LumenalBy similarityAdd BLAST20
Transmembranei155 – 176Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini177 – 182CytoplasmicBy similarity6
Transmembranei183 – 203Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini204 – 215LumenalBy similarityAdd BLAST12
Transmembranei216 – 236Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini237 – 241CytoplasmicBy similarity5
Transmembranei242 – 262Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini263 – 319LumenalBy similarityAdd BLAST57
Transmembranei320 – 340Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini341 – 379CytoplasmicBy similarityAdd BLAST39
Transmembranei380 – 400Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini401 – 404LumenalBy similarity4

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002032161 – 404Dihydrosphingosine 1-phosphate phosphatase YSR3Add BLAST404

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP23501
PRIDEiP23501

Interactioni

Protein-protein interaction databases

BioGridi34184, 134 interactors
DIPiDIP-5258N
IntActiP23501, 1 interactor
STRINGi4932.YKR053C

Structurei

3D structure databases

ProteinModelPortaliP23501
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni129 – 137Phosphatase sequence motif ICurated9
Regioni158 – 161Phosphatase sequence motif IICurated4
Regioni204 – 215Phosphatase sequence motif IIICuratedAdd BLAST12

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000017322
HOGENOMiHOG000066080
InParanoidiP23501
KOiK04717
OMAiYKFVTYS
OrthoDBiEOG092C3MDD

Family and domain databases

InterProiView protein in InterPro
IPR036938 P_Acid_Pase_2/haloperoxi_sf
IPR000326 P_Acid_Pase_2/haloperoxidase
PfamiView protein in Pfam
PF01569 PAP2, 1 hit
SMARTiView protein in SMART
SM00014 acidPPc, 1 hit
SUPFAMiSSF48317 SSF48317, 1 hit

Sequencei

Sequence statusi: Complete.

P23501-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIIQTVTEL GVTEDTIKVQ MAPSGGKHLL ADPGNHPAEH FESQMSWLRF
60 70 80 90 100
QTRQYLTRFT DNQSDFVHSL QKKHRTPFRD VYFKYTSLMG SHMFYVIVLP
110 120 130 140 150
MPVWLGYRDL TRDMIYVLGY SIYLSGYLKD YWCLPRPKSP PVDRITLSEY
160 170 180 190 200
TTKEYGAPSS HSANATAVSL LFFWRICLSD TLVWPTKLLL LSLVIFYYLT
210 220 230 240 250
LVFGRVYCGM HGMLDLFSGA AVGAICFFIR IWVVHALRNF QIGEHLWFPL
260 270 280 290 300
LSVAWGLFIL FNHVRPIDEC PCFEDSVAFI GVVSGLDCSD WLTERYGWNL
310 320 330 340 350
VCSRYASCGS KVFLRPLVGV ASVIVWKDVI SKTAVYTLLI KLLRFHDDRS
360 370 380 390 400
EKVHFHNETS EEEECLLYSG VSKVEIVGRF LIYAGIPTTV FLLCPVFFTW

TNLR
Length:404
Mass (Da):46,488
Last modified:June 1, 1994 - v2
Checksum:i0CDB272FBF868BF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28278 Genomic DNA Translation: CAA82131.1
X56444 Genomic DNA Translation: CAA39827.1
BK006944 Genomic DNA Translation: DAA09204.1
PIRiS38127
RefSeqiNP_012979.3, NM_001179843.3

Genome annotation databases

EnsemblFungiiYKR053C; YKR053C; YKR053C
GeneIDi853927
KEGGisce:YKR053C

Similar proteinsi

Entry informationi

Entry nameiDS1P2_YEAST
AccessioniPrimary (citable) accession number: P23501
Secondary accession number(s): D6VXB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. Protein nomenclature information
    List of publications dealing with protein nomenclature and links to specialized websites

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