Reviewed, UniProtKB/Swiss-Prot P23468 (PTPRD_HUMAN)

Names and origin

Protein names

Recommended name:
    Receptor-type tyrosine-protein phosphatase delta
      Short name=Protein-tyrosine phosphatase delta
      Short name=R-PTP-delta
    EC=3.1.3.48

Gene names

Name:

PTPRD

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1912 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Subunit structure	Interacts with PPFIA1, PPFIA2 and PPFIA3.
Subcellular location	Membrane; Single-pass type I membrane protein.
Post-translational modification	A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. Contains 8 fibronectin type-III domains. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 2 tyrosine-protein phosphatase domains.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane
Molecular function	Hydrolase Protein phosphatase Receptor
PTM	Glycoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	protein amino acid dephosphorylation Ref.1 Traceable author statement. Source: ProtInc transmembrane receptor protein tyrosine phosphatase signaling pathway Ref.1 Traceable author statement. Source: ProtInc
Cellular component	integral to plasma membrane Ref.1 Traceable author statement. Source: ProtInc
Molecular function	transmembrane receptor protein tyrosine phosphatase activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Notes: Additional isoforms seem to exist.

Isoform 1 (identifier: P23468-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Notes: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 2 (identifier: P23468-2)

Also known as: Kidney;

The sequence of this isoform differs from the canonical sequence as follows:
     181-189: Missing.
     226-229: Missing.
     775-783: Missing.

Isoform 3 (identifier: P23468-3)

Also known as: Fetal brain;

The sequence of this isoform differs from the canonical sequence as follows:
     609-1137: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 20

20

Potential

Chain

21 – 1912

1892

Receptor-type tyrosine-protein phosphatase delta

PRO_0000025437

Regions

Topological domain

21 – 1265

1245

Extracellular Potential

Transmembrane

1266 – 1290

25

Potential

Topological domain

1291 – 1912

622

Cytoplasmic Potential

Domain

24 – 114

91

Ig-like C2-type 1

Domain

126 – 224

99

Ig-like C2-type 2

Domain

236 – 318

83

Ig-like C2-type 3

Domain

323 – 411

89

Fibronectin type-III 1

Domain

417 – 511

95

Fibronectin type-III 2

Domain

516 – 604

89

Fibronectin type-III 3

Domain

609 – 706

98

Fibronectin type-III 4

Domain

711 – 819

109

Fibronectin type-III 5

Domain

824 – 913

90

Fibronectin type-III 6

Domain

918 – 1013

96

Fibronectin type-III 7

Domain

1017 – 1103

87

Fibronectin type-III 8

Domain

1357 – 1612

256

Tyrosine-protein phosphatase 1

Domain

1644 – 1903

260

Tyrosine-protein phosphatase 2

Sites

Active site

1553

1

Phosphocysteine intermediate By similarity

Active site

1844

1

Phosphocysteine intermediate By similarity

Site

1181 – 1182

2

Cleavage Probable

Amino acid modifications

Glycosylation

254

1

N-linked (GlcNAc...) Potential

Glycosylation

299

1

N-linked (GlcNAc...) Potential

Glycosylation

724

1

N-linked (GlcNAc...) Potential

Glycosylation

832

1

N-linked (GlcNAc...) Potential

Disulfide bond

45 ↔ 98

Potential

Disulfide bond

147 ↔ 207

Potential

Disulfide bond

257 ↔ 302

Potential

Natural variations

Alternative sequence

181 – 189

9

Missing in isoform 2.

VSP_005147

Alternative sequence

226 – 229

4

Missing in isoform 2.

VSP_005148

Alternative sequence

609 – 1137

529

Missing in isoform 3.

VSP_005150

Alternative sequence

775 – 783

9

Missing in isoform 2.

VSP_005149

Natural variant

28

1

R → Q in a colorectal cancer sample; somatic mutation.

VAR_035645

Natural variant

276

1

L → P in a colorectal cancer sample; somatic mutation.

VAR_035646

Natural variant

447

1

Q → E: dbSNP rs10977171.

VAR_024581

Natural variant

901

1

V → A in a colorectal cancer sample; somatic mutation.

VAR_035647

Experimental info

Mutagenesis

1178

1

R → A: 2.5-fold reduction in cleavage. 10-fold reduction in cleavage; when associated with A-1181

Mutagenesis

1181

1

R → A: No reduction in cleavage. 10-fold reduction in cleavage; when associated with A-1178

Secondary structure

1

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1912

Helix Strand Turn

Details...

