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Protein

Protein FecR

Gene

fecR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regulation of iron dicitrate transport. In the absence of citrate FecR inactivates fecI. FecR is probably a sensor that recognizes iron dicitrate in the periplasm.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Sensory transduction, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciEcoCyc:EG10292-MONOMER.
ECOL316407:JW4252-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FecR
Gene namesi
Name:fecR
Ordered Locus Names:b4292, JW4252
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10292. fecR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Protein FecRPRO_0000087218Add
BLAST

Proteomic databases

PaxDbiP23485.

Expressioni

Inductioni

Induced by hydroxyurea.1 Publication

Interactioni

Protein-protein interaction databases

DIPiDIP-9589N.
IntActiP23485. 3 interactions.
MINTiMINT-119295.
STRINGi511145.b4292.

Structurei

3D structure databases

ProteinModelPortaliP23485.
SMRiP23485. Positions 10-63, 123-303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4108S3W. Bacteria.
COG3712. LUCA.
HOGENOMiHOG000258943.
InParanoidiP23485.
KOiK07165.
OMAiAWERTCK.
PhylomeDBiP23485.

Family and domain databases

InterProiIPR006860. FecR.
IPR032508. FecR_C.
IPR032623. FecR_N.
IPR012373. Ferrdict_sens_TM.
[Graphical view]
PANTHERiPTHR30273. PTHR30273. 1 hit.
PfamiPF16220. DUF4880. 1 hit.
PF16344. DUF4974. 1 hit.
PF04773. FecR. 1 hit.
[Graphical view]
PIRSFiPIRSF018266. FecR. 1 hit.

Sequencei

Sequence statusi: Complete.

P23485-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPLLTDSRR QALRSASHWY AVLSGERVSP QQEARWQQWY EQDQDNQWAW
60 70 80 90 100
QQVENLRNQL GGVPGDVASR ALHDTRLTRR HVMKGLLLLL GAGGGWQLWQ
110 120 130 140 150
SETGEGLRAD YRTAKGTVSR QQLEDGSLLT LNTQSAADVR FDAHQRTVRL
160 170 180 190 200
WYGEIAITTA KDALQRPFRV LTRQGQLTAL GTEFTVRQQD NFTQLDVQQH
210 220 230 240 250
AVEVLLASAP AQKRIVNAGE SLQFSASEFG AVKPLDDEST SWTKDILSFS
260 270 280 290 300
DKPLGEVIAT LTRYRNGVLR CDPAVAGLRL SGTFPLKNTD AILNVIAQTL
310
PVKIQSITRY WINISPL
Length:317
Mass (Da):35,532
Last modified:November 1, 1991 - v1
Checksum:i798EC615815AF9D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63115 Genomic DNA. Translation: AAA23767.1.
U14003 Genomic DNA. Translation: AAA97188.1.
U00096 Genomic DNA. Translation: AAC77248.1.
AP009048 Genomic DNA. Translation: BAE78283.1.
PIRiB37804.
RefSeqiNP_418712.1. NC_000913.3.
WP_001068910.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77248; AAC77248; b4292.
BAE78283; BAE78283; BAE78283.
GeneIDi949104.
KEGGiecj:JW4252.
eco:b4292.
PATRICi32124163. VBIEscCol129921_4425.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63115 Genomic DNA. Translation: AAA23767.1.
U14003 Genomic DNA. Translation: AAA97188.1.
U00096 Genomic DNA. Translation: AAC77248.1.
AP009048 Genomic DNA. Translation: BAE78283.1.
PIRiB37804.
RefSeqiNP_418712.1. NC_000913.3.
WP_001068910.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP23485.
SMRiP23485. Positions 10-63, 123-303.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-9589N.
IntActiP23485. 3 interactions.
MINTiMINT-119295.
STRINGi511145.b4292.

Proteomic databases

PaxDbiP23485.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77248; AAC77248; b4292.
BAE78283; BAE78283; BAE78283.
GeneIDi949104.
KEGGiecj:JW4252.
eco:b4292.
PATRICi32124163. VBIEscCol129921_4425.

Organism-specific databases

EchoBASEiEB0288.
EcoGeneiEG10292. fecR.

Phylogenomic databases

eggNOGiENOG4108S3W. Bacteria.
COG3712. LUCA.
HOGENOMiHOG000258943.
InParanoidiP23485.
KOiK07165.
OMAiAWERTCK.
PhylomeDBiP23485.

Enzyme and pathway databases

BioCyciEcoCyc:EG10292-MONOMER.
ECOL316407:JW4252-MONOMER.

Miscellaneous databases

PROiP23485.

Family and domain databases

InterProiIPR006860. FecR.
IPR032508. FecR_C.
IPR032623. FecR_N.
IPR012373. Ferrdict_sens_TM.
[Graphical view]
PANTHERiPTHR30273. PTHR30273. 1 hit.
PfamiPF16220. DUF4880. 1 hit.
PF16344. DUF4974. 1 hit.
PF04773. FecR. 1 hit.
[Graphical view]
PIRSFiPIRSF018266. FecR. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFECR_ECOLI
AccessioniPrimary (citable) accession number: P23485
Secondary accession number(s): Q2M623
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.