P23471 (PTPRZ_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Receptor-type tyrosine-protein phosphatase zeta
Short name=R-PTP-zeta
EC=3.1.3.48

Alternative name(s):
Protein-tyrosine phosphatase receptor type Z polypeptide 1
Protein-tyrosine phosphatase receptor type Z polypeptide 2
R-PTP-zeta-2

Gene names

Name:	PTPRZ1
Synonyms:	HTPZP2, PTPRZ, PTPRZ2, PTPZ

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2315 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in the regulation of specific developmental processes in the CNS.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Subunit structure	The carbonic-anhydrase like domain binds to contactin By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Specifically expressed in the central nervous system, where it is localized in the Purkinje cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral ventricle. Developmentally regulated in the brain. Ref.6
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily. Contains 1 alpha-carbonic anhydrase domain. Contains 1 fibronectin type-III domain. Contains 2 tyrosine-protein phosphatase domains.
Caution	Was termed (Ref.2 and Ref.7) RPTPase beta. The human genome was initially thought to contain 2 genes for PTPRZ: PTPRZ1 (on chr 7) and PTPRZ2 (on chr 1). However, PTPRZ2 probably does not exist and corresponds to PTPRZ1.
Sequence caution	The sequence AAC39934.1 differs from that shown. Reason: Contaminating sequence. The N-terminus may be contaminated with vector sequence.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	Hydrolase Protein phosphatase
PTM	Glycoprotein Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axonogenesis Inferred from electronic annotation. Source: Compara central nervous system development Traceable author statement Ref.2. Source: ProtInc
Cellular_component	integral to plasma membrane Traceable author statement Ref.2. Source: ProtInc perineuronal net Inferred from electronic annotation. Source: Compara proteinaceous extracellular matrix Inferred from electronic annotation. Source: Compara
Molecular_function	protein tyrosine/threonine phosphatase activity Non-traceable author statement Ref.6. Source: UniProtKB transmembrane receptor protein tyrosine phosphatase activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform Long (identifier: P23471-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Short (identifier: P23471-2)

The sequence of this isoform differs from the canonical sequence as follows:
     755-1615: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 24

