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P23468

- PTPRD_HUMAN

UniProt

P23468 - PTPRD_HUMAN

Protein

Receptor-type tyrosine-protein phosphatase delta

Gene

PTPRD

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 157 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei1181 – 11822CleavageCurated
    Binding sitei1521 – 15211SubstrateBy similarity
    Active sitei1553 – 15531Phosphocysteine intermediateBy similarity
    Binding sitei1597 – 15971SubstrateBy similarity
    Active sitei1844 – 18441Phosphocysteine intermediateBy similarity

    GO - Molecular functioni

    1. cell adhesion molecule binding Source: BHF-UCL
    2. protein binding Source: UniProtKB
    3. receptor binding Source: BHF-UCL
    4. transmembrane receptor protein tyrosine phosphatase activity Source: ProtInc

    GO - Biological processi

    1. heterophilic cell-cell adhesion Source: BHF-UCL
    2. neuron differentiation Source: BHF-UCL
    3. peptidyl-tyrosine dephosphorylation Source: GOC
    4. phosphate-containing compound metabolic process Source: ProtInc
    5. positive regulation of dendrite morphogenesis Source: BHF-UCL
    6. presynaptic membrane assembly Source: BHF-UCL
    7. protein dephosphorylation Source: ProtInc
    8. transmembrane receptor protein tyrosine phosphatase signaling pathway Source: ProtInc

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase, Receptor

    Enzyme and pathway databases

    SignaLinkiP23468.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Receptor-type tyrosine-protein phosphatase delta (EC:3.1.3.48)
    Short name:
    Protein-tyrosine phosphatase delta
    Short name:
    R-PTP-delta
    Gene namesi
    Name:PTPRD
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:9668. PTPRD.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi1178 – 11781R → A: 2.5-fold reduction in cleavage. 10-fold reduction in cleavage; when associated with A-1181. 1 Publication
    Mutagenesisi1181 – 11811R → A: No reduction in cleavage. 10-fold reduction in cleavage; when associated with A-1178. 1 Publication

    Organism-specific databases

    PharmGKBiPA34013.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 19121892Receptor-type tyrosine-protein phosphatase deltaPRO_0000025437Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi45 ↔ 98PROSITE-ProRule annotation
    Disulfide bondi147 ↔ 207PROSITE-ProRule annotation
    Glycosylationi254 – 2541N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi257 ↔ 302PROSITE-ProRule annotation
    Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi724 – 7241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi832 – 8321N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP23468.
    PaxDbiP23468.
    PRIDEiP23468.

    PTM databases

    PhosphoSiteiP23468.

    Expressioni

    Gene expression databases

    ArrayExpressiP23468.
    BgeeiP23468.
    CleanExiHS_PTPRD.
    GenevestigatoriP23468.

    Organism-specific databases

    HPAiCAB026474.

    Interactioni

    Subunit structurei

    Interacts with IL1RAPL1 (via extracellular region); interaction is required for IL1RAPL1-mediated synapse formation By similarity. Interacts with PPFIA1, PPFIA2 and PPFIA3.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi111753. 3 interactions.
    DIPiDIP-17023N.
    IntActiP23468. 3 interactions.
    MINTiMINT-1350159.
    STRINGi9606.ENSP00000348812.

