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P23470

- PTPRG_HUMAN

UniProt

P23470 - PTPRG_HUMAN

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Protein
Receptor-type tyrosine-protein phosphatase gamma
Gene
PTPRG, PTPG
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Possesses tyrosine phosphatase activity.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1028 – 10281Substrate By similarity
Active sitei1060 – 10601Phosphocysteine intermediate By similarity
Binding sitei1104 – 11041Substrate By similarity
Sitei1351 – 13511Ancestral active site

GO - Molecular functioni

  1. identical protein binding Source: UniProtKB
  2. protein binding Source: IntAct
  3. protein tyrosine phosphatase activity Source: UniProtKB
  4. transmembrane receptor protein tyrosine phosphatase activity Source: ProtInc
Complete GO annotation...

GO - Biological processi

  1. brain development Source: Ensembl
  2. negative regulation of neuron projection development Source: Ensembl
  3. peptidyl-tyrosine dephosphorylation Source: GOC
  4. transmembrane receptor protein tyrosine kinase signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

SignaLinkiP23470.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase gamma (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase gamma
Short name:
R-PTP-gamma
Gene namesi
Name:PTPRG
Synonyms:PTPG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:9671. PTPRG.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 736717Extracellular Reviewed prediction
Add
BLAST
Transmembranei737 – 76226Helical; Reviewed prediction
Add
BLAST
Topological domaini763 – 1445683Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. extracellular vesicular exosome Source: UniProt
  3. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi958 – 9581R → E: Loss of dimerization; when associated with E-960. 1 Publication
Mutagenesisi960 – 9601K → E: Loss of dimerization; when associated with E-958. 1 Publication
Mutagenesisi1305 – 13051D → K: Loss of dimerization; when associated with K-1306. 1 Publication
Mutagenesisi1306 – 13061D → K: Loss of dimerization; when associated with K-1305. 1 Publication

Organism-specific databases

PharmGKBiPA34016.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919
Add
BLAST
Chaini20 – 14451426Receptor-type tyrosine-protein phosphatase gamma
PRO_0000025441Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi78 ↔ 2611 Publication
Glycosylationi109 – 1091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi113 – 1131N-linked (GlcNAc...)1 Publication
Glycosylationi156 – 1561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi359 – 3591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi444 – 4441N-linked (GlcNAc...)1 Publication
Glycosylationi619 – 6191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi631 – 6311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi722 – 7221N-linked (GlcNAc...) Reviewed prediction
Modified residuei1182 – 11821Phosphoserine1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP23470.
PaxDbiP23470.
PRIDEiP23470.

PTM databases

PhosphoSiteiP23470.

Expressioni

Tissue specificityi

Found in a variety of tissues.

Gene expression databases

ArrayExpressiP23470.
BgeeiP23470.
CleanExiHS_PTPRG.
GenevestigatoriP23470.

Interactioni

Subunit structurei

Monomer; active form. Homodimer; inactive form Inferred. Interacts with CNTN3, CNTN4, CNTN5 and CNTN6.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CTNNB1P352222EBI-2258115,EBI-491549

Protein-protein interaction databases

BioGridi111757. 6 interactions.
IntActiP23470. 22 interactions.
MINTiMINT-1349880.
STRINGi9606.ENSP00000418112.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi64 – 663
Helixi68 – 703
Helixi71 – 744
Helixi76 – 794
Helixi90 – 923
Beta strandi103 – 1064
Beta strandi116 – 1194
Beta strandi124 – 1274
Beta strandi133 – 1353
Beta strandi143 – 15210
Beta strandi162 – 1654
Beta strandi171 – 1799
Turni181 – 1833
Helixi187 – 1926
Beta strandi197 – 20913
Helixi212 – 2143
Helixi215 – 2239
Beta strandi230 – 2323
Helixi238 – 2414
Beta strandi249 – 2546
Beta strandi265 – 2728
Beta strandi274 – 2774
Helixi278 – 2858
Beta strandi288 – 2903
Beta strandi299 – 3013
Helixi831 – 86131
Turni867 – 8704
Helixi872 – 8776
Helixi887 – 8893
Beta strandi890 – 8923
Turni899 – 9013
Helixi902 – 9054
Beta strandi906 – 9127
Beta strandi915 – 9173
Beta strandi921 – 9244
Helixi929 – 9313
Helixi932 – 94211
Beta strandi946 – 9494
Beta strandi953 – 9553
Beta strandi967 – 9737
Beta strandi976 – 98510
Beta strandi987 – 99812
Beta strandi1016 – 10238
Beta strandi1028 – 10314
Helixi1036 – 104712
Beta strandi1056 – 10649
Helixi1065 – 108218
Beta strandi1084 – 10863
Helixi1088 – 10958
Turni1096 – 10983
Helixi1106 – 112116
Helixi1129 – 11313
Helixi1132 – 11398
Helixi1149 – 11579
Beta strandi1172 – 11743
Beta strandi1207 – 12115
Beta strandi1219 – 12246
Helixi1228 – 12303
Helixi1231 – 124111
Beta strandi1245 – 12484
Beta strandi1270 – 12723
Beta strandi1275 – 128612
Beta strandi1292 – 130514
Beta strandi1308 – 13158
Beta strandi1318 – 13203
Helixi1326 – 13283
Helixi1329 – 134012
Beta strandi1347 – 13548
Helixi1356 – 137419
Beta strandi1375 – 13773
Helixi1379 – 138911
Helixi1397 – 140812

