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P23468

- PTPRD_HUMAN

UniProt

P23468 - PTPRD_HUMAN

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Protein

Receptor-type tyrosine-protein phosphatase delta

Gene

PTPRD

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei1181 – 11822CleavageCurated
Binding sitei1521 – 15211SubstrateBy similarity
Active sitei1553 – 15531Phosphocysteine intermediateBy similarity
Binding sitei1597 – 15971SubstrateBy similarity
Active sitei1844 – 18441Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. cell adhesion molecule binding Source: BHF-UCL
  2. receptor binding Source: BHF-UCL
  3. transmembrane receptor protein tyrosine phosphatase activity Source: ProtInc

GO - Biological processi

  1. heterophilic cell-cell adhesion Source: BHF-UCL
  2. neuron differentiation Source: BHF-UCL
  3. peptidyl-tyrosine dephosphorylation Source: GOC
  4. phosphate-containing compound metabolic process Source: ProtInc
  5. positive regulation of dendrite morphogenesis Source: BHF-UCL
  6. presynaptic membrane assembly Source: BHF-UCL
  7. protein dephosphorylation Source: ProtInc
  8. transmembrane receptor protein tyrosine phosphatase signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Enzyme and pathway databases

SignaLinkiP23468.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase delta (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase delta
Short name:
R-PTP-delta
Gene namesi
Name:PTPRD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:9668. PTPRD.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1178 – 11781R → A: 2.5-fold reduction in cleavage. 10-fold reduction in cleavage; when associated with A-1181. 1 Publication
Mutagenesisi1181 – 11811R → A: No reduction in cleavage. 10-fold reduction in cleavage; when associated with A-1178. 1 Publication

Organism-specific databases

PharmGKBiPA34013.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 19121892Receptor-type tyrosine-protein phosphatase deltaPRO_0000025437Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi45 ↔ 98PROSITE-ProRule annotation
Disulfide bondi147 ↔ 207PROSITE-ProRule annotation
Glycosylationi254 – 2541N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi257 ↔ 302PROSITE-ProRule annotation
Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi724 – 7241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi832 – 8321N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP23468.
PaxDbiP23468.
PRIDEiP23468.

PTM databases

PhosphoSiteiP23468.

Expressioni

Gene expression databases

BgeeiP23468.
CleanExiHS_PTPRD.
ExpressionAtlasiP23468. baseline and differential.
GenevestigatoriP23468.

Organism-specific databases

HPAiCAB026474.

Interactioni

Subunit structurei

Interacts with IL1RAPL1 (via extracellular region); interaction is required for IL1RAPL1-mediated synapse formation (By similarity). Interacts with PPFIA1, PPFIA2 and PPFIA3.By similarity1 Publication

Protein-protein interaction databases

BioGridi111753. 7 interactions.
DIPiDIP-17023N.
IntActiP23468. 3 interactions.
MINTiMINT-1350159.
STRINGi9606.ENSP00000348812.

Structurei

Secondary structure

1
1912
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi22 – 287
Beta strandi33 – 364
Beta strandi41 – 5111
Beta strandi54 – 596
Beta strandi69 – 746
Helixi75 – 773
Beta strandi79 – 846
Turni89 – 924
Beta strandi94 – 1029
Beta strandi105 – 11612
Helixi118 – 1203
Beta strandi127 – 1304
Beta strandi135 – 1384
Beta strandi143 – 1508
Beta strandi156 – 1616
Beta strandi175 – 1806
Beta strandi191 – 1944
Helixi199 – 2013
Beta strandi203 – 2119
Beta strandi214 – 2174
Beta strandi221 – 2266
Beta strandi422 – 4265
Beta strandi430 – 4334
Beta strandi436 – 4394
Beta strandi448 – 4547
Turni463 – 4653
Beta strandi475 – 4773
Beta strandi487 – 49812
Beta strandi507 – 5104
Beta strandi520 – 5256
Beta strandi527 – 53711
Beta strandi546 – 5494
Beta strandi551 – 5566
Beta strandi566 – 5738
Beta strandi580 – 5834
Beta strandi585 – 5884
Beta strandi593 – 5964
Beta strandi600 – 6034

