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P23456

- L_HANTV

UniProt

P23456 - L_HANTV

Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Hantaan virus (strain 76-118) (Korean hemorrhagic fever virus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 3 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. cap snatching Source: UniProtKB-KW
    2. transcription, DNA-templated Source: InterPro
    3. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

    Keywords - Biological processi

    Cap snatching, Viral RNA replication

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-directed RNA polymerase L (EC:2.7.7.48)
    Short name:
    Protein L
    Alternative name(s):
    Large structural protein
    Replicase
    Transcriptase
    Gene namesi
    Name:L
    OrganismiHantaan virus (strain 76-118) (Korean hemorrhagic fever virus)
    Taxonomic identifieri11602 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
    Virus hostiApodemus agrarius (Eurasian field mouse) [TaxID: 39030]
    Homo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000008627: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 21512151RNA-directed RNA polymerase LPRO_0000222021Add
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini956 – 1142187RdRp catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the hantavirus RNA polymerase family.Curated
    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR026382. CapSnatchArena.
    IPR016268. RNA-dir_pol_hantavirus.
    IPR024378. RNA-dir_pol_N_hantavirus.
    IPR007099. RNA-dir_pol_NSvirus.
    IPR007322. RNA_pol_bunyavir.
    [Graphical view]
    PfamiPF04196. Bunya_RdRp. 1 hit.
    PF12426. DUF3674. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000825. L_HantaV. 1 hit.
    TIGRFAMsiTIGR04202. capSnatchArena. 1 hit.
    PROSITEiPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P23456-1 [UniParc]FASTAAdd to Basket

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    MDKYREIHNK LKEFSPGTLT AVECIDYLDR LYAVRHDIVD QMIKHDWSDN     50
    KDSEEAIGKV LLFAGVPSNI ITALEKKIIP NHPTGKSLKA FFKMTPDNYK 100
    ISGTTIEFVE VTVTADVDKG IREKKLKYEA GLTYIEQELH KFFLKGEIPQ 150
    PYKITFNVVA VRTDGSNITT QWPSRRNDGV VQYMRLVQAE ISYVREHLIK 200
    TEERAALEAM FNLKFNISTH KSQPYYIPDY KGMEPIGANI EDLVDYSKDW 250
    LSRARNFSFF EVKGTAVFEC FNSNEANHCQ RYPMSRKPRN FLLIQCSLIT 300
    SYKPATTLSD QIDSRRACSY ILNLIPDTPA SYLIHDMAYR YINLTREDMI 350
    NYYAPRIQFK QTQNVREPGT FKLTSSMLRA ESKAMLDLLN NHKSGEKHGA 400
    QIESLNIASH IVQSESVSLI TKILSDLELN ITEPSTQEYS TTKHTYVDTV 450
    LDKFFQNETQ KYLIDVLKKT TAWHIGHLIR DITESLIAHS GLKRSKYWSL 500
    HSYNNGNVIL FILPSKSLEV AGSFIRFITV FRIGPGLVDK DNLDTILIDG 550
    DSQWGVSKVM SIDLNRLLAL NIAFEKALIA TATWFQYYTE DQGQFPLQYA 600
    IRSVFANHFL LAICQKMKLC AIFDNLRYLI PAVTSLYSGF PSLIEKLFER 650
    PFKSSLEVYI YYNIKSLLVA LAQNNKARFY SKVKLLGLTV DQSTVGASGV 700
    YPSFMSRIVY KHYRSLISEV TTCFFLFEKG LHGNMNEEAK IHLETVEWAL 750
    KFREKEEKYG ESLVENGYMM WELRANAELA EQQLYCQDAI ELAAIELNKV 800
    LATKSSVVAN SILSKNWEEP YFSQTRNISL KGMSGQVQED GHLSSSVTII 850
    EAIRYLSNSR HNPSLLKLYE ETREQKAMAR IVRKYQRTEA DRGFFITTLP 900
    TRCRLEIIED YYDAIAKNIS EEYISYGGEK KILAIQGALE KALRWASGES 950
    FIELSNHKFI RMKRKLMYVS ADATKWSPGD NSAKFRRFTS MLHNGLPNNK 1000
    LKNCVIDALK QVYKTDFFMS RKLRNYIDSM ESLDPHIKQF LDFFPDGHHG 1050
    EVKGNWLQGN LNKCSSLFGV AMSLLFKQVW TNLFPELDCF FEFAHHSDDA 1100
    LFIYGYLEPV DDGTDWFLFV SQQIQAGHLH WFSVNTEMWK SMFNLHEHIL 1150
    LLGSIKISPK KTTVSPTNAE FLSTFFEGCA VSIPFVKILL GSLSDLPGLG 1200
    YFDDLAAAQS RCVKALDLGA SPQVAQLAVA LCTSKVERLY GTAPGMVNHP 1250
    AAYLQVKHTD TPIPLGGNGA MSIMELATAG IGMSDKNLLK RALLGYSHKR 1300
    QKSMLYILGL FKFLMKLSDE TFQHERLGQF SFIGKVQWKI FTPKSEFEFA 1350
    DMYTSKFLEL WSSQHVTYDY IIPKGRDNLL IYLVRKLNDP SIVTAMTMQS 1400
    PLQLRFRMQA KQHMKVCRLD GEWVTFREVL AAANSFAENY SATSQDMDLF 1450
    QTLTSCTFSK EYAWKDFLNG IHCDVIPTKQ VQRAKVARTF TVREKDQIIQ 1500
    NSIPAVIGYK FAVTVEEMSD VLDTAKFPDS LSVDLKTMKD GVYRELGLDI 1550
    SLPDVMKRIA PMLYKSSKSR VVIVQGNVEG TAEAICRYWL KSMSLVKTIR 1600
    VKPHKEVLQA VSIFNRKEDI GQQKDLAALK LCIEVWRWCK ANSAPYRDWF 1650
    QALWFEDKTF SEWLDRFCRV GVPPIDPEIQ CAALMIADIK GDYSVLQLQA 1700
    NRRAYSGKQY DAYCVQTYNE VTKLYEGDLR VTFNFGLDCA RLEIFWDKKA 1750
    YILETSITQK HVLKIMMDEV SKELIKCGMR FNTEQVQGVR HMVLFKTESG 1800
    FEWGKPNIPC IVYKNCVLRT SLRTTQAINH KFMITIKDDG LRAIAQHDED 1850
    SPRFLLAHAF HTIRDIRYQA VDAVSNVWFI HKGVKLYLNP IISSGLLENF 1900
    MKNLPAAIPP AAYSLIMNRA KISVDLFMFN DLLKLINPRN TLDLSGLETT 1950
    GDEFSTVSSM SSRLWSEEMS LVDDDEELDD EFTIDLQDVD FENIDIEADI 2000
    EHFLQDESSY TGDLLISTEE TESKKMRGIV KILEPVRLIK SWVSRGLSIE 2050
    KVYSPVNIIL MSRYISKTFN LSTKQVSLLD PYDLTELESI VRGWGECVID 2100
    QFESLDREAQ NMVVNKGICP EDVIPDSLFS FRHTMVLLRR LFPQDSISSF 2150
    Y 2151
    Length:2,151
    Mass (Da):246,499
    Last modified:February 1, 1996 - v3
    Checksum:iDBD2A901351DFE0B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55901 Genomic RNA. Translation: CAA39394.1.
    PIRiS13553.
    RefSeqiNP_941982.1. NC_005222.1.

    Genome annotation databases

    GeneIDi2943080.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55901 Genomic RNA. Translation: CAA39394.1 .
    PIRi S13553.
    RefSeqi NP_941982.1. NC_005222.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2943080.

    Family and domain databases

    InterProi IPR026382. CapSnatchArena.
    IPR016268. RNA-dir_pol_hantavirus.
    IPR024378. RNA-dir_pol_N_hantavirus.
    IPR007099. RNA-dir_pol_NSvirus.
    IPR007322. RNA_pol_bunyavir.
    [Graphical view ]
    Pfami PF04196. Bunya_RdRp. 1 hit.
    PF12426. DUF3674. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000825. L_HantaV. 1 hit.
    TIGRFAMsi TIGR04202. capSnatchArena. 1 hit.
    PROSITEi PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the L genome segment of Hantaan virus."
      Schmaljohn C.S.
      Nucleic Acids Res. 18:6728-6728(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Comparison of the deduced gene products of the L, M and S genome segments of hantaviruses."
      Antic D., Kang C.Y., Spik K., Schmaljohn C.S., Vapalahti O., Vaheri A.
      Virus Res. 24:35-46(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    3. Schmaljohn C.S.
      Submitted (JUN-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 353-354; 916 AND 1953.

    Entry informationi

    Entry nameiL_HANTV
    AccessioniPrimary (citable) accession number: P23456
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 65 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3