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P23463

- HXD8_MOUSE

UniProt

P23463 - HXD8_MOUSE

Protein

Homeobox protein Hox-D8

Gene

Hoxd8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 4 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi195 – 25460HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    3. skeletal system morphogenesis Source: MGI
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-D8
    Alternative name(s):
    Homeobox protein Hox-4.3
    Homeobox protein Hox-5.4
    Gene namesi
    Name:Hoxd8
    Synonyms:Hox-4.3, Hoxd-8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:96209. Hoxd8.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289Homeobox protein Hox-D8PRO_0000200217Add
    BLAST

    Proteomic databases

    PRIDEiP23463.

    PTM databases

    PhosphoSiteiP23463.

    Expressioni

    Gene expression databases

    CleanExiMM_HOXD8.
    GenevestigatoriP23463.

    Structurei

    3D structure databases

    ProteinModelPortaliP23463.
    SMRiP23463. Positions 199-254.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi183 – 1886Antp-type hexapeptide

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi15 – 2814Poly-AlaAdd
    BLAST
    Compositional biasi62 – 8928Gly/Pro-richAdd
    BLAST
    Compositional biasi108 – 11710Poly-Pro

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG314669.
    GeneTreeiENSGT00730000110212.
    HOGENOMiHOG000231181.
    HOVERGENiHBG016849.
    InParanoidiP23463.
    KOiK09308.
    OMAiGQEYFHP.
    TreeFamiTF316310.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P23463-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSYFVNPLY SKYKAAAAAA AAAAAAAAGE AINPTYYDCH FAPEVSGRHA    50
    AALQLYGNSA AGFPHAHPHP HPHPSPPPGC GGGGGPGPGQ DYFHAGAGSP 100
    TAAYQAAPPP PHPPPPPPPP PCGGIACHGE PAKFYGYDNL QRQPIFTTQQ 150
    EAELVQYPDC KSSSGNIGED PDHLNQSSSP SQMFPWMRPQ AAPGRRRGRQ 200
    TYSRFQTLEL EKEFLFNPYL TRKRRIEVSH TLALTERQVK IWFQNRRMKW 250
    KKENNKDKFP ASRPEAKDGD PKKEVSGLEE DGAEGCPTN 289
    Length:289
    Mass (Da):31,363
    Last modified:October 3, 2012 - v4
    Checksum:iE9996BB134A3A22E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56561 Genomic DNA. Translation: CAA39911.1.
    AL928644 Genomic DNA. Translation: CAM20532.1.
    M87803 Genomic DNA. Translation: AAA37852.1.
    CCDSiCCDS16143.1.
    PIRiA43562.
    S16177. A41605.
    RefSeqiNP_032302.2. NM_008276.3.
    UniGeneiMm.280673.
    Mm.486465.

    Genome annotation databases

    EnsembliENSMUST00000019749; ENSMUSP00000019749; ENSMUSG00000027102.
    GeneIDi15437.
    KEGGimmu:15437.
    UCSCiuc008kea.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56561 Genomic DNA. Translation: CAA39911.1 .
    AL928644 Genomic DNA. Translation: CAM20532.1 .
    M87803 Genomic DNA. Translation: AAA37852.1 .
    CCDSi CCDS16143.1.
    PIRi A43562.
    S16177. A41605.
    RefSeqi NP_032302.2. NM_008276.3.
    UniGenei Mm.280673.
    Mm.486465.

    3D structure databases

    ProteinModelPortali P23463.
    SMRi P23463. Positions 199-254.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P23463.

    Proteomic databases

    PRIDEi P23463.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000019749 ; ENSMUSP00000019749 ; ENSMUSG00000027102 .
    GeneIDi 15437.
    KEGGi mmu:15437.
    UCSCi uc008kea.1. mouse.

    Organism-specific databases

    CTDi 3234.
    MGIi MGI:96209. Hoxd8.

    Phylogenomic databases

    eggNOGi NOG314669.
    GeneTreei ENSGT00730000110212.
    HOGENOMi HOG000231181.
    HOVERGENi HBG016849.
    InParanoidi P23463.
    KOi K09308.
    OMAi GQEYFHP.
    TreeFami TF316310.

    Miscellaneous databases

    NextBioi 288214.
    PROi P23463.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_HOXD8.
    Genevestigatori P23463.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure and embryonic expression pattern of the mouse Hox-4.3 homeobox gene."
      Izpisua-Belmonte J.-C., Dolle P., Renucci A., Zappavigna V., Falkenstein H., Duboule D.
      Development 110:733-745(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Sequence analysis of the homeobox-containing exon of the murine Hox-4.3 homeogene."
      Sadoul R., Featherstone M.
      Biochim. Biophys. Acta 1089:259-261(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 191-289.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 195-254.
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 192-260.

    Entry informationi

    Entry nameiHXD8_MOUSE
    AccessioniPrimary (citable) accession number: P23463
    Secondary accession number(s): A2ASN2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 122 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3