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X5ZNMR-A506-607[»]
2DLHNMR-A407-514[»]
2YD6X-ray1.35A21-226[»]
2YD7X-ray1.98A/B21-226[»]
ProteinModelPortaliP23468.
SMRiP23468. Positions 21-318, 323-719, 921-1016, 1331-1906.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23468.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 12651245ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1291 – 1912622CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1266 – 129025HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 11491Ig-like C2-type 1Add
BLAST
Domaini126 – 22499Ig-like C2-type 2Add
BLAST
Domaini236 – 31883Ig-like C2-type 3Add
BLAST
Domaini325 – 41591Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini420 – 51697Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini518 – 60790Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini612 – 70998Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini714 – 822109Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST
Domaini823 – 91694Fibronectin type-III 6PROSITE-ProRule annotationAdd
BLAST
Domaini921 – 101696Fibronectin type-III 7PROSITE-ProRule annotationAdd
BLAST
Domaini1020 – 110687Fibronectin type-III 8PROSITE-ProRule annotationAdd
BLAST
Domaini1357 – 1612256Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
BLAST
Domaini1644 – 1903260Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni180 – 18910Interaction with IL1RAPL1By similarity
Regioni1553 – 15597Substrate bindingBy similarity

Sequence similaritiesi

Contains 8 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00760000118900.
HOGENOMiHOG000010250.
HOVERGENiHBG053758.
InParanoidiP23468.
KOiK06777.
OMAiTMDPSQH.
OrthoDBiEOG7M98FB.
PhylomeDBiP23468.
TreeFamiTF312900.

Family and domain databases

Gene3Di2.60.40.10. 11 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 7 hits.
PF07679. I-set. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 8 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 6 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: P23468-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVHVARLLLL LLTFFLRTDA ETPPRFTRTP VDQTGVSGGV ASFICQATGD
60 70 80 90 100
PRPKIVWNKK GKKVSNQRFE VIEFDDGSGS VLRIQPLRTP RDEAIYECVA
110 120 130 140 150
SNNVGEISVS TRLTVLREDQ IPRGFPTIDM GPQLKVVERT RTATMLCAAS
160 170 180 190 200
GNPDPEITWF KDFLPVDTSN NNGRIKQLRS ESIGGTPIRG ALQIEQSEES
210 220 230 240 250
DQGKYECVAT NSAGTRYSAP ANLYVRELRE VRRVPPRFSI PPTNHEIMPG
260 270 280 290 300
GSVNITCVAV GSPMPYVKWM LGAEDLTPED DMPIGRNVLE LNDVRQSANY
310 320 330 340 350
TCVAMSTLGV IEAIAQITVK ALPKPPGTPV VTESTATSIT LTWDSGNPEP
360 370 380 390 400
VSYYIIQHKP KNSEELYKEI DGVATTRYSV AGLSPYSDYE FRVVAVNNIG
410 420 430 440 450
RGPPSEPVLT QTSEQAPSSA PRDVQARMLS STTILVQWKE PEEPNGQIQG
460 470 480 490 500
YRVYYTMDPT QHVNNWMKHN VADSQITTIG NLVPQKTYSV KVLAFTSIGD
510 520 530 540 550
GPLSSDIQVI TQTGVPGQPL NFKAEPESET SILLSWTPPR SDTIANYELV
560 570 580 590 600
YKDGEHGEEQ RITIEPGTSY RLQGLKPNSL YYFRLAARSP QGLGASTAEI
610 620 630 640 650
SARTMQSKPS APPQDISCTS PSSTSILVSW QPPPVEKQNG IITEYSIKYT
660 670 680 690 700
AVDGEDDKPH EILGIPSDTT KYLLEQLEKW TEYRITVTAH TDVGPGPESL
710 720 730 740 750
SVLIRTNEDV PSGPPRKVEV EAVNSTSVKV SWRSPVPNKQ HGQIRGYQVH
760 770 780 790 800
YVRMENGEPK GQPMLKDVML ADAQWEFDDT TEHDMIISGL QPETSYSLTV
810 820 830 840 850
TAYTTKGDGA RSKPKLVSTT GAVPGKPRLV INHTQMNTAL IQWHPPVDTF
860 870 880 890 900
GPLQGYRLKF GRKDMEPLTT LEFSEKEDHF TATDIHKGAS YVFRLSARNK
910 920 930 940 950
VGFGEEMVKE ISIPEEVPTG FPQNLHSEGT TSTSVQLSWQ PPVLAERNGI
960 970 980 990 1000
ITKYTLLYRD INIPLLPMEQ LIVPADTTMT LTGLKPDTTY DVKVRAHTSK
1010 1020 1030 1040 1050
GPGPYSPSVQ FRTLPVDQVF AKNFHVKAVM KTSVLLSWEI PENYNSAMPF
1060 1070 1080 1090 1100
KILYDDGKMV EEVDGRATQK LIVNLKPEKS YSFVLTNRGN SAGGLQHRVT
1110 1120 1130 1140 1150
AKTAPDVLRT KPAFIGKTNL DGMITVQLPE VPANENIKGY YIIIVPLKKS
1160 1170 1180 1190 1200
RGKFIKPWES PDEMELDELL KEISRKRRSI RYGREVELKP YIAAHFDVLP
1210 1220 1230 1240 1250
TEFTLGDDKH YGGFTNKQLQ SGQEYVFFVL AVMEHAESKM YATSPYSDPV
1260 1270 1280 1290 1300
VSMDLDPQPI TDEEEGLIWV VGPVLAVVFI ICIVIAILLY KRKRAESDSR
1310 1320 1330 1340 1350
KSSIPNNKEI PSHHPTDPVE LRRLNFQTPG MASHPPIPIL ELADHIERLK
1360 1370 1380 1390 1400
ANDNLKFSQE YESIDPGQQF TWEHSNLEVN KPKNRYANVI AYDHSRVLLS
1410 1420 1430 1440 1450
AIEGIPGSDY VNANYIDGYR KQNAYIATQG SLPETFGDFW RMIWEQRSAT
1460 1470 1480 1490 1500
VVMMTKLEER SRVKCDQYWP SRGTETHGLV QVTLLDTVEL ATYCVRTFAL
1510 1520 1530 1540 1550
YKNGSSEKRE VRQFQFTAWP DHGVPEHPTP FLAFLRRVKT CNPPDAGPMV
1560 1570 1580 1590 1600
VHCSAGVGRT GCFIVIDAML ERIKHEKTVD IYGHVTLMRA QRNYMVQTED
1610 1620 1630 1640 1650
QYIFIHDALL EAVTCGNTEV PARNLYAYIQ KLTQIETGEN VTGMELEFKR
1660 1670 1680 1690 1700
LASSKAHTSR FISANLPCNK FKNRLVNIMP YESTRVCLQP IRGVEGSDYI
1710 1720 1730 1740 1750
NASFIDGYRQ QKAYIATQGP LAETTEDFWR MLWEHNSTIV VMLTKLREMG
1760 1770 1780 1790 1800
REKCHQYWPA ERSARYQYFV VDPMAEYNMP QYILREFKVT DARDGQSRTV
1810 1820 1830 1840 1850
RQFQFTDWPE QGVPKSGEGF IDFIGQVHKT KEQFGQDGPI SVHCSAGVGR
1860 1870 1880 1890 1900
TGVFITLSIV LERMRYEGVV DIFQTVKMLR TQRPAMVQTE DQYQFSYRAA
1910
LEYLGSFDHY AT

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Length:1,912
Mass (Da):214,760
Last modified:October 1, 1996 - v2
Checksum:i3AE8CBCD32182E26
GO
Isoform 2 (identifier: P23468-2) [UniParc]FASTAAdd to Basket

Also known as: Kidney

The sequence of this isoform differs from the canonical sequence as follows:
     181-189: Missing.
     226-229: Missing.
     775-783: Missing.

Show »
Length:1,890
Mass (Da):212,133
Checksum:iF67473E6C295C0D3
GO
Isoform 3 (identifier: P23468-3) [UniParc]FASTAAdd to Basket

Also known as: Fetal brain

The sequence of this isoform differs from the canonical sequence as follows:
     609-1137: Missing.

Show »
Length:1,383
Mass (Da):156,088
Checksum:i6FA7F02992F7AEFF
GO
Isoform 4 (identifier: P23468-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     184-189: Missing.
     227-230: Missing.
     608-608: K → M
     609-1019: Missing.
     1330-1330: G → GSDDSGYPGNLHSSS

Note: No experimental confirmation available.

Show »
Length:1,505
Mass (Da):169,474
Checksum:i737878C2930FBF68
GO
Isoform 5 (identifier: P23468-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     608-608: K → M
     609-1019: Missing.
     1291-1291: K → KSKPD

Note: No experimental confirmation available.

Show »
Length:1,505
Mass (Da):169,606
Checksum:i7F25884835F91CDB
GO
Isoform 6 (identifier: P23468-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     608-608: K → M
     609-1019: Missing.
     1291-1291: K → KSSKPD

Note: No experimental confirmation available.

Show »
Length:1,506
Mass (Da):169,693
Checksum:i136D13489D0BEA56
GO
Isoform 7 (identifier: P23468-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     181-183: Missing.
     608-1019: KPSAPPQDIS...QFRTLPVDQV → M
     1291-1291: K → KSKPD

Show »
Length:1,502
Mass (Da):169,277
Checksum:iCDEDB66CFBBE5D0D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 281R → Q in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035645
Natural varianti276 – 2761L → P in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035646
Natural varianti447 – 4471Q → E.
Corresponds to variant rs10977171 [ dbSNP | Ensembl ].
VAR_024581
Natural varianti901 – 9011V → A in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035647
Natural varianti995 – 9951R → C.
Corresponds to variant rs35929428 [ dbSNP | Ensembl ].
VAR_061761
Natural varianti1078 – 10781E → D.
Corresponds to variant rs7869444 [ dbSNP | Ensembl ].
VAR_051761

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei181 – 1899Missing in isoform 2. CuratedVSP_005147
Alternative sequencei181 – 1833Missing in isoform 7. CuratedVSP_054220
Alternative sequencei184 – 1896Missing in isoform 4. 1 PublicationVSP_043384
Alternative sequencei226 – 2294Missing in isoform 2. CuratedVSP_005148
Alternative sequencei227 – 2304Missing in isoform 4. 1 PublicationVSP_043385
Alternative sequencei608 – 1019412KPSAP…PVDQV → M in isoform 7. CuratedVSP_054221Add
BLAST
Alternative sequencei608 – 6081K → M in isoform 4, isoform 5 and isoform 6. 1 PublicationVSP_043386
Alternative sequencei609 – 1137529Missing in isoform 3. CuratedVSP_005150Add
BLAST
Alternative sequencei609 – 1019411Missing in isoform 4, isoform 5 and isoform 6. 1 PublicationVSP_043387Add
BLAST
Alternative sequencei775 – 7839Missing in isoform 2. CuratedVSP_005149
Alternative sequencei1291 – 12911K → KSKPD in isoform 5 and isoform 7. 1 PublicationVSP_043388
Alternative sequencei1291 – 12911K → KSSKPD in isoform 6. 1 PublicationVSP_043389
Alternative sequencei1330 – 13301G → GSDDSGYPGNLHSSS in isoform 4. 1 PublicationVSP_043390

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L38929 mRNA. Translation: AAC41749.1.
AL137125
, AL356584, AL445926, AL583805, AL590397 Genomic DNA. Translation: CAH70912.2.
AL356584
, AL137125, AL445926, AL583805, AL590397 Genomic DNA. Translation: CAI16146.2.
AL445926
, AL137125, AL356584, AL583805, AL590397 Genomic DNA. Translation: CAH73847.2.
AL583805
, AL137125, AL356584, AL445926, AL590397 Genomic DNA. Translation: CAH70443.2.
AL590397
, AL137125, AL356584, AL445926, AL583805 Genomic DNA. Translation: CAH73128.2.
AL133479 Genomic DNA. No translation available.
AL135790 Genomic DNA. No translation available.
AL137069 Genomic DNA. No translation available.
AL137851 Genomic DNA. No translation available.
AL157826 Genomic DNA. No translation available.
AL353638 Genomic DNA. No translation available.
AL353733 Genomic DNA. No translation available.
AL354722 Genomic DNA. No translation available.
AL356054 Genomic DNA. No translation available.
AL390723 Genomic DNA. No translation available.
AL391864 Genomic DNA. No translation available.
AL441884 Genomic DNA. No translation available.
AL451130 Genomic DNA. No translation available.
AL513422 Genomic DNA. No translation available.
AL590307 Genomic DNA. No translation available.
AL591133 Genomic DNA. No translation available.
AL591622 Genomic DNA. No translation available.
AL596451 Genomic DNA. No translation available.
AL669908 Genomic DNA. No translation available.
BC106713 mRNA. Translation: AAI06714.1.
BC106714 mRNA. Translation: AAI06715.1.
BC106715 mRNA. Translation: AAI06716.1.
X54133 mRNA. Translation: CAA38068.1.
CCDSiCCDS43786.1. [P23468-1]
CCDS55288.1. [P23468-7]
CCDS55289.1. [P23468-4]
CCDS55290.1. [P23468-6]
CCDS6472.2. [P23468-5]
PIRiA56178.
RefSeqiNP_001164496.1. NM_001171025.1. [P23468-4]
NP_002830.1. NM_002839.3. [P23468-1]
NP_569075.2. NM_130391.3. [P23468-5]
NP_569076.2. NM_130392.3. [P23468-6]
XP_006716887.1. XM_006716824.1. [P23468-1]
XP_006716894.1. XM_006716831.1. [P23468-6]
XP_006716895.1. XM_006716832.1. [P23468-4]
XP_006716896.1. XM_006716833.1. [P23468-5]
XP_006716898.1. XM_006716835.1. [P23468-7]
UniGeneiHs.446083.

