Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Receptor-type tyrosine-protein phosphatase delta

Gene

PTPRD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1521SubstrateBy similarity1
Active sitei1553Phosphocysteine intermediateBy similarity1
Binding sitei1597SubstrateBy similarity1
Active sitei1844Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Enzyme and pathway databases

BioCyciZFISH:HS07918-MONOMER.
BRENDAi3.1.3.48. 2681.
ReactomeiR-HSA-8849932. SALM protein interactions at the synapses.
SignaLinkiP23468.
SIGNORiP23468.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase delta (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase delta
Short name:
R-PTP-delta
Gene namesi
Name:PTPRD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:9668. PTPRD.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 1265ExtracellularSequence analysisAdd BLAST1245
Transmembranei1266 – 1290HelicalSequence analysisAdd BLAST25
Topological domaini1291 – 1912CytoplasmicSequence analysisAdd BLAST622

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1178R → A: 2.5-fold reduction in cleavage. 10-fold reduction in cleavage; when associated with A-1181. 1 Publication1
Mutagenesisi1181R → A: No reduction in cleavage. 10-fold reduction in cleavage; when associated with A-1178. 1 Publication1

Organism-specific databases

DisGeNETi5789.
OpenTargetsiENSG00000153707.
ENSG00000282932.
PharmGKBiPA34013.

Polymorphism and mutation databases

BioMutaiPTPRD.
DMDMi1709906.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002543721 – 1912Receptor-type tyrosine-protein phosphatase deltaAdd BLAST1892

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 98PROSITE-ProRule annotation
Disulfide bondi147 ↔ 207PROSITE-ProRule annotation
Glycosylationi254N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi257 ↔ 302PROSITE-ProRule annotation
Glycosylationi299N-linked (GlcNAc...)Sequence analysis1
Glycosylationi724N-linked (GlcNAc...)Sequence analysis1
Glycosylationi832N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei1181 – 1182CleavageCurated2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP23468.
MaxQBiP23468.
PaxDbiP23468.
PeptideAtlasiP23468.
PRIDEiP23468.

PTM databases

DEPODiP23468.
iPTMnetiP23468.
PhosphoSitePlusiP23468.

Expressioni

Gene expression databases

BgeeiENSG00000153707.
CleanExiHS_PTPRD.
ExpressionAtlasiP23468. baseline and differential.
GenevisibleiP23468. HS.

Organism-specific databases

HPAiHPA054829.

Interactioni

Subunit structurei

Interacts with IL1RAPL1 (via extracellular region); interaction is required for IL1RAPL1-mediated synapse formation (By similarity). Interacts with PPFIA1, PPFIA2 and PPFIA3.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111753. 35 interactors.
DIPiDIP-17023N.
IntActiP23468. 5 interactors.
MINTiMINT-1350159.
STRINGi9606.ENSP00000348812.

Structurei

Secondary structure

11912
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi22 – 28Combined sources7
Beta strandi33 – 36Combined sources4
Beta strandi41 – 51Combined sources11
Beta strandi54 – 59Combined sources6
Beta strandi69 – 74Combined sources6
Helixi75 – 77Combined sources3
Beta strandi79 – 84Combined sources6
Turni89 – 92Combined sources4
Beta strandi94 – 102Combined sources9
Beta strandi105 – 116Combined sources12
Helixi118 – 120Combined sources3
Beta strandi127 – 130Combined sources4
Beta strandi135 – 138Combined sources4
Beta strandi143 – 150Combined sources8
Beta strandi156 – 161Combined sources6
Beta strandi170 – 172Combined sources3
Beta strandi175 – 180Combined sources6
Beta strandi184 – 186Combined sources3
Beta strandi191 – 194Combined sources4
Helixi199 – 201Combined sources3
Beta strandi203 – 211Combined sources9
Beta strandi214 – 217Combined sources4
Beta strandi221 – 226Combined sources6
Beta strandi234 – 240Combined sources7
Beta strandi245 – 247Combined sources3
Beta strandi251 – 263Combined sources13
Beta strandi266 – 271Combined sources6
Helixi279 – 281Combined sources3
Beta strandi284 – 294Combined sources11
Beta strandi298 – 306Combined sources9
Beta strandi309 – 319Combined sources11
Beta strandi422 – 426Combined sources5
Beta strandi430 – 433Combined sources4
Beta strandi436 – 439Combined sources4
Beta strandi448 – 454Combined sources7
Turni463 – 465Combined sources3
Beta strandi475 – 477Combined sources3
Beta strandi487 – 498Combined sources12
Beta strandi507 – 510Combined sources4
Beta strandi520 – 525Combined sources6
Beta strandi527 – 537Combined sources11
Beta strandi546 – 549Combined sources4
Beta strandi551 – 556Combined sources6
Beta strandi566 – 573Combined sources8
Beta strandi580 – 583Combined sources4
Beta strandi585 – 588Combined sources4
Beta strandi593 – 596Combined sources4
Beta strandi600 – 603Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X5ZNMR-A506-607[»]
2DLHNMR-A407-514[»]
2YD6X-ray1.35A21-226[»]
2YD7X-ray1.98A/B21-226[»]
4RCAX-ray2.99A21-322[»]
ProteinModelPortaliP23468.
SMRiP23468.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23468.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 114Ig-like C2-type 1Add BLAST91
Domaini126 – 224Ig-like C2-type 2Add BLAST99
Domaini236 – 318Ig-like C2-type 3Add BLAST83
Domaini325 – 415Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST91
Domaini420 – 516Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST97
Domaini518 – 607Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST90
Domaini612 – 709Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST98
Domaini714 – 822Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST109
Domaini823 – 916Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST94
Domaini921 – 1016Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST96
Domaini1020 – 1106Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST87
Domaini1357 – 1612Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST256
Domaini1644 – 1903Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST260

