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Protein

Receptor-type tyrosine-protein phosphatase gamma

Gene

PTPRG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possesses tyrosine phosphatase activity.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1028SubstrateBy similarity1
Active sitei1060Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei1104SubstrateBy similarity1
Sitei1351Ancestral active site1

GO - Molecular functioni

  • identical protein binding Source: UniProtKB
  • protein tyrosine phosphatase activity Source: UniProtKB
  • transmembrane receptor protein tyrosine phosphatase activity Source: ProtInc

GO - Biological processi

  • brain development Source: Ensembl
  • negative regulation of epithelial cell migration Source: UniProtKB
  • negative regulation of neuron projection development Source: Ensembl
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: ProtInc

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

BRENDAi3.1.3.48 2681
SignaLinkiP23470
SIGNORiP23470

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase gamma (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase gamma
Short name:
R-PTP-gamma
Gene namesi
Name:PTPRG
Synonyms:PTPG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000144724.18
HGNCiHGNC:9671 PTPRG
MIMi176886 gene
neXtProtiNX_P23470

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 736ExtracellularSequence analysisAdd BLAST717
Transmembranei737 – 762HelicalSequence analysisAdd BLAST26
Topological domaini763 – 1445CytoplasmicSequence analysisAdd BLAST683

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi958R → E: Loss of dimerization; when associated with E-960. 1 Publication1
Mutagenesisi960K → E: Loss of dimerization; when associated with E-958. 1 Publication1
Mutagenesisi1305D → K: Loss of dimerization; when associated with K-1306. 1 Publication1
Mutagenesisi1306D → K: Loss of dimerization; when associated with K-1305. 1 Publication1

Organism-specific databases

DisGeNETi5793
OpenTargetsiENSG00000144724
PharmGKBiPA34016

Chemistry databases

ChEMBLiCHEMBL4905
GuidetoPHARMACOLOGYi1856

Polymorphism and mutation databases

BioMutaiPTPRG
DMDMi229463033

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000002544120 – 1445Receptor-type tyrosine-protein phosphatase gammaAdd BLAST1426

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi78 ↔ 2611 Publication
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi113N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi359N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi444N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi619N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi631N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi722N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1182PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP23470
MaxQBiP23470
PaxDbiP23470
PeptideAtlasiP23470
PRIDEiP23470

PTM databases

DEPODiP23470
iPTMnetiP23470
PhosphoSitePlusiP23470
SwissPalmiP23470

Expressioni

Tissue specificityi

Found in a variety of tissues.

Gene expression databases

BgeeiENSG00000144724
CleanExiHS_PTPRG
GenevisibleiP23470 HS

Organism-specific databases

HPAiHPA064237

Interactioni

Subunit structurei

Monomer; active form. Homodimer; inactive form (Probable). Interacts with CNTN3, CNTN4, CNTN5 and CNTN6.Curated2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi111757, 48 interactors
IntActiP23470, 24 interactors
MINTiP23470
STRINGi9606.ENSP00000418112

Chemistry databases

BindingDBiP23470

Structurei

Secondary structure

11445
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi64 – 66Combined sources3
Helixi68 – 70Combined sources3
Helixi71 – 74Combined sources4
Helixi76 – 79Combined sources4
Beta strandi80 – 82Combined sources3
Helixi90 – 92Combined sources3
Beta strandi103 – 106Combined sources4
Beta strandi116 – 119Combined sources4
Beta strandi124 – 127Combined sources4
Beta strandi133 – 135Combined sources3
Beta strandi143 – 152Combined sources10
Beta strandi162 – 165Combined sources4
Beta strandi171 – 179Combined sources9
Turni181 – 183Combined sources3
Helixi187 – 192Combined sources6
Beta strandi197 – 209Combined sources13
Helixi212 – 214Combined sources3
Helixi215 – 223Combined sources9
Beta strandi230 – 232Combined sources3
Helixi238 – 241Combined sources4
Beta strandi249 – 254Combined sources6
Beta strandi265 – 272Combined sources8
Beta strandi274 – 277Combined sources4
Helixi278 – 285Combined sources8
Beta strandi288 – 290Combined sources3
Beta strandi299 – 301Combined sources3
Beta strandi318 – 320Combined sources3
Helixi831 – 861Combined sources31
Turni867 – 870Combined sources4
Helixi872 – 877Combined sources6
Helixi887 – 889Combined sources3
Beta strandi890 – 892Combined sources3
Turni899 – 901Combined sources3
Helixi902 – 905Combined sources4
Beta strandi906 – 912Combined sources7
Beta strandi915 – 917Combined sources3
Beta strandi921 – 924Combined sources4
Helixi929 – 931Combined sources3
Helixi932 – 942Combined sources11
Beta strandi946 – 949Combined sources4
Beta strandi953 – 955Combined sources3
Beta strandi967 – 973Combined sources7
Beta strandi976 – 985Combined sources10
Beta strandi987 – 998Combined sources12
Beta strandi1016 – 1023Combined sources8
Beta strandi1028 – 1031Combined sources4
Helixi1036 – 1047Combined sources12
Beta strandi1056 – 1064Combined sources9
Helixi1065 – 1082Combined sources18
Beta strandi1084 – 1086Combined sources3
Helixi1088 – 1095Combined sources8
Turni1096 – 1098Combined sources3
Helixi1106 – 1121Combined sources16
Helixi1129 – 1131Combined sources3
Helixi1132 – 1139Combined sources8
Helixi1149 – 1157Combined sources9
Beta strandi1172 – 1174Combined sources3
Beta strandi1207 – 1211Combined sources5
Beta strandi1219 – 1224Combined sources6
Helixi1228 – 1230Combined sources3
Helixi1231 – 1241Combined sources11
Beta strandi1245 – 1248Combined sources4
Beta strandi1270 – 1272Combined sources3
Beta strandi1275 – 1286Combined sources12
Beta strandi1292 – 1305Combined sources14
Beta strandi1308 – 1315Combined sources8
Beta strandi1318 – 1320Combined sources3
Helixi1326 – 1328Combined sources3
Helixi1329 – 1340Combined sources12
Beta strandi1347 – 1354Combined sources8
Helixi1356 – 1374Combined sources19
Beta strandi1375 – 1377Combined sources3
Helixi1379 – 1389Combined sources11
Helixi1397 – 1408Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H4VX-ray1.55A/B831-1127[»]
2HY3X-ray2.60A/B820-1130[»]
2NLKX-ray2.40A827-1445[»]
2PBNX-ray1.70A820-1130[»]
3JXHX-ray1.70C56-320[»]
3QCBX-ray2.10A/B825-1128[»]
3QCCX-ray2.10A/B825-1128[»]
3QCDX-ray1.80A825-1128[»]
3QCEX-ray2.10A/B825-1128[»]
3QCFX-ray2.50A/B825-1128[»]
3QCGX-ray2.05A825-1128[»]
3QCHX-ray2.40A825-1128[»]
3QCIX-ray2.27A825-1128[»]
3QCJX-ray2.26A825-1128[»]
3QCKX-ray2.05A825-1128[»]
3QCLX-ray2.40A825-1128[»]
3QCMX-ray2.40A/B825-1128[»]
3QCNX-ray2.41A825-1128[»]
5E5RX-ray2.60A/C56-320[»]
ProteinModelPortaliP23470
SMRiP23470
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23470

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 321Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST264
Domaini349 – 448Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST100
Domaini848 – 1119Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST272
Domaini1150 – 1410Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST261

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1060 – 1066Substrate bindingBy similarity7

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0382 Eukaryota
KOG0789 Eukaryota
COG3338 LUCA
COG5599 LUCA
GeneTreeiENSGT00760000118900
HOGENOMiHOG000060222
HOVERGENiHBG053760
InParanoidiP23470
KOiK16667
OMAiWRGCNKI
OrthoDBiEOG091G018S
PhylomeDBiP23470
TreeFamiTF351978

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 1 hit
3.10.200.10, 1 hit
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
PF00041 fn3, 1 hit
PF00102 Y_phosphatase, 2 hits
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SM00060 FN3, 1 hit
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits
SUPFAMiSSF49265 SSF49265, 1 hit
SSF51069 SSF51069, 1 hit
SSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS51144 ALPHA_CA_2, 1 hit
PS50853 FN3, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P23470-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRLLEPCWW ILFLKITSSV LHYVVCFPAL TEGYVGALHE NRHGSAVQIR
60 70 80 90 100
RRKASGDPYW AYSGAYGPEH WVTSSVSCGG RHQSPIDILD QYARVGEEYQ
110 120 130 140 150
ELQLDGFDNE SSNKTWMKNT GKTVAILLKD DYFVSGAGLP GRFKAEKVEF
160 170 180 190 200
HWGHSNGSAG SEHSINGRRF PVEMQIFFYN PDDFDSFQTA ISENRIIGAM
210 220 230 240 250
AIFFQVSPRD NSALDPIIHG LKGVVHHEKE TFLDPFVLRD LLPASLGSYY
260 270 280 290 300
RYTGSLTTPP CSEIVEWIVF RRPVPISYHQ LEAFYSIFTT EQQDHVKSVE
310 320 330 340 350
YLRNNFRPQQ RLHDRVVSKS AVRDSWNHDM TDFLENPLGT EASKVCSSPP
360 370 380 390 400
IHMKVQPLNQ TALQVSWSQP ETIYHPPIMN YMISYSWTKN EDEKEKTFTK
410 420 430 440 450
DSDKDLKATI SHVSPDSLYL FRVQAVCRND MRSDFSQTML FQANTTRIFQ
460 470 480 490 500
GTRIVKTGVP TASPASSADM APISSGSSTW TSSGIPFSFV SMATGMGPSS
510 520 530 540 550
SGSQATVASV VTSTLLAGLG FGGGGISSFP STVWPTRLPT AASASKQAAR
560 570 580 590 600
PVLATTEALA SPGPDGDSSP TKDGEGTEEG EKDEKSESED GEREHEEDGE
610 620 630 640 650
KDSEKKEKSG VTHAAEERNQ TEPSPTPSSP NRTAEGGHQT IPGHEQDHTA
660 670 680 690 700
VPTDQTGGRR DAGPGLDPDM VTSTQVPPTA TEEQYAGSDP KRPEMPSKKP
710 720 730 740 750
MSRGDRFSED SRFITVNPAE KNTSGMISRP APGRMEWIIP LIVVSALTFV
760 770 780 790 800
CLILLIAVLV YWRGCNKIKS KGFPRRFREV PSSGERGEKG SRKCFQTAHF
810 820 830 840 850
YVEDSSSPRV VPNESIPIIP IPDDMEAIPV KQFVKHIGEL YSNNQHGFSE
860 870 880 890 900
DFEEVQRCTA DMNITAEHSN HPENKHKNRY INILAYDHSR VKLRPLPGKD
910 920 930 940 950
SKHSDYINAN YVDGYNKAKA YIATQGPLKS TFEDFWRMIW EQNTGIIVMI
960 970 980 990 1000
TNLVEKGRRK CDQYWPTENS EEYGNIIVTL KSTKIHACYT VRRFSIRNTK
1010 1020 1030 1040 1050
VKKGQKGNPK GRQNERVVIQ YHYTQWPDMG VPEYALPVLT FVRRSSAARM
1060 1070 1080 1090 1100
PETGPVLVHC SAGVGRTGTY IVIDSMLQQI KDKSTVNVLG FLKHIRTQRN
1110 1120 1130 1140 1150
YLVQTEEQYI FIHDALLEAI LGKETEVSSN QLHSYVNSIL IPGVGGKTRL
1160 1170 1180 1190 1200
EKQFKLVTQC NAKYVECFSA QKECNKEKNR NSSVVPSERA RVGLAPLPGM
1210 1220 1230 1240 1250
KGTDYINASY IMGYYRSNEF IITQHPLPHT TKDFWRMIWD HNAQIIVMLP
1260 1270 1280 1290 1300
DNQSLAEDEF VYWPSREESM NCEAFTVTLI SKDRLCLSNE EQIIIHDFIL
1310 1320 1330 1340 1350
EATQDDYVLE VRHFQCPKWP NPDAPISSTF ELINVIKEEA LTRDGPTIVH
1360 1370 1380 1390 1400
DEYGAVSAGM LCALTTLSQQ LENENAVDVF QVAKMINLMR PGVFTDIEQY
1410 1420 1430 1440
QFIYKAMLSL VSTKENGNGP MTVDKNGAVL IADESDPAES MESLV
Length:1,445
Mass (Da):162,003
Last modified:May 5, 2009 - v4
Checksum:iA48A007BA14082BC
GO
Isoform 2 (identifier: P23470-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     764-792: Missing.

