Reviewed,
UniProtKB/Swiss-Prot P23466 (CYAA_SACKL)
Last modified
June 16, 2009.
Version 63.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Adenylate cyclase EC=4.6.1.1 Alternative name(s): ATP pyrophosphate-lyase Adenylyl cyclase | ||
| Gene names |
| ||
| Organism | Saccharomyces kluyveri (Yeast) (Saccharomyces silvestris) | ||
| Taxonomic identifier | 4934 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Lachancea |
Protein attributes
| Sequence length | 1839 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP. |
| Catalytic activity | ATP = 3',5'-cyclic AMP + diphosphate. |
| Cofactor | Binds 1 magnesium ion per subunit By similarity. |
| Sequence similarities | Belongs to the adenylyl cyclase class-3 family. Contains 1 guanylate cyclase domain. Contains 21 LRR (leucine-rich) repeats. Contains 1 PP2C-like domain. Contains 1 Ras-associating domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | cAMP biosynthesis |
| Domain | Leucine-rich repeat Repeat |
| Ligand | ATP-binding Magnesium Metal-binding Nucleotide-binding |
| Molecular function | Lyase |
| Gene Ontology (GO) | |
| Biological process | cAMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW intracellular signaling cascadeInferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate cyclase activityInferred from electronic annotation. Source: EC magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW protein bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1839 | 1839 | Adenylate cyclase | PRO_0000195732 | |||||
Regions | |||||||||
| Domain | 494 – 574 | 81 | Ras-associating | ||||||
| Repeat | 632 – 655 | 24 | LRR 1 | ||||||
| Repeat | 659 – 679 | 21 | LRR 2 | ||||||
| Repeat | 680 – 702 | 23 | LRR 3 | ||||||
| Repeat | 703 – 724 | 22 | LRR 4 | ||||||
| Repeat | 726 – 748 | 23 | LRR 5 | ||||||
| Repeat | 749 – 771 | 23 | LRR 6 | ||||||
| Repeat | 773 – 793 | 21 | LRR 7 | ||||||
| Repeat | 794 – 818 | 25 | LRR 8 | ||||||
| Repeat | 820 – 833 | 14 | LRR 9 | ||||||
| Repeat | 834 – 857 | 24 | LRR 10 | ||||||
| Repeat | 859 – 879 | 21 | LRR 11 | ||||||
| Repeat | 880 – 903 | 24 | LRR 12 | ||||||
| Repeat | 905 – 926 | 22 | LRR 13 | ||||||
| Repeat | 927 – 949 | 23 | LRR 14 | ||||||
| Repeat | 951 – 974 | 24 | LRR 15 | ||||||
| Repeat | 1004 – 1025 | 22 | LRR 16 | ||||||
| Repeat | 1026 – 1048 | 23 | LRR 17 | ||||||
| Repeat | 1050 – 1072 | 23 | LRR 18 | ||||||
| Repeat | 1074 – 1096 | 23 | LRR 19 | ||||||
| Repeat | 1101 – 1124 | 24 | LRR 20 | ||||||
| Repeat | 1135 – 1160 | 26 | LRR 21 | ||||||
| Domain | 1185 – 1440 | 256 | PP2C-like | ||||||
| Domain | 1483 – 1620 | 138 | Guanylate cyclase | ||||||
Sites | |||||||||
| Metal binding | 1488 | 1 | Magnesium By similarity | ||||||
| Metal binding | 1531 | 1 | Magnesium By similarity | ||||||
Sequences
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References
| [1] | "The adenylyl cyclase-encoding gene from Saccharomyces kluyveri." Young D., O'Neill K., Broek D., Wigler M. Gene 102:129-132(1991) [PubMed: 1864503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| X56042 Genomic DNA. Translation: CAA39513.1. | |
| PIR | OYBYK. JQ1145. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1FX4 based on UniProtKB Q99280. |
| ModBase | Search... |
Enzyme and pathway databases | |
| BRENDA | 4.6.1.1. 274780. |
Family and domain databases | |
| InterPro | IPR001054. A/G_cyclase. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR001932. PP2C-related. IPR014045. PP2C_N. IPR000159. Ras-assoc. [Graphical view] |
| Gene3D | G3DSA:3.30.70.1230. A/G_cyclase. 1 hit. G3DSA:3.60.40.10. PP2C-related. 1 hit. |
| Pfam | PF00211. Guanylate_cyc. 1 hit. PF00560. LRR_1. 10 hits. PF00481. PP2C. 1 hit. PF00788. RA. 1 hit. [Graphical view] |
| SMART | SM00044. CYCc. 1 hit. SM00369. LRR_TYP. 2 hits. SM00332. PP2Cc. 1 hit. SM00314. RA. 1 hit. [Graphical view] |
| PROSITE | PS50125. GUANYLATE_CYCLASE_2. 1 hit. PS50200. RA. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CYAA_SACKL | ||||||||
| Accession | Primary (citable) accession number: P23466 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