24

By similarity

Chain

25 – 2315

2291

Receptor-type tyrosine-protein phosphatase zeta

PRO_0000025468

Regions

Topological domain

25 – 1636

1612

Extracellular Potential

Transmembrane

1637 – 1662

26

Helical; Potential

Topological domain

1663 – 2315

653

Cytoplasmic Potential

Domain

36 – 300

265

Alpha-carbonic anhydrase

Domain

311 – 406

96

Fibronectin type-III

Domain

1717 – 1992

276

Tyrosine-protein phosphatase 1

Domain

2023 – 2282

260

Tyrosine-protein phosphatase 2

Region

1933 – 1939

7

Substrate binding By similarity

Sites

Active site

1933

1

Phosphocysteine intermediate By similarity

Binding site

1901

1

Substrate By similarity

Binding site

1977

1

Substrate By similarity

Site

2223

1

Ancestral active site

Amino acid modifications

Modified residue

2055

1

Phosphoserine Ref.10

Glycosylation

105

1

N-linked (GlcNAc...) Ref.9

Glycosylation

134

1

N-linked (GlcNAc...) Potential

Glycosylation

223

1

N-linked (GlcNAc...) Potential

Glycosylation

232

1

N-linked (GlcNAc...) Potential

Glycosylation

324

1

N-linked (GlcNAc...) Potential

Glycosylation

381

1

N-linked (GlcNAc...) Potential

Glycosylation

497

1

N-linked (GlcNAc...) Potential

Glycosylation

501

1

N-linked (GlcNAc...) Potential

Glycosylation

552

1

N-linked (GlcNAc...) Potential

Glycosylation

587

1

O-linked (Xyl...) (chondroitin sulfate) Potential

Glycosylation

602

1

N-linked (GlcNAc...) Potential

Glycosylation

629

1

N-linked (GlcNAc...) Potential

Glycosylation

637

1

O-linked (Xyl...) (chondroitin sulfate) Potential

Glycosylation

677

1

N-linked (GlcNAc...) Potential

Glycosylation

997

1

O-linked (Xyl...) (chondroitin sulfate) Potential

Glycosylation

1017

1

N-linked (GlcNAc...) Potential

Glycosylation

1050

1

N-linked (GlcNAc...) Potential

Glycosylation

1082

1

N-linked (GlcNAc...) Potential

Glycosylation

1122

1

N-linked (GlcNAc...) Potential

Glycosylation

1457

1

N-linked (GlcNAc...) Potential

Glycosylation

1549

1

O-linked (Xyl...) (chondroitin sulfate) Potential

Glycosylation

1551

1

O-linked (Xyl...) (chondroitin sulfate) Potential

Glycosylation

1562

1

N-linked (GlcNAc...) Potential

Glycosylation

1618

1

N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence

755 – 1615

861

Missing in isoform Short.

VSP_005151

Natural variant

3

1

I → S.
Corresponds to variant rs740965 [ dbSNP | Ensembl ].

VAR_038942

Natural variant

6

1

R → L.
Corresponds to variant rs11980387 [ dbSNP | Ensembl ].

VAR_038943

Natural variant

1433

1

G → D. Ref.1 Ref.4 Ref.5
Corresponds to variant rs1147504 [ dbSNP | Ensembl ].

VAR_038944

Experimental info

Sequence conflict

310

1

V → A in AAC39934. Ref.6

Sequence conflict

312

1

S → R in AAC39934. Ref.6

Sequence conflict

1426

1

Missing in AAA60225. Ref.1

Sequence conflict

1426

1

Missing Ref.2

Sequence conflict

1426

1

Missing in EAL24344. Ref.4

Sequence conflict

1426

1

Missing in EAW83561. Ref.5

Sequence conflict

1723 – 1729

7

Missing Ref.2

Secondary structure

1

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2315

Helix Strand Turn

Details...