Note: No experimental confirmation available.
Show »
Length:1,416
Mass (Da):158,771
Checksum:i8DFA46915A799CFD
GO

Sequence cautioni

The sequence BAD93108 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti80G → S in AAA60224 (PubMed:8382771).Curated1
Sequence conflicti549A → V in AAC50439 (PubMed:8833149).Curated1
Sequence conflicti756I → T in AAC50439 (PubMed:8833149).Curated1
Sequence conflicti805S → R in CAH18125 (PubMed:17974005).Curated1
Sequence conflicti1316C → Y in CAH18125 (PubMed:17974005).Curated1
Sequence conflicti1407M → R in AAA60224 (PubMed:8382771).Curated1
Sequence conflicti1407M → R in AAC50439 (PubMed:8833149).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07089292Y → H2 PublicationsCorresponds to variant dbSNP:rs62620047Ensembl.1
Natural variantiVAR_020301574G → S. Corresponds to variant dbSNP:rs2292245Ensembl.1
Natural variantiVAR_031562639Q → R. Corresponds to variant dbSNP:rs9870460Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024353764 – 792Missing in isoform 2. 2 PublicationsAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09247 mRNA Translation: AAA60224.1
U46116
, U46089, U46090, U46091, U46092, U46093, U46094, U46095, U46096, U46097, U46098, U46099, U46100, U46101, U46102, U46103, U46104, U46105, U46106, U46107, U46108, U46109, U46110, U46111, U46112, U46113, U46114, U46115 Genomic DNA Translation: AAC50439.1
AB209871 mRNA Translation: BAD93108.1 Different initiation.
AC004695 Genomic DNA No translation available.
AC092502 Genomic DNA No translation available.
AC096919 Genomic DNA No translation available.
AC098482 Genomic DNA No translation available.
AC103587 Genomic DNA No translation available.
AC103921 Genomic DNA No translation available.
AC104849 Genomic DNA No translation available.
AC105939 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65397.1
BC140904 mRNA Translation: AAI40905.1
BC144110 mRNA Translation: AAI44111.1
CR749269 mRNA Translation: CAH18125.1
X54132 mRNA Translation: CAA38067.1
CCDSiCCDS2895.1 [P23470-1]
PIRiA48148
RefSeqiNP_002832.3, NM_002841.3 [P23470-1]
XP_005265410.1, XM_005265353.3 [P23470-2]
UniGeneiHs.595541

Genome annotation databases

EnsembliENST00000295874; ENSP00000295874; ENSG00000144724 [P23470-2]
ENST00000474889; ENSP00000418112; ENSG00000144724 [P23470-1]
GeneIDi5793
KEGGihsa:5793
UCSCiuc003dlb.4 human [P23470-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPTPRG_HUMAN
AccessioniPrimary (citable) accession number: P23470
Secondary accession number(s): B2RU12
, B7ZLX5, Q15623, Q59EE0, Q68DU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: May 5, 2009
Last modified: May 23, 2018
This is version 193 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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