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P23466 (CYAA_LACKL) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenylate cyclase
EC=4.6.1.1
Alternative name(s):
ATP pyrophosphate-lyase
Adenylyl cyclase
Gene names
Name:CYR1
OrganismLachancea kluyveri (Yeast) (Saccharomyces kluyveri)
Taxonomic identifier4934 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Lachancea

Protein attributes

Sequence length1839 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.

Catalytic activity

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Sequence similarities

Belongs to the adenylyl cyclase class-3 family.

Contains 1 guanylate cyclase domain.

Contains 22 LRR (leucine-rich) repeats.

Contains 1 PP2C-like domain.

Contains 1 Ras-associating domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 18391839Adenylate cyclase
PRO_0000195732

Regions

Domain494 – 57481Ras-associating
Repeat632 – 65524LRR 1
Repeat659 – 67921LRR 2
Repeat681 – 70222LRR 3
Repeat704 – 72623LRR 4
Repeat727 – 74822LRR 5
Repeat750 – 77122LRR 6
Repeat773 – 79422LRR 7
Repeat795 – 81622LRR 8
Repeat817 – 83418LRR 9
Repeat835 – 85622LRR 10
Repeat858 – 87922LRR 11
Repeat882 – 90322LRR 12
Repeat905 – 92622LRR 13
Repeat928 – 95023LRR 14
Repeat951 – 97121LRR 15
Repeat982 – 100423LRR 16
Repeat1006 – 102722LRR 17
Repeat1028 – 104821LRR 18
Repeat1051 – 107323LRR 19
Repeat1074 – 109623LRR 20
Repeat1103 – 112422LRR 21
Repeat1135 – 116026LRR 22
Domain1185 – 1440256PP2C-like
Domain1483 – 1620138Guanylate cyclase

Sites

Metal binding14881Magnesium By similarity
Metal binding15311Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
P23466 [UniParc].

Last modified November 1, 1991. Version 1.
Checksum: 86A69BCB1F2733CB

FASTA1,839206,896
        10         20         30         40         50         60 
MSSPTDAERV NMRREKHPQI EETFEEHVHN AMPKFKKHYA LGITTHTNDE DDDPRDHRQR 

        70         80         90        100        110        120 
GIHNPNFIHS PNDPRPPLSQ PIKPRFSVHG TASNASVFSH GDIAPVRKTS RAGSLFKRLA 

       130        140        150        160        170        180 
GKKSTTSLLG TEHQQRQQQQ SSNSLVPAAG LRRKMSTFIH GGSGSQSNES RGTRSSIFFP 

       190        200        210        220        230        240 
STSNSRRGSA TSTMTSGSRS SHPPDTPPIT SQQQEQQYDQ QRQQRPETRE QEQKPPTLSD 

       250        260        270        280        290        300 
MPIVSRSPSF FMLDTDLNNL SDITNIISAT PKNTESDEVR STGANKTLKY PKPPLSSHKS 

       310        320        330        340        350        360 
TSASDLSHHK AQWTAPESWD IEEDANKLLA TKRKAKHHHH YHHPQHPRPP HRKHYSNFSK 

       370        380        390        400        410        420 
PIEDKAVVEK EQEPPEKCPQ PISTDSNDAQ GLEIAKPIDE SSGIQHSAST QSVSSFSSGA 

       430        440        450        460        470        480 
TGASGATGKQ IGGDQETEST ISTVGEDEEV TNLRSIDSEQ TDDTSFSKFD EEYDKAEYQL 

       490        500        510        520        530        540 
EKYYNDFSDV DLNRRYAIRI FNIDDTFTTL SCTPNTTLQD MMPQLKRKFN VGQGSYQVSL 

       550        560        570        580        590        600 
KVGKLSKILR PTAKPILIQR RLLLLNGYLK SDPLHIMGIE DLSFIFSFVF HPVATSHLNY 

       610        620        630        640        650        660 
EQEQRLSRGD FVHVDLRNMD LTTPPIILYQ HTSDIESLDV SNNANIFLPL DFIESAIKLS 

       670        680        690        700        710        720 
SLRMVNIRAS KFPANVTDAY KLVSLDLERN FIKKVPDSIF KLNNLTIVNL QCNNLERLPP 

       730        740        750        760        770        780 
GFSKLKNLQL LDISSNKFVN YPEVINSCTN LLQIDLSYNK IHSLPVSINQ LVKLAKMNLF 

       790        800        810        820        830        840 
NNRLTSVGDL SQMKNLRTLN LRCNRVTSIE CHAPNLQNLF LTDNRISTFD DDLTRLRTLE 

