P23459 (HXD8_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-D8

Alternative name(s):
Homeobox protein Hox-M
Short name=Chox-M

Gene names

Name:	HOXD8
Synonyms:	CHOX-M

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	188 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro transcription regulatory region sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 188	188	Homeobox protein Hox-D8		PRO_0000200218
Regions
	DNA binding	95 – 154	60	Homeobox
	Motif	83 – 88	6	Antp-type hexapeptide
	Compositional bias	15 – 25	11	Poly-Ala

Sequences

	Sequence		Length	Mass (Da)
	P23459 [UniParc]. Last modified November 1, 1991. Version 1. Checksum: D4560E8807FE29FE	FASTA	188	21,729
	10 20 30 40 50 60 MSSYFVNPLY SKYKAAAAAA AAVAAGEPLP APYYDCHFAP ERQQIFTTQQ EAELVQYPDC 70 80 90 100 110 120 KSSSANIGEE PDHLNQSSSP AQMFPWMRPQ AAPGRRRGRQ TYSRFQTLEL EKEFLFNPYL 130 140 150 160 170 180 TRKRRIEVSH ALGLTERQVK IWFQNRRMKW KKENNKDKFP ASKQEGKEGE AKKETHDLED DRAESHTN

References

[1]	"cDNA cloning of a homeobox-containing gene expressed in avian myeloblastic virus-transformed chicken monoblastic leukaemia cells." Crompton M.R., McGregor A.D., Goodwin G.H. Leukemia 5:357-360(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X57158 mRNA. Translation: CAA40445.1.
IPI	IPI00576774.
PIR	I50145.
RefSeq	NP_997060.1. NM_207177.1.
UniGene	Gga.3187.
3D structure databases
ProteinModelPortal	P23459.
SMR	P23459. Positions 95-161.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	396301.
KEGG	gga:396301.
Organism-specific databases
CTD	3234.
Phylogenomic databases
HOVERGEN	HBG016849.
KO	K09308.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. IPR000047. HTH_motif. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX. PR00031. HTHREPRESSR.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20816351.

Entry information

Entry name

HXD8_CHICK

Accession

Primary (citable) accession number: P23459

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	November 1, 1991
Last modified:	April 3, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program