    Structurei

    Secondary structure

    1
    1912
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi22 – 287
    Beta strandi33 – 364
    Beta strandi41 – 5111
    Beta strandi54 – 596
    Beta strandi69 – 746
    Helixi75 – 773
    Beta strandi79 – 846
    Turni89 – 924
    Beta strandi94 – 1029
    Beta strandi105 – 11612
    Helixi118 – 1203
    Beta strandi127 – 1304
    Beta strandi135 – 1384
    Beta strandi143 – 1508
    Beta strandi156 – 1616
    Beta strandi175 – 1806
    Beta strandi191 – 1944
    Helixi199 – 2013
    Beta strandi203 – 2119
    Beta strandi214 – 2174
    Beta strandi221 – 2266
    Beta strandi422 – 4265
    Beta strandi430 – 4334
    Beta strandi436 – 4394
    Beta strandi448 – 4547
    Turni463 – 4653
    Beta strandi475 – 4773
    Beta strandi487 – 49812
    Beta strandi507 – 5104
    Beta strandi520 – 5256
    Beta strandi527 – 53711
    Beta strandi546 – 5494
    Beta strandi551 – 5566
    Beta strandi566 – 5738
    Beta strandi580 – 5834
    Beta strandi585 – 5884
    Beta strandi593 – 5964
    Beta strandi600 – 6034

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1X5ZNMR-A506-607[»]
    2DLHNMR-A407-514[»]
    2YD6X-ray1.35A21-226[»]
    2YD7X-ray1.98A/B21-226[»]
    ProteinModelPortaliP23468.
    SMRiP23468. Positions 21-318, 323-719, 921-1016, 1331-1906.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP23468.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 12651245ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1291 – 1912622CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1266 – 129025HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 11491Ig-like C2-type 1Add
    BLAST
    Domaini126 – 22499Ig-like C2-type 2Add
    BLAST
    Domaini236 – 31883Ig-like C2-type 3Add
    BLAST
    Domaini325 – 41591Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini420 – 51697Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini518 – 60790Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini612 – 70998Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini714 – 822109Fibronectin type-III 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini823 – 91694Fibronectin type-III 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini921 – 101696Fibronectin type-III 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini1020 – 110687Fibronectin type-III 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini1357 – 1612256Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1644 – 1903260Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni180 – 18910Interaction with IL1RAPL1By similarity
    Regioni1553 – 15597Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 8 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5599.
    HOGENOMiHOG000010250.
    HOVERGENiHBG053758.
    InParanoidiP23468.
    KOiK06777.
    OMAiTMDPSQH.
    OrthoDBiEOG7M98FB.
    PhylomeDBiP23468.
    TreeFamiTF312900.

