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P23456

- L_HANTV

UniProt

P23456 - L_HANTV

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Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Hantaan virus (strain 76-118) (Korean hemorrhagic fever virus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. cap snatching Source: UniProtKB-KW
  2. transcription, DNA-templated Source: InterPro
  3. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Cap snatching, Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase L (EC:2.7.7.48)
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Gene namesi
Name:L
OrganismiHantaan virus (strain 76-118) (Korean hemorrhagic fever virus)
Taxonomic identifieri11602 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
Virus hostiApodemus agrarius (Eurasian field mouse) [TaxID: 39030]
Homo sapiens (Human) [TaxID: 9606]
ProteomesiUP000008627: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21512151RNA-directed RNA polymerase LPRO_0000222021Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini956 – 1142187RdRp catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the hantavirus RNA polymerase family.Curated
Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR026382. CapSnatchArena.
IPR016268. RNA-dir_pol_hantavirus.
IPR024378. RNA-dir_pol_N_hantavirus.
IPR007099. RNA-dir_pol_NSvirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view]
PfamiPF04196. Bunya_RdRp. 1 hit.
PF12426. DUF3674. 1 hit.
[Graphical view]
PIRSFiPIRSF000825. L_HantaV. 1 hit.
TIGRFAMsiTIGR04202. capSnatchArena. 1 hit.
PROSITEiPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23456-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MDKYREIHNK LKEFSPGTLT AVECIDYLDR LYAVRHDIVD QMIKHDWSDN
60 70 80 90 100
KDSEEAIGKV LLFAGVPSNI ITALEKKIIP NHPTGKSLKA FFKMTPDNYK
110 120 130 140 150
ISGTTIEFVE VTVTADVDKG IREKKLKYEA GLTYIEQELH KFFLKGEIPQ
160 170 180 190 200
PYKITFNVVA VRTDGSNITT QWPSRRNDGV VQYMRLVQAE ISYVREHLIK
210 220 230 240 250
TEERAALEAM FNLKFNISTH KSQPYYIPDY KGMEPIGANI EDLVDYSKDW
260 270 280 290 300
LSRARNFSFF EVKGTAVFEC FNSNEANHCQ RYPMSRKPRN FLLIQCSLIT
310 320 330 340 350
SYKPATTLSD QIDSRRACSY ILNLIPDTPA SYLIHDMAYR YINLTREDMI
360 370 380 390 400
NYYAPRIQFK QTQNVREPGT FKLTSSMLRA ESKAMLDLLN NHKSGEKHGA
410 420 430 440 450
QIESLNIASH IVQSESVSLI TKILSDLELN ITEPSTQEYS TTKHTYVDTV
460 470 480 490 500
LDKFFQNETQ KYLIDVLKKT TAWHIGHLIR DITESLIAHS GLKRSKYWSL
510 520 530 540 550
HSYNNGNVIL FILPSKSLEV AGSFIRFITV FRIGPGLVDK DNLDTILIDG
560 570 580 590 600
DSQWGVSKVM SIDLNRLLAL NIAFEKALIA TATWFQYYTE DQGQFPLQYA
610 620 630 640 650
IRSVFANHFL LAICQKMKLC AIFDNLRYLI PAVTSLYSGF PSLIEKLFER
660 670 680 690 700
PFKSSLEVYI YYNIKSLLVA LAQNNKARFY SKVKLLGLTV DQSTVGASGV
710 720 730 740 750
YPSFMSRIVY KHYRSLISEV TTCFFLFEKG LHGNMNEEAK IHLETVEWAL
760 770 780 790 800
KFREKEEKYG ESLVENGYMM WELRANAELA EQQLYCQDAI ELAAIELNKV
810 820 830 840 850
LATKSSVVAN SILSKNWEEP YFSQTRNISL KGMSGQVQED GHLSSSVTII
860 870 880 890 900
EAIRYLSNSR HNPSLLKLYE ETREQKAMAR IVRKYQRTEA DRGFFITTLP
910 920 930 940 950
TRCRLEIIED YYDAIAKNIS EEYISYGGEK KILAIQGALE KALRWASGES
960 970 980 990 1000
FIELSNHKFI RMKRKLMYVS ADATKWSPGD NSAKFRRFTS MLHNGLPNNK
1010 1020 1030 1040 1050
LKNCVIDALK QVYKTDFFMS RKLRNYIDSM ESLDPHIKQF LDFFPDGHHG
1060 1070 1080 1090 1100
EVKGNWLQGN LNKCSSLFGV AMSLLFKQVW TNLFPELDCF FEFAHHSDDA
1110 1120 1130 1140 1150
LFIYGYLEPV DDGTDWFLFV SQQIQAGHLH WFSVNTEMWK SMFNLHEHIL
1160 1170 1180 1190 1200
LLGSIKISPK KTTVSPTNAE FLSTFFEGCA VSIPFVKILL GSLSDLPGLG
1210 1220 1230 1240 1250
YFDDLAAAQS RCVKALDLGA SPQVAQLAVA LCTSKVERLY GTAPGMVNHP
1260 1270 1280 1290 1300
AAYLQVKHTD TPIPLGGNGA MSIMELATAG IGMSDKNLLK RALLGYSHKR
1310 1320 1330 1340 1350
QKSMLYILGL FKFLMKLSDE TFQHERLGQF SFIGKVQWKI FTPKSEFEFA
1360 1370 1380 1390 1400
DMYTSKFLEL WSSQHVTYDY IIPKGRDNLL IYLVRKLNDP SIVTAMTMQS
1410 1420 1430 1440 1450
PLQLRFRMQA KQHMKVCRLD GEWVTFREVL AAANSFAENY SATSQDMDLF
1460 1470 1480 1490 1500
QTLTSCTFSK EYAWKDFLNG IHCDVIPTKQ VQRAKVARTF TVREKDQIIQ
1510 1520 1530 1540 1550
NSIPAVIGYK FAVTVEEMSD VLDTAKFPDS LSVDLKTMKD GVYRELGLDI
1560 1570 1580 1590 1600
SLPDVMKRIA PMLYKSSKSR VVIVQGNVEG TAEAICRYWL KSMSLVKTIR
1610 1620 1630 1640 1650
VKPHKEVLQA VSIFNRKEDI GQQKDLAALK LCIEVWRWCK ANSAPYRDWF
1660 1670 1680 1690 1700
QALWFEDKTF SEWLDRFCRV GVPPIDPEIQ CAALMIADIK GDYSVLQLQA
1710 1720 1730 1740 1750
NRRAYSGKQY DAYCVQTYNE VTKLYEGDLR VTFNFGLDCA RLEIFWDKKA
1760 1770 1780 1790 1800
YILETSITQK HVLKIMMDEV SKELIKCGMR FNTEQVQGVR HMVLFKTESG
1810 1820 1830 1840 1850
FEWGKPNIPC IVYKNCVLRT SLRTTQAINH KFMITIKDDG LRAIAQHDED
1860 1870 1880 1890 1900
SPRFLLAHAF HTIRDIRYQA VDAVSNVWFI HKGVKLYLNP IISSGLLENF
1910 1920 1930 1940 1950
MKNLPAAIPP AAYSLIMNRA KISVDLFMFN DLLKLINPRN TLDLSGLETT
1960 1970 1980 1990 2000
GDEFSTVSSM SSRLWSEEMS LVDDDEELDD EFTIDLQDVD FENIDIEADI
2010 2020 2030 2040 2050
EHFLQDESSY TGDLLISTEE TESKKMRGIV KILEPVRLIK SWVSRGLSIE
2060 2070 2080 2090 2100
KVYSPVNIIL MSRYISKTFN LSTKQVSLLD PYDLTELESI VRGWGECVID
2110 2120 2130 2140 2150
QFESLDREAQ NMVVNKGICP EDVIPDSLFS FRHTMVLLRR LFPQDSISSF