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni180 – 189Interaction with IL1RAPL1By similarity10
Regioni1553 – 1559Substrate bindingBy similarity7

Sequence similaritiesi

Contains 8 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00760000118900.
HOGENOMiHOG000010250.
HOVERGENiHBG053758.
InParanoidiP23468.
KOiK06777.
OMAiPSDTTQY.
OrthoDBiEOG091G11WG.
PhylomeDBiP23468.
TreeFamiTF312900.

Family and domain databases

CDDicd00063. FN3. 8 hits.
Gene3Di2.60.40.10. 11 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 7 hits.
PF07679. I-set. 2 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 8 hits.
SM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF49265. SSF49265. 6 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P23468-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVHVARLLLL LLTFFLRTDA ETPPRFTRTP VDQTGVSGGV ASFICQATGD
60 70 80 90 100
PRPKIVWNKK GKKVSNQRFE VIEFDDGSGS VLRIQPLRTP RDEAIYECVA
110 120 130 140 150
SNNVGEISVS TRLTVLREDQ IPRGFPTIDM GPQLKVVERT RTATMLCAAS
160 170 180 190 200
GNPDPEITWF KDFLPVDTSN NNGRIKQLRS ESIGGTPIRG ALQIEQSEES
210 220 230 240 250
DQGKYECVAT NSAGTRYSAP ANLYVRELRE VRRVPPRFSI PPTNHEIMPG
260 270 280 290 300
GSVNITCVAV GSPMPYVKWM LGAEDLTPED DMPIGRNVLE LNDVRQSANY
310 320 330 340 350
TCVAMSTLGV IEAIAQITVK ALPKPPGTPV VTESTATSIT LTWDSGNPEP
360 370 380 390 400
VSYYIIQHKP KNSEELYKEI DGVATTRYSV AGLSPYSDYE FRVVAVNNIG
410 420 430 440 450
RGPPSEPVLT QTSEQAPSSA PRDVQARMLS STTILVQWKE PEEPNGQIQG
460 470 480 490 500
YRVYYTMDPT QHVNNWMKHN VADSQITTIG NLVPQKTYSV KVLAFTSIGD
510 520 530 540 550
GPLSSDIQVI TQTGVPGQPL NFKAEPESET SILLSWTPPR SDTIANYELV
560 570 580 590 600
YKDGEHGEEQ RITIEPGTSY RLQGLKPNSL YYFRLAARSP QGLGASTAEI
610 620 630 640 650
SARTMQSKPS APPQDISCTS PSSTSILVSW QPPPVEKQNG IITEYSIKYT
660 670 680 690 700
AVDGEDDKPH EILGIPSDTT KYLLEQLEKW TEYRITVTAH TDVGPGPESL
710 720 730 740 750
SVLIRTNEDV PSGPPRKVEV EAVNSTSVKV SWRSPVPNKQ HGQIRGYQVH
760 770 780 790 800
YVRMENGEPK GQPMLKDVML ADAQWEFDDT TEHDMIISGL QPETSYSLTV
810 820 830 840 850
TAYTTKGDGA RSKPKLVSTT GAVPGKPRLV INHTQMNTAL IQWHPPVDTF
860 870 880 890 900
GPLQGYRLKF GRKDMEPLTT LEFSEKEDHF TATDIHKGAS YVFRLSARNK
910 920 930 940 950
VGFGEEMVKE ISIPEEVPTG FPQNLHSEGT TSTSVQLSWQ PPVLAERNGI
960 970 980 990 1000
ITKYTLLYRD INIPLLPMEQ LIVPADTTMT LTGLKPDTTY DVKVRAHTSK
1010 1020 1030 1040 1050
GPGPYSPSVQ FRTLPVDQVF AKNFHVKAVM KTSVLLSWEI PENYNSAMPF
1060 1070 1080 1090 1100
KILYDDGKMV EEVDGRATQK LIVNLKPEKS YSFVLTNRGN SAGGLQHRVT
1110 1120 1130 1140 1150
AKTAPDVLRT KPAFIGKTNL DGMITVQLPE VPANENIKGY YIIIVPLKKS
1160 1170 1180 1190 1200
RGKFIKPWES PDEMELDELL KEISRKRRSI RYGREVELKP YIAAHFDVLP
1210 1220 1230 1240 1250
TEFTLGDDKH YGGFTNKQLQ SGQEYVFFVL AVMEHAESKM YATSPYSDPV
1260 1270 1280 1290 1300
VSMDLDPQPI TDEEEGLIWV VGPVLAVVFI ICIVIAILLY KRKRAESDSR
1310 1320 1330 1340 1350
KSSIPNNKEI PSHHPTDPVE LRRLNFQTPG MASHPPIPIL ELADHIERLK
1360 1370 1380 1390 1400
ANDNLKFSQE YESIDPGQQF TWEHSNLEVN KPKNRYANVI AYDHSRVLLS
1410 1420 1430 1440 1450
AIEGIPGSDY VNANYIDGYR KQNAYIATQG SLPETFGDFW RMIWEQRSAT
1460 1470 1480 1490 1500
VVMMTKLEER SRVKCDQYWP SRGTETHGLV QVTLLDTVEL ATYCVRTFAL
1510 1520 1530 1540 1550
YKNGSSEKRE VRQFQFTAWP DHGVPEHPTP FLAFLRRVKT CNPPDAGPMV
1560 1570 1580 1590 1600
VHCSAGVGRT GCFIVIDAML ERIKHEKTVD IYGHVTLMRA QRNYMVQTED
1610 1620 1630 1640 1650
QYIFIHDALL EAVTCGNTEV PARNLYAYIQ KLTQIETGEN VTGMELEFKR
1660 1670 1680 1690 1700
LASSKAHTSR FISANLPCNK FKNRLVNIMP YESTRVCLQP IRGVEGSDYI
1710 1720 1730 1740 1750
NASFIDGYRQ QKAYIATQGP LAETTEDFWR MLWEHNSTIV VMLTKLREMG
1760 1770 1780 1790 1800
REKCHQYWPA ERSARYQYFV VDPMAEYNMP QYILREFKVT DARDGQSRTV
1810 1820 1830 1840 1850
RQFQFTDWPE QGVPKSGEGF IDFIGQVHKT KEQFGQDGPI SVHCSAGVGR
1860 1870 1880 1890 1900
TGVFITLSIV LERMRYEGVV DIFQTVKMLR TQRPAMVQTE DQYQFSYRAA
1910
LEYLGSFDHY AT
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Length:1,912
Mass (Da):214,760
Last modified:October 1, 1996 - v2
Checksum:i3AE8CBCD32182E26
GO
Isoform 2 (identifier: P23468-2) [UniParc]FASTAAdd to basket
Also known as: Kidney

The sequence of this isoform differs from the canonical sequence as follows:
     181-189: Missing.
     226-229: Missing.
     775-783: Missing.

Show »
Length:1,890
Mass (Da):212,133
Checksum:iF67473E6C295C0D3
GO
Isoform 3 (identifier: P23468-3) [UniParc]FASTAAdd to basket
Also known as: Fetal brain

The sequence of this isoform differs from the canonical sequence as follows:
     609-1137: Missing.

