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P23456

- L_HANTV

UniProt

P23456 - L_HANTV

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Protein

RNA-directed RNA polymerase L

Gene
L
Organism
Hantaan virus (strain 76-118) (Korean hemorrhagic fever virus)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. cap snatching Source: UniProtKB-KW
  2. transcription, DNA-templated Source: InterPro
  3. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Cap snatching, Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase L (EC:2.7.7.48)
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Gene namesi
Name:L
OrganismiHantaan virus (strain 76-118) (Korean hemorrhagic fever virus)
Taxonomic identifieri11602 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
Virus hostiApodemus agrarius (Eurasian field mouse) [TaxID: 39030]
Homo sapiens (Human) [TaxID: 9606]
ProteomesiUP000008627: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21512151RNA-directed RNA polymerase LPRO_0000222021Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini956 – 1142187RdRp catalyticAdd
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR026382. CapSnatchArena.
IPR016268. RNA-dir_pol_hantavirus.
IPR024378. RNA-dir_pol_N_hantavirus.
IPR007099. RNA-dir_pol_NSvirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view]
PfamiPF04196. Bunya_RdRp. 1 hit.
PF12426. DUF3674. 1 hit.
[Graphical view]
PIRSFiPIRSF000825. L_HantaV. 1 hit.
TIGRFAMsiTIGR04202. capSnatchArena. 1 hit.
PROSITEiPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23456-1 [UniParc]FASTAAdd to Basket

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MDKYREIHNK LKEFSPGTLT AVECIDYLDR LYAVRHDIVD QMIKHDWSDN     50
KDSEEAIGKV LLFAGVPSNI ITALEKKIIP NHPTGKSLKA FFKMTPDNYK 100
ISGTTIEFVE VTVTADVDKG IREKKLKYEA GLTYIEQELH KFFLKGEIPQ 150
PYKITFNVVA VRTDGSNITT QWPSRRNDGV VQYMRLVQAE ISYVREHLIK 200
TEERAALEAM FNLKFNISTH KSQPYYIPDY KGMEPIGANI EDLVDYSKDW 250
LSRARNFSFF EVKGTAVFEC FNSNEANHCQ RYPMSRKPRN FLLIQCSLIT 300
SYKPATTLSD QIDSRRACSY ILNLIPDTPA SYLIHDMAYR YINLTREDMI 350
NYYAPRIQFK QTQNVREPGT FKLTSSMLRA ESKAMLDLLN NHKSGEKHGA 400
QIESLNIASH IVQSESVSLI TKILSDLELN ITEPSTQEYS TTKHTYVDTV 450
LDKFFQNETQ KYLIDVLKKT TAWHIGHLIR DITESLIAHS GLKRSKYWSL 500
HSYNNGNVIL FILPSKSLEV AGSFIRFITV FRIGPGLVDK DNLDTILIDG 550
DSQWGVSKVM SIDLNRLLAL NIAFEKALIA TATWFQYYTE DQGQFPLQYA 600
IRSVFANHFL LAICQKMKLC AIFDNLRYLI PAVTSLYSGF PSLIEKLFER 650
PFKSSLEVYI YYNIKSLLVA LAQNNKARFY SKVKLLGLTV DQSTVGASGV 700
YPSFMSRIVY KHYRSLISEV TTCFFLFEKG LHGNMNEEAK IHLETVEWAL 750
KFREKEEKYG ESLVENGYMM WELRANAELA EQQLYCQDAI ELAAIELNKV 800
LATKSSVVAN SILSKNWEEP YFSQTRNISL KGMSGQVQED GHLSSSVTII 850
EAIRYLSNSR HNPSLLKLYE ETREQKAMAR IVRKYQRTEA DRGFFITTLP 900
TRCRLEIIED YYDAIAKNIS EEYISYGGEK KILAIQGALE KALRWASGES 950
FIELSNHKFI RMKRKLMYVS ADATKWSPGD NSAKFRRFTS MLHNGLPNNK 1000
LKNCVIDALK QVYKTDFFMS RKLRNYIDSM ESLDPHIKQF LDFFPDGHHG 1050
EVKGNWLQGN LNKCSSLFGV AMSLLFKQVW TNLFPELDCF FEFAHHSDDA 1100
LFIYGYLEPV DDGTDWFLFV SQQIQAGHLH WFSVNTEMWK SMFNLHEHIL 1150
LLGSIKISPK KTTVSPTNAE FLSTFFEGCA VSIPFVKILL GSLSDLPGLG 1200
YFDDLAAAQS RCVKALDLGA SPQVAQLAVA LCTSKVERLY GTAPGMVNHP 1250
AAYLQVKHTD TPIPLGGNGA MSIMELATAG IGMSDKNLLK RALLGYSHKR 1300
QKSMLYILGL FKFLMKLSDE TFQHERLGQF SFIGKVQWKI FTPKSEFEFA 1350
DMYTSKFLEL WSSQHVTYDY IIPKGRDNLL IYLVRKLNDP SIVTAMTMQS 1400
PLQLRFRMQA KQHMKVCRLD GEWVTFREVL AAANSFAENY SATSQDMDLF 1450
QTLTSCTFSK EYAWKDFLNG IHCDVIPTKQ VQRAKVARTF TVREKDQIIQ 1500
NSIPAVIGYK FAVTVEEMSD VLDTAKFPDS LSVDLKTMKD GVYRELGLDI 1550
SLPDVMKRIA PMLYKSSKSR VVIVQGNVEG TAEAICRYWL KSMSLVKTIR 1600
VKPHKEVLQA VSIFNRKEDI GQQKDLAALK LCIEVWRWCK ANSAPYRDWF 1650
QALWFEDKTF SEWLDRFCRV GVPPIDPEIQ CAALMIADIK GDYSVLQLQA 1700
NRRAYSGKQY DAYCVQTYNE VTKLYEGDLR VTFNFGLDCA RLEIFWDKKA 1750
YILETSITQK HVLKIMMDEV SKELIKCGMR FNTEQVQGVR HMVLFKTESG 1800
FEWGKPNIPC IVYKNCVLRT SLRTTQAINH KFMITIKDDG LRAIAQHDED 1850
SPRFLLAHAF HTIRDIRYQA VDAVSNVWFI HKGVKLYLNP IISSGLLENF 1900
MKNLPAAIPP AAYSLIMNRA KISVDLFMFN DLLKLINPRN TLDLSGLETT 1950
GDEFSTVSSM SSRLWSEEMS LVDDDEELDD EFTIDLQDVD FENIDIEADI 2000
EHFLQDESSY TGDLLISTEE TESKKMRGIV KILEPVRLIK SWVSRGLSIE 2050
KVYSPVNIIL MSRYISKTFN LSTKQVSLLD PYDLTELESI VRGWGECVID 2100
QFESLDREAQ NMVVNKGICP EDVIPDSLFS FRHTMVLLRR LFPQDSISSF 2150
Y 2151
Length:2,151
Mass (Da):246,499
Last modified:February 1, 1996 - v3
Checksum:iDBD2A901351DFE0B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55901 Genomic RNA. Translation: CAA39394.1.
PIRiS13553.
RefSeqiNP_941982.1. NC_005222.1.

Genome annotation databases

GeneIDi2943080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55901 Genomic RNA. Translation: CAA39394.1 .
PIRi S13553.
RefSeqi NP_941982.1. NC_005222.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2943080.

Family and domain databases

InterProi IPR026382. CapSnatchArena.
IPR016268. RNA-dir_pol_hantavirus.
IPR024378. RNA-dir_pol_N_hantavirus.
IPR007099. RNA-dir_pol_NSvirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view ]
Pfami PF04196. Bunya_RdRp. 1 hit.
PF12426. DUF3674. 1 hit.
[Graphical view ]
PIRSFi PIRSF000825. L_HantaV. 1 hit.
TIGRFAMsi TIGR04202. capSnatchArena. 1 hit.
PROSITEi PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the L genome segment of Hantaan virus."
    Schmaljohn C.S.
    Nucleic Acids Res. 18:6728-6728(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Comparison of the deduced gene products of the L, M and S genome segments of hantaviruses."
    Antic D., Kang C.Y., Spik K., Schmaljohn C.S., Vapalahti O., Vaheri A.
    Virus Res. 24:35-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. Schmaljohn C.S.
    Submitted (JUN-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 353-354; 916 AND 1953.

Entry informationi

Entry nameiL_HANTV
AccessioniPrimary (citable) accession number: P23456
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 64 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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