P23456 (L_HANTV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RNA-directed RNA polymerase L
Short name=Protein L
EC=2.7.7.48

Alternative name(s):
Large structural protein
Replicase
Transcriptase

Gene names

Name:

L

Organism

Hantaan virus (strain 76-118) (Korean hemorrhagic fever virus) [Reference proteome]

Taxonomic identifier

11602 [NCBI]

Taxonomic lineage

Viruses › ssRNA viruses › ssRNA negative-strand viruses › Bunyaviridae › Hantavirus › Hantaan virus

Virus host

Apodemus agrarius (Eurasian field mouse) [TaxID: 39030]
Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	2151 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
Sequence similarities	Belongs to the hantavirus RNA polymerase family. Contains 1 RdRp catalytic domain.

Ontologies

Keywords
Biological process	Cap snatching Viral RNA replication
Ligand	Nucleotide-binding
Molecular function	Nucleotidyltransferase RNA-directed RNA polymerase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro viral genome replication Inferred from electronic annotation. Source: InterPro
Molecular_function	RNA-directed RNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2151	2151	RNA-directed RNA polymerase L		PRO_0000222021
Regions
	Domain	956 – 1142	187	RdRp catalytic

Sequences

	Sequence		Length	Mass (Da)
	P23456 [UniParc]. Last modified February 1, 1996. Version 3. Checksum: DBD2A901351DFE0B	FASTA	2,151	246,499
	10 20 30 40 50 60 MDKYREIHNK LKEFSPGTLT AVECIDYLDR LYAVRHDIVD QMIKHDWSDN KDSEEAIGKV 70 80 90 100 110 120 LLFAGVPSNI ITALEKKIIP NHPTGKSLKA FFKMTPDNYK ISGTTIEFVE VTVTADVDKG 130 140 150 160 170 180 IREKKLKYEA GLTYIEQELH KFFLKGEIPQ PYKITFNVVA VRTDGSNITT QWPSRRNDGV 190 200 210 220 230 240 VQYMRLVQAE ISYVREHLIK TEERAALEAM FNLKFNISTH KSQPYYIPDY KGMEPIGANI 250 260 270 280 290 300 EDLVDYSKDW LSRARNFSFF EVKGTAVFEC FNSNEANHCQ RYPMSRKPRN FLLIQCSLIT 310 320 330 340 350 360 SYKPATTLSD QIDSRRACSY ILNLIPDTPA SYLIHDMAYR YINLTREDMI NYYAPRIQFK 370 380 390 400 410 420 QTQNVREPGT FKLTSSMLRA ESKAMLDLLN NHKSGEKHGA QIESLNIASH IVQSESVSLI 430 440 450 460 470 480 TKILSDLELN ITEPSTQEYS TTKHTYVDTV LDKFFQNETQ KYLIDVLKKT TAWHIGHLIR 490 500 510 520 530 540 DITESLIAHS GLKRSKYWSL HSYNNGNVIL FILPSKSLEV AGSFIRFITV FRIGPGLVDK 550 560 570 580 590 600 DNLDTILIDG DSQWGVSKVM SIDLNRLLAL NIAFEKALIA TATWFQYYTE DQGQFPLQYA 610 620 630 640 650 660 IRSVFANHFL LAICQKMKLC AIFDNLRYLI PAVTSLYSGF PSLIEKLFER PFKSSLEVYI 670 680 690 700 710 720 YYNIKSLLVA LAQNNKARFY SKVKLLGLTV DQSTVGASGV YPSFMSRIVY KHYRSLISEV 730 740 750 760 770 780 TTCFFLFEKG LHGNMNEEAK IHLETVEWAL KFREKEEKYG ESLVENGYMM WELRANAELA 790 800 810 820 830 840 EQQLYCQDAI ELAAIELNKV LATKSSVVAN SILSKNWEEP YFSQTRNISL KGMSGQVQED 850 860 870 880 890 900 GHLSSSVTII EAIRYLSNSR HNPSLLKLYE ETREQKAMAR IVRKYQRTEA DRGFFITTLP 910 920 930 940 950 960 TRCRLEIIED YYDAIAKNIS EEYISYGGEK KILAIQGALE KALRWASGES FIELSNHKFI 970 980 990 1000 1010 1020 RMKRKLMYVS ADATKWSPGD NSAKFRRFTS MLHNGLPNNK LKNCVIDALK QVYKTDFFMS 1030 1040 1050 1060 1070 1080 RKLRNYIDSM ESLDPHIKQF LDFFPDGHHG EVKGNWLQGN LNKCSSLFGV AMSLLFKQVW 1090 1100 1110 1120 1130 1140 TNLFPELDCF FEFAHHSDDA LFIYGYLEPV DDGTDWFLFV SQQIQAGHLH WFSVNTEMWK 1150 1160 1170 1180 1190 1200 SMFNLHEHIL LLGSIKISPK KTTVSPTNAE FLSTFFEGCA VSIPFVKILL GSLSDLPGLG 1210 1220 1230 1240 1250 1260 YFDDLAAAQS RCVKALDLGA SPQVAQLAVA LCTSKVERLY GTAPGMVNHP AAYLQVKHTD 1270 1280 1290 1300 1310 1320 TPIPLGGNGA MSIMELATAG IGMSDKNLLK RALLGYSHKR QKSMLYILGL FKFLMKLSDE 1330 1340 1350 1360 1370 1380 TFQHERLGQF SFIGKVQWKI FTPKSEFEFA DMYTSKFLEL WSSQHVTYDY IIPKGRDNLL 1390 1400 1410 1420 1430 1440 IYLVRKLNDP SIVTAMTMQS PLQLRFRMQA KQHMKVCRLD GEWVTFREVL AAANSFAENY 1450 1460 1470 1480 1490 1500 SATSQDMDLF QTLTSCTFSK EYAWKDFLNG IHCDVIPTKQ VQRAKVARTF TVREKDQIIQ 1510 1520 1530 1540 1550 1560 NSIPAVIGYK FAVTVEEMSD VLDTAKFPDS LSVDLKTMKD GVYRELGLDI SLPDVMKRIA 1570 1580 1590 1600 1610 1620 PMLYKSSKSR VVIVQGNVEG TAEAICRYWL KSMSLVKTIR VKPHKEVLQA VSIFNRKEDI 1630 1640 1650 1660 1670 1680 GQQKDLAALK LCIEVWRWCK ANSAPYRDWF QALWFEDKTF SEWLDRFCRV GVPPIDPEIQ 1690 1700 1710 1720 1730 1740 CAALMIADIK GDYSVLQLQA NRRAYSGKQY DAYCVQTYNE VTKLYEGDLR VTFNFGLDCA 1750 1760 1770 1780 1790 1800 RLEIFWDKKA YILETSITQK HVLKIMMDEV SKELIKCGMR FNTEQVQGVR HMVLFKTESG 1810 1820 1830 1840 1850 1860 FEWGKPNIPC IVYKNCVLRT SLRTTQAINH KFMITIKDDG LRAIAQHDED SPRFLLAHAF 1870 1880 1890 1900 1910 1920 HTIRDIRYQA VDAVSNVWFI HKGVKLYLNP IISSGLLENF MKNLPAAIPP AAYSLIMNRA 1930 1940 1950 1960 1970 1980 KISVDLFMFN DLLKLINPRN TLDLSGLETT GDEFSTVSSM SSRLWSEEMS LVDDDEELDD 1990 2000 2010 2020 2030 2040 EFTIDLQDVD FENIDIEADI EHFLQDESSY TGDLLISTEE TESKKMRGIV KILEPVRLIK 2050 2060 2070 2080 2090 2100 SWVSRGLSIE KVYSPVNIIL MSRYISKTFN LSTKQVSLLD PYDLTELESI VRGWGECVID 2110 2120 2130 2140 2150 QFESLDREAQ NMVVNKGICP EDVIPDSLFS FRHTMVLLRR LFPQDSISSF Y

