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P23463 (HXD8_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-D8
Alternative name(s):
Homeobox protein Hox-4.3
Homeobox protein Hox-5.4
Gene names
Name:Hoxd8
Synonyms:Hox-4.3, Hoxd-8
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Homeobox protein Hox-D8
PRO_0000200217

Regions

DNA binding195 – 25460Homeobox
Motif183 – 1886Antp-type hexapeptide
Compositional bias15 – 2814Poly-Ala
Compositional bias62 – 8928Gly/Pro-rich
Compositional bias108 – 11710Poly-Pro

Sequences

Sequence LengthMass (Da)Tools
P23463 [UniParc].

Last modified October 3, 2012. Version 4.
Checksum: E9996BB134A3A22E

FASTA28931,363
        10         20         30         40         50         60 
MSSYFVNPLY SKYKAAAAAA AAAAAAAAGE AINPTYYDCH FAPEVSGRHA AALQLYGNSA 

        70         80         90        100        110        120 
AGFPHAHPHP HPHPSPPPGC GGGGGPGPGQ DYFHAGAGSP TAAYQAAPPP PHPPPPPPPP 

       130        140        150        160        170        180 
PCGGIACHGE PAKFYGYDNL QRQPIFTTQQ EAELVQYPDC KSSSGNIGED PDHLNQSSSP 

       190        200        210        220        230        240 
SQMFPWMRPQ AAPGRRRGRQ TYSRFQTLEL EKEFLFNPYL TRKRRIEVSH TLALTERQVK 

       250        260        270        280 
IWFQNRRMKW KKENNKDKFP ASRPEAKDGD PKKEVSGLEE DGAEGCPTN 

« Hide

References

« Hide 'large scale' references
[1]"Primary structure and embryonic expression pattern of the mouse Hox-4.3 homeobox gene."
Izpisua-Belmonte J.-C., Dolle P., Renucci A., Zappavigna V., Falkenstein H., Duboule D.
Development 110:733-745(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"Sequence analysis of the homeobox-containing exon of the murine Hox-4.3 homeogene."
Sadoul R., Featherstone M.
Biochim. Biophys. Acta 1089:259-261(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 191-289.
[4]"Identification of 10 murine homeobox genes."
Singh G., Kaur S., Stock J.L., Jenkins N.A., Gilbert D.J., Copeland N.G., Potter S.S.
Proc. Natl. Acad. Sci. U.S.A. 88:10706-10710(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 195-254.
[5]"Hox-1.11 and Hox-4.9 homeobox genes."
Nazarali A., Kim Y., Nirenberg M.
Proc. Natl. Acad. Sci. U.S.A. 89:2883-2887(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 192-260.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X56561 Genomic DNA. Translation: CAA39911.1.
AL928644 Genomic DNA. Translation: CAM20532.1.
M87803 Genomic DNA. Translation: AAA37852.1.
CCDSCCDS16143.1.
PIRA43562.
A41605. S16177.
RefSeqNP_032302.2. NM_008276.3.
UniGeneMm.280673.
Mm.486465.

3D structure databases

ProteinModelPortalP23463.
SMRP23463. Positions 199-254.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP23463.

Proteomic databases

PRIDEP23463.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000019749; ENSMUSP00000019749; ENSMUSG00000027102.
GeneID15437.
KEGGmmu:15437.
UCSCuc008kea.1. mouse.

Organism-specific databases

CTD3234.
MGIMGI:96209. Hoxd8.

Phylogenomic databases

eggNOGNOG314669.
GeneTreeENSGT00730000110212.
HOGENOMHOG000231181.
HOVERGENHBG016849.
InParanoidP23463.
KOK09308.
OMAGQEYFHP.
TreeFamTF316310.

Gene expression databases

CleanExMM_HOXD8.
GenevestigatorP23463.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288214.
PROP23463.
SOURCESearch...

Entry information

Entry nameHXD8_MOUSE
AccessionPrimary (citable) accession number: P23463
Secondary accession number(s): A2ASN2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 121 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries