P23470 (PTPRG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Receptor-type tyrosine-protein phosphatase gamma
Short name=Protein-tyrosine phosphatase gamma
Short name=R-PTP-gamma
EC=3.1.3.48

Gene names

Name:	PTPRG
Synonyms:	PTPG

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1445 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Possesses tyrosine phosphatase activity. Ref.12
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. Ref.12
Subunit structure	Monomer; active form. Homodimer; inactive form Probable. Ref.12
Subcellular location	Membrane; Single-pass type I membrane protein Probable.
Tissue specificity	Found in a variety of tissues.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily. Contains 1 alpha-carbonic anhydrase domain. Contains 1 fibronectin type-III domain. Contains 2 tyrosine-protein phosphatase domains.
Sequence caution	The sequence BAD93108.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	Hydrolase Protein phosphatase
PTM	Glycoprotein Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	transmembrane receptor protein tyrosine kinase signaling pathway Traceable author statement. Source: ProtInc
Cellular component	integral to plasma membrane Traceable author statement. Source: ProtInc
Molecular function	identical protein binding Inferred from physical interaction Ref.12. Source: UniProtKB transmembrane receptor protein tyrosine phosphatase activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P23470-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P23470-2)

The sequence of this isoform differs from the canonical sequence as follows:
     764-792: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 19

19

Chain

20 – 1445

1426

Receptor-type tyrosine-protein phosphatase gamma

PRO_0000025441

Regions

Topological domain

20 – 736

717

Extracellular Potential

Transmembrane

737 – 762

26

Helical; Potential

Topological domain

763 – 1445

683

Cytoplasmic Potential

Domain

58 – 321

264

Alpha-carbonic anhydrase

Domain

346 – 443

98

Fibronectin type-III

Domain

848 – 1119

272

Tyrosine-protein phosphatase 1

Domain

1150 – 1410

261

Tyrosine-protein phosphatase 2

Region

1060 – 1066

7

Substrate binding By similarity

Sites

Active site

1060

1

Phosphocysteine intermediate By similarity

Binding site

1028

1

Substrate By similarity

Binding site

1104

1

Substrate By similarity

Site

1351

1

Ancestral active site

Amino acid modifications

Modified residue

115

1

Phosphothreonine By similarity

Modified residue

1435

1

Phosphoserine Ref.11

Glycosylation

109

1

N-linked (GlcNAc...) Potential

Glycosylation

113

1

N-linked (GlcNAc...) Ref.10

Glycosylation

156

1

N-linked (GlcNAc...) Potential

Glycosylation

359

1

N-linked (GlcNAc...) Potential

Glycosylation

444

1

N-linked (GlcNAc...) Ref.10

Glycosylation

619

1

N-linked (GlcNAc...) Potential

Glycosylation

631

1

N-linked (GlcNAc...) Potential

Glycosylation

722

1

N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence

764 – 792

29

Missing in isoform 2.

VSP_024353

Natural variant

574

1

G → S.
Corresponds to variant rs2292245 [ dbSNP | Ensembl ].

VAR_020301

Natural variant

639

1

Q → R.
Corresponds to variant rs9870460 [ dbSNP | Ensembl ].

VAR_031562

Experimental info

Mutagenesis

958

1

R → E: Loss of dimerization; when associated with E-960. Ref.12

Mutagenesis

960

1

K → E: Loss of dimerization; when associated with E-958. Ref.12

Mutagenesis

1305

1

D → K: Loss of dimerization; when associated with K-1306. Ref.12

Mutagenesis

1306

1

D → K: Loss of dimerization; when associated with K-1305. Ref.12

Sequence conflict

80

1

G → S in AAA60224. Ref.1

Sequence conflict

92

1

Y → H in AAC50439. Ref.2

Sequence conflict

549

1

A → V in AAC50439. Ref.2

Sequence conflict

756

1

I → T in AAC50439. Ref.2

Sequence conflict

805

1

S → R in CAH18125. Ref.7

Sequence conflict

1316

1

C → Y in CAH18125. Ref.7

Sequence conflict

1407

1

M → R in AAA60224. Ref.1

Sequence conflict

1407

1

M → R in AAC50439. Ref.2

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1445

Helix Strand Turn

Details...

Helix

831 – 861

31

Turn

867 – 870

4

Helix

872 – 877

6

Helix

887 – 889

3

Beta strand

890 – 892

3

Beta strand

906 – 912

7

Beta strand

921 – 924

4

Helix

929 – 931

3

Helix

932 – 942

11

Beta strand

946 – 949

4

Beta strand

953 – 955

3

Beta strand

967 – 973

7

Beta strand

976 – 985

10

Beta strand

987 – 998

12

Beta strand

1016 – 1023

8

Beta strand

1028 – 1031

4

Helix

1036 – 1047

12

Beta strand

1056 – 1064

9

Helix

1065 – 1082

18

Helix

1088 – 1095

8

Turn

1096 – 1098

3

Helix

1106 – 1121

16

Helix

1129 – 1131

3

Helix

1132 – 1139

8

Helix

1149 – 1157

9

Beta strand

1172 – 1174

3

Beta strand

1207 – 1211

5

Beta strand

1219 – 1224

6

Helix

1228 – 1230

3

Helix

1231 – 1241

11

Beta strand

1245 – 1248

4

Beta strand

1270 – 1272

3

Beta strand

1275 – 1286

12

Beta strand

1292 – 1305

14

Beta strand

1308 – 1315

8

Beta strand

1318 – 1320

3

Helix

1326 – 1328

3

Helix

1329 – 1340

12

Beta strand

1347 – 1354

8

Helix

1356 – 1374

19

Beta strand

1375 – 1377

3

Helix

1379 – 1389

11

Helix

1397 – 1408

12

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 5, 2009. Version 4. Checksum: A48A007BA14082BC	FASTA	1,445	162,003
	10 20 30 40 50 60 MRRLLEPCWW ILFLKITSSV LHYVVCFPAL TEGYVGALHE NRHGSAVQIR RRKASGDPYW 70 80 90 100 110 120 AYSGAYGPEH WVTSSVSCGG RHQSPIDILD QYARVGEEYQ ELQLDGFDNE SSNKTWMKNT 130 140 150 160 170 180 GKTVAILLKD DYFVSGAGLP GRFKAEKVEF HWGHSNGSAG SEHSINGRRF PVEMQIFFYN 190 200 210 220 230 240 PDDFDSFQTA ISENRIIGAM AIFFQVSPRD NSALDPIIHG LKGVVHHEKE TFLDPFVLRD 250 260 270 280 290 300 LLPASLGSYY RYTGSLTTPP CSEIVEWIVF RRPVPISYHQ LEAFYSIFTT EQQDHVKSVE 310 320 330 340 350 360 YLRNNFRPQQ RLHDRVVSKS AVRDSWNHDM TDFLENPLGT EASKVCSSPP IHMKVQPLNQ 370 380 390 400 410 420 TALQVSWSQP ETIYHPPIMN YMISYSWTKN EDEKEKTFTK DSDKDLKATI SHVSPDSLYL 430 440 450 460 470 480 FRVQAVCRND MRSDFSQTML FQANTTRIFQ GTRIVKTGVP TASPASSADM APISSGSSTW 490 500 510 520 530 540 TSSGIPFSFV SMATGMGPSS SGSQATVASV VTSTLLAGLG FGGGGISSFP STVWPTRLPT 550 560 570 580 590 600 AASASKQAAR PVLATTEALA SPGPDGDSSP TKDGEGTEEG EKDEKSESED GEREHEEDGE 610 620 630 640 650 660 KDSEKKEKSG VTHAAEERNQ TEPSPTPSSP NRTAEGGHQT IPGHEQDHTA VPTDQTGGRR 670 680 690 700 710 720 DAGPGLDPDM VTSTQVPPTA TEEQYAGSDP KRPEMPSKKP MSRGDRFSED SRFITVNPAE 730 740 750 760 770 780 KNTSGMISRP APGRMEWIIP LIVVSALTFV CLILLIAVLV YWRGCNKIKS KGFPRRFREV 790 800 810 820 830 840 PSSGERGEKG SRKCFQTAHF YVEDSSSPRV VPNESIPIIP IPDDMEAIPV KQFVKHIGEL 850 860 870 880 890 900 YSNNQHGFSE DFEEVQRCTA DMNITAEHSN HPENKHKNRY INILAYDHSR VKLRPLPGKD 910 920 930 940 950 960 SKHSDYINAN YVDGYNKAKA YIATQGPLKS TFEDFWRMIW EQNTGIIVMI TNLVEKGRRK 970 980 990 1000 1010 1020 CDQYWPTENS EEYGNIIVTL KSTKIHACYT VRRFSIRNTK VKKGQKGNPK GRQNERVVIQ 1030 1040 1050 1060 1070 1080 YHYTQWPDMG VPEYALPVLT FVRRSSAARM PETGPVLVHC SAGVGRTGTY IVIDSMLQQI 1090 1100 1110 1120 1130 1140 KDKSTVNVLG FLKHIRTQRN YLVQTEEQYI FIHDALLEAI LGKETEVSSN QLHSYVNSIL 1150 1160 1170 1180 1190 1200 IPGVGGKTRL EKQFKLVTQC NAKYVECFSA QKECNKEKNR NSSVVPSERA RVGLAPLPGM 1210 1220 1230 1240 1250 1260 KGTDYINASY IMGYYRSNEF IITQHPLPHT TKDFWRMIWD HNAQIIVMLP DNQSLAEDEF 1270 1280 1290 1300 1310 1320 VYWPSREESM NCEAFTVTLI SKDRLCLSNE EQIIIHDFIL EATQDDYVLE VRHFQCPKWP 1330 1340 1350 1360 1370 1380 NPDAPISSTF ELINVIKEEA LTRDGPTIVH DEYGAVSAGM LCALTTLSQQ LENENAVDVF 1390 1400 1410 1420 1430 1440 QVAKMINLMR PGVFTDIEQY QFIYKAMLSL VSTKENGNGP MTVDKNGAVL IADESDPAES MESLV
	Isoform 2 [UniParc]. Checksum: 8DFA46915A799CFD	FASTA	1,416	158,771
	10 20 30 40 50 60 MRRLLEPCWW ILFLKITSSV LHYVVCFPAL TEGYVGALHE NRHGSAVQIR RRKASGDPYW 70 80 90 100 110 120 AYSGAYGPEH WVTSSVSCGG RHQSPIDILD QYARVGEEYQ ELQLDGFDNE SSNKTWMKNT 130 140 150 160 170 180 GKTVAILLKD DYFVSGAGLP GRFKAEKVEF HWGHSNGSAG SEHSINGRRF PVEMQIFFYN 190 200 210 220 230 240 PDDFDSFQTA ISENRIIGAM AIFFQVSPRD NSALDPIIHG LKGVVHHEKE TFLDPFVLRD 250 260 270 280 290 300 LLPASLGSYY RYTGSLTTPP CSEIVEWIVF RRPVPISYHQ LEAFYSIFTT EQQDHVKSVE 310 320 330 340 350 360 YLRNNFRPQQ RLHDRVVSKS AVRDSWNHDM TDFLENPLGT EASKVCSSPP IHMKVQPLNQ 370 380 390 400 410 420 TALQVSWSQP ETIYHPPIMN YMISYSWTKN EDEKEKTFTK DSDKDLKATI SHVSPDSLYL 430 440 450 460 470 480 FRVQAVCRND MRSDFSQTML FQANTTRIFQ GTRIVKTGVP TASPASSADM APISSGSSTW 490 500 510 520 530 540 TSSGIPFSFV SMATGMGPSS SGSQATVASV VTSTLLAGLG FGGGGISSFP STVWPTRLPT 550 560 570 580 590 600 AASASKQAAR PVLATTEALA SPGPDGDSSP TKDGEGTEEG EKDEKSESED GEREHEEDGE 610 620 630 640 650 660 KDSEKKEKSG VTHAAEERNQ TEPSPTPSSP NRTAEGGHQT IPGHEQDHTA VPTDQTGGRR 670 680 690 700 710 720 DAGPGLDPDM VTSTQVPPTA TEEQYAGSDP KRPEMPSKKP MSRGDRFSED SRFITVNPAE 730 740 750 760 770 780 KNTSGMISRP APGRMEWIIP LIVVSALTFV CLILLIAVLV YWRKCFQTAH FYVEDSSSPR 790 800 810 820 830 840 VVPNESIPII PIPDDMEAIP VKQFVKHIGE LYSNNQHGFS EDFEEVQRCT ADMNITAEHS 850 860 870 880 890 900 NHPENKHKNR YINILAYDHS RVKLRPLPGK DSKHSDYINA NYVDGYNKAK AYIATQGPLK 910 920 930 940 950 960 STFEDFWRMI WEQNTGIIVM ITNLVEKGRR KCDQYWPTEN SEEYGNIIVT LKSTKIHACY 970 980 990 1000 1010 1020 TVRRFSIRNT KVKKGQKGNP KGRQNERVVI QYHYTQWPDM GVPEYALPVL TFVRRSSAAR 1030 1040 1050 1060 1070 1080 MPETGPVLVH CSAGVGRTGT YIVIDSMLQQ IKDKSTVNVL GFLKHIRTQR NYLVQTEEQY 1090 1100 1110 1120 1130 1140 IFIHDALLEA ILGKETEVSS NQLHSYVNSI LIPGVGGKTR LEKQFKLVTQ CNAKYVECFS 1150 1160 1170 1180 1190 1200 AQKECNKEKN RNSSVVPSER ARVGLAPLPG MKGTDYINAS YIMGYYRSNE FIITQHPLPH 1210 1220 1230 1240 1250 1260 TTKDFWRMIW DHNAQIIVML PDNQSLAEDE FVYWPSREES MNCEAFTVTL ISKDRLCLSN 1270 1280 1290 1300 1310 1320 EEQIIIHDFI LEATQDDYVL EVRHFQCPKW PNPDAPISST FELINVIKEE ALTRDGPTIV 1330 1340 1350 1360 1370 1380 HDEYGAVSAG MLCALTTLSQ QLENENAVDV FQVAKMINLM RPGVFTDIEQ YQFIYKAMLS 1390 1400 1410 LVSTKENGNG PMTVDKNGAV LIADESDPAE SMESLV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a carbonic anhydrase-like domain in the extracellular region of RPTP gamma defines a new subfamily of receptor tyrosine phosphatases." Barnea G., Silvennoinen O., Shaanan B., Honegger A.M., Canoll P.D., D'Eustachio P., Morse B., Levy J.B., Laforgia S., Huebner K., Musacchio J.M., Sap J., Schlessinger J. Mol. Cell. Biol. 13:1497-1506(1993) [PubMed: 8382771] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Structure of the human receptor tyrosine phosphatase gamma gene (PTPRG) and relation to the familial RCC t(3;8) chromosome translocation." Kastury K., Ohta M., Lasota J., Moir D., Dorman T., Laforgia S., Druck T., Huebner K. Genomics 32:225-235(1996) [PubMed: 8833149] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Aortic endothelium.
[4]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed: 16641997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 711-1445 (ISOFORM 2). Tissue: Prostate.
[8]	"Structural diversity and evolution of human receptor-like protein tyrosine phosphatases." Krueger N.X., Streuli M., Saito H. EMBO J. 9:3241-3252(1990) [PubMed: 2170109] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 836-1445. Tissue: Placenta.
[9]	"Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain." Kaplan R., Morse B., Huebner K., Croce C., Howk R., Ravera M., Ricca G., Jaye M., Schlessinger J. Proc. Natl. Acad. Sci. U.S.A. 87:7000-7004(1990) [PubMed: 2169617] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 874-1118 AND 1175-1409. Tissue: Brain.
[10]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed: 16335952] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-113 AND ASN-444, MASS SPECTROMETRY. Tissue: Plasma.
[11]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1435, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[12]	"Large-scale structural analysis of the classical human protein tyrosine phosphatome." Barr A.J., Ugochukwu E., Lee W.H., King O.N.F., Filippakopoulos P., Alfano I., Savitsky P., Burgess-Brown N.A., Mueller S., Knapp S. Cell 136:352-363(2009) [PubMed: 19167335] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 827-1445, FUNCTION, CATALYTIC ACTIVITY, SUBUNIT, MUTAGENESIS OF ARG-958; LYS-960; ASP-1305 AND ASP-1306.
[13]	"Crystal structure of the human receptor phosphatase PTPRG." Structural genomics consortium (SGC) Submitted (JUL-2006) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 830-1127.
[14]	"Structural genomics of protein phosphatases." New York structural genomix research consortium (NYSGXRC) Submitted (MAR-2008) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 819-1130.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L09247 mRNA. Translation: AAA60224.1.
U46116 , U46089, U46090, U46091, U46092, U46093, U46094, U46095, U46096, U46097, U46098, U46099, U46100, U46101, U46102, U46103, U46104, U46105, U46106, U46107, U46108, U46109, U46110, U46111, U46112, U46113, U46114, U46115 Genomic DNA. Translation: AAC50439.1.
AB209871 mRNA. Translation: BAD93108.1. Different initiation.
AC004695 Genomic DNA. No translation available.
AC092502 Genomic DNA. No translation available.
AC096919 Genomic DNA. No translation available.
AC098482 Genomic DNA. No translation available.
AC103587 Genomic DNA. No translation available.
AC103921 Genomic DNA. No translation available.
AC104849 Genomic DNA. No translation available.
AC105939 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65397.1.
BC140904 mRNA. Translation: AAI40905.1.
CR749269 mRNA. Translation: CAH18125.1.
X54132 mRNA. Translation: CAA38067.1.

IPI

IPI00011651.
IPI00796281.

PIR

A48148.

RefSeq

NP_002832.3. NM_002841.3.

UniGene

Hs.595541.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2H4V	X-ray	1.55	A/B	831-1127	[»]
2HY3	X-ray	2.60	A/B	820-1130	[»]
2NLK	X-ray	2.40	A	827-1445	[»]
2PBN	X-ray	1.70	A	820-1130	[»]
3JXH	X-ray	1.70	C	56-320	[»]

ProteinModelPortal

P23470.

SMR

P23470. Positions 58-320, 344-438, 826-1412.

ModBase

Search...

Protein-protein interaction databases

IntAct

P23470. 24 interactions.

MINT

MINT-1349880.

STRING

P23470.

PTM databases

PhosphoSite

P23470.

Polymorphism databases

DMDM

229463033.

Proteomic databases

PRIDE

P23470.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000474889; ENSP00000418112; ENSG00000144724.

GeneID

5793.

KEGG

hsa:5793.

Organism-specific databases

CTD

5793.

GeneCards

GC03P061522.

H-InvDB

HIX0024329.

HGNC

HGNC:9671. PTPRG.

MIM

176886. gene.

neXtProt

NX_P23470.

PharmGKB

PA34016.

GenAtlas

Search...

Phylogenomic databases

GeneTree

ENSGT00600000084078.

HOGENOM

HBG446367.

HOVERGEN

HBG053760.

OMA

WRGCNKI.

OrthoDB

EOG4FN4GW.

PhylomeDB

P23470.

Gene expression databases

ArrayExpress

P23470.

Bgee

P23470.

CleanEx

HS_PTPRG.

Genevestigator

P23470.

Family and domain databases

InterPro

IPR001148. a_carbonic_anhydrase.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR000387. Tyr/Dual-specificity_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]

Gene3D

G3DSA:3.10.200.10. Euk_COanhd. 1 hit.
G3DSA:2.60.40.10. Ig-like_fold. 1 hit.

KO

K01104.

Pfam

PF00194. Carb_anhydrase. 1 hit.
PF00041. fn3. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]

PRINTS

PR00700. PRTYPHPHTASE.

SMART

SM01057. Carb_anhydrase. 1 hit.
SM00060. FN3. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view]

SUPFAM

SSF51069. Euk_COanhd. 1 hit.
SSF49265. FN_III-like. 1 hit.

PROSITE

PS51144. ALPHA_CA_2. 1 hit.
PS50853. FN3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

NextBio

22556.

SOURCE

Search...

Entry information

Entry name

PTPRG_HUMAN

Accession

Primary (citable) accession number: P23470
Secondary accession number(s): B2RU12 , Q15623, Q59EE0, Q68DU5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	May 5, 2009
Last modified:	January 25, 2012
This is version 133 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.