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2H4VX-ray1.55A/B831-1127[»]
2HY3X-ray2.60A/B820-1130[»]
2NLKX-ray2.40A827-1445[»]
2PBNX-ray1.70A820-1130[»]
3JXHX-ray1.70C56-320[»]
3QCBX-ray2.10A/B825-1128[»]
3QCCX-ray2.10A/B825-1128[»]
3QCDX-ray1.80A825-1128[»]
3QCEX-ray2.10A/B825-1128[»]
3QCFX-ray2.50A/B825-1128[»]
3QCGX-ray2.05A825-1128[»]
3QCHX-ray2.40A825-1128[»]
3QCIX-ray2.27A825-1128[»]
3QCJX-ray2.26A825-1128[»]
3QCKX-ray2.05A825-1128[»]
3QCLX-ray2.40A825-1128[»]
3QCMX-ray2.40A/B825-1128[»]
3QCNX-ray2.41A825-1128[»]
ProteinModelPortaliP23470.
SMRiP23470. Positions 58-320, 347-445, 826-1412.

Miscellaneous databases

EvolutionaryTraceiP23470.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 321264Alpha-carbonic anhydrase
Add
BLAST
Domaini349 – 448100Fibronectin type-III
Add
BLAST
Domaini848 – 1119272Tyrosine-protein phosphatase 1
Add
BLAST
Domaini1150 – 1410261Tyrosine-protein phosphatase 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1060 – 10667Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000060222.
HOVERGENiHBG053760.
KOiK16667.
OMAiWRGCNKI.
OrthoDBiEOG7K6PT4.
PhylomeDBiP23470.
TreeFamiTF351978.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.200.10. 1 hit.
3.90.190.10. 2 hits.
InterProiIPR001148. Carbonic_anhydrase_a.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00194. Carb_anhydrase. 1 hit.
PF00041. fn3. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM01057. Carb_anhydrase. 1 hit.
SM00060. FN3. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF51069. SSF51069. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS51144. ALPHA_CA_2. 1 hit.
PS50853. FN3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P23470-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRRLLEPCWW ILFLKITSSV LHYVVCFPAL TEGYVGALHE NRHGSAVQIR     50
RRKASGDPYW AYSGAYGPEH WVTSSVSCGG RHQSPIDILD QYARVGEEYQ 100
ELQLDGFDNE SSNKTWMKNT GKTVAILLKD DYFVSGAGLP GRFKAEKVEF 150
HWGHSNGSAG SEHSINGRRF PVEMQIFFYN PDDFDSFQTA ISENRIIGAM 200
AIFFQVSPRD NSALDPIIHG LKGVVHHEKE TFLDPFVLRD LLPASLGSYY 250
RYTGSLTTPP CSEIVEWIVF RRPVPISYHQ LEAFYSIFTT EQQDHVKSVE 300
YLRNNFRPQQ RLHDRVVSKS AVRDSWNHDM TDFLENPLGT EASKVCSSPP 350
IHMKVQPLNQ TALQVSWSQP ETIYHPPIMN YMISYSWTKN EDEKEKTFTK 400
DSDKDLKATI SHVSPDSLYL FRVQAVCRND MRSDFSQTML FQANTTRIFQ 450
GTRIVKTGVP TASPASSADM APISSGSSTW TSSGIPFSFV SMATGMGPSS 500
SGSQATVASV VTSTLLAGLG FGGGGISSFP STVWPTRLPT AASASKQAAR 550
PVLATTEALA SPGPDGDSSP TKDGEGTEEG EKDEKSESED GEREHEEDGE 600
KDSEKKEKSG VTHAAEERNQ TEPSPTPSSP NRTAEGGHQT IPGHEQDHTA 650
VPTDQTGGRR DAGPGLDPDM VTSTQVPPTA TEEQYAGSDP KRPEMPSKKP 700
MSRGDRFSED SRFITVNPAE KNTSGMISRP APGRMEWIIP LIVVSALTFV 750
CLILLIAVLV YWRGCNKIKS KGFPRRFREV PSSGERGEKG SRKCFQTAHF 800
YVEDSSSPRV VPNESIPIIP IPDDMEAIPV KQFVKHIGEL YSNNQHGFSE 850
DFEEVQRCTA DMNITAEHSN HPENKHKNRY INILAYDHSR VKLRPLPGKD 900
SKHSDYINAN YVDGYNKAKA YIATQGPLKS TFEDFWRMIW EQNTGIIVMI 950
TNLVEKGRRK CDQYWPTENS EEYGNIIVTL KSTKIHACYT VRRFSIRNTK 1000
VKKGQKGNPK GRQNERVVIQ YHYTQWPDMG VPEYALPVLT FVRRSSAARM 1050
PETGPVLVHC SAGVGRTGTY IVIDSMLQQI KDKSTVNVLG FLKHIRTQRN 1100
YLVQTEEQYI FIHDALLEAI LGKETEVSSN QLHSYVNSIL IPGVGGKTRL 1150
EKQFKLVTQC NAKYVECFSA QKECNKEKNR NSSVVPSERA RVGLAPLPGM 1200
KGTDYINASY IMGYYRSNEF IITQHPLPHT TKDFWRMIWD HNAQIIVMLP 1250
DNQSLAEDEF VYWPSREESM NCEAFTVTLI SKDRLCLSNE EQIIIHDFIL 1300
EATQDDYVLE VRHFQCPKWP NPDAPISSTF ELINVIKEEA LTRDGPTIVH 1350
DEYGAVSAGM LCALTTLSQQ LENENAVDVF QVAKMINLMR PGVFTDIEQY 1400
QFIYKAMLSL VSTKENGNGP MTVDKNGAVL IADESDPAES MESLV 1445
Length:1,445
Mass (Da):162,003
Last modified:May 5, 2009 - v4
Checksum:iA48A007BA14082BC
GO
Isoform 2 (identifier: P23470-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     764-792: Missing.

Note: No experimental confirmation available.

Show »
Length:1,416
Mass (Da):158,771
Checksum:i8DFA46915A799CFD
GO

Sequence cautioni

The sequence BAD93108.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti92 – 921Y → H.2 Publications
Corresponds to variant rs62620047 [ dbSNP | Ensembl ].
VAR_070892
Natural varianti574 – 5741G → S.
Corresponds to variant rs2292245 [ dbSNP | Ensembl ].
VAR_020301
Natural varianti639 – 6391Q → R.
Corresponds to variant rs9870460 [ dbSNP | Ensembl ].
VAR_031562

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei764 – 79229Missing in isoform 2.
VSP_024353Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti80 – 801G → S in AAA60224. 1 Publication
Sequence conflicti549 – 5491A → V in AAC50439. 1 Publication
Sequence conflicti756 – 7561I → T in AAC50439. 1 Publication
Sequence conflicti805 – 8051S → R in CAH18125. 1 Publication
Sequence conflicti1316 – 13161C → Y in CAH18125. 1 Publication
Sequence conflicti1407 – 14071M → R in AAA60224. 1 Publication
Sequence conflicti1407 – 14071M → R in AAC50439. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L09247 mRNA. Translation: AAA60224.1.
U46116
, U46089, U46090, U46091, U46092, U46093, U46094, U46095, U46096, U46097, U46098, U46099, U46100, U46101, U46102, U46103, U46104, U46105, U46106, U46107, U46108, U46109, U46110, U46111, U46112, U46113, U46114, U46115 Genomic DNA. Translation: AAC50439.1.
AB209871 mRNA. Translation: BAD93108.1. Different initiation.
AC004695 Genomic DNA. No translation available.
AC092502 Genomic DNA. No translation available.
AC096919 Genomic DNA. No translation available.
AC098482 Genomic DNA. No translation available.
AC103587 Genomic DNA. No translation available.
AC103921 Genomic DNA. No translation available.
AC104849 Genomic DNA. No translation available.
AC105939 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65397.1.
BC140904 mRNA. Translation: AAI40905.1.
BC144110 mRNA. Translation: AAI44111.1.
CR749269 mRNA. Translation: CAH18125.1.
X54132 mRNA. Translation: CAA38067.1.
CCDSiCCDS2895.1. [P23470-1]
PIRiA48148.
RefSeqiNP_002832.3. NM_002841.3. [P23470-1]
XP_005265410.1. XM_005265353.2. [P23470-2]
UniGeneiHs.595541.

Genome annotation databases

EnsembliENST00000295874; ENSP00000295874; ENSG00000144724. [P23470-2]
ENST00000474889; ENSP00000418112; ENSG00000144724. [P23470-1]
GeneIDi5793.
KEGGihsa:5793.
UCSCiuc003dlb.3. human. [P23470-1]
uc003dlc.3. human. [P23470-2]

Polymorphism databases

DMDMi229463033.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L09247 mRNA. Translation: AAA60224.1 .
U46116
, U46089 , U46090 , U46091 , U46092 , U46093 , U46094 , U46095 , U46096 , U46097 , U46098 , U46099 , U46100 , U46101 , U46102 , U46103 , U46104 , U46105 , U46106 , U46107 , U46108 , U46109 , U46110 , U46111 , U46112 , U46113 , U46114 , U46115 Genomic DNA. Translation: AAC50439.1 .
AB209871 mRNA. Translation: BAD93108.1 . Different initiation.
AC004695 Genomic DNA. No translation available.
AC092502 Genomic DNA. No translation available.
AC096919 Genomic DNA. No translation available.
AC098482 Genomic DNA. No translation available.
AC103587 Genomic DNA. No translation available.
AC103921 Genomic DNA. No translation available.
AC104849 Genomic DNA. No translation available.
AC105939 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65397.1 .
BC140904 mRNA. Translation: AAI40905.1 .
BC144110 mRNA. Translation: AAI44111.1 .
CR749269 mRNA. Translation: CAH18125.1 .
X54132 mRNA. Translation: CAA38067.1 .
CCDSi CCDS2895.1. [P23470-1 ]
PIRi A48148.
RefSeqi NP_002832.3. NM_002841.3. [P23470-1 ]
XP_005265410.1. XM_005265353.2. [P23470-2 ]
UniGenei Hs.595541.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2H4V X-ray 1.55 A/B 831-1127 [» ]
2HY3 X-ray 2.60 A/B 820-1130 [» ]
2NLK X-ray 2.40 A 827-1445 [» ]
2PBN X-ray 1.70 A 820-1130 [» ]
3JXH X-ray 1.70 C 56-320 [» ]
3QCB X-ray 2.10 A/B 825-1128 [» ]
3QCC X-ray 2.10 A/B 825-1128 [» ]
3QCD X-ray 1.80 A 825-1128 [» ]
3QCE X-ray 2.10 A/B 825-1128 [» ]
3QCF X-ray 2.50 A/B 825-1128 [» ]
3QCG X-ray 2.05 A 825-1128 [» ]
3QCH X-ray 2.40 A 825-1128 [» ]
3QCI X-ray 2.27 A 825-1128 [» ]
3QCJ X-ray 2.26 A 825-1128 [» ]
3QCK X-ray 2.05 A 825-1128 [» ]
3QCL X-ray 2.40 A 825-1128 [» ]
3QCM X-ray 2.40 A/B 825-1128 [» ]
3QCN X-ray 2.41 A 825-1128 [» ]
ProteinModelPortali P23470.
SMRi P23470. Positions 58-320, 347-445, 826-1412.
ModBasei Search...

Protein-protein interaction databases

BioGridi 111757. 6 interactions.
IntActi P23470. 22 interactions.
MINTi MINT-1349880.
STRINGi 9606.ENSP00000418112.

Chemistry

BindingDBi P23470.
ChEMBLi CHEMBL4905.

PTM databases

PhosphoSitei P23470.

Polymorphism databases

DMDMi 229463033.

Proteomic databases

MaxQBi P23470.
PaxDbi P23470.
PRIDEi P23470.

Protocols and materials databases

DNASUi 5793.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000295874 ; ENSP00000295874 ; ENSG00000144724 . [P23470-2 ]
ENST00000474889 ; ENSP00000418112 ; ENSG00000144724 . [P23470-1 ]
GeneIDi 5793.
KEGGi hsa:5793.
UCSCi uc003dlb.3. human. [P23470-1 ]
uc003dlc.3. human. [P23470-2 ]

Organism-specific databases

CTDi 5793.
GeneCardsi GC03P061522.
H-InvDB HIX0024329.
HGNCi HGNC:9671. PTPRG.
MIMi 176886. gene.
neXtProti NX_P23470.
PharmGKBi PA34016.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5599.
HOGENOMi HOG000060222.
HOVERGENi HBG053760.
KOi K16667.
OMAi WRGCNKI.
OrthoDBi EOG7K6PT4.
PhylomeDBi P23470.
TreeFami TF351978.

Enzyme and pathway databases

SignaLinki P23470.

Miscellaneous databases

ChiTaRSi PTPRG. human.
EvolutionaryTracei P23470.
GeneWikii PTPRG.
GenomeRNAii 5793.
NextBioi 22556.
PROi P23470.
SOURCEi Search...

Gene expression databases

ArrayExpressi P23470.
Bgeei P23470.
CleanExi HS_PTPRG.
Genevestigatori P23470.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.10.200.10. 1 hit.
3.90.190.10. 2 hits.
InterProi IPR001148. Carbonic_anhydrase_a.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00194. Carb_anhydrase. 1 hit.
PF00041. fn3. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM01057. Carb_anhydrase. 1 hit.
SM00060. FN3. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
SSF51069. SSF51069. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEi PS51144. ALPHA_CA_2. 1 hit.
PS50853. FN3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a carbonic anhydrase-like domain in the extracellular region of RPTP gamma defines a new subfamily of receptor tyrosine phosphatases."
    Barnea G., Silvennoinen O., Shaanan B., Honegger A.M., Canoll P.D., D'Eustachio P., Morse B., Levy J.B., Laforgia S., Huebner K., Musacchio J.M., Sap J., Schlessinger J.
    Mol. Cell. Biol. 13:1497-1506(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Structure of the human receptor tyrosine phosphatase gamma gene (PTPRG) and relation to the familial RCC t(3;8) chromosome translocation."
    Kastury K., Ohta M., Lasota J., Moir D., Dorman T., Laforgia S., Druck T., Huebner K.
    Genomics 32:225-235(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT HIS-92.
  3. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Aortic endothelium.
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT HIS-92.
    Tissue: Brain.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 711-1445 (ISOFORM 2).
    Tissue: Prostate.
  8. "Structural diversity and evolution of human receptor-like protein tyrosine phosphatases."
    Krueger N.X., Streuli M., Saito H.
    EMBO J. 9:3241-3252(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 836-1445.
    Tissue: Placenta.
  9. "Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain."
    Kaplan R., Morse B., Huebner K., Croce C., Howk R., Ravera M., Ricca G., Jaye M., Schlessinger J.
    Proc. Natl. Acad. Sci. U.S.A. 87:7000-7004(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 874-1118 AND 1175-1409.
    Tissue: Brain.
  10. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-113 AND ASN-444.
    Tissue: Plasma.
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1182, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Large-scale structural analysis of the classical human protein tyrosine phosphatome."
    Barr A.J., Ugochukwu E., Lee W.H., King O.N.F., Filippakopoulos P., Alfano I., Savitsky P., Burgess-Brown N.A., Mueller S., Knapp S.
    Cell 136:352-363(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 827-1445, FUNCTION, CATALYTIC ACTIVITY, SUBUNIT, MUTAGENESIS OF ARG-958; LYS-960; ASP-1305 AND ASP-1306.
  13. "Crystal structure of the human receptor phosphatase PTPRG."
    Structural genomics consortium (SGC)
    Submitted (JUL-2006) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 830-1127.
  14. "Structural genomics of protein phosphatases."
    New York structural genomix research consortium (NYSGXRC)
    Submitted (MAR-2008) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 819-1130.
  15. "The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules."
    Bouyain S., Watkins D.J.
    Proc. Natl. Acad. Sci. U.S.A. 107:2443-2448(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 56-320, INTERACTION WITH CNTN3; CNTN4; CNTN5 AND CNTN6, DISULFIDE BOND.

Entry informationi

Entry nameiPTPRG_HUMAN
AccessioniPrimary (citable) accession number: P23470
Secondary accession number(s): B2RU12
, B7ZLX5, Q15623, Q59EE0, Q68DU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: May 5, 2009
Last modified: September 3, 2014
This is version 159 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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