Beta strand

40 – 42

3

Helix

46 – 48

3

Helix

49 – 52

4

Helix

54 – 57

4

Beta strand

58 – 60

3

Helix

68 – 70

3

Beta strand

71 – 73

3

Beta strand

78 – 84

7

Beta strand

94 – 97

4

Beta strand

102 – 105

4

Beta strand

111 – 116

6

Beta strand

121 – 134

14

Beta strand

141 – 144

4

Beta strand

150 – 158

9

Turn

160 – 162

3

Helix

166 – 171

6

Beta strand

176 – 185

10

Helix

191 – 193

3

Helix

194 – 202

9

Beta strand

209 – 211

3

Helix

217 – 220

4

Beta strand

226 – 233

8

Beta strand

244 – 251

8

Beta strand

253 – 255

3

Helix

257 – 261

5

Helix

262 – 265

4

Beta strand

267 – 272

6

Beta strand

275 – 280

6

Sequences

	Sequence		Length	Mass (Da)
	Isoform Long [UniParc]. Last modified March 24, 2009. Version 4. Checksum: ED9DD98D4CCA2883	FASTA	2,315	254,587
	10 20 30 40 50 60 MRILKRFLAC IQLLCVCRLD WANGYYRQQR KLVEEIGWSY TGALNQKNWG KKYPTCNSPK 70 80 90 100 110 120 QSPINIDEDL TQVNVNLKKL KFQGWDKTSL ENTFIHNTGK TVEINLTNDY RVSGGVSEMV 130 140 150 160 170 180 FKASKITFHW GKCNMSSDGS EHSLEGQKFP LEMQIYCFDA DRFSSFEEAV KGKGKLRALS 190 200 210 220 230 240 ILFEVGTEEN LDFKAIIDGV ESVSRFGKQA ALDPFILLNL LPNSTDKYYI YNGSLTSPPC 250 260 270 280 290 300 TDTVDWIVFK DTVSISESQL AVFCEVLTMQ QSGYVMLMDY LQNNFREQQY KFSRQVFSSY 310 320 330 340 350 360 TGKEEIHEAV CSSEPENVQA DPENYTSLLV TWERPRVVYD TMIEKFAVLY QQLDGEDQTK 370 380 390 400 410 420 HEFLTDGYQD LGAILNNLLP NMSYVLQIVA ICTNGLYGKY SDQLIVDMPT DNPELDLFPE 430 440 450 460 470 480 LIGTEEIIKE EEEGKDIEEG AIVNPGRDSA TNQIRKKEPQ ISTTTHYNRI GTKYNEAKTN 490 500 510 520 530 540 RSPTRGSEFS GKGDVPNTSL NSTSQPVTKL ATEKDISLTS QTVTELPPHT VEGTSASLND 550 560 570 580 590 600 GSKTVLRSPH MNLSGTAESL NTVSITEYEE ESLLTSFKLD TGAEDSSGSS PATSAIPFIS 610 620 630 640 650 660 ENISQGYIFS SENPETITYD VLIPESARNA SEDSTSSGSE ESLKDPSMEG NVWFPSSTDI 670 680 690 700 710 720 TAQPDVGSGR ESFLQTNYTE IRVDESEKTT KSFSAGPVMS QGPSVTDLEM PHYSTFAYFP 730 740 750 760 770 780 TEVTPHAFTP SSRQQDLVST VNVVYSQTTQ PVYNGETPLQ PSYSSEVFPL VTPLLLDNQI 790 800 810 820 830 840 LNTTPAASSS DSALHATPVF PSVDVSFESI LSSYDGAPLL PFSSASFSSE LFRHLHTVSQ 850 860 870 880 890 900 ILPQVTSATE SDKVPLHASL PVAGGDLLLE PSLAQYSDVL STTHAASETL EFGSESGVLY 910 920 930 940 950 960 KTLMFSQVEP PSSDAMMHAR SSGPEPSYAL SDNEGSQHIF TVSYSSAIPV HDSVGVTYQG 970 980 990 1000 1010 1020 SLFSGPSHIP IPKSSLITPT ASLLQPTHAL SGDGEWSGAS SDSEFLLPDT DGLTALNISS 1030 1040 1050 1060 1070 1080 PVSVAEFTYT TSVFGDDNKA LSKSEIIYGN ETELQIPSFN EMVYPSESTV MPNMYDNVNK 1090 1100 1110 1120 1130 1140 LNASLQETSV SISSTKGMFP GSLAHTTTKV FDHEISQVPE NNFSVQPTHT VSQASGDTSL 1150 1160 1170 1180 1190 1200 KPVLSANSEP ASSDPASSEM LSPSTQLLFY ETSASFSTEV LLQPSFQASD VDTLLKTVLP 1210 1220 1230 1240 1250 1260 AVPSDPILVE TPKVDKISST MLHLIVSNSA SSENMLHSTS VPVFDVSPTS HMHSASLQGL 1270 1280 1290 1300 1310 1320 TISYASEKYE PVLLKSESSH QVVPSLYSND ELFQTANLEI NQAHPPKGRH VFATPVLSID 1330 1340 1350 1360 1370 1380 EPLNTLINKL IHSDEILTST KSSVTGKVFA GIPTVASDTF VSTDHSVPIG NGHVAITAVS 1390 1400 1410 1420 