Y
Length:2,151
Mass (Da):246,499
Last modified:February 1, 1996 - v3
Checksum:iDBD2A901351DFE0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55901 Genomic RNA. Translation: CAA39394.1.
PIRiS13553.
RefSeqiNP_941982.1. NC_005222.1.

Genome annotation databases

GeneIDi2943080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55901 Genomic RNA. Translation: CAA39394.1 .
PIRi S13553.
RefSeqi NP_941982.1. NC_005222.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2943080.

Family and domain databases

InterProi IPR026382. CapSnatchArena.
IPR016268. RNA-dir_pol_hantavirus.
IPR024378. RNA-dir_pol_N_hantavirus.
IPR007099. RNA-dir_pol_NSvirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view ]
Pfami PF04196. Bunya_RdRp. 1 hit.
PF12426. DUF3674. 1 hit.
[Graphical view ]
PIRSFi PIRSF000825. L_HantaV. 1 hit.
TIGRFAMsi TIGR04202. capSnatchArena. 1 hit.
PROSITEi PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the L genome segment of Hantaan virus."
    Schmaljohn C.S.
    Nucleic Acids Res. 18:6728-6728(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Comparison of the deduced gene products of the L, M and S genome segments of hantaviruses."
    Antic D., Kang C.Y., Spik K., Schmaljohn C.S., Vapalahti O., Vaheri A.
    Virus Res. 24:35-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. Schmaljohn C.S.
    Submitted (JUN-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 353-354; 916 AND 1953.

Entry informationi

Entry nameiL_HANTV
AccessioniPrimary (citable) accession number: P23456
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: February 1, 1996
Last modified: October 1, 2014
This is version 65 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3