    Family and domain databases

    Gene3Di2.60.40.10. 11 hits.
    3.90.190.10. 2 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00041. fn3. 7 hits.
    PF07679. I-set. 3 hits.
    PF00102. Y_phosphatase. 2 hits.
    [Graphical view]
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM00060. FN3. 8 hits.
    SM00408. IGc2. 3 hits.
    SM00194. PTPc. 2 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 6 hits.
    SSF52799. SSF52799. 2 hits.
    PROSITEiPS50853. FN3. 8 hits.
    PS50835. IG_LIKE. 3 hits.
    PS00383. TYR_PHOSPHATASE_1. 2 hits.
    PS50056. TYR_PHOSPHATASE_2. 2 hits.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: P23468-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVHVARLLLL LLTFFLRTDA ETPPRFTRTP VDQTGVSGGV ASFICQATGD     50
    PRPKIVWNKK GKKVSNQRFE VIEFDDGSGS VLRIQPLRTP RDEAIYECVA 100
    SNNVGEISVS TRLTVLREDQ IPRGFPTIDM GPQLKVVERT RTATMLCAAS 150
    GNPDPEITWF KDFLPVDTSN NNGRIKQLRS ESIGGTPIRG ALQIEQSEES 200
    DQGKYECVAT NSAGTRYSAP ANLYVRELRE VRRVPPRFSI PPTNHEIMPG 250
    GSVNITCVAV GSPMPYVKWM LGAEDLTPED DMPIGRNVLE LNDVRQSANY 300
    TCVAMSTLGV IEAIAQITVK ALPKPPGTPV VTESTATSIT LTWDSGNPEP 350
    VSYYIIQHKP KNSEELYKEI DGVATTRYSV AGLSPYSDYE FRVVAVNNIG 400
    RGPPSEPVLT QTSEQAPSSA PRDVQARMLS STTILVQWKE PEEPNGQIQG 450
    YRVYYTMDPT QHVNNWMKHN VADSQITTIG NLVPQKTYSV KVLAFTSIGD 500
    GPLSSDIQVI TQTGVPGQPL NFKAEPESET SILLSWTPPR SDTIANYELV 550
    YKDGEHGEEQ RITIEPGTSY RLQGLKPNSL YYFRLAARSP QGLGASTAEI 600
    SARTMQSKPS APPQDISCTS PSSTSILVSW QPPPVEKQNG IITEYSIKYT 650
    AVDGEDDKPH EILGIPSDTT KYLLEQLEKW TEYRITVTAH TDVGPGPESL 700
    SVLIRTNEDV PSGPPRKVEV EAVNSTSVKV SWRSPVPNKQ HGQIRGYQVH 750
    YVRMENGEPK GQPMLKDVML ADAQWEFDDT TEHDMIISGL QPETSYSLTV 800
    TAYTTKGDGA RSKPKLVSTT GAVPGKPRLV INHTQMNTAL IQWHPPVDTF 850
    GPLQGYRLKF GRKDMEPLTT LEFSEKEDHF TATDIHKGAS YVFRLSARNK 900
    VGFGEEMVKE ISIPEEVPTG FPQNLHSEGT TSTSVQLSWQ PPVLAERNGI 950
    ITKYTLLYRD INIPLLPMEQ LIVPADTTMT LTGLKPDTTY DVKVRAHTSK 1000
    GPGPYSPSVQ FRTLPVDQVF AKNFHVKAVM KTSVLLSWEI PENYNSAMPF 1050
    KILYDDGKMV EEVDGRATQK LIVNLKPEKS YSFVLTNRGN SAGGLQHRVT 1100
    AKTAPDVLRT KPAFIGKTNL DGMITVQLPE VPANENIKGY YIIIVPLKKS 1150
    RGKFIKPWES PDEMELDELL KEISRKRRSI RYGREVELKP YIAAHFDVLP 1200
    TEFTLGDDKH YGGFTNKQLQ SGQEYVFFVL AVMEHAESKM YATSPYSDPV 1250
    VSMDLDPQPI TDEEEGLIWV VGPVLAVVFI ICIVIAILLY KRKRAESDSR 1300
    KSSIPNNKEI PSHHPTDPVE LRRLNFQTPG MASHPPIPIL ELADHIERLK 1350
    ANDNLKFSQE YESIDPGQQF TWEHSNLEVN KPKNRYANVI AYDHSRVLLS 1400
    AIEGIPGSDY VNANYIDGYR KQNAYIATQG SLPETFGDFW RMIWEQRSAT 1450
    VVMMTKLEER SRVKCDQYWP SRGTETHGLV QVTLLDTVEL ATYCVRTFAL 1500
    YKNGSSEKRE VRQFQFTAWP DHGVPEHPTP FLAFLRRVKT CNPPDAGPMV 1550
    VHCSAGVGRT GCFIVIDAML ERIKHEKTVD IYGHVTLMRA QRNYMVQTED 1600
    QYIFIHDALL EAVTCGNTEV PARNLYAYIQ KLTQIETGEN VTGMELEFKR 1650
    LASSKAHTSR FISANLPCNK FKNRLVNIMP YESTRVCLQP IRGVEGSDYI 1700
    NASFIDGYRQ QKAYIATQGP LAETTEDFWR MLWEHNSTIV VMLTKLREMG 1750
    REKCHQYWPA ERSARYQYFV VDPMAEYNMP QYILREFKVT DARDGQSRTV 1800
    RQFQFTDWPE QGVPKSGEGF IDFIGQVHKT KEQFGQDGPI SVHCSAGVGR 1850
    TGVFITLSIV LERMRYEGVV DIFQTVKMLR TQRPAMVQTE DQYQFSYRAA 1900
    LEYLGSFDHY AT 1912

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Length:1,912
    Mass (Da):214,760
    Last modified:October 1, 1996 - v2
    Checksum:i3AE8CBCD32182E26
    GO
    Isoform 2 (identifier: P23468-2) [UniParc]FASTAAdd to Basket

    Also known as: Kidney

    The sequence of this isoform differs from the canonical sequence as follows:
         181-189: Missing.
         226-229: Missing.
         775-783: Missing.

    Show »
    Length:1,890
    Mass (Da):212,133
    Checksum:iF67473E6C295C0D3
    GO
    Isoform 3 (identifier: P23468-3) [UniParc]FASTAAdd to Basket

    Also known as: Fetal brain

    The sequence of this isoform differs from the canonical sequence as follows:
         609-1137: Missing.

    Show »
    Length:1,383
    Mass (Da):156,088
    Checksum:i6FA7F02992F7AEFF
    GO
    Isoform 4 (identifier: P23468-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         184-189: Missing.
         227-230: Missing.
         608-608: K → M
         609-1019: Missing.
         1330-1330: G → GSDDSGYPGNLHSSS

    Note: No experimental confirmation available.

    Show »
    Length:1,505
    Mass (Da):169,474
    Checksum:i737878C2930FBF68
    GO
    Isoform 5 (identifier: P23468-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         608-608: K → M
         609-1019: Missing.
         1291-1291: K → KSKPD

    Note: No experimental confirmation available.

    Show »
    Length:1,505
    Mass (Da):169,606
    Checksum:i7F25884835F91CDB
    GO
    Isoform 6 (identifier: P23468-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         608-608: K → M
         609-1019: Missing.
         1291-1291: K → KSSKPD

    Note: No experimental confirmation available.

    Show »
    Length:1,506
    Mass (Da):169,693
    Checksum:i136D13489D0BEA56
    GO
    Isoform 7 (identifier: P23468-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         181-183: Missing.
         608-1019: KPSAPPQDIS...QFRTLPVDQV → M
         1291-1291: K → KSKPD

    Show »
    Length:1,502
    Mass (Da):169,277
    Checksum:iCDEDB66CFBBE5D0D
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti28 – 281R → Q in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035645
    Natural varianti276 – 2761L → P in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035646
    Natural varianti447 – 4471Q → E.
    Corresponds to variant rs10977171 [ dbSNP | Ensembl ].
    VAR_024581
    Natural varianti901 – 9011V → A in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035647
    Natural varianti995 – 9951R → C.
    Corresponds to variant rs35929428 [ dbSNP | Ensembl ].
    VAR_061761
    Natural varianti1078 – 10781E → D.
    Corresponds to variant rs7869444 [ dbSNP | Ensembl ].
    VAR_051761

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei181 – 1899Missing in isoform 2. CuratedVSP_005147
    Alternative sequencei181 – 1833Missing in isoform 7. CuratedVSP_054220
    Alternative sequencei184 – 1896Missing in isoform 4. 1 PublicationVSP_043384
    Alternative sequencei226 – 2294Missing in isoform 2. CuratedVSP_005148
    Alternative sequencei227 – 2304Missing in isoform 4. 1 PublicationVSP_043385
    Alternative sequencei608 – 1019412KPSAP…PVDQV → M in isoform 7. CuratedVSP_054221Add
    BLAST
    Alternative sequencei608 – 6081K → M in isoform 4, isoform 5 and isoform 6. 1 PublicationVSP_043386
    Alternative sequencei609 – 1137529Missing in isoform 3. CuratedVSP_005150Add
    BLAST
    Alternative sequencei609 – 1019411Missing in isoform 4, isoform 5 and isoform 6. 1 PublicationVSP_043387Add
    BLAST
    Alternative sequencei775 – 7839Missing in isoform 2. CuratedVSP_005149
    Alternative sequencei1291 – 12911K → KSKPD in isoform 5 and isoform 7. 1 PublicationVSP_043388
    Alternative sequencei1291 – 12911K → KSSKPD in isoform 6. 1 PublicationVSP_043389
    Alternative sequencei1330 – 13301G → GSDDSGYPGNLHSSS in isoform 4. 1 PublicationVSP_043390