References

[1]	"Nucleotide sequence of the L genome segment of Hantaan virus." Schmaljohn C.S. Nucleic Acids Res. 18:6728-6728(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]	"Comparison of the deduced gene products of the L, M and S genome segments of hantaviruses." Antic D., Kang C.Y., Spik K., Schmaljohn C.S., Vapalahti O., Vaheri A. Virus Res. 24:35-46(1992) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[3]	Schmaljohn C.S. Submitted (JUN-1994) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 353-354; 916 AND 1953.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X55901 Genomic RNA. Translation: CAA39394.1.
PIR	S13553.
RefSeq	NP_941982.1. NC_005222.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2943080.
Family and domain databases
InterPro	IPR026382. CapSnatchArena. IPR016268. RNA-dir_pol_hantavirus. IPR024378. RNA-dir_pol_N_hantavirus. IPR007099. RNA-dir_pol_NSvirus. IPR007322. RNA_pol_bunyavir. [Graphical view]
Pfam	PF04196. Bunya_RdRp. 1 hit. PF12426. DUF3674. 1 hit. [Graphical view]
PIRSF	PIRSF000825. L_HantaV. 1 hit.
TIGRFAMs	TIGR04202. capSnatchArena. 1 hit.
PROSITE	PS50525. RDRP_SSRNA_NEG_SEG. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

L_HANTV

Accession

Primary (citable) accession number: P23456

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	February 1, 1996
Last modified:	April 3, 2013
This is version 60 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program