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P23456 (L_HANTV) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
RNA-directed RNA polymerase L

Short name=Protein L
EC=2.7.7.48
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Gene names
Name:L
OrganismHantaan virus (strain 76-118) (Korean hemorrhagic fever virus) [Reference proteome]
Taxonomic identifier11602 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
Virus hostApodemus agrarius (Eurasian field mouse) [TaxID: 39030]
Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length2151 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Sequence similarities

Belongs to the hantavirus RNA polymerase family.

Contains 1 RdRp catalytic domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 21512151RNA-directed RNA polymerase L
PRO_0000222021

Regions

Domain956 – 1142187RdRp catalytic

Sequences

Sequence LengthMass (Da)Tools
P23456 [UniParc].

Last modified February 1, 1996. Version 3.
Checksum: DBD2A901351DFE0B

FASTA2,151246,499
        10         20         30         40         50         60 
MDKYREIHNK LKEFSPGTLT AVECIDYLDR LYAVRHDIVD QMIKHDWSDN KDSEEAIGKV 

        70         80         90        100        110        120 
LLFAGVPSNI ITALEKKIIP NHPTGKSLKA FFKMTPDNYK ISGTTIEFVE VTVTADVDKG 

       130        140        150        160        170        180 
IREKKLKYEA GLTYIEQELH KFFLKGEIPQ PYKITFNVVA VRTDGSNITT QWPSRRNDGV 

       190        200        210        220        230        240 
VQYMRLVQAE ISYVREHLIK TEERAALEAM FNLKFNISTH KSQPYYIPDY KGMEPIGANI 

       250        260        270        280        290        300 
EDLVDYSKDW LSRARNFSFF EVKGTAVFEC FNSNEANHCQ RYPMSRKPRN FLLIQCSLIT 

       310        320        330        340        350        360 
SYKPATTLSD QIDSRRACSY ILNLIPDTPA SYLIHDMAYR YINLTREDMI NYYAPRIQFK 

       370        380        390        400        410        420 
QTQNVREPGT FKLTSSMLRA ESKAMLDLLN NHKSGEKHGA QIESLNIASH IVQSESVSLI 

       430        440        450        460        470        480 
TKILSDLELN ITEPSTQEYS TTKHTYVDTV LDKFFQNETQ KYLIDVLKKT TAWHIGHLIR 

       490        500        510        520        530        540 
DITESLIAHS GLKRSKYWSL HSYNNGNVIL FILPSKSLEV AGSFIRFITV FRIGPGLVDK 

       550        560        570        580        590        600 
DNLDTILIDG DSQWGVSKVM SIDLNRLLAL NIAFEKALIA TATWFQYYTE DQGQFPLQYA 

       610        620        630        640        650        660 
IRSVFANHFL LAICQKMKLC AIFDNLRYLI PAVTSLYSGF PSLIEKLFER PFKSSLEVYI 

       670        680        690        700        710        720 
YYNIKSLLVA LAQNNKARFY SKVKLLGLTV DQSTVGASGV YPSFMSRIVY KHYRSLISEV 

       730        740        750        760        770        780 
TTCFFLFEKG LHGNMNEEAK IHLETVEWAL KFREKEEKYG ESLVENGYMM WELRANAELA 

       790        800        810        820        830        840 
EQQLYCQDAI ELAAIELNKV LATKSSVVAN SILSKNWEEP YFSQTRNISL KGMSGQVQED 

       850        860        870        880        890        900 
GHLSSSVTII EAIRYLSNSR HNPSLLKLYE ETREQKAMAR IVRKYQRTEA DRGFFITTLP 

       910        920        930        940        950        960 
TRCRLEIIED YYDAIAKNIS EEYISYGGEK KILAIQGALE KALRWASGES FIELSNHKFI 

       970        980        990       1000       1010       1020 
RMKRKLMYVS ADATKWSPGD NSAKFRRFTS MLHNGLPNNK LKNCVIDALK QVYKTDFFMS 

      1030       1040       1050       1060       1070       1080 
RKLRNYIDSM ESLDPHIKQF LDFFPDGHHG EVKGNWLQGN LNKCSSLFGV AMSLLFKQVW 

      1090       1100       1110       1120       1130       1140 
TNLFPELDCF FEFAHHSDDA LFIYGYLEPV DDGTDWFLFV SQQIQAGHLH WFSVNTEMWK 

      1150       1160       1170       1180       1190       1200 
SMFNLHEHIL LLGSIKISPK KTTVSPTNAE FLSTFFEGCA VSIPFVKILL GSLSDLPGLG 

      1210       1220       1230       1240       1250       1260 
YFDDLAAAQS RCVKALDLGA SPQVAQLAVA LCTSKVERLY GTAPGMVNHP AAYLQVKHTD 

      1270       1280       1290       1300       1310       1320 
TPIPLGGNGA MSIMELATAG IGMSDKNLLK RALLGYSHKR QKSMLYILGL FKFLMKLSDE 

      1330       1340       1350       1360       1370       1380 
TFQHERLGQF SFIGKVQWKI FTPKSEFEFA DMYTSKFLEL WSSQHVTYDY IIPKGRDNLL 

      1390       1400       1410       1420       1430       1440 
IYLVRKLNDP SIVTAMTMQS PLQLRFRMQA KQHMKVCRLD GEWVTFREVL AAANSFAENY 

      1450       1460       1470       1480       1490       1500 
SATSQDMDLF QTLTSCTFSK EYAWKDFLNG IHCDVIPTKQ VQRAKVARTF TVREKDQIIQ 

      1510       1520       1530       1540       1550       1560 
NSIPAVIGYK FAVTVEEMSD VLDTAKFPDS LSVDLKTMKD GVYRELGLDI SLPDVMKRIA 

      1570       1580       1590       1600       1610       1620 
PMLYKSSKSR VVIVQGNVEG TAEAICRYWL KSMSLVKTIR VKPHKEVLQA VSIFNRKEDI 

      1630       1640       1650       1660       1670       1680 
GQQKDLAALK LCIEVWRWCK ANSAPYRDWF QALWFEDKTF SEWLDRFCRV GVPPIDPEIQ 

      1690       1700       1710       1720       1730       1740 
CAALMIADIK GDYSVLQLQA NRRAYSGKQY DAYCVQTYNE VTKLYEGDLR VTFNFGLDCA 

      1750       1760       1770       1780       1790       1800 
RLEIFWDKKA YILETSITQK HVLKIMMDEV SKELIKCGMR FNTEQVQGVR HMVLFKTESG 

      1810       1820       1830       1840       1850       1860 
FEWGKPNIPC IVYKNCVLRT SLRTTQAINH KFMITIKDDG LRAIAQHDED SPRFLLAHAF 

      1870       1880       1890       1900       1910       1920 
HTIRDIRYQA VDAVSNVWFI HKGVKLYLNP IISSGLLENF MKNLPAAIPP AAYSLIMNRA 

      1930       1940       1950       1960       1970       1980 
KISVDLFMFN DLLKLINPRN TLDLSGLETT GDEFSTVSSM SSRLWSEEMS LVDDDEELDD 

      1990       2000       2010       2020       2030       2040 
EFTIDLQDVD FENIDIEADI EHFLQDESSY TGDLLISTEE TESKKMRGIV KILEPVRLIK 

      2050       2060       2070       2080       2090       2100 
SWVSRGLSIE KVYSPVNIIL MSRYISKTFN LSTKQVSLLD PYDLTELESI VRGWGECVID 

      2110       2120       2130       2140       2150 
QFESLDREAQ NMVVNKGICP EDVIPDSLFS FRHTMVLLRR LFPQDSISSF Y 

« Hide

References

[1]"Nucleotide sequence of the L genome segment of Hantaan virus."
Schmaljohn C.S.
Nucleic Acids Res. 18:6728-6728(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Comparison of the deduced gene products of the L, M and S genome segments of hantaviruses."
Antic D., Kang C.Y., Spik K., Schmaljohn C.S., Vapalahti O., Vaheri A.
Virus Res. 24:35-46(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[3]Schmaljohn C.S.
Submitted (JUN-1994) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 353-354; 916 AND 1953.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X55901 Genomic RNA. Translation: CAA39394.1.
PIRS13553.
RefSeqNP_941982.1. NC_005222.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2943080.

Family and domain databases

InterProIPR026382. CapSnatchArena.
IPR016268. RNA-dir_pol_hantavirus.
IPR024378. RNA-dir_pol_N_hantavirus.
IPR007099. RNA-dir_pol_NSvirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view]
PfamPF04196. Bunya_RdRp. 1 hit.
PF12426. DUF3674. 1 hit.
[Graphical view]
PIRSFPIRSF000825. L_HantaV. 1 hit.
TIGRFAMsTIGR04202. capSnatchArena. 1 hit.
PROSITEPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameL_HANTV
AccessionPrimary (citable) accession number: P23456
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 64 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families