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Protein

Receptor-type tyrosine-protein phosphatase beta

Gene

PTPRB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).By similarity2 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1870Substrate1
Active sitei1904Phosphocysteine intermediatePROSITE-ProRule annotation1 Publication1
Binding sitei1948SubstrateBy similarity1

GO - Molecular functioni

  • transmembrane receptor protein tyrosine phosphatase activity Source: ProtInc

GO - Biological processi

  • angiogenesis Source: UniProtKB-KW
  • dephosphorylation Source: UniProtKB
  • phosphate-containing compound metabolic process Source: ProtInc
  • protein dephosphorylation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Angiogenesis

Enzyme and pathway databases

BioCyciZFISH:HS05085-MONOMER.
BRENDAi3.1.3.48. 2681.
ReactomeiR-HSA-6798695. Neutrophil degranulation.
SignaLinkiP23467.
SIGNORiP23467.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase beta (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase beta
Short name:
R-PTP-beta
Alternative name(s):
Vascular endothelial protein tyrosine phosphatase
Short name:
VE-PTP
Gene namesi
Name:PTPRB
Synonyms:PTPB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:9665. PTPRB.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 1621ExtracellularSequence analysisAdd BLAST1599
Transmembranei1622 – 1642HelicalSequence analysisAdd BLAST21
Topological domaini1643 – 1997CytoplasmicSequence analysisAdd BLAST355

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5787.
OpenTargetsiENSG00000127329.
PharmGKBiPA34010.

Chemistry databases

ChEMBLiCHEMBL2706.
GuidetoPHARMACOLOGYi1851.

Polymorphism and mutation databases

BioMutaiPTPRB.
DMDMi317373518.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002543623 – 1997Receptor-type tyrosine-protein phosphatase betaAdd BLAST1975

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...)Sequence analysis1
Glycosylationi53N-linked (GlcNAc...)Sequence analysis1
Glycosylationi75N-linked (GlcNAc...)Sequence analysis1
Glycosylationi172N-linked (GlcNAc...)Sequence analysis1
Glycosylationi198N-linked (GlcNAc...)Sequence analysis1
Glycosylationi267N-linked (GlcNAc...)Sequence analysis1
Glycosylationi321N-linked (GlcNAc...)Sequence analysis1
Glycosylationi414N-linked (GlcNAc...)Sequence analysis1
Glycosylationi421N-linked (GlcNAc...)Sequence analysis1
Glycosylationi479N-linked (GlcNAc...)Sequence analysis1
Glycosylationi544N-linked (GlcNAc...)Sequence analysis1
Glycosylationi574N-linked (GlcNAc...)Sequence analysis1
Glycosylationi598N-linked (GlcNAc...)Sequence analysis1
Glycosylationi652N-linked (GlcNAc...)Sequence analysis1
Glycosylationi721N-linked (GlcNAc...)Sequence analysis1
Glycosylationi829N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1040N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1096N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1163N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1185N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1212N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1274N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1367N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1470N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1474N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1518N-linked (GlcNAc...)Sequence analysis1
Modified residuei1981PhosphotyrosineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP23467.
PaxDbiP23467.
PeptideAtlasiP23467.
PRIDEiP23467.

PTM databases

DEPODiP23467.
iPTMnetiP23467.
PhosphoSitePlusiP23467.

Expressioni

Inductioni

Up-regulated by hypoxia.1 Publication

Gene expression databases

BgeeiENSG00000127329.
CleanExiHS_PTPRB.
ExpressionAtlasiP23467. baseline and differential.
GenevisibleiP23467. HS.

Organism-specific databases

HPAiCAB004782.

Interactioni

Subunit structurei

Monomer. Interacts with TEK (PubMed:19451274). Interacts via fibronectin type-III 17 domain with CDH5. Detected in a complex with CNTN1 and NRCAM (By similarity). Interacts (phosphorylated form) with FYN and GRB2 (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ERBB2P046262EBI-1265766,EBI-641062
GHRP109123EBI-1265766,EBI-286316
MAPK3P273612EBI-1265766,EBI-73995
METP085812EBI-1265766,EBI-1039152
TEKQ027633EBI-1265766,EBI-2257090

Protein-protein interaction databases

BioGridi111751. 5 interactors.
IntActiP23467. 27 interactors.
MINTiMINT-1349770.
STRINGi9606.ENSP00000334928.

Chemistry databases

BindingDBiP23467.

