P23491ZP3_MESAUZona pellucida sperm-binding protein 3Sperm receptorZona pellucida glycoprotein 3Zp-3Zona pellucida protein CProcessed zona pellucida sperm-binding protein 3ZP3ZPCMesocricetus auratusGolden hamsterEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeMesocricetusGenomic organization and polypeptide primary structure of zona pellucida glycoprotein hZP3, the hamster sperm receptor.NUCLEOTIDE SEQUENCE [MRNA]Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers. Interacts with ZP1 and ZP2.Processed zona pellucida sperm-binding protein 3Zona pellucidaCell membraneSingle-pass type I membrane proteinExpressed in oocytes.Expressed in growing oocytes.The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.N-glycosylated.O-glycosylated; removal of O-linked glycans may play an important role in the post-fertilization block to polyspermy.Belongs to the ZP domain family. ZPC subfamily.Molecular chastity - Issue 93 of April 2008Cell membraneCleavage on pair of basic residuesDisulfide bondExtracellular matrixFertilizationGlycoproteinMembranePyrrolidone carboxylic acidReceptorReference proteomeSecretedSignalTransmembraneTransmembrane helixMGLSYQLLLCLLLCGGAKQCCSQPLWLLPGGTPTPGKLTSSVEVECLEAELVVTVSRDLFGTGKLIQPEDLTLGSENCRPLVSVATDVVRFKAQLHECSNRVQVTEDALVYSTVLLHQPRPVPGLSILRTNRADVPIECRYPRQGNVSSHAIRPTWVPFSTTVSSEEKLVFSLRLMEENWNTEKLSPTSHLGEVAYLQAEVQTGSHLPLLLFVDRCVPTPSPDQTASPYHVIVDFHGCLVDGLSESFSAFQVPRPRPETLQFTVDVFHFANSSRNTIYITCHLKVTPANQTPDELNKACSFNRSSKSWSPVEGDAEVCGCCSSGDCGSSSRSRYQAHGVSQWPKSASRRRRHVRDEADVTVGPLIFLGKASDQAVEGWASSAQTSLALGLGLAAVAFLTLAAIVLGVTRSCHTPSHVVSLSQ
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License