Genome annotation databases

EnsembliENST00000355233; ENSP00000347373; ENSG00000153707. [P23468-6]
ENST00000356435; ENSP00000348812; ENSG00000153707. [P23468-1]
ENST00000381196; ENSP00000370593; ENSG00000153707. [P23468-1]
ENST00000397606; ENSP00000380731; ENSG00000153707. [P23468-4]
ENST00000397611; ENSP00000380735; ENSG00000153707. [P23468-7]
ENST00000486161; ENSP00000417093; ENSG00000153707. [P23468-5]
ENST00000540109; ENSP00000438164; ENSG00000153707. [P23468-1]
GeneIDi5789.
KEGGihsa:5789.
UCSCiuc003zkk.3. human. [P23468-1]
uc003zkp.3. human. [P23468-6]
uc003zkq.3. human. [P23468-5]
uc003zks.3. human. [P23468-4]

Polymorphism databases

DMDMi1709906.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L38929 mRNA. Translation: AAC41749.1 .
AL137125
, AL356584 , AL445926 , AL583805 , AL590397 Genomic DNA. Translation: CAH70912.2 .
AL356584
, AL137125 , AL445926 , AL583805 , AL590397 Genomic DNA. Translation: CAI16146.2 .
AL445926
, AL137125 , AL356584 , AL583805 , AL590397 Genomic DNA. Translation: CAH73847.2 .
AL583805
, AL137125 , AL356584 , AL445926 , AL590397 Genomic DNA. Translation: CAH70443.2 .
AL590397
, AL137125 , AL356584 , AL445926 , AL583805 Genomic DNA. Translation: CAH73128.2 .
AL133479 Genomic DNA. No translation available.
AL135790 Genomic DNA. No translation available.
AL137069 Genomic DNA. No translation available.
AL137851 Genomic DNA. No translation available.
AL157826 Genomic DNA. No translation available.
AL353638 Genomic DNA. No translation available.
AL353733 Genomic DNA. No translation available.
AL354722 Genomic DNA. No translation available.
AL356054 Genomic DNA. No translation available.
AL390723 Genomic DNA. No translation available.
AL391864 Genomic DNA. No translation available.
AL441884 Genomic DNA. No translation available.
AL451130 Genomic DNA. No translation available.
AL513422 Genomic DNA. No translation available.
AL590307 Genomic DNA. No translation available.
AL591133 Genomic DNA. No translation available.
AL591622 Genomic DNA. No translation available.
AL596451 Genomic DNA. No translation available.
AL669908 Genomic DNA. No translation available.
BC106713 mRNA. Translation: AAI06714.1 .
BC106714 mRNA. Translation: AAI06715.1 .
BC106715 mRNA. Translation: AAI06716.1 .
X54133 mRNA. Translation: CAA38068.1 .
CCDSi CCDS43786.1. [P23468-1 ]
CCDS55288.1. [P23468-7 ]
CCDS55289.1. [P23468-4 ]
CCDS55290.1. [P23468-6 ]
CCDS6472.2. [P23468-5 ]
PIRi A56178.
RefSeqi NP_001164496.1. NM_001171025.1. [P23468-4 ]
NP_002830.1. NM_002839.3. [P23468-1 ]
NP_569075.2. NM_130391.3. [P23468-5 ]
NP_569076.2. NM_130392.3. [P23468-6 ]
XP_006716887.1. XM_006716824.1. [P23468-1 ]
XP_006716894.1. XM_006716831.1. [P23468-6 ]
XP_006716895.1. XM_006716832.1. [P23468-4 ]
XP_006716896.1. XM_006716833.1. [P23468-5 ]
XP_006716898.1. XM_006716835.1. [P23468-7 ]
UniGenei Hs.446083.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1X5Z NMR - A 506-607 [» ]
2DLH NMR - A 407-514 [» ]
2YD6 X-ray 1.35 A 21-226 [» ]
2YD7 X-ray 1.98 A/B 21-226 [» ]
ProteinModelPortali P23468.
SMRi P23468. Positions 21-318, 323-719, 921-1016, 1331-1906.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111753. 7 interactions.
DIPi DIP-17023N.
IntActi P23468. 3 interactions.
MINTi MINT-1350159.
STRINGi 9606.ENSP00000348812.