Beta strand

406 – 408

3

Beta strand

422 – 426

5

Beta strand

430 – 433

4

Beta strand

436 – 439

4

Beta strand

448 – 454

7

Turn

463 – 465

3

Beta strand

475 – 477

3

Beta strand

487 – 498

12

Beta strand

520 – 525

6

Beta strand

527 – 537

11

Beta strand

546 – 549

4

Beta strand

551 – 556

6

Beta strand

566 – 573

8

Beta strand

580 – 583

4

Beta strand

585 – 588

4

Beta strand

593 – 596

4

Beta strand

600 – 603

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 1996. Version 2. Checksum: 3AE8CBCD32182E26	FASTA	1,912	214,760
	10 20 30 40 50 60 MVHVARLLLL LLTFFLRTDA ETPPRFTRTP VDQTGVSGGV ASFICQATGD PRPKIVWNKK 70 80 90 100 110 120 GKKVSNQRFE VIEFDDGSGS VLRIQPLRTP RDEAIYECVA SNNVGEISVS TRLTVLREDQ 130 140 150 160 170 180 IPRGFPTIDM GPQLKVVERT RTATMLCAAS GNPDPEITWF KDFLPVDTSN NNGRIKQLRS 190 200 210 220 230 240 ESIGGTPIRG ALQIEQSEES DQGKYECVAT NSAGTRYSAP ANLYVRELRE VRRVPPRFSI 250 260 270 280 290 300 PPTNHEIMPG GSVNITCVAV GSPMPYVKWM LGAEDLTPED DMPIGRNVLE LNDVRQSANY 310 320 330 340 350 360 TCVAMSTLGV IEAIAQITVK ALPKPPGTPV VTESTATSIT LTWDSGNPEP VSYYIIQHKP 370 380 390 400 410 420 KNSEELYKEI DGVATTRYSV AGLSPYSDYE FRVVAVNNIG RGPPSEPVLT QTSEQAPSSA 430 440 450 460 470 480 PRDVQARMLS STTILVQWKE PEEPNGQIQG YRVYYTMDPT QHVNNWMKHN VADSQITTIG 490 500 510 520 530 540 NLVPQKTYSV KVLAFTSIGD GPLSSDIQVI TQTGVPGQPL NFKAEPESET SILLSWTPPR 550 560 570 580 590 600 SDTIANYELV YKDGEHGEEQ RITIEPGTSY RLQGLKPNSL YYFRLAARSP QGLGASTAEI 610 620 630 640 650 660 SARTMQSKPS APPQDISCTS PSSTSILVSW QPPPVEKQNG IITEYSIKYT AVDGEDDKPH 670 680 690 700 710 720 EILGIPSDTT KYLLEQLEKW TEYRITVTAH TDVGPGPESL SVLIRTNEDV PSGPPRKVEV 730 740 750 760 770 780 EAVNSTSVKV SWRSPVPNKQ HGQIRGYQVH YVRMENGEPK GQPMLKDVML ADAQWEFDDT 790 800 810 820 830 840 TEHDMIISGL QPETSYSLTV TAYTTKGDGA RSKPKLVSTT GAVPGKPRLV INHTQMNTAL 850 860 870 880 890 900 IQWHPPVDTF GPLQGYRLKF GRKDMEPLTT LEFSEKEDHF TATDIHKGAS YVFRLSARNK 910 920 930 940 950 960 VGFGEEMVKE ISIPEEVPTG FPQNLHSEGT TSTSVQLSWQ PPVLAERNGI ITKYTLLYRD 970 980 990 1000 1010 1020 INIPLLPMEQ LIVPADTTMT LTGLKPDTTY DVKVRAHTSK GPGPYSPSVQ FRTLPVDQVF 1030 1040 1050 1060 1070 1080 AKNFHVKAVM KTSVLLSWEI PENYNSAMPF KILYDDGKMV EEVDGRATQK LIVNLKPEKS 1090 1100 1110 1120 1130 1140 YSFVLTNRGN SAGGLQHRVT AKTAPDVLRT KPAFIGKTNL DGMITVQLPE VPANENIKGY 1150 1160 1170 1180 1190 1200 YIIIVPLKKS RGKFIKPWES PDEMELDELL KEISRKRRSI RYGREVELKP YIAAHFDVLP 1210 1220 1230 1240 1250 1260 TEFTLGDDKH YGGFTNKQLQ SGQEYVFFVL AVMEHAESKM YATSPYSDPV VSMDLDPQPI 1270 1280 1290 1300 1310 1320 TDEEEGLIWV VGPVLAVVFI ICIVIAILLY KRKRAESDSR KSSIPNNKEI PSHHPTDPVE 1330 1340 1350 1360 1370 1380 LRRLNFQTPG MASHPPIPIL ELADHIERLK ANDNLKFSQE YESIDPGQQF TWEHSNLEVN 1390 1400 1410 1420 1430 1440 KPKNRYANVI AYDHSRVLLS AIEGIPGSDY VNANYIDGYR KQNAYIATQG SLPETFGDFW 1450 1460 1470 1480 1490 1500 RMIWEQRSAT VVMMTKLEER SRVKCDQYWP SRGTETHGLV QVTLLDTVEL ATYCVRTFAL 1510 1520 1530 1540 1550 1560 YKNGSSEKRE VRQFQFTAWP DHGVPEHPTP FLAFLRRVKT CNPPDAGPMV VHCSAGVGRT 1570 1580 1590 1600 1610 1620 GCFIVIDAML ERIKHEKTVD IYGHVTLMRA QRNYMVQTED QYIFIHDALL EAVTCGNTEV 1630 1640 1650 1660 1670 1680 PARNLYAYIQ KLTQIETGEN VTGMELEFKR LASSKAHTSR FISANLPCNK FKNRLVNIMP 1690 1700 1710 1720 1730 1740 YESTRVCLQP IRGVEGSDYI NASFIDGYRQ QKAYIATQGP LAETTEDFWR MLWEHNSTIV 1750 1760 1770 1780 1790 1800 VMLTKLREMG REKCHQYWPA ERSARYQYFV VDPMAEYNMP QYILREFKVT DARDGQSRTV 1810 1820 1830 1840 1850 1860 RQFQFTDWPE QGVPKSGEGF IDFIGQVHKT KEQFGQDGPI SVHCSAGVGR TGVFITLSIV 1870 1880 1890 1900 1910 LERMRYEGVV DIFQTVKMLR TQRPAMVQTE DQYQFSYRAA LEYLGSFDHY AT
	Isoform 2 (Kidney) [UniParc]. Checksum: F67473E6C295C0D3		1,890	212,133
	10 20 30 40 50 60 MVHVARLLLL LLTFFLRTDA ETPPRFTRTP VDQTGVSGGV ASFICQATGD PRPKIVWNKK 70 80 90 100 110 120 GKKVSNQRFE VIEFDDGSGS VLRIQPLRTP RDEAIYECVA SNNVGEISVS TRLTVLREDQ 130 140 150 160 170 180 IPRGFPTIDM GPQLKVVERT RTATMLCAAS GNPDPEITWF KDFLPVDTSN NNGRIKQLRS 190 200 210 220 230 240 GALQIEQSEE SDQGKYECVA TNSAGTRYSA PANLYVEVRR VPPRFSIPPT NHEIMPGGSV 250 260 270 280 290 300 NITCVAVGSP MPYVKWMLGA EDLTPEDDMP IGRNVLELND VRQSANYTCV AMSTLGVIEA 310 320 330 340 350 360 IAQITVKALP KPPGTPVVTE STATSITLTW DSGNPEPVSY YIIQHKPKNS EELYKEIDGV 370 380 390 400 410 420 ATTRYSVAGL SPYSDYEFRV VAVNNIGRGP PSEPVLTQTS EQAPSSAPRD VQARMLSSTT 430 440 450 460 470 480 ILVQWKEPEE PNGQIQGYRV YYTMDPTQHV NNWMKHNVAD SQITTIGNLV PQKTYSVKVL 490 500 510 520 530 540 AFTSIGDGPL SSDIQVITQT GVPGQPLNFK AEPESETSIL LSWTPPRSDT IANYELVYKD 550 560 570 580 590 600 GEHGEEQRIT IEPGTSYRLQ GLKPNSLYYF RLAARSPQGL GASTAEISAR TMQSKPSAPP 610 620 630 640 650 660 QDISCTSPSS TSILVSWQPP PVEKQNGIIT EYSIKYTAVD GEDDKPHEIL GIPSDTTKYL 670 680 690 700 710 720 LEQLEKWTEY RITVTAHTDV GPGPESLSVL IRTNEDVPSG PPRKVEVEAV NSTSVKVSWR 730 740 750 760 770 780 SPVPNKQHGQ IRGYQVHYVR MENGEPKGQP MLKDVMLADA QDMIISGLQP ETSYSLTVTA 790 800 810 820 830 840 YTTKGDGARS KPKLVSTTGA VPGKPRLVIN HTQMNTALIQ WHPPVDTFGP LQGYRLKFGR 850 860 870 880 890 900 KDMEPLTTLE FSEKEDHFTA TDIHKGASYV FRLSARNKVG FGEEMVKEIS IPEEVPTGFP 910 920 930 940 950 960 QNLHSEGTTS TSVQLSWQPP VLAERNGIIT KYTLLYRDIN IPLLPMEQLI VPADTTMTLT 970 980 990 1000 1010 1020 GLKPDTTYDV KVRAHTSKGP GPYSPSVQFR TLPVDQVFAK NFHVKAVMKT SVLLSWEIPE 1030 1040 1050 1060 1070 1080 NYNSAMPFKI LYDDGKMVEE VDGRATQKLI VNLKPEKSYS FVLTNRGNSA GGLQHRVTAK 1090 1100 1110 1120 1130 1140 TAPDVLRTKP AFIGKTNLDG MITVQLPEVP ANENIKGYYI IIVPLKKSRG KFIKPWESPD 1150 1160 1170 1180 1190 1200 EMELDELLKE ISRKRRSIRY GREVELKPYI AAHFDVLPTE FTLGDDKHYG GFTNKQLQSG 1210 1220 1230 1240 1250 1260 QEYVFFVLAV MEHAESKMYA TSPYSDPVVS MDLDPQPITD EEEGLIWVVG PVLAVVFIIC 1270 1280 1290 1300 1310 1320 IVIAILLYKR KRAESDSRKS SIPNNKEIPS HHPTDPVELR RLNFQTPGMA SHPPIPILEL 1330 1340 1350 1360 1370 1380 ADHIERLKAN DNLKFSQEYE SIDPGQQFTW EHSNLEVNKP KNRYANVIAY DHSRVLLSAI 1390 1400 1410 1420 1430 1440 EGIPGSDYVN ANYIDGYRKQ NAYIATQGSL PETFGDFWRM IWEQRSATVV MMTKLEERSR 1450 1460 1470 1480 1490 1500 VKCDQYWPSR GTETHGLVQV TLLDTVELAT YCVRTFALYK NGSSEKREVR QFQFTAWPDH 1510 1520 1530 1540 1550 1560 GVPEHPTPFL AFLRRVKTCN PPDAGPMVVH CSAGVGRTGC FIVIDAMLER IKHEKTVDIY 1570 1580 1590 1600 1610 1620 GHVTLMRAQR NYMVQTEDQY IFIHDALLEA VTCGNTEVPA RNLYAYIQKL TQIETGENVT 1630 1640 1650 1660 1670 1680 GMELEFKRLA SSKAHTSRFI SANLPCNKFK NRLVNIMPYE STRVCLQPIR GVEGSDYINA 1690 1700 1710 1720 1730 1740 SFIDGYRQQK AYIATQGPLA ETTEDFWRML WEHNSTIVVM LTKLREMGRE KCHQYWPAER 1750 1760 1770 1780 1790 1800 SARYQYFVVD PMAEYNMPQY ILREFKVTDA RDGQSRTVRQ FQFTDWPEQG VPKSGEGFID 1810 1820 1830 1840 1850 1860 FIGQVHKTKE QFGQDGPISV HCSAGVGRTG VFITLSIVLE RMRYEGVVDI FQTVKMLRTQ 1870 1880 1890 RPAMVQTEDQ YQFSYRAALE YLGSFDHYAT
	Isoform 3 (Fetal brain) [UniParc]. Checksum: 6FA7F02992F7AEFF		1,383	156,088
	10 20 30 40 50 60 MVHVARLLLL LLTFFLRTDA ETPPRFTRTP VDQTGVSGGV ASFICQATGD PRPKIVWNKK 70 80 90 100 110 120 GKKVSNQRFE VIEFDDGSGS VLRIQPLRTP RDEAIYECVA SNNVGEISVS TRLTVLREDQ 130 140 150 160 170 180 IPRGFPTIDM GPQLKVVERT RTATMLCAAS GNPDPEITWF KDFLPVDTSN NNGRIKQLRS 190 200 210 220 230 240 ESIGGTPIRG ALQIEQSEES DQGKYECVAT NSAGTRYSAP ANLYVRELRE VRRVPPRFSI 250 260 270 280 290 300 PPTNHEIMPG GSVNITCVAV GSPMPYVKWM LGAEDLTPED DMPIGRNVLE LNDVRQSANY 310 320 330 340 350 360 TCVAMSTLGV IEAIAQITVK ALPKPPGTPV VTESTATSIT LTWDSGNPEP VSYYIIQHKP 370 380 390 400 410 420 KNSEELYKEI DGVATTRYSV AGLSPYSDYE FRVVAVNNIG RGPPSEPVLT QTSEQAPSSA 430 440 450 460 470 480 PRDVQARMLS STTILVQWKE PEEPNGQIQG YRVYYTMDPT QHVNNWMKHN VADSQITTIG 490 500 510 520 530 540 NLVPQKTYSV KVLAFTSIGD GPLSSDIQVI TQTGVPGQPL NFKAEPESET SILLSWTPPR 550 560 570 580 590 600 SDTIANYELV YKDGEHGEEQ RITIEPGTSY RLQGLKPNSL YYFRLAARSP QGLGASTAEI 610 620 630 640 650 660 SARTMQSKKG YYIIIVPLKK SRGKFIKPWE SPDEMELDEL LKEISRKRRS IRYGREVELK 670 680 690 700 710 720 PYIAAHFDVL PTEFTLGDDK HYGGFTNKQL QSGQEYVFFV LAVMEHAESK MYATSPYSDP 730 740 750 760 770 780 VVSMDLDPQP ITDEEEGLIW VVGPVLAVVF IICIVIAILL YKRKRAESDS RKSSIPNNKE 790 800 810 820 830 840 IPSHHPTDPV ELRRLNFQTP GMASHPPIPI LELADHIERL KANDNLKFSQ EYESIDPGQQ 850 860 870 880 890 900 FTWEHSNLEV NKPKNRYANV IAYDHSRVLL SAIEGIPGSD YVNANYIDGY RKQNAYIATQ 910 920 930 940 950 960 GSLPETFGDF WRMIWEQRSA TVVMMTKLEE RSRVKCDQYW PSRGTETHGL VQVTLLDTVE 970 980 990 1000 1010 1020 LATYCVRTFA LYKNGSSEKR EVRQFQFTAW PDHGVPEHPT PFLAFLRRVK TCNPPDAGPM 1030 1040 1050 1060 1070 1080 VVHCSAGVGR TGCFIVIDAM LERIKHEKTV DIYGHVTLMR AQRNYMVQTE DQYIFIHDAL 1090 1100 1110 1120 1130 1140 LEAVTCGNTE VPARNLYAYI QKLTQIETGE NVTGMELEFK RLASSKAHTS RFISANLPCN 1150 1160 1170 1180 1190 1200 KFKNRLVNIM PYESTRVCLQ PIRGVEGSDY INASFIDGYR QQKAYIATQG PLAETTEDFW 1210 1220 1230 1240 1250 1260 RMLWEHNSTI VVMLTKLREM GREKCHQYWP AERSARYQYF VVDPMAEYNM PQYILREFKV 1270 1280 1290 1300 1310 1320 TDARDGQSRT VRQFQFTDWP EQGVPKSGEG FIDFIGQVHK TKEQFGQDGP ISVHCSAGVG 1330 1340 1350 1360 1370 1380 RTGVFITLSI VLERMRYEGV VDIFQTVKML RTQRPAMVQT EDQYQFSYRA ALEYLGSFDH YAT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization of the human transmembrane protein-tyrosine phosphatase delta. Evidence for tissue-specific expression of alternative human transmembrane protein-tyrosine phosphatase delta isoforms." Pulido R., Krueger N.X., Serra-Pages C., Saito H., Streuli M. J. Biol. Chem. 270:6722-6728(1995) [PubMed: 7896816] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CLEAVAGE SITE, MUTAGENESIS OF ARG-1178 AND ARG-1181.
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,