       850        860        870        880        890        900 
LQQNPITSMV CGGNYMANMT SLSLNKAKLS SFSAELLSKL PRLEKLELNE NNLTQLPPEI 

       910        920        930        940        950        960 
NKLTRLIYLS VARNKLESIP DEISDLRSLK SLDLHSNNLR MLMNNLEDLE LTSLNVSSNL 

       970        980        990       1000       1010       1020 
LTGFHGSPAK FFASPSPKLA KSLLFLSVAD NNLTDSIWPL VNTFQNLKTL NLSYNNFVEI 

      1030       1040       1050       1060       1070       1080 
SDLKLQNLTE LYLSGNNFTS LPGEAVQHLR SLKVLMLNGN KLLSLPAELS QLSRLSVLDV 

      1090       1100       1110       1120       1130       1140 
GSNQLKYNIS NYHYDWNWRN NKDLKYLNFS GNKRFEIKSA LDPEGKNDLS DLGILKQLRV 

      1150       1160       1170       1180       1190       1200 
LGLMDVTLKT SKVPDESVSI RLRTTASMIN GMRYGVADTL GQSDSVCSRD VTFERFRGRE 

      1210       1220       1230       1240       1250       1260 
DECLICLYDG KNENASSGHK ISKIIRDIYD KILIRLLEKY GEESDGIKRA LRYSFLQLNK 

      1270       1280       1290       1300       1310       1320 
EINGMLVSVE DGNTDSGLTS ADLLSGSSAT VVYLKGKKIY TANIGDTMAV LSKNNGDFVT 

      1330       1340       1350       1360       1370       1380 
LTKLHVPAER EEYERIRTSG GYVNNQKLDG VSEVSRAVGF FDLLPHIHAS PDISETVLSY 

      1390       1400       1410       1420       1430       1440 
SDEMLIIATH KLWEYLDYET VCDISRENKS QPMSAAEKMK DYAISYGCSD NITILCVSLD 

      1450       1460       1470       1480       1490       1500 
KSVNQQSQFT LNREDLISRK NTFEDTVLRR LQPEIAPPTG NVAIVFTDIK NSTFLWELFP 

      1510       1520       1530       1540       1550       1560 
DAMRAAIKTH NDIMRRQLRI YGGYEVKTEG DAFMVAFPTP TSALVWCLSV QLKLLEAEWP 

      1570       1580       1590       1600       1610       1620 
EEITSIQDGC LITDNSGTKV YLGLSVRMGV HWGCPVPEID LVTQRMDYLG PVVNKAARVS 

      1630       1640       1650       1660       1670       1680 
GVADGGQITL SSDFCSEFKK IMKFHKRVVE NQEPLKEVYG EDFIGEVLER EIHMLENVGW 

      1690       1700       1710       1720       1730       1740 
VFKDLGEQKL KGLETKEFIT IAYPKTLASR HDLATKNQNS SVLNDDLLFQ LRTISNKLEN 

      1750       1760       1770       1780       1790       1800 
ILSSINGGLI ESETPGNSSI YMTFDKNTKD AVITKSTESD WISFLDHLVT RVESTVAILQ 

      1810       1820       1830 
LRQKLQGGLE LYTSSDSTMH KSVFELLDEI LKIQTDQKQ

« Hide

References

[1]"The adenylyl cyclase-encoding gene from Saccharomyces kluyveri."
Young D., O'Neill K., Broek D., Wigler M.
Gene 102:129-132(1991) [PubMed: 1864503] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X56042 Genomic DNA. Translation: CAA39513.1.
PIROYBYK. JQ1145.

3D structure databases

ProteinModelPortalP23466.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

PhylomeDBP23466.

Family and domain databases

InterProIPR001054. A/G_cyclase.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR001932. PP2C-like.
IPR000159. Ras-assoc.
[Graphical view]
Gene3DG3DSA:3.30.70.1230. A/G_cyclase. 2 hits.
G3DSA:3.60.40.10. PP2C-related. 1 hit.
PfamPF00211. Guanylate_cyc. 1 hit.
PF00481. PP2C. 1 hit.
PF00788. RA. 1 hit.
[Graphical view]
SMARTSM00044. CYCc. 1 hit.
SM00369. LRR_TYP. 2 hits.
SM00332. PP2Cc. 1 hit.
SM00314. RA. 1 hit.
[Graphical view]
SUPFAMSSF55073. A/G_cyclase. 1 hit.
SSF81606. PP2C-related. 1 hit.
PROSITEPS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS51450. LRR. 18 hits.
PS50200. RA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYAA_LACKL
AccessionPrimary (citable) accession number: P23466
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: December 14, 2011
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents