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P23493

- MBR1_YEAST

UniProt

P23493 - MBR1_YEAST

Protein

Mitochondrial biogenesis regulation protein 1

Gene

MBR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Participates in mitochondrial biogenesis and stress response.2 Publications

    GO - Biological processi

    1. aerobic respiration Source: SGD
    2. response to stress Source: UniProtKB-KW

    Keywords - Biological processi

    Stress response

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31884-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial biogenesis regulation protein 1
    Gene namesi
    Name:MBR1
    Ordered Locus Names:YKL093W
    ORF Names:YKL440
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XI

    Organism-specific databases

    CYGDiYKL093w.
    SGDiS000001576. MBR1.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 339339Mitochondrial biogenesis regulation protein 1PRO_0000096271Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei159 – 1591Phosphothreonine1 Publication
    Modified residuei177 – 1771Phosphoserine1 Publication
    Modified residuei224 – 2241Phosphoserine1 Publication
    Modified residuei227 – 2271Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP23493.

    Expressioni

    Inductioni

    Expression is induced in the late growth phase and is negatively controlled by the cAMP-dependent protein kinase A (PKA).1 Publication

    Gene expression databases

    GenevestigatoriP23493.

    Interactioni

    Protein-protein interaction databases

    BioGridi34040. 62 interactions.
    DIPiDIP-4119N.
    MINTiMINT-574488.
    STRINGi4932.YKL093W.

    Structurei

    3D structure databases

    ProteinModelPortaliP23493.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ISF1/MBR1 family.Curated

    Phylogenomic databases

    eggNOGiNOG78631.
    OMAiCERERED.
    OrthoDBiEOG74N5TB.

    Sequencei

    Sequence statusi: Complete.

    P23493-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRMEKTTDKP LSAGDMNDEY SRGPIDDIDC LNFFERAVQD PCCEACDTED    50
    ADEELRAKLS SFNFQPDSSP CNAKCQQTLN PLCKIDEALP AESELAPSRN 100
    GSVSEANSDT NSIASTVHDP VDSKYGGMPS LRKAKTTSYF TSSSSNNTTM 150
    RNPLKKCNTN INGLLVNGRS SSSSRQSIPE LFSGACTKKK NNVLLKSETP 200
    NSEFSSNSLQ HCNSRSFSLP RSRSRSSAIA IPTHLYGLEK YVSPGLDTLT 250
    ADPEESIERF SNNRPREISS CCPNDTGDTS SSLSHSNTSS SLNFPLGTNT 300
    NQFHQPRQPV QQQQSSKPNF GAGRKKSFIE MSLASSFAG 339
    Length:339
    Mass (Da):36,935
    Last modified:June 1, 1994 - v2
    Checksum:iA38E7EA7049754A0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti88 – 881A → G in AAA88725. (PubMed:8208248)Curated
    Sequence conflicti168 – 1681G → R in AAA88725. (PubMed:8208248)Curated
    Sequence conflicti206 – 2061S → T in AAA88725. (PubMed:8208248)Curated
    Sequence conflicti245 – 2451G → E in AAA88725. (PubMed:8208248)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M63309 Genomic DNA. Translation: AAA88725.1.
    X71133 Genomic DNA. Translation: CAA50464.1.
    Z28093 Genomic DNA. Translation: CAA81931.1.
    X75561 Genomic DNA. Translation: CAA53240.1.
    AY899251 mRNA. Translation: AAX83936.1.
    BK006944 Genomic DNA. Translation: DAA09065.1.
    PIRiS37920.
    RefSeqiNP_012830.1. NM_001179659.1.

    Genome annotation databases

    EnsemblFungiiYKL093W; YKL093W; YKL093W.
    GeneIDi853769.
    KEGGisce:YKL093W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M63309 Genomic DNA. Translation: AAA88725.1 .
    X71133 Genomic DNA. Translation: CAA50464.1 .
    Z28093 Genomic DNA. Translation: CAA81931.1 .
    X75561 Genomic DNA. Translation: CAA53240.1 .
    AY899251 mRNA. Translation: AAX83936.1 .
    BK006944 Genomic DNA. Translation: DAA09065.1 .
    PIRi S37920.
    RefSeqi NP_012830.1. NM_001179659.1.

    3D structure databases

    ProteinModelPortali P23493.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34040. 62 interactions.
    DIPi DIP-4119N.
    MINTi MINT-574488.
    STRINGi 4932.YKL093W.

    Proteomic databases

    PaxDbi P23493.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YKL093W ; YKL093W ; YKL093W .
    GeneIDi 853769.
    KEGGi sce:YKL093W.

    Organism-specific databases

    CYGDi YKL093w.
    SGDi S000001576. MBR1.

    Phylogenomic databases

    eggNOGi NOG78631.
    OMAi CERERED.
    OrthoDBi EOG74N5TB.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31884-MONOMER.

    Miscellaneous databases

    NextBioi 974864.

    Gene expression databases

    Genevestigatori P23493.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "MBR1 and MBR3, two related yeast genes that can suppress the growth defect of hap2, hap3 and hap4 mutants."
      Daignan-Fornier B., Nguyen C.C., Reisdorf P., Lemeignan B., Bolotin-Fukuhara M.
      Mol. Gen. Genet. 243:575-583(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
      Strain: R100.
    2. "DNA sequence analysis of a 17 kb fragment of yeast chromosome XI physically localizes the MRB1 gene and reveals eight new open reading frames, including a homologue of the KIN1/KIN2 and SNF1 protein kinases."
      Pallier C., Valens M., Puzos V., Fukuhara H., Cheret G., Sor F., Bolotin-Fukuhara M.
      Yeast 9:1149-1155(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. "Complete DNA sequence of yeast chromosome XI."
      Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
      , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
      Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. "Mapping of transcription start sites in Saccharomyces cerevisiae using 5' SAGE."
      Zhang Z., Dietrich F.S.
      Nucleic Acids Res. 33:2838-2851(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-98.
      Strain: ATCC 208353 / W303-1A.
    6. "Sequence analysis of a 3.5 Kb EcoRI fragment from the left arm of Saccharomyces cerevisiae chromosome XI reveals the location of the MBR1 gene and a sequence related to a GTPase-activating protein."
      James C.M., Gent M.E., Oliver S.G.
      Yeast 10:257-264(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 169-339.
    7. "Identification of nuclear genes which participate in mitochondrial translation in Saccharomyces cerevisiae."
      Valens M., Rinaldi T., Daignan-Fornier B., Bolotin-Fukuhara M.
      Biochimie 73:1525-1532(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    8. "The MBR1 gene from Saccharomyces cerevisiae is activated by and required for growth under sub-optimal conditions."
      Reisdorf P., Boy-Marcotte E., Bolotin-Fukuhara M.
      Mol. Gen. Genet. 255:400-409(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-159; SER-177; SER-224 AND SER-227, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMBR1_YEAST
    AccessioniPrimary (citable) accession number: P23493
    Secondary accession number(s): D6VXJ5, Q2VQW7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XI
      Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

    External Data

    Dasty 3