1430 1440 PHRDGSVTST KLLFPSKATS ELSHSAKSDA GLVGGGEDGD TDDDGDDDDD DRGSDGLSIH 1450 1460 1470 1480 1490 1500 KCMSCSSYRE SQEKVMNDSD THENSLMDQN NPISYSLSEN SEEDNRVTSV SSDSQTGMDR 1510 1520 1530 1540 1550 1560 SPGKSPSANG LSQKHNDGKE ENDIQTGSAL LPLSPESKAW AVLTSDEESG SGQGTSDSLN 1570 1580 1590 1600 1610 1620 ENETSTDFSF ADTNEKDADG ILAAGDSEIT PGFPQSPTSS VTSENSEVFH VSEAEASNSS 1630 1640 1650 1660 1670 1680 HESRIGLAEG LESEKKAVIP LVIVSALTFI CLVVLVGILI YWRKCFQTAH FYLEDSTSPR 1690 1700 1710 1720 1730 1740 VISTPPTPIF PISDDVGAIP IKHFPKHVAD LHASSGFTEE FETLKEFYQE VQSCTVDLGI 1750 1760 1770 1780 1790 1800 TADSSNHPDN KHKNRYINIV AYDHSRVKLA QLAEKDGKLT DYINANYVDG YNRPKAYIAA 1810 1820 1830 1840 1850 1860 QGPLKSTAED FWRMIWEHNV EVIVMITNLV EKGRRKCDQY WPADGSEEYG NFLVTQKSVQ 1870 1880 1890 1900 1910 1920 VLAYYTVRNF TLRNTKIKKG SQKGRPSGRV VTQYHYTQWP DMGVPEYSLP VLTFVRKAAY 1930 1940 1950 1960 1970 1980 AKRHAVGPVV VHCSAGVGRT GTYIVLDSML QQIQHEGTVN IFGFLKHIRS QRNYLVQTEE 1990 2000 2010 2020 2030 2040 QYVFIHDTLV EAILSKETEV LDSHIHAYVN ALLIPGPAGK TKLEKQFQLL SQSNIQQSDY 2050 2060 2070 2080 2090 2100 SAALKQCNRE KNRTSSIIPV ERSRVGISSL SGEGTDYINA SYIMGYYQSN EFIITQHPLL 2110 2120 2130 2140 2150 2160 HTIKDFWRMI WDHNAQLVVM IPDGQNMAED EFVYWPNKDE PINCESFKVT LMAEEHKCLS 2170 2180 2190 2200 2210 2220 NEEKLIIQDF ILEATQDDYV LEVRHFQCPK WPNPDSPISK TFELISVIKE EAANRDGPMI 2230 2240 2250 2260 2270 2280 VHDEHGGVTA GTFCALTTLM HQLEKENSVD VYQVAKMINL MRPGVFADIE QYQFLYKVIL 2290 2300 2310 SLVSTRQEEN PSTSLDSNGA ALPDGNIAES LESLV
	Isoform Short [UniParc]. Checksum: BC304DB735AE359A	FASTA	1,454	163,444
	10 20 30 40 50 60 MRILKRFLAC IQLLCVCRLD WANGYYRQQR KLVEEIGWSY TGALNQKNWG KKYPTCNSPK 70 80 90 100 110 120 QSPINIDEDL TQVNVNLKKL KFQGWDKTSL ENTFIHNTGK TVEINLTNDY RVSGGVSEMV 130 140 150 160 170 180 FKASKITFHW GKCNMSSDGS EHSLEGQKFP LEMQIYCFDA DRFSSFEEAV KGKGKLRALS 190 200 210 220 230 240 ILFEVGTEEN LDFKAIIDGV ESVSRFGKQA ALDPFILLNL LPNSTDKYYI YNGSLTSPPC 250 260 270 280 290 300 TDTVDWIVFK DTVSISESQL AVFCEVLTMQ QSGYVMLMDY LQNNFREQQY KFSRQVFSSY 310 320 330 340 350 360 TGKEEIHEAV CSSEPENVQA DPENYTSLLV TWERPRVVYD TMIEKFAVLY QQLDGEDQTK 370 380 390 400 410 420 HEFLTDGYQD LGAILNNLLP NMSYVLQIVA ICTNGLYGKY SDQLIVDMPT DNPELDLFPE 430 440 450 460 470 480 LIGTEEIIKE EEEGKDIEEG AIVNPGRDSA TNQIRKKEPQ ISTTTHYNRI GTKYNEAKTN 490 500 510 520 530 540 RSPTRGSEFS GKGDVPNTSL NSTSQPVTKL ATEKDISLTS QTVTELPPHT VEGTSASLND 550 560 570 580 590 600 GSKTVLRSPH MNLSGTAESL NTVSITEYEE ESLLTSFKLD TGAEDSSGSS PATSAIPFIS 610 620 630 640 650 660 ENISQGYIFS SENPETITYD VLIPESARNA SEDSTSSGSE ESLKDPSMEG NVWFPSSTDI 670 680 690 700 710 720 TAQPDVGSGR ESFLQTNYTE IRVDESEKTT KSFSAGPVMS QGPSVTDLEM PHYSTFAYFP 730 740 750 760 770 780 TEVTPHAFTP SSRQQDLVST VNVVYSQTTQ PVYNASNSSH ESRIGLAEGL ESEKKAVIPL 790 800 810 820 830 840 VIVSALTFIC LVVLVGILIY WRKCFQTAHF YLEDSTSPRV ISTPPTPIFP ISDDVGAIPI 850 860 870 880 890 900 KHFPKHVADL HASSGFTEEF ETLKEFYQEV QSCTVDLGIT ADSSNHPDNK HKNRYINIVA 910 920 930 940 950 960 YDHSRVKLAQ LAEKDGKLTD YINANYVDGY NRPKAYIAAQ GPLKSTAEDF WRMIWEHNVE 970 980 990 1000 1010 1020 VIVMITNLVE KGRRKCDQYW PADGSEEYGN FLVTQKSVQV LAYYTVRNFT LRNTKIKKGS 1030 1040 1050 1060 1070 1080 QKGRPSGRVV TQYHYTQWPD MGVPEYSLPV LTFVRKAAYA KRHAVGPVVV HCSAGVGRTG 1090 1100 1110 1120 1130 1140 TYIVLDSMLQ QIQHEGTVNI FGFLKHIRSQ RNYLVQTEEQ YVFIHDTLVE AILSKETEVL 1150 1160 1170 1180 1190 1200 DSHIHAYVNA LLIPGPAGKT KLEKQFQLLS QSNIQQSDYS AALKQCNREK NRTSSIIPVE 1210 1220 1230 1240 1250 1260 RSRVGISSLS GEGTDYINAS YIMGYYQSNE FIITQHPLLH TIKDFWRMIW DHNAQLVVMI 1270 1280 1290 1300 1310 1320 PDGQNMAEDE FVYWPNKDEP INCESFKVTL MAEEHKCLSN EEKLIIQDFI LEATQDDYVL 1330 1340 1350 1360 1370 1380 EVRHFQCPKW PNPDSPISKT FELISVIKEE AANRDGPMIV HDEHGGVTAG TFCALTTLMH 1390 1400 1410 1420 1430 1440 QLEKENSVDV YQVAKMINLM RPGVFADIEQ YQFLYKVILS LVSTRQEENP STSLDSNGAA 1450 LPDGNIAESL ESLV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases." Krueger N.X., Saito H. Proc. Natl. Acad. Sci. U.S.A. 89:7417-7421(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), VARIANT ASP-1433. Tissue: Brain.
[2]	"The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system." Levy J.B., Canoll P.D., Silvennoinen O., Barnea G., Morse B., Honegger A.M., Huang J.-T., Cannizzaro L.A., Park S.-H., Druck T., Huebner K., Sap J., Ehrlich M., Musacchio J.M., Schlessinger J. J. Biol. Chem. 268:10573-10581(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT). Tissue: Brain stem.
[3]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASP-1433.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASP-1433.
[6]	"Molecular cloning and expression analysis of five novel genes in chromosome 1p36." Onyango P., Lubyova B., Gardellin P., Kurzbauer R., Weith A. Genomics 50:187-198(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-999 (ISOFORM LONG), TISSUE SPECIFICITY.
[7]	"Structural diversity and evolution of human receptor-like protein tyrosine phosphatases." Krueger N.X., Streuli M., Saito H. EMBO J. 9:3241-3252(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1480-2092 (ISOFORM LONG). Tissue: Liver.
[8]	"Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain." Kaplan R., Morse B., Huebner K., Croce C., Howk R., Ravera M., Ricca G., Jaye M., Schlessinger J. Proc. Natl. Acad. Sci. U.S.A. 87:7000-7004(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1750-1991 AND 2048-2281 (ISOFORM LONG). Tissue: Brain stem.
[9]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-105, MASS SPECTROMETRY. Tissue: Plasma.
[10]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2055, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M93426 mRNA. Translation: AAA60225.1.
AC006020 Genomic DNA. Translation: AAF03527.1.
AC006353 Genomic DNA. No translation available.
AC073095 Genomic DNA. No translation available.
CH236947 Genomic DNA. Translation: EAL24344.1.
CH471070 Genomic DNA. Translation: EAW83561.1.
U88967 mRNA. Translation: AAC39934.1. Sequence problems.
X54135 mRNA. Translation: CAA38070.1.

