Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P23459 (HXD8_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-D8
Alternative name(s):
Homeobox protein Hox-M
Short name=Chox-M
Gene names
Name:HOXD8
Synonyms:CHOX-M
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length188 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 188188Homeobox protein Hox-D8
PRO_0000200218

Regions

DNA binding95 – 15460Homeobox
Motif83 – 886Antp-type hexapeptide
Compositional bias15 – 2511Poly-Ala

Sequences

Sequence LengthMass (Da)Tools
P23459 [UniParc].

Last modified November 1, 1991. Version 1.
Checksum: D4560E8807FE29FE

FASTA18821,729
        10         20         30         40         50         60 
MSSYFVNPLY SKYKAAAAAA AAVAAGEPLP APYYDCHFAP ERQQIFTTQQ EAELVQYPDC 

        70         80         90        100        110        120 
KSSSANIGEE PDHLNQSSSP AQMFPWMRPQ AAPGRRRGRQ TYSRFQTLEL EKEFLFNPYL 

       130        140        150        160        170        180 
TRKRRIEVSH ALGLTERQVK IWFQNRRMKW KKENNKDKFP ASKQEGKEGE AKKETHDLED 


DRAESHTN 

« Hide

References

[1]"cDNA cloning of a homeobox-containing gene expressed in avian myeloblastic virus-transformed chicken monoblastic leukaemia cells."
Crompton M.R., McGregor A.D., Goodwin G.H.
Leukemia 5:357-360(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X57158 mRNA. Translation: CAA40445.1.
PIRI50145.
RefSeqNP_997060.1. NM_207177.1.
UniGeneGga.3187.

3D structure databases

ProteinModelPortalP23459.
SMRP23459. Positions 95-161.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000038689; ENSGALP00000037897; ENSGALG00000028128.
GeneID396301.
KEGGgga:396301.

Organism-specific databases

CTD3234.

Phylogenomic databases

GeneTreeENSGT00730000110212.
HOVERGENHBG016849.
KOK09308.
PhylomeDBP23459.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816351.

Entry information

Entry nameHXD8_CHICK
AccessionPrimary (citable) accession number: P23459
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries