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Protein

Probable RNA polymerase sigma factor FecI

Gene

fecI

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor regulates the fec genes for iron dicitrate transport (Probable).Curated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi139 – 15820H-T-H motifBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Sigma factor

Keywords - Biological processi

Ion transport, Iron transport, Transcription, Transcription regulation, Transport

Keywords - Ligandi

DNA-binding, Iron

Enzyme and pathway databases

BioCyciEcoCyc:PD00440.
ECOL316407:JW4253-MONOMER.
MetaCyc:PD00440.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable RNA polymerase sigma factor FecI
Gene namesi
Name:fecI
Ordered Locus Names:b4293, JW4253
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10291. fecI.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 173172Probable RNA polymerase sigma factor FecIPRO_0000094011Add
BLAST

Proteomic databases

PaxDbiP23484.

Expressioni

Inductioni

Induced 2.1-fold by hydroxyurea.1 Publication

Interactioni

Protein-protein interaction databases

DIPiDIP-9588N.
IntActiP23484. 8 interactions.
MINTiMINT-119346.
STRINGi511145.b4293.

Structurei

3D structure databases

ProteinModelPortaliP23484.
SMRiP23484. Positions 1-78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5213Polymerase core bindingAdd
BLAST

Sequence similaritiesi

Belongs to the sigma-70 factor family. ECF subfamily.Curated

Phylogenomic databases

eggNOGiENOG4108SF5. Bacteria.
COG1595. LUCA.
HOGENOMiHOG000094759.
InParanoidiP23484.
KOiK03088.
OMAiDIREPRP.
PhylomeDBiP23484.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR014284. RNA_pol_sigma-70_dom.
IPR000838. RNA_pol_sigma70_ECF_CS.
IPR007627. RNA_pol_sigma70_r2.
IPR013249. RNA_pol_sigma70_r4_t2.
IPR013325. RNA_pol_sigma_r2.
IPR013324. RNA_pol_sigma_r3_r4.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF04542. Sigma70_r2. 1 hit.
PF08281. Sigma70_r4_2. 1 hit.
[Graphical view]
SUPFAMiSSF88659. SSF88659. 1 hit.
SSF88946. SSF88946. 1 hit.
TIGRFAMsiTIGR02937. sigma70-ECF. 1 hit.
PROSITEiPS01063. SIGMA70_ECF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23484-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDRATTTAS LTFESLYGTH HGWLKSWLTR KLQSAFDADD IAQDTFLRVM
60 70 80 90 100
VSETLSTIRD PRSFLCTIAK RVMVDLFRRN ALEKAYLEML ALMPEGGAPS
110 120 130 140 150
PEERESQLET LQLLDSMLDG LNGKTREAFL LSQLDGLTYS EIAHKLGVSI
160 170
SSVKKYVAKA VEHCLLFRLE YGL
Length:173
Mass (Da):19,480
Last modified:January 23, 2007 - v3
Checksum:i5CAD4F4840E71FAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63115 Genomic DNA. Translation: AAA23766.1.
U14003 Genomic DNA. Translation: AAA97189.1.
U00096 Genomic DNA. Translation: AAC77249.1.
AP009048 Genomic DNA. Translation: BAE78284.1.
PIRiJV0111.
RefSeqiNP_418713.1. NC_000913.3.
WP_001283626.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77249; AAC77249; b4293.
BAE78284; BAE78284; BAE78284.
GeneIDi946839.
KEGGiecj:JW4253.
eco:b4293.
PATRICi32124165. VBIEscCol129921_4426.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63115 Genomic DNA. Translation: AAA23766.1.
U14003 Genomic DNA. Translation: AAA97189.1.
U00096 Genomic DNA. Translation: AAC77249.1.
AP009048 Genomic DNA. Translation: BAE78284.1.
PIRiJV0111.
RefSeqiNP_418713.1. NC_000913.3.
WP_001283626.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP23484.
SMRiP23484. Positions 1-78.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-9588N.
IntActiP23484. 8 interactions.
MINTiMINT-119346.
STRINGi511145.b4293.

Proteomic databases

PaxDbiP23484.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77249; AAC77249; b4293.
BAE78284; BAE78284; BAE78284.
GeneIDi946839.
KEGGiecj:JW4253.
eco:b4293.
PATRICi32124165. VBIEscCol129921_4426.

Organism-specific databases

EchoBASEiEB0287.
EcoGeneiEG10291. fecI.

Phylogenomic databases

eggNOGiENOG4108SF5. Bacteria.
COG1595. LUCA.
HOGENOMiHOG000094759.
InParanoidiP23484.
KOiK03088.
OMAiDIREPRP.
PhylomeDBiP23484.

Enzyme and pathway databases

BioCyciEcoCyc:PD00440.
ECOL316407:JW4253-MONOMER.
MetaCyc:PD00440.

Miscellaneous databases

PROiP23484.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR014284. RNA_pol_sigma-70_dom.
IPR000838. RNA_pol_sigma70_ECF_CS.
IPR007627. RNA_pol_sigma70_r2.
IPR013249. RNA_pol_sigma70_r4_t2.
IPR013325. RNA_pol_sigma_r2.
IPR013324. RNA_pol_sigma_r3_r4.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF04542. Sigma70_r2. 1 hit.
PF08281. Sigma70_r4_2. 1 hit.
[Graphical view]
SUPFAMiSSF88659. SSF88659. 1 hit.
SSF88946. SSF88946. 1 hit.
TIGRFAMsiTIGR02937. sigma70-ECF. 1 hit.
PROSITEiPS01063. SIGMA70_ECF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFECI_ECOLI
AccessioniPrimary (citable) accession number: P23484
Secondary accession number(s): Q2M622
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.