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L38929 mRNA. Translation: AAC41749.1.
    AL137125
    , AL356584, AL445926, AL583805, AL590397 Genomic DNA. Translation: CAH70912.2.
    AL356584
    , AL137125, AL445926, AL583805, AL590397 Genomic DNA. Translation: CAI16146.2.
    AL445926
    , AL137125, AL356584, AL583805, AL590397 Genomic DNA. Translation: CAH73847.2.
    AL583805
    , AL137125, AL356584, AL445926, AL590397 Genomic DNA. Translation: CAH70443.2.
    AL590397
    , AL137125, AL356584, AL445926, AL583805 Genomic DNA. Translation: CAH73128.2.
    AL133479 Genomic DNA. No translation available.
    AL135790 Genomic DNA. No translation available.
    AL137069 Genomic DNA. No translation available.
    AL137851 Genomic DNA. No translation available.
    AL157826 Genomic DNA. No translation available.
    AL353638 Genomic DNA. No translation available.
    AL353733 Genomic DNA. No translation available.
    AL354722 Genomic DNA. No translation available.
    AL356054 Genomic DNA. No translation available.
    AL390723 Genomic DNA. No translation available.
    AL391864 Genomic DNA. No translation available.
    AL441884 Genomic DNA. No translation available.
    AL451130 Genomic DNA. No translation available.
    AL513422 Genomic DNA. No translation available.
    AL590307 Genomic DNA. No translation available.
    AL591133 Genomic DNA. No translation available.
    AL591622 Genomic DNA. No translation available.
    AL596451 Genomic DNA. No translation available.
    AL669908 Genomic DNA. No translation available.
    BC106713 mRNA. Translation: AAI06714.1.
    BC106714 mRNA. Translation: AAI06715.1.
    BC106715 mRNA. Translation: AAI06716.1.
    X54133 mRNA. Translation: CAA38068.1.
    CCDSiCCDS43786.1. [P23468-1]
    CCDS55288.1. [P23468-7]
    CCDS55289.1. [P23468-4]
    CCDS55290.1. [P23468-6]
    CCDS6472.2. [P23468-5]
    PIRiA56178.
    RefSeqiNP_001164496.1. NM_001171025.1. [P23468-4]
    NP_002830.1. NM_002839.3. [P23468-1]
    NP_569075.2. NM_130391.3. [P23468-5]
    NP_569076.2. NM_130392.3. [P23468-6]
    XP_006716887.1. XM_006716824.1. [P23468-1]
    XP_006716894.1. XM_006716831.1. [P23468-6]
    XP_006716895.1. XM_006716832.1. [P23468-4]
    XP_006716896.1. XM_006716833.1. [P23468-5]
    XP_006716898.1. XM_006716835.1. [P23468-7]
    UniGeneiHs.446083.

    Genome annotation databases

    EnsembliENST00000355233; ENSP00000347373; ENSG00000153707. [P23468-6]
    ENST00000356435; ENSP00000348812; ENSG00000153707. [P23468-1]
    ENST00000381196; ENSP00000370593; ENSG00000153707. [P23468-1]
    ENST00000397606; ENSP00000380731; ENSG00000153707. [P23468-4]
    ENST00000397611; ENSP00000380735; ENSG00000153707. [P23468-7]
    ENST00000486161; ENSP00000417093; ENSG00000153707. [P23468-5]
    ENST00000540109; ENSP00000438164; ENSG00000153707. [P23468-1]
    GeneIDi5789.
    KEGGihsa:5789.
    UCSCiuc003zkk.3. human. [P23468-1]
    uc003zkp.3. human. [P23468-6]
    uc003zkq.3. human. [P23468-5]
    uc003zks.3. human. [P23468-4]

    Polymorphism databases

    DMDMi1709906.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L38929 mRNA. Translation: AAC41749.1 .
    AL137125
    , AL356584 , AL445926 , AL583805 , AL590397 Genomic DNA. Translation: CAH70912.2 .
    AL356584
    , AL137125 , AL445926 , AL583805 , AL590397 Genomic DNA. Translation: CAI16146.2 .
    AL445926
    , AL137125 , AL356584 , AL583805 , AL590397 Genomic DNA. Translation: CAH73847.2 .
    AL583805
    , AL137125 , AL356584 , AL445926 , AL590397 Genomic DNA. Translation: CAH70443.2 .
    AL590397
    , AL137125 , AL356584 , AL445926 , AL583805 Genomic DNA. Translation: CAH73128.2 .
    AL133479 Genomic DNA. No translation available.
    AL135790 Genomic DNA. No translation available.
    AL137069 Genomic DNA. No translation available.
    AL137851 Genomic DNA. No translation available.
    AL157826 Genomic DNA. No translation available.
    AL353638 Genomic DNA. No translation available.
    AL353733 Genomic DNA. No translation available.
    AL354722 Genomic DNA. No translation available.
    AL356054 Genomic DNA. No translation available.
    AL390723 Genomic DNA. No translation available.
    AL391864 Genomic DNA. No translation available.
    AL441884 Genomic DNA. No translation available.
    AL451130 Genomic DNA. No translation available.
    AL513422 Genomic DNA. No translation available.
    AL590307 Genomic DNA. No translation available.
    AL591133 Genomic DNA. No translation available.
    AL591622 Genomic DNA. No translation available.
    AL596451 Genomic DNA. No translation available.
    AL669908 Genomic DNA. No translation available.
    BC106713 mRNA. Translation: AAI06714.1 .
    BC106714 mRNA. Translation: AAI06715.1 .
    BC106715 mRNA. Translation: AAI06716.1 .
    X54133 mRNA. Translation: CAA38068.1 .
    CCDSi CCDS43786.1. [P23468-1 ]
    CCDS55288.1. [P23468-7 ]
    CCDS55289.1. [P23468-4 ]
    CCDS55290.1. [P23468-6 ]
    CCDS6472.2. [P23468-5 ]
    PIRi A56178.
    RefSeqi NP_001164496.1. NM_001171025.1. [P23468-4 ]
    NP_002830.1. NM_002839.3. [P23468-1 ]
    NP_569075.2. NM_130391.3. [P23468-5 ]
    NP_569076.2. NM_130392.3. [P23468-6 ]
    XP_006716887.1. XM_006716824.1. [P23468-1 ]
    XP_006716894.1. XM_006716831.1. [P23468-6 ]
    XP_006716895.1. XM_006716832.1. [P23468-4 ]
    XP_006716896.1. XM_006716833.1. [P23468-5 ]
    XP_006716898.1. XM_006716835.1. [P23468-7 ]
    UniGenei Hs.446083.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1X5Z NMR - A 506-607 [» ]
    2DLH NMR - A 407-514 [» ]
    2YD6 X-ray 1.35 A 21-226 [» ]
    2YD7 X-ray 1.98 A/B 21-226 [» ]
    ProteinModelPortali P23468.
    SMRi P23468. Positions 21-318, 323-719, 921-1016, 1331-1906.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111753. 3 interactions.
    DIPi DIP-17023N.
    IntActi P23468. 3 interactions.
    MINTi MINT-1350159.
    STRINGi 9606.ENSP00000348812.

    PTM databases

    PhosphoSitei P23468.

    Polymorphism databases

    DMDMi 1709906.

