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P23493

- MBR1_YEAST

UniProt

P23493 - MBR1_YEAST

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Protein

Mitochondrial biogenesis regulation protein 1

Gene

MBR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Participates in mitochondrial biogenesis and stress response.2 Publications

GO - Biological processi

  1. aerobic respiration Source: SGD
  2. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciYEAST:G3O-31884-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial biogenesis regulation protein 1
Gene namesi
Name:MBR1
Ordered Locus Names:YKL093W
ORF Names:YKL440
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XI

Organism-specific databases

CYGDiYKL093w.
SGDiS000001576. MBR1.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Mitochondrial biogenesis regulation protein 1PRO_0000096271Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei159 – 1591Phosphothreonine1 Publication
Modified residuei177 – 1771Phosphoserine1 Publication
Modified residuei224 – 2241Phosphoserine1 Publication
Modified residuei227 – 2271Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP23493.

Expressioni

Inductioni

Expression is induced in the late growth phase and is negatively controlled by the cAMP-dependent protein kinase A (PKA).1 Publication

Gene expression databases

GenevestigatoriP23493.

Interactioni

Protein-protein interaction databases

BioGridi34040. 62 interactions.
DIPiDIP-4119N.
MINTiMINT-574488.
STRINGi4932.YKL093W.

Structurei

3D structure databases

ProteinModelPortaliP23493.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ISF1/MBR1 family.Curated

Phylogenomic databases

eggNOGiNOG78631.
InParanoidiP23493.
OMAiCERERED.
OrthoDBiEOG74N5TB.

Sequencei

Sequence statusi: Complete.

P23493-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRMEKTTDKP LSAGDMNDEY SRGPIDDIDC LNFFERAVQD PCCEACDTED
60 70 80 90 100
ADEELRAKLS SFNFQPDSSP CNAKCQQTLN PLCKIDEALP AESELAPSRN
110 120 130 140 150
GSVSEANSDT NSIASTVHDP VDSKYGGMPS LRKAKTTSYF TSSSSNNTTM
160 170 180 190 200
RNPLKKCNTN INGLLVNGRS SSSSRQSIPE LFSGACTKKK NNVLLKSETP
210 220 230 240 250
NSEFSSNSLQ HCNSRSFSLP RSRSRSSAIA IPTHLYGLEK YVSPGLDTLT
260 270 280 290 300
ADPEESIERF SNNRPREISS CCPNDTGDTS SSLSHSNTSS SLNFPLGTNT
310 320 330
NQFHQPRQPV QQQQSSKPNF GAGRKKSFIE MSLASSFAG
Length:339
Mass (Da):36,935
Last modified:June 1, 1994 - v2
Checksum:iA38E7EA7049754A0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti88 – 881A → G in AAA88725. (PubMed:8208248)Curated
Sequence conflicti168 – 1681G → R in AAA88725. (PubMed:8208248)Curated
Sequence conflicti206 – 2061S → T in AAA88725. (PubMed:8208248)Curated
Sequence conflicti245 – 2451G → E in AAA88725. (PubMed:8208248)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63309 Genomic DNA. Translation: AAA88725.1.
X71133 Genomic DNA. Translation: CAA50464.1.
Z28093 Genomic DNA. Translation: CAA81931.1.
X75561 Genomic DNA. Translation: CAA53240.1.
AY899251 mRNA. Translation: AAX83936.1.
BK006944 Genomic DNA. Translation: DAA09065.1.
PIRiS37920.
RefSeqiNP_012830.1. NM_001179659.1.

Genome annotation databases

EnsemblFungiiYKL093W; YKL093W; YKL093W.
GeneIDi853769.
KEGGisce:YKL093W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63309 Genomic DNA. Translation: AAA88725.1 .
X71133 Genomic DNA. Translation: CAA50464.1 .
Z28093 Genomic DNA. Translation: CAA81931.1 .
X75561 Genomic DNA. Translation: CAA53240.1 .
AY899251 mRNA. Translation: AAX83936.1 .
BK006944 Genomic DNA. Translation: DAA09065.1 .
PIRi S37920.
RefSeqi NP_012830.1. NM_001179659.1.

3D structure databases

ProteinModelPortali P23493.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34040. 62 interactions.
DIPi DIP-4119N.
MINTi MINT-574488.
STRINGi 4932.YKL093W.

Proteomic databases

PaxDbi P23493.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YKL093W ; YKL093W ; YKL093W .
GeneIDi 853769.
KEGGi sce:YKL093W.

Organism-specific databases

CYGDi YKL093w.
SGDi S000001576. MBR1.

Phylogenomic databases

eggNOGi NOG78631.
InParanoidi P23493.
OMAi CERERED.
OrthoDBi EOG74N5TB.

Enzyme and pathway databases

BioCyci YEAST:G3O-31884-MONOMER.

Miscellaneous databases

NextBioi 974864.

Gene expression databases

Genevestigatori P23493.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "MBR1 and MBR3, two related yeast genes that can suppress the growth defect of hap2, hap3 and hap4 mutants."
    Daignan-Fornier B., Nguyen C.C., Reisdorf P., Lemeignan B., Bolotin-Fukuhara M.
    Mol. Gen. Genet. 243:575-583(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    Strain: R100.
  2. "DNA sequence analysis of a 17 kb fragment of yeast chromosome XI physically localizes the MRB1 gene and reveals eight new open reading frames, including a homologue of the KIN1/KIN2 and SNF1 protein kinases."
    Pallier C., Valens M., Puzos V., Fukuhara H., Cheret G., Sor F., Bolotin-Fukuhara M.
    Yeast 9:1149-1155(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "Mapping of transcription start sites in Saccharomyces cerevisiae using 5' SAGE."
    Zhang Z., Dietrich F.S.
    Nucleic Acids Res. 33:2838-2851(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-98.
    Strain: ATCC 208353 / W303-1A.
  6. "Sequence analysis of a 3.5 Kb EcoRI fragment from the left arm of Saccharomyces cerevisiae chromosome XI reveals the location of the MBR1 gene and a sequence related to a GTPase-activating protein."
    James C.M., Gent M.E., Oliver S.G.
    Yeast 10:257-264(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 169-339.
  7. "Identification of nuclear genes which participate in mitochondrial translation in Saccharomyces cerevisiae."
    Valens M., Rinaldi T., Daignan-Fornier B., Bolotin-Fukuhara M.
    Biochimie 73:1525-1532(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  8. "The MBR1 gene from Saccharomyces cerevisiae is activated by and required for growth under sub-optimal conditions."
    Reisdorf P., Boy-Marcotte E., Bolotin-Fukuhara M.
    Mol. Gen. Genet. 255:400-409(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-159; SER-177; SER-224 AND SER-227, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMBR1_YEAST
AccessioniPrimary (citable) accession number: P23493
Secondary accession number(s): D6VXJ5, Q2VQW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: June 1, 1994
Last modified: October 29, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

External Data

Dasty 3