IPI

IPI00748312.
IPI00871792.

PIR

A46151.

RefSeq

NP_001193767.1. NM_001206838.1.
NP_001193768.1. NM_001206839.1.
NP_002842.2. NM_002851.2.

UniGene

Hs.489824.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3JXF	X-ray	2.00	A/B	34-302	[»]
3S97	X-ray	2.30	A/B	34-302	[»]

ProteinModelPortal

P23471.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-42063N.

IntAct

P23471. 8 interactions.

MINT

MINT-1350337.

STRING

9606.ENSP00000377047.

PTM databases

PhosphoSite

P23471.

Polymorphism databases

DMDM

229485537.

Proteomic databases

PaxDb

P23471.

PRIDE

P23471.

Protocols and materials databases

DNASU

5803.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000393386; ENSP00000377047; ENSG00000106278.

GeneID

5803.

KEGG

hsa:5803.

UCSC

uc003vjy.3. human.

Organism-specific databases

CTD

5803.

GeneCards

GC07P121513.

HGNC

HGNC:9685. PTPRZ1.

HPA

CAB025106.
HPA015103.

MIM

176891. gene.
604008. gene.

neXtProt

NX_P23471.

PharmGKB

PA34029.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5599.

HOGENOM

HOG000090262.

HOVERGEN

HBG053760.

InParanoid

P23471.

KO

K08114.

OMA

MHARSSG.

OrthoDB

EOG4CZBDZ.

PhylomeDB

P23471.

Gene expression databases

ArrayExpress

P23471.

Bgee

P23471.

CleanEx

HS_PTPRZ1.

Genevestigator

P23471.

GermOnline

ENSG00000106278. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 1 hit.
3.10.200.10. 1 hit.

InterPro

IPR001148. Carbonic_anhydrase_a.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]

Pfam

PF00194. Carb_anhydrase. 1 hit.
PF00041. fn3. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]

PRINTS

PR00700. PRTYPHPHTASE.

SMART

SM01057. Carb_anhydrase. 1 hit.
SM00060. FN3. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view]

SUPFAM

SSF51069. Euk_COanhd. 1 hit.
SSF49265. FN_III-like. 1 hit.

PROSITE

PS51144. ALPHA_CA_2. 1 hit.
PS50853. FN3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

PTPRZ1. human.

EvolutionaryTrace

P23471.

GenomeRNAi

5803.

NextBio

22622.

SOURCE

Search...

Entry information

Entry name

PTPRZ_HUMAN

Accession

Primary (citable) accession number: P23471
Secondary accession number(s): A4D0W5, O76043, Q9UDR6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	March 24, 2009
Last modified:	May 1, 2013
This is version 151 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.