Structurei

Secondary structure

11997
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1685 – 1687Combined sources3
Helixi1688 – 1709Combined sources22
Turni1710 – 1716Combined sources7
Turni1720 – 1723Combined sources4
Helixi1728 – 1730Combined sources3
Helixi1740 – 1742Combined sources3
Beta strandi1743 – 1745Combined sources3
Helixi1753 – 1756Combined sources4
Beta strandi1757 – 1763Combined sources7
Beta strandi1766 – 1769Combined sources4
Beta strandi1771 – 1775Combined sources5
Turni1780 – 1782Combined sources3
Helixi1783 – 1792Combined sources10
Beta strandi1797 – 1800Combined sources4
Beta strandi1804 – 1806Combined sources3
Beta strandi1818 – 1821Combined sources4
Beta strandi1823 – 1825Combined sources3
Beta strandi1828 – 1837Combined sources10
Beta strandi1839 – 1849Combined sources11
Beta strandi1856 – 1865Combined sources10
Beta strandi1870 – 1872Combined sources3
Helixi1877 – 1893Combined sources17
Beta strandi1894 – 1896Combined sources3
Beta strandi1900 – 1903Combined sources4
Beta strandi1905 – 1908Combined sources4
Helixi1909 – 1926Combined sources18
Beta strandi1928 – 1930Combined sources3
Helixi1932 – 1940Combined sources9
Helixi1950 – 1965Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AHSX-ray2.10A/B1686-1971[»]
2H02X-ray2.30A/B1662-1973[»]
2H03X-ray1.65A1676-1970[»]
2H04X-ray2.30A1662-1973[»]
2HC1X-ray1.30A1676-1965[»]
2HC2X-ray1.40A1676-1965[»]
2I3RX-ray1.85A/B1662-1973[»]
2I3UX-ray1.85A1662-1973[»]
2I4EX-ray1.75A/B1662-1973[»]
2I4GX-ray1.65A1662-1973[»]
2I4HX-ray2.15A1662-1973[»]
2I5XX-ray1.70A/B1662-1973[»]
ProteinModelPortaliP23467.
SMRiP23467.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23467.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 111Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST89
Domaini112 – 207Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini203 – 288Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST86
Domaini291 – 378Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST88
Domaini379 – 471Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST93
Domaini467 – 552Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST86
Domaini556 – 641Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST86
Domaini642 – 729Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST88
Domaini730 – 829Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST100
Domaini819 – 906Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST88
Domaini909 – 1001Fibronectin type-III 11PROSITE-ProRule annotationAdd BLAST93
Domaini995 – 1083Fibronectin type-III 12PROSITE-ProRule annotationAdd BLAST89
Domaini1087 – 1175Fibronectin type-III 13PROSITE-ProRule annotationAdd BLAST89
Domaini1173 – 1260Fibronectin type-III 14PROSITE-ProRule annotationAdd BLAST88
Domaini1260 – 1356Fibronectin type-III 15PROSITE-ProRule annotationAdd BLAST97
Domaini1357 – 1448Fibronectin type-III 16PROSITE-ProRule annotationAdd BLAST92
Domaini1458 – 1554Fibronectin type-III 17PROSITE-ProRule annotationAdd BLAST97
Domaini1703 – 1963Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST261

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1904 – 1910Substrate bindingBy similarity7

Sequence similaritiesi

Contains 17 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0791. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00770000120452.
HOGENOMiHOG000060224.
HOVERGENiHBG053759.
InParanoidiP23467.
KOiK05694.
OMAiRVYQTNY.
OrthoDBiEOG091G00JF.
PhylomeDBiP23467.
TreeFamiTF351926.