    Proteomic databases

    MaxQBi P23468.
    PaxDbi P23468.
    PRIDEi P23468.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000355233 ; ENSP00000347373 ; ENSG00000153707 . [P23468-6 ]
    ENST00000356435 ; ENSP00000348812 ; ENSG00000153707 . [P23468-1 ]
    ENST00000381196 ; ENSP00000370593 ; ENSG00000153707 . [P23468-1 ]
    ENST00000397606 ; ENSP00000380731 ; ENSG00000153707 . [P23468-4 ]
    ENST00000397611 ; ENSP00000380735 ; ENSG00000153707 . [P23468-7 ]
    ENST00000486161 ; ENSP00000417093 ; ENSG00000153707 . [P23468-5 ]
    ENST00000540109 ; ENSP00000438164 ; ENSG00000153707 . [P23468-1 ]
    GeneIDi 5789.
    KEGGi hsa:5789.
    UCSCi uc003zkk.3. human. [P23468-1 ]
    uc003zkp.3. human. [P23468-6 ]
    uc003zkq.3. human. [P23468-5 ]
    uc003zks.3. human. [P23468-4 ]

    Organism-specific databases

    CTDi 5789.
    GeneCardsi GC09M008307.
    HGNCi HGNC:9668. PTPRD.
    HPAi CAB026474.
    MIMi 601598. gene.
    neXtProti NX_P23468.
    PharmGKBi PA34013.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5599.
    HOGENOMi HOG000010250.
    HOVERGENi HBG053758.
    InParanoidi P23468.
    KOi K06777.
    OMAi TMDPSQH.
    OrthoDBi EOG7M98FB.
    PhylomeDBi P23468.
    TreeFami TF312900.

    Enzyme and pathway databases

    SignaLinki P23468.

    Miscellaneous databases

    ChiTaRSi PTPRD. human.
    EvolutionaryTracei P23468.
    GeneWikii PTPRD.
    GenomeRNAii 5789.
    NextBioi 22528.
    PROi P23468.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P23468.
    Bgeei P23468.
    CleanExi HS_PTPRD.
    Genevestigatori P23468.

    Family and domain databases

    Gene3Di 2.60.40.10. 11 hits.
    3.90.190.10. 2 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00041. fn3. 7 hits.
    PF07679. I-set. 3 hits.
    PF00102. Y_phosphatase. 2 hits.
    [Graphical view ]
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM00060. FN3. 8 hits.
    SM00408. IGc2. 3 hits.
    SM00194. PTPc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 6 hits.
    SSF52799. SSF52799. 2 hits.
    PROSITEi PS50853. FN3. 8 hits.
    PS50835. IG_LIKE. 3 hits.
    PS00383. TYR_PHOSPHATASE_1. 2 hits.
    PS50056. TYR_PHOSPHATASE_2. 2 hits.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of the human transmembrane protein-tyrosine phosphatase delta. Evidence for tissue-specific expression of alternative human transmembrane protein-tyrosine phosphatase delta isoforms."
      Pulido R., Krueger N.X., Serra-Pages C., Saito H., Streuli M.
      J. Biol. Chem. 270:6722-6728(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CLEAVAGE SITE, MUTAGENESIS OF ARG-1178 AND ARG-1181.
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 5 AND 6).
    4. "Structural diversity and evolution of human receptor-like protein tyrosine phosphatases."
      Krueger N.X., Streuli M., Saito H.
      EMBO J. 9:3241-3252(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 390-1912.
      Tissue: Placenta.
    5. "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins."
      Serra-Pages C., Medley Q.G., Tang M., Hart A., Streuli M.
      J. Biol. Chem. 273:15611-15620(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PPFIA1; PPFIA2 AND PPFIA3.
    6. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
    7. "Solution structure of the second and third FN3 domain of human receptor-type tyrosine-protein phosphatase delta."
      RIKEN structural genomics initiative (RSGI)
      Submitted (OCT-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 405-607.
    8. Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLN-28; PRO-276 AND ALA-901.

    Entry informationi

    Entry nameiPTPRD_HUMAN
    AccessioniPrimary (citable) accession number: P23468
    Secondary accession number(s): B1ALA0
    , F5GWT7, Q3KPJ0, Q3KPJ1, Q3KPJ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 157 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3