Show »
Length:1,383
Mass (Da):156,088
Checksum:i6FA7F02992F7AEFF
GO
Isoform 4 (identifier: P23468-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     184-189: Missing.
     227-230: Missing.
     608-608: K → M
     609-1019: Missing.
     1330-1330: G → GSDDSGYPGNLHSSS

Note: No experimental confirmation available.
Show »
Length:1,505
Mass (Da):169,474
Checksum:i737878C2930FBF68
GO
Isoform 5 (identifier: P23468-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     608-608: K → M
     609-1019: Missing.
     1291-1291: K → KSKPD

Note: No experimental confirmation available.
Show »
Length:1,505
Mass (Da):169,606
Checksum:i7F25884835F91CDB
GO
Isoform 6 (identifier: P23468-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     608-608: K → M
     609-1019: Missing.
     1291-1291: K → KSSKPD

Note: No experimental confirmation available.
Show »
Length:1,506
Mass (Da):169,693
Checksum:i136D13489D0BEA56
GO
Isoform 7 (identifier: P23468-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     181-183: Missing.
     608-1019: KPSAPPQDIS...QFRTLPVDQV → M
     1291-1291: K → KSKPD

Show »
Length:1,502
Mass (Da):169,277
Checksum:iCDEDB66CFBBE5D0D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03564528R → Q in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_035646276L → P in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_024581447Q → E.Corresponds to variant rs10977171dbSNPEnsembl.1
Natural variantiVAR_035647901V → A in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_061761995R → C.Corresponds to variant rs35929428dbSNPEnsembl.1
Natural variantiVAR_0517611078E → D.Corresponds to variant rs7869444dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005147181 – 189Missing in isoform 2. Curated9
Alternative sequenceiVSP_054220181 – 183Missing in isoform 7. Curated3
Alternative sequenceiVSP_043384184 – 189Missing in isoform 4. 1 Publication6
Alternative sequenceiVSP_005148226 – 229Missing in isoform 2. Curated4
Alternative sequenceiVSP_043385227 – 230Missing in isoform 4. 1 Publication4
Alternative sequenceiVSP_054221608 – 1019KPSAP…PVDQV → M in isoform 7. CuratedAdd BLAST412
Alternative sequenceiVSP_043386608K → M in isoform 4, isoform 5 and isoform 6. 1 Publication1
Alternative sequenceiVSP_005150609 – 1137Missing in isoform 3. CuratedAdd BLAST529
Alternative sequenceiVSP_043387609 – 1019Missing in isoform 4, isoform 5 and isoform 6. 1 PublicationAdd BLAST411
Alternative sequenceiVSP_005149775 – 783Missing in isoform 2. Curated9
Alternative sequenceiVSP_0433881291K → KSKPD in isoform 5 and isoform 7. 1 Publication1
Alternative sequenceiVSP_0433891291K → KSSKPD in isoform 6. 1 Publication1
Alternative sequenceiVSP_0433901330G → GSDDSGYPGNLHSSS in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38929 mRNA. Translation: AAC41749.1.
AL137125
, AL356584, AL445926, AL583805, AL590397 Genomic DNA. Translation: CAH70912.2.
AL356584
, AL137125, AL445926, AL583805, AL590397 Genomic DNA. Translation: CAI16146.2.
AL445926
, AL137125, AL356584, AL583805, AL590397 Genomic DNA. Translation: CAH73847.2.
AL583805
, AL137125, AL356584, AL445926, AL590397 Genomic DNA. Translation: CAH70443.2.
AL590397
, AL137125, AL356584, AL445926, AL583805 Genomic DNA. Translation: CAH73128.2.
AL133479 Genomic DNA. No translation available.
AL135790 Genomic DNA. No translation available.
AL137069 Genomic DNA. No translation available.
AL137851 Genomic DNA. No translation available.
AL157826 Genomic DNA. No translation available.
AL353638 Genomic DNA. No translation available.
AL353733 Genomic DNA. No translation available.
AL354722 Genomic DNA. No translation available.
AL356054 Genomic DNA. No translation available.
AL390723 Genomic DNA. No translation available.
AL391864 Genomic DNA. No translation available.
AL441884 Genomic DNA. No translation available.
AL451130 Genomic DNA. No translation available.
AL513422 Genomic DNA. No translation available.
AL590307 Genomic DNA. No translation available.
AL591133 Genomic DNA. No translation available.
AL591622 Genomic DNA. No translation available.
AL596451 Genomic DNA. No translation available.
AL669908 Genomic DNA. No translation available.
BC106713 mRNA. Translation: AAI06714.1.
BC106714 mRNA. Translation: AAI06715.1.
BC106715 mRNA. Translation: AAI06716.1.
X54133 mRNA. Translation: CAA38068.1.
CCDSiCCDS43786.1. [P23468-1]
CCDS55288.1. [P23468-7]
CCDS55289.1. [P23468-4]
CCDS55290.1. [P23468-6]
CCDS6472.2. [P23468-5]
PIRiA56178.
RefSeqiNP_001164496.1. NM_001171025.1. [P23468-4]
NP_002830.1. NM_002839.3. [P23468-1]
NP_569075.2. NM_130391.3. [P23468-5]
NP_569076.2. NM_130392.3. [P23468-6]
XP_006716895.1. XM_006716832.3. [P23468-4]
XP_006716896.1. XM_006716833.3. [P23468-5]
XP_006716898.1. XM_006716835.3. [P23468-7]
XP_011516294.1. XM_011517992.2. [P23468-1]
XP_016870480.1. XM_017014991.1. [P23468-6]
UniGeneiHs.446083.

Genome annotation databases

EnsembliENST00000355233; ENSP00000347373; ENSG00000153707. [P23468-6]
ENST00000356435; ENSP00000348812; ENSG00000153707. [P23468-1]
ENST00000381196; ENSP00000370593; ENSG00000153707. [P23468-1]
ENST00000397606; ENSP00000380731; ENSG00000153707. [P23468-4]
ENST00000397611; ENSP00000380735; ENSG00000153707. [P23468-7]
ENST00000486161; ENSP00000417093; ENSG00000153707. [P23468-5]
ENST00000540109; ENSP00000438164; ENSG00000153707. [P23468-1]
ENST00000634556; ENSP00000489063; ENSG00000282932. [P23468-1]
ENST00000634583; ENSP00000489509; ENSG00000282932. [P23468-5]
ENST00000634608; ENSP00000489257; ENSG00000282932. [P23468-1]
ENST00000635012; ENSP00000489439; ENSG00000282932. [P23468-1]
ENST00000635279; ENSP00000488982; ENSG00000282932. [P23468-4]
ENST00000635611; ENSP00000489155; ENSG00000282932. [P23468-7]
ENST00000635613; ENSP00000489038; ENSG00000282932. [P23468-6]
GeneIDi5789.
KEGGihsa:5789.
UCSCiuc003zkp.4. human. [P23468-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38929 mRNA. Translation: AAC41749.1.
AL137125
, AL356584, AL445926, AL583805, AL590397 Genomic DNA. Translation: CAH70912.2.
AL356584
, AL137125, AL445926, AL583805, AL590397 Genomic DNA. Translation: CAI16146.2.
AL445926
, AL137125, AL356584, AL583805, AL590397 Genomic DNA. Translation: CAH73847.2.
AL583805
, AL137125, AL356584, AL445926, AL590397 Genomic DNA. Translation: CAH70443.2.
AL590397
, AL137125, AL356584, AL445926, AL583805 Genomic DNA. Translation: CAH73128.2.
AL133479 Genomic DNA. No translation available.
AL135790 Genomic DNA. No translation available.
AL137069 Genomic DNA. No translation available.
AL137851 Genomic DNA. No translation available.
AL157826 Genomic DNA. No translation available.
AL353638 Genomic DNA. No translation available.
AL353733 Genomic DNA. No translation available.
AL354722 Genomic DNA. No translation available.
AL356054 Genomic DNA. No translation available.
AL390723 Genomic DNA. No translation available.
AL391864 Genomic DNA. No translation available.
AL441884 Genomic DNA. No translation available.
AL451130 Genomic DNA. No translation available.
AL513422 Genomic DNA. No translation available.
AL590307 Genomic DNA. No translation available.
AL591133 Genomic DNA. No translation available.
AL591622 Genomic DNA. No translation available.
AL596451 Genomic DNA. No translation available.
AL669908 Genomic DNA. No translation available.
BC106713 mRNA. Translation: AAI06714.1.
BC106714 mRNA. Translation: AAI06715.1.
BC106715 mRNA. Translation: AAI06716.1.
X54133 mRNA. Translation: CAA38068.1.
CCDSiCCDS43786.1. [P23468-1]
CCDS55288.1. [P23468-7]
CCDS55289.1. [P23468-4]
CCDS55290.1. [P23468-6]
CCDS6472.2. [P23468-5]
PIRiA56178.
RefSeqiNP_001164496.1. NM_001171025.1. [P23468-4]
NP_002830.1. NM_002839.3. [P23468-1]
NP_569075.2. NM_130391.3. [P23468-5]
NP_569076.2. NM_130392.3. [P23468-6]
XP_006716895.1. XM_006716832.3. [P23468-4]
XP_006716896.1. XM_006716833.3. [P23468-5]
XP_006716898.1. XM_006716835.3. [P23468-7]
XP_011516294.1. XM_011517992.2. [P23468-1]
XP_016870480.1. XM_017014991.1. [P23468-6]
UniGeneiHs.446083.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X5ZNMR-A506-607[»]
2DLHNMR-A407-514[»]
2YD6X-ray1.35A21-226[»]
2YD7X-ray1.98A/B21-226[»]
4RCAX-ray2.99A21-322[»]
ProteinModelPortaliP23468.
SMRiP23468.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111753. 35 interactors.
DIPiDIP-17023N.
IntActiP23468. 5 interactors.
MINTiMINT-1350159.
STRINGi9606.ENSP00000348812.

PTM databases

DEPODiP23468.
iPTMnetiP23468.
PhosphoSitePlusiP23468.

Polymorphism and mutation databases

BioMutaiPTPRD.
DMDMi1709906.

Proteomic databases

EPDiP23468.
MaxQBiP23468.
PaxDbiP23468.
PeptideAtlasiP23468.
PRIDEiP23468.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355233; ENSP00000347373; ENSG00000153707. [P23468-6]
ENST00000356435; ENSP00000348812; ENSG00000153707. [P23468-1]
ENST00000381196; ENSP00000370593; ENSG00000153707. [P23468-1]
ENST00000397606; ENSP00000380731; ENSG00000153707. [P23468-4]
ENST00000397611; ENSP00000380735; ENSG00000153707. [P23468-7]
ENST00000486161; ENSP00000417093; ENSG00000153707. [P23468-5]
ENST00000540109; ENSP00000438164; ENSG00000153707. [P23468-1]
ENST00000634556; ENSP00000489063; ENSG00000282932. [P23468-1]
ENST00000634583; ENSP00000489509; ENSG00000282932. [P23468-5]
ENST00000634608; ENSP00000489257; ENSG00000282932. [P23468-1]
ENST00000635012; ENSP00000489439; ENSG00000282932. [P23468-1]
ENST00000635279; ENSP00000488982; ENSG00000282932. [P23468-4]
ENST00000635611; ENSP00000489155; ENSG00000282932. [P23468-7]
ENST00000635613; ENSP00000489038; ENSG00000282932. [P23468-6]
GeneIDi5789.
KEGGihsa:5789.
UCSCiuc003zkp.4. human. [P23468-1]

Organism-specific databases

CTDi5789.
DisGeNETi5789.
GeneCardsiPTPRD.
HGNCiHGNC:9668. PTPRD.
HPAiHPA054829.
MIMi601598. gene.
neXtProtiNX_P23468.
OpenTargetsiENSG00000153707.
ENSG00000282932.
PharmGKBiPA34013.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00760000118900.
HOGENOMiHOG000010250.
HOVERGENiHBG053758.
InParanoidiP23468.
KOiK06777.
OMAiPSDTTQY.
OrthoDBiEOG091G11WG.
PhylomeDBiP23468.
TreeFamiTF312900.

Enzyme and pathway databases

BioCyciZFISH:HS07918-MONOMER.
BRENDAi3.1.3.48. 2681.
ReactomeiR-HSA-8849932. SALM protein interactions at the synapses.
SignaLinkiP23468.
SIGNORiP23468.

Miscellaneous databases

ChiTaRSiPTPRD. human.
EvolutionaryTraceiP23468.
GeneWikiiPTPRD.
GenomeRNAii5789.
PROiP23468.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153707.
CleanExiHS_PTPRD.
ExpressionAtlasiP23468. baseline and differential.
GenevisibleiP23468. HS.

Family and domain databases

CDDicd00063. FN3. 8 hits.
Gene3Di2.60.40.10. 11 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 7 hits.
PF07679. I-set. 2 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 8 hits.
SM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF49265. SSF49265. 6 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTPRD_HUMAN
AccessioniPrimary (citable) accession number: P23468
Secondary accession number(s): B1ALA0
, F5GWT7, Q3KPJ0, Q3KPJ1, Q3KPJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 181 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.