Family and domain databases

CDDicd00063. FN3. 14 hits.
Gene3Di2.60.40.10. 15 hits.
3.90.190.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 15 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 17 hits.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 17 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50853. FN3. 12 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P23467-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSHGAGLAL WITLSLLQTG LAEPERCNFT LAESKASSHS VSIQWRILGS
60 70 80 90 100
PCNFSLIYSS DTLGAALCPT FRIDNTTYGC NLQDLQAGTI YNFRIISLDE
110 120 130 140 150
ERTVVLQTDP LPPARFGVSK EKTTSTSLHV WWTPSSGKVT SYEVQLFDEN
160 170 180 190 200
NQKIQGVQIQ ESTSWNEYTF FNLTAGSKYN IAITAVSGGK RSFSVYTNGS
210 220 230 240 250
TVPSPVKDIG ISTKANSLLI SWSHGSGNVE RYRLMLMDKG ILVHGGVVDK
260 270 280 290 300
HATSYAFHGL TPGYLYNLTV MTEAAGLQNY RWKLVRTAPM EVSNLKVTND
310 320 330 340 350
GSLTSLKVKW QRPPGNVDSY NITLSHKGTI KESRVLAPWI TETHFKELVP
360 370 380 390 400
GRLYQVTVSC VSGELSAQKM AVGRTFPDKV ANLEANNNGR MRSLVVSWSP
410 420 430 440 450
PAGDWEQYRI LLFNDSVVLL NITVGKEETQ YVMDDTGLVP GRQYEVEVIV
460 470 480 490 500
ESGNLKNSER CQGRTVPLAV LQLRVKHANE TSLSIMWQTP VAEWEKYIIS
510 520 530 540 550
LADRDLLLIH KSLSKDAKEF TFTDLVPGRK YMATVTSISG DLKNSSSVKG
560 570 580 590 600
RTVPAQVTDL HVANQGMTSS LFTNWTQAQG DVEFYQVLLI HENVVIKNES
610 620 630 640 650
ISSETSRYSF HSLKSGSLYS VVVTTVSGGI SSRQVVVEGR TVPSSVSGVT
660 670 680 690 700
VNNSGRNDYL SVSWLLAPGD VDNYEVTLSH DGKVVQSLVI AKSVRECSFS
710 720 730 740 750
SLTPGRLYTV TITTRSGKYE NHSFSQERTV PDKVQGVSVS NSARSDYLRV
760 770 780 790 800
SWVHATGDFD HYEVTIKNKN NFIQTKSIPK SENECVFVQL VPGRLYSVTV
810 820 830 840 850
TTKSGQYEAN EQGNGRTIPE PVKDLTLRNR STEDLHVTWS GANGDVDQYE
860 870 880 890 900
IQLLFNDMKV FPPFHLVNTA TEYRFTSLTP GRQYKILVLT ISGDVQQSAF
910 920 930 940 950
IEGFTVPSAV KNIHISPNGA TDSLTVNWTP GGGDVDSYTV SAFRHSQKVD
960 970 980 990 1000
SQTIPKHVFE HTFHRLEAGE QYQIMIASVS GSLKNQINVV GRTVPASVQG
1010 1020 1030 1040 1050
VIADNAYSSY SLIVSWQKAA GVAERYDILL LTENGILLRN TSEPATTKQH
1060 1070 1080 1090 1100
KFEDLTPGKK YKIQILTVSG GLFSKEAQTE GRTVPAAVTD LRITENSTRH
1110 1120 1130 1140 1150
LSFRWTASEG ELSWYNIFLY NPDGNLQERA QVDPLVQSFS FQNLLQGRMY
1160 1170 1180 1190 1200
KMVIVTHSGE LSNESFIFGR TVPASVSHLR GSNRNTTDSL WFNWSPASGD
1210 1220 1230 1240 1250
FDFYELILYN PNGTKKENWK DKDLTEWRFQ GLVPGRKYVL WVVTHSGDLS
1260 1270 1280 1290 1300
NKVTAESRTA PSPPSLMSFA DIANTSLAIT WKGPPDWTDY NDFELQWLPR
1310 1320 1330 1340 1350
DALTVFNPYN NRKSEGRIVY GLRPGRSYQF NVKTVSGDSW KTYSKPIFGS
1360 1370 1380 1390 1400
VRTKPDKIQN LHCRPQNSTA IACSWIPPDS DFDGYSIECR KMDTQEVEFS
1410 1420 1430 1440 1450
RKLEKEKSLL NIMMLVPHKR YLVSIKVQSA GMTSEVVEDS TITMIDRPPP
1460 1470 1480 1490 1500
PPPHIRVNEK DVLISKSSIN FTVNCSWFSD TNGAVKYFTV VVREADGSDE
1510 1520 1530 1540 1550
LKPEQQHPLP SYLEYRHNAS IRVYQTNYFA SKCAENPNSN SKSFNIKLGA
1560 1570 1580 1590 1600
EMESLGGKCD PTQQKFCDGP LKPHTAYRIS IRAFTQLFDE DLKEFTKPLY
1610 1620 1630 1640 1650
SDTFFSLPIT TESEPLFGAI EGVSAGLFLI GMLVAVVALL ICRQKVSHGR
1660 1670 1680 1690 1700
ERPSARLSIR RDRPLSVHLN LGQKGNRKTS CPIKINQFEG HFMKLQADSN
1710 1720 1730 1740 1750
YLLSKEYEEL KDVGRNQSCD IALLPENRGK NRYNNILPYD ATRVKLSNVD
1760 1770 1780 1790 1800
DDPCSDYINA SYIPGNNFRR EYIVTQGPLP GTKDDFWKMV WEQNVHNIVM
1810 1820 1830 1840 1850
VTQCVEKGRV KCDHYWPADQ DSLYYGDLIL QMLSESVLPE WTIREFKICG
1860 1870 1880 1890 1900
EEQLDAHRLI RHFHYTVWPD HGVPETTQSL IQFVRTVRDY INRSPGAGPT
1910 1920 1930 1940 1950
VVHCSAGVGR TGTFIALDRI LQQLDSKDSV DIYGAVHDLR LHRVHMVQTE
1960 1970 1980 1990
CQYVYLHQCV RDVLRARKLR SEQENPLFPI YENVNPEYHR DPVYSRH
Length:1,997
Mass (Da):224,301
Last modified:January 11, 2011 - v3
Checksum:i76E67B4A6109AA0F
GO
Isoform 2 (identifier: P23467-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     377-466: Missing.

Show »
Length:1,907
Mass (Da):214,209
Checksum:iC8A61E610D7ECC31
GO
Isoform 3 (identifier: P23467-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MLSHGAGLALWITLSLLQ → MEAEFYMVIL...TQPFSSTTEE

Show »
Length:2,215
Mass (Da):249,143
Checksum:i605BB45BA4541F02
GO
Isoform 4 (identifier: P23467-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     997-1086: Missing.

Show »
Length:1,907
Mass (Da):214,505
Checksum:i237BC55F05D696E7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti261T → S in CAA38066 (PubMed:2170109).Curated1
Sequence conflicti666L → V in CAA38066 (PubMed:2170109).Curated1
Sequence conflicti926V → A in BX648245 (PubMed:17974005).Curated1
Sequence conflicti1559C → R in CAA38066 (PubMed:2170109).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06225194R → K.2 PublicationsCorresponds to variant rs2252784dbSNPEnsembl.1
Natural variantiVAR_062252127S → G.1 PublicationCorresponds to variant rs2465811dbSNPEnsembl.1
Natural variantiVAR_057135395V → A.Corresponds to variant rs36027530dbSNPEnsembl.1
Natural variantiVAR_057136415D → E.Corresponds to variant rs2165627dbSNPEnsembl.1
Natural variantiVAR_057137939T → M.Corresponds to variant rs2304821dbSNPEnsembl.1
Natural variantiVAR_0571381032T → I.Corresponds to variant rs34902691dbSNPEnsembl.1
Natural variantiVAR_0571391934G → A.Corresponds to variant rs17226367dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0404841 – 18MLSHG…LSLLQ → MEAEFYMVILTCLIFRNSEG FQIVHVQKQQCLFKNEKVVV GSCNRTIQNQQWMWTEDEKL LHVKSALCLAISNSSRGPSR SAILDRCSQAPRWTCYDQEG FLEVENASLFLQKQGSRVVV KKARKYLHSWMKIDVNKEGK LVNESLCLQKAGLGAEVSVR STRNTAPPQILTTFNAVPDG LVFLIRNTTEAFIRNAAENY SQNSSERQHPNLHMTGITDT SWVLSTTQPFSSTTEE in isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_038521377 – 466Missing in isoform 2. 1 PublicationAdd BLAST90
Alternative sequenceiVSP_053944997 – 1086Missing in isoform 4. 1 PublicationAdd BLAST90

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54131 mRNA. Translation: CAA38066.1.
BX648245 mRNA. No translation available.
AC025569 Genomic DNA. No translation available.
AC083809 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97254.1.
BC101679 mRNA. Translation: AAI01680.1.
BC113463 mRNA. Translation: AAI13464.1.
BC143356 mRNA. Translation: AAI43357.1.
BC143360 mRNA. Translation: AAI43361.1.
CCDSiCCDS44943.1. [P23467-3]
CCDS44944.1. [P23467-1]
CCDS55845.1. [P23467-2]
CCDS55846.1. [P23467-4]
PIRiS12050.
RefSeqiNP_001103224.1. NM_001109754.3. [P23467-3]
NP_001193900.1. NM_001206971.2. [P23467-2]
NP_001193901.1. NM_001206972.2. [P23467-4]
NP_001317133.1. NM_001330204.1.
NP_002828.3. NM_002837.5. [P23467-1]
UniGeneiHs.201030.
Hs.434375.

Genome annotation databases

EnsembliENST00000261266; ENSP00000261266; ENSG00000127329. [P23467-1]
ENST00000334414; ENSP00000334928; ENSG00000127329. [P23467-3]
ENST00000538708; ENSP00000438927; ENSG00000127329. [P23467-4]
ENST00000550857; ENSP00000447302; ENSG00000127329. [P23467-2]
GeneIDi5787.
KEGGihsa:5787.
UCSCiuc001swb.6. human. [P23467-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54131 mRNA. Translation: CAA38066.1.
BX648245 mRNA. No translation available.
AC025569 Genomic DNA. No translation available.
AC083809 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97254.1.
BC101679 mRNA. Translation: AAI01680.1.
BC113463 mRNA. Translation: AAI13464.1.
BC143356 mRNA. Translation: AAI43357.1.
BC143360 mRNA. Translation: AAI43361.1.
CCDSiCCDS44943.1. [P23467-3]
CCDS44944.1. [P23467-1]
CCDS55845.1. [P23467-2]
CCDS55846.1. [P23467-4]
PIRiS12050.
RefSeqiNP_001103224.1. NM_001109754.3. [P23467-3]
NP_001193900.1. NM_001206971.2. [P23467-2]
NP_001193901.1. NM_001206972.2. [P23467-4]
NP_001317133.1. NM_001330204.1.
NP_002828.3. NM_002837.5. [P23467-1]
UniGeneiHs.201030.
Hs.434375.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AHSX-ray2.10A/B1686-1971[»]
2H02X-ray2.30A/B1662-1973[»]
2H03X-ray1.65A1676-1970[»]
2H04X-ray2.30A1662-1973[»]
2HC1X-ray1.30A1676-1965[»]
2HC2X-ray1.40A1676-1965[»]
2I3RX-ray1.85A/B1662-1973[»]
2I3UX-ray1.85A1662-1973[»]
2I4EX-ray1.75A/B1662-1973[»]
2I4GX-ray1.65A1662-1973[»]
2I4HX-ray2.15A1662-1973[»]
2I5XX-ray1.70A/B1662-1973[»]
ProteinModelPortaliP23467.
SMRiP23467.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111751. 5 interactors.
IntActiP23467. 27 interactors.
MINTiMINT-1349770.
STRINGi9606.ENSP00000334928.

Chemistry databases

BindingDBiP23467.
ChEMBLiCHEMBL2706.
GuidetoPHARMACOLOGYi1851.

PTM databases

DEPODiP23467.
iPTMnetiP23467.
PhosphoSitePlusiP23467.

Polymorphism and mutation databases

BioMutaiPTPRB.
DMDMi317373518.

Proteomic databases

MaxQBiP23467.
PaxDbiP23467.
PeptideAtlasiP23467.
PRIDEiP23467.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261266; ENSP00000261266; ENSG00000127329. [P23467-1]
ENST00000334414; ENSP00000334928; ENSG00000127329. [P23467-3]
ENST00000538708; ENSP00000438927; ENSG00000127329. [P23467-4]
ENST00000550857; ENSP00000447302; ENSG00000127329. [P23467-2]
GeneIDi5787.
KEGGihsa:5787.
UCSCiuc001swb.6. human. [P23467-1]

Organism-specific databases

CTDi5787.
DisGeNETi5787.
GeneCardsiPTPRB.
H-InvDBHIX0017674.
HIX0037045.
HGNCiHGNC:9665. PTPRB.
HPAiCAB004782.
MIMi176882. gene.
neXtProtiNX_P23467.
OpenTargetsiENSG00000127329.
PharmGKBiPA34010.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0791. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00770000120452.
HOGENOMiHOG000060224.
HOVERGENiHBG053759.
InParanoidiP23467.
KOiK05694.
OMAiRVYQTNY.
OrthoDBiEOG091G00JF.
PhylomeDBiP23467.
TreeFamiTF351926.

Enzyme and pathway databases

BioCyciZFISH:HS05085-MONOMER.
BRENDAi3.1.3.48. 2681.
ReactomeiR-HSA-6798695. Neutrophil degranulation.
SignaLinkiP23467.
SIGNORiP23467.

Miscellaneous databases

ChiTaRSiPTPRB. human.
EvolutionaryTraceiP23467.
GeneWikiiPTPRB.
GenomeRNAii5787.
PROiP23467.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000127329.
CleanExiHS_PTPRB.
ExpressionAtlasiP23467. baseline and differential.
GenevisibleiP23467. HS.

Family and domain databases

CDDicd00063. FN3. 14 hits.
Gene3Di2.60.40.10. 15 hits.
3.90.190.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 15 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 17 hits.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 17 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50853. FN3. 12 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTPRB_HUMAN
AccessioniPrimary (citable) accession number: P23467
Secondary accession number(s): B7ZKS8
, B7ZKT0, C9JX87, F5H3G6, Q14D85, Q3MIV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 170 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.