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P23493 (MBR1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial biogenesis regulation protein 1
Gene names
Name:MBR1
Ordered Locus Names:YKL093W
ORF Names:YKL440
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Participates in mitochondrial biogenesis and stress response. Ref.1 Ref.8

Subcellular location

Mitochondrion Probable.

Induction

Expression is induced in the late growth phase and is negatively controlled by the cAMP-dependent protein kinase A (PKA). Ref.8

Sequence similarities

Belongs to the ISF1/MBR1 family.

Ontologies

Keywords
   Biological processStress response
   Cellular componentMitochondrion
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaerobic respiration

Inferred from mutant phenotype Ref.1. Source: SGD

response to stress

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 339339Mitochondrial biogenesis regulation protein 1
PRO_0000096271

Amino acid modifications

Modified residue1591Phosphothreonine Ref.9
Modified residue1771Phosphoserine Ref.9
Modified residue2241Phosphoserine Ref.9
Modified residue2271Phosphoserine Ref.9

Experimental info

Sequence conflict881A → G in AAA88725. Ref.1
Sequence conflict1681G → R in AAA88725. Ref.1
Sequence conflict2061S → T in AAA88725. Ref.1
Sequence conflict2451G → E in AAA88725. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P23493 [UniParc].

Last modified June 1, 1994. Version 2.
Checksum: A38E7EA7049754A0

FASTA33936,935
        10         20         30         40         50         60 
MRMEKTTDKP LSAGDMNDEY SRGPIDDIDC LNFFERAVQD PCCEACDTED ADEELRAKLS 

        70         80         90        100        110        120 
SFNFQPDSSP CNAKCQQTLN PLCKIDEALP AESELAPSRN GSVSEANSDT NSIASTVHDP 

       130        140        150        160        170        180 
VDSKYGGMPS LRKAKTTSYF TSSSSNNTTM RNPLKKCNTN INGLLVNGRS SSSSRQSIPE 

       190        200        210        220        230        240 
LFSGACTKKK NNVLLKSETP NSEFSSNSLQ HCNSRSFSLP RSRSRSSAIA IPTHLYGLEK 

       250        260        270        280        290        300 
YVSPGLDTLT ADPEESIERF SNNRPREISS CCPNDTGDTS SSLSHSNTSS SLNFPLGTNT 

       310        320        330 
NQFHQPRQPV QQQQSSKPNF GAGRKKSFIE MSLASSFAG 

« Hide

References

« Hide 'large scale' references
[1]"MBR1 and MBR3, two related yeast genes that can suppress the growth defect of hap2, hap3 and hap4 mutants."
Daignan-Fornier B., Nguyen C.C., Reisdorf P., Lemeignan B., Bolotin-Fukuhara M.
Mol. Gen. Genet. 243:575-583(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
Strain: R100.
[2]"DNA sequence analysis of a 17 kb fragment of yeast chromosome XI physically localizes the MRB1 gene and reveals eight new open reading frames, including a homologue of the KIN1/KIN2 and SNF1 protein kinases."
Pallier C., Valens M., Puzos V., Fukuhara H., Cheret G., Sor F., Bolotin-Fukuhara M.
Yeast 9:1149-1155(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"Complete DNA sequence of yeast chromosome XI."
Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. expand/collapse author list , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Mapping of transcription start sites in Saccharomyces cerevisiae using 5' SAGE."
Zhang Z., Dietrich F.S.
Nucleic Acids Res. 33:2838-2851(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-98.
Strain: ATCC 208353 / W303-1A.
[6]"Sequence analysis of a 3.5 Kb EcoRI fragment from the left arm of Saccharomyces cerevisiae chromosome XI reveals the location of the MBR1 gene and a sequence related to a GTPase-activating protein."
James C.M., Gent M.E., Oliver S.G.
Yeast 10:257-264(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 169-339.
[7]"Identification of nuclear genes which participate in mitochondrial translation in Saccharomyces cerevisiae."
Valens M., Rinaldi T., Daignan-Fornier B., Bolotin-Fukuhara M.
Biochimie 73:1525-1532(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[8]"The MBR1 gene from Saccharomyces cerevisiae is activated by and required for growth under sub-optimal conditions."
Reisdorf P., Boy-Marcotte E., Bolotin-Fukuhara M.
Mol. Gen. Genet. 255:400-409(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION.
[9]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-159; SER-177; SER-224 AND SER-227, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M63309 Genomic DNA. Translation: AAA88725.1.
X71133 Genomic DNA. Translation: CAA50464.1.
Z28093 Genomic DNA. Translation: CAA81931.1.
X75561 Genomic DNA. Translation: CAA53240.1.
AY899251 mRNA. Translation: AAX83936.1.
BK006944 Genomic DNA. Translation: DAA09065.1.
PIRS37920.
RefSeqNP_012830.1. NM_001179659.1.

3D structure databases

ProteinModelPortalP23493.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34040. 62 interactions.
DIPDIP-4119N.
MINTMINT-574488.
STRING4932.YKL093W.

Proteomic databases

PaxDbP23493.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYKL093W; YKL093W; YKL093W.
GeneID853769.
KEGGsce:YKL093W.

Organism-specific databases

CYGDYKL093w.
SGDS000001576. MBR1.

Phylogenomic databases

eggNOGNOG78631.
OrthoDBEOG74N5TB.

Enzyme and pathway databases

BioCycYEAST:G3O-31884-MONOMER.

Gene expression databases

GenevestigatorP23493.

Family and domain databases

ProtoNetSearch...

Other

NextBio974864.

Entry information

Entry nameMBR1_YEAST
AccessionPrimary (citable) accession number: P23493
Secondary accession number(s): D6VXJ5, Q2VQW7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: June 1, 1994
Last modified: March 19, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XI

Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families