P23493 (MBR1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mitochondrial biogenesis regulation protein 1

Gene names

Name:	MBR1
Ordered Locus Names:	YKL093W
ORF Names:	YKL440

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Participates in mitochondrial biogenesis and stress response. Ref.1 Ref.8
Subcellular location	Mitochondrion Probable.
Induction	Expression is induced in the late growth phase and is negatively controlled by the cAMP-dependent protein kinase A (PKA). Ref.8
Sequence similarities	Belongs to the ISF1/MBR1 family.

Ontologies

Keywords
Biological process	Stress response
Cellular component	Mitochondrion
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aerobic respiration Inferred from mutant phenotype Ref.1. Source: SGD response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 339	339	Mitochondrial biogenesis regulation protein 1		PRO_0000096271
Amino acid modifications
	Modified residue	226	1	Phosphoserine Ref.9
	Modified residue	227	1	Phosphoserine Ref.9
Experimental info
	Sequence conflict	88	1	A → G in AAA88725. Ref.1
	Sequence conflict	168	1	G → R in AAA88725. Ref.1
	Sequence conflict	206	1	S → T in AAA88725. Ref.1
	Sequence conflict	245	1	G → E in AAA88725. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P23493 [UniParc]. Last modified June 1, 1994. Version 2. Checksum: A38E7EA7049754A0	FASTA	339	36,935
	10 20 30 40 50 60 MRMEKTTDKP LSAGDMNDEY SRGPIDDIDC LNFFERAVQD PCCEACDTED ADEELRAKLS 70 80 90 100 110 120 SFNFQPDSSP CNAKCQQTLN PLCKIDEALP AESELAPSRN GSVSEANSDT NSIASTVHDP 130 140 150 160 170 180 VDSKYGGMPS LRKAKTTSYF TSSSSNNTTM RNPLKKCNTN INGLLVNGRS SSSSRQSIPE 190 200 210 220 230 240 LFSGACTKKK NNVLLKSETP NSEFSSNSLQ HCNSRSFSLP RSRSRSSAIA IPTHLYGLEK 250 260 270 280 290 300 YVSPGLDTLT ADPEESIERF SNNRPREISS CCPNDTGDTS SSLSHSNTSS SLNFPLGTNT 310 320 330 NQFHQPRQPV QQQQSSKPNF GAGRKKSFIE MSLASSFAG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"MBR1 and MBR3, two related yeast genes that can suppress the growth defect of hap2, hap3 and hap4 mutants." Daignan-Fornier B., Nguyen C.C., Reisdorf P., Lemeignan B., Bolotin-Fukuhara M. Mol. Gen. Genet. 243:575-583(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION. Strain: R100.
[2]	"DNA sequence analysis of a 17 kb fragment of yeast chromosome XI physically localizes the MRB1 gene and reveals eight new open reading frames, including a homologue of the KIN1/KIN2 and SNF1 protein kinases." Pallier C., Valens M., Puzos V., Fukuhara H., Cheret G., Sor F., Bolotin-Fukuhara M. Yeast 9:1149-1155(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	"Complete DNA sequence of yeast chromosome XI." Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W. Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[5]	"Mapping of transcription start sites in Saccharomyces cerevisiae using 5' SAGE." Zhang Z., Dietrich F.S. Nucleic Acids Res. 33:2838-2851(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-98. Strain: ATCC 208353 / W303-1A.
[6]	"Sequence analysis of a 3.5 Kb EcoRI fragment from the left arm of Saccharomyces cerevisiae chromosome XI reveals the location of the MBR1 gene and a sequence related to a GTPase-activating protein." James C.M., Gent M.E., Oliver S.G. Yeast 10:257-264(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 169-339.
[7]	"Identification of nuclear genes which participate in mitochondrial translation in Saccharomyces cerevisiae." Valens M., Rinaldi T., Daignan-Fornier B., Bolotin-Fukuhara M. Biochimie 73:1525-1532(1991) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[8]	"The MBR1 gene from Saccharomyces cerevisiae is activated by and required for growth under sub-optimal conditions." Reisdorf P., Boy-Marcotte E., Bolotin-Fukuhara M. Mol. Gen. Genet. 255:400-409(1997) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INDUCTION.
[9]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-226 AND SER-227, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M63309 Genomic DNA. Translation: AAA88725.1. X71133 Genomic DNA. Translation: CAA50464.1. Z28093 Genomic DNA. Translation: CAA81931.1. X75561 Genomic DNA. Translation: CAA53240.1. AY899251 mRNA. Translation: AAX83936.1. BK006944 Genomic DNA. Translation: DAA09065.1.
PIR	S37920.
RefSeq	NP_012830.1. NM_001179659.1.
3D structure databases
ProteinModelPortal	P23493.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4119N.
MINT	MINT-574488.
STRING	4932.YKL093W.
Proteomic databases
PaxDb	P23493.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YKL093W; YKL093W; YKL093W.
GeneID	853769.
KEGG	sce:YKL093W.
Organism-specific databases
CYGD	YKL093w.
SGD	S000001576. MBR1.
Phylogenomic databases
eggNOG	NOG78631.
Gene expression databases
Genevestigator	P23493.
GermOnline	YKL093W. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	974864.

Entry information

Entry name

MBR1_YEAST

Accession

Primary (citable) accession number: P23493
Secondary accession number(s): D6VXJ5, Q2VQW7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	June 1, 1994
Last modified:	April 3, 2013
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program