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Protein

Homeobox protein Hox-D8

Gene

Hoxd8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi195 – 25460HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • skeletal system morphogenesis Source: MGI
  • transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D8
Alternative name(s):
Homeobox protein Hox-4.3
Homeobox protein Hox-5.4
Gene namesi
Name:Hoxd8
Synonyms:Hox-4.3, Hoxd-8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96209. Hoxd8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Homeobox protein Hox-D8PRO_0000200217Add
BLAST

Proteomic databases

PRIDEiP23463.

PTM databases

PhosphoSiteiP23463.

Expressioni

Gene expression databases

CleanExiMM_HOXD8.
ExpressionAtlasiP23463. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019749.

Structurei

3D structure databases

ProteinModelPortaliP23463.
SMRiP23463. Positions 199-254.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi183 – 1886Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 2814Poly-AlaAdd
BLAST
Compositional biasi62 – 8928Gly/Pro-richAdd
BLAST
Compositional biasi108 – 11710Poly-Pro

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG314669.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP23463.
OMAiGPGQDYF.
TreeFamiTF316310.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23463-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSYFVNPLY SKYKAAAAAA AAAAAAAAGE AINPTYYDCH FAPEVSGRHA
60 70 80 90 100
AALQLYGNSA AGFPHAHPHP HPHPSPPPGC GGGGGPGPGQ DYFHAGAGSP
110 120 130 140 150
TAAYQAAPPP PHPPPPPPPP PCGGIACHGE PAKFYGYDNL QRQPIFTTQQ
160 170 180 190 200
EAELVQYPDC KSSSGNIGED PDHLNQSSSP SQMFPWMRPQ AAPGRRRGRQ
210 220 230 240 250
TYSRFQTLEL EKEFLFNPYL TRKRRIEVSH TLALTERQVK IWFQNRRMKW
260 270 280
KKENNKDKFP ASRPEAKDGD PKKEVSGLEE DGAEGCPTN
Length:289
Mass (Da):31,363
Last modified:October 3, 2012 - v4
Checksum:iE9996BB134A3A22E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56561 Genomic DNA. Translation: CAA39911.1.
AL928644 Genomic DNA. Translation: CAM20532.1.
M87803 Genomic DNA. Translation: AAA37852.1.
CCDSiCCDS16143.1.
PIRiA43562.
S16177. A41605.
RefSeqiNP_032302.2. NM_008276.3.
UniGeneiMm.280673.
Mm.486465.

Genome annotation databases

EnsembliENSMUST00000019749; ENSMUSP00000019749; ENSMUSG00000027102.
GeneIDi15437.
UCSCiuc008kea.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56561 Genomic DNA. Translation: CAA39911.1.
AL928644 Genomic DNA. Translation: CAM20532.1.
M87803 Genomic DNA. Translation: AAA37852.1.
CCDSiCCDS16143.1.
PIRiA43562.
S16177. A41605.
RefSeqiNP_032302.2. NM_008276.3.
UniGeneiMm.280673.
Mm.486465.

3D structure databases

ProteinModelPortaliP23463.
SMRiP23463. Positions 199-254.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019749.

PTM databases

PhosphoSiteiP23463.

Proteomic databases

PRIDEiP23463.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019749; ENSMUSP00000019749; ENSMUSG00000027102.
GeneIDi15437.
UCSCiuc008kea.2. mouse.

Organism-specific databases

CTDi3234.
MGIiMGI:96209. Hoxd8.

Phylogenomic databases

eggNOGiNOG314669.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP23463.
OMAiGPGQDYF.
TreeFamiTF316310.

Miscellaneous databases

NextBioi288214.
PROiP23463.
SOURCEiSearch...

Gene expression databases

CleanExiMM_HOXD8.
ExpressionAtlasiP23463. baseline and differential.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure and embryonic expression pattern of the mouse Hox-4.3 homeobox gene."
    Izpisua-Belmonte J.-C., Dolle P., Renucci A., Zappavigna V., Falkenstein H., Duboule D.
    Development 110:733-745(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Sequence analysis of the homeobox-containing exon of the murine Hox-4.3 homeogene."
    Sadoul R., Featherstone M.
    Biochim. Biophys. Acta 1089:259-261(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 191-289.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 195-254.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 192-260.

Entry informationi

Entry nameiHXD8_MOUSE
AccessioniPrimary (citable) accession number: P23463
Secondary accession number(s): A2ASN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: October 3, 2012
Last modified: July 22, 2015
This is version 128 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.