PTM databases

PhosphoSitei P23468.

Polymorphism databases

DMDMi 1709906.

Proteomic databases

MaxQBi P23468.
PaxDbi P23468.
PRIDEi P23468.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000355233 ; ENSP00000347373 ; ENSG00000153707 . [P23468-6 ]
ENST00000356435 ; ENSP00000348812 ; ENSG00000153707 . [P23468-1 ]
ENST00000381196 ; ENSP00000370593 ; ENSG00000153707 . [P23468-1 ]
ENST00000397606 ; ENSP00000380731 ; ENSG00000153707 . [P23468-4 ]
ENST00000397611 ; ENSP00000380735 ; ENSG00000153707 . [P23468-7 ]
ENST00000486161 ; ENSP00000417093 ; ENSG00000153707 . [P23468-5 ]
ENST00000540109 ; ENSP00000438164 ; ENSG00000153707 . [P23468-1 ]
GeneIDi 5789.
KEGGi hsa:5789.
UCSCi uc003zkk.3. human. [P23468-1 ]
uc003zkp.3. human. [P23468-6 ]
uc003zkq.3. human. [P23468-5 ]
uc003zks.3. human. [P23468-4 ]

Organism-specific databases

CTDi 5789.
GeneCardsi GC09M008307.
HGNCi HGNC:9668. PTPRD.
HPAi CAB026474.
MIMi 601598. gene.
neXtProti NX_P23468.
PharmGKBi PA34013.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00760000118900.
HOGENOMi HOG000010250.
HOVERGENi HBG053758.
InParanoidi P23468.
KOi K06777.
OMAi TMDPSQH.
OrthoDBi EOG7M98FB.
PhylomeDBi P23468.
TreeFami TF312900.

Enzyme and pathway databases

SignaLinki P23468.

Miscellaneous databases

ChiTaRSi PTPRD. human.
EvolutionaryTracei P23468.
GeneWikii PTPRD.
GenomeRNAii 5789.
NextBioi 22528.
PROi P23468.
SOURCEi Search...

Gene expression databases

Bgeei P23468.
CleanExi HS_PTPRD.
ExpressionAtlasi P23468. baseline and differential.
Genevestigatori P23468.

Family and domain databases

Gene3Di 2.60.40.10. 11 hits.
3.90.190.10. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 7 hits.
PF07679. I-set. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 8 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 6 hits.
SSF52799. SSF52799. 2 hits.
PROSITEi PS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of the human transmembrane protein-tyrosine phosphatase delta. Evidence for tissue-specific expression of alternative human transmembrane protein-tyrosine phosphatase delta isoforms."
    Pulido R., Krueger N.X., Serra-Pages C., Saito H., Streuli M.
    J. Biol. Chem. 270:6722-6728(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CLEAVAGE SITE, MUTAGENESIS OF ARG-1178 AND ARG-1181.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 5 AND 6).
  4. "Structural diversity and evolution of human receptor-like protein tyrosine phosphatases."
    Krueger N.X., Streuli M., Saito H.
    EMBO J. 9:3241-3252(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 390-1912.
    Tissue: Placenta.
  5. "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins."
    Serra-Pages C., Medley Q.G., Tang M., Hart A., Streuli M.
    J. Biol. Chem. 273:15611-15620(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PPFIA1; PPFIA2 AND PPFIA3.
  6. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
  7. "Solution structure of the second and third FN3 domain of human receptor-type tyrosine-protein phosphatase delta."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 405-607.
  8. Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLN-28; PRO-276 AND ALA-901.

Entry informationi

Entry nameiPTPRD_HUMAN
AccessioniPrimary (citable) accession number: P23468
Secondary accession number(s): B1ALA0
, F5GWT7, Q3KPJ0, Q3KPJ1, Q3KPJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 158 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3