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P23418 (CHS1_SOLLC) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase 1

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase 1
Gene names
Name:CHS1
OrganismSolanum lycopersicum (Tomato) (Lycopersicon esculentum) [Reference proteome]
Taxonomic identifier4081 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon

Protein attributes

Sequence length389 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 389389Chalcone synthase 1
PRO_0000216001

Sites

Active site1641 By similarity

Sequences

Sequence LengthMass (Da)Tools
P23418 [UniParc].

Last modified April 1, 1993. Version 2.
Checksum: 553DC69E5EA96A8B

FASTA38942,552
        10         20         30         40         50         60 
MVTVEEYRKA QRAEGPATIL AIGTSTPSNC VDQSTYPDYY FRITNSEHKT ELKEKFKRMC 

        70         80         90        100        110        120 
DKSMIKKRYM HLTEEILKEN PNMCAYMAPS LDARQDIVVV EVPKLGKRGT QKAIKEWGQP 

       130        140        150        160        170        180 
KSKITHLVFC TTSGVDMPAC DYQLAKLLPV RPSVKRLMMY QQGCFAGGTV LRLAKDLAEN 

       190        200        210        220        230        240 
NKGARVLVVC SEITAVTFRG PSESHLDSLV GQALFGDGAA AIIIGSDPII GVERPLFELV 

       250        260        270        280        290        300 
SAAQTLVPDS EGAIDGHLRE VGLTFHLLKD VPGLISKNIE KSLLEAFQPL GISDWNSLFW 

       310        320        330        340        350        360 
IAHPGGPAIL DQVELKLGLK PEKLRATREV LSNYGNMSSA CVLFILDEMR KASTKEGLGT 

       370        380 
TGEGLEWGVL FGFGPGLTVE TVVLHSVAA 

« Hide

References

[1]"Molecular genetic analysis of chalcone synthase in Lycopersicon esculentum and an anthocyanin-deficient mutant."
O'Neill S.D., Tong Y., Spoerlein B., Forkmann G., Yoder J.I.
Mol. Gen. Genet. 224:279-288(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Cotyledon, Hypocotyl and Leaf.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X55194 mRNA. Translation: CAA38980.1.
PIRS12223.
RefSeqNP_001234033.1. NM_001247104.1.
UniGeneLes.16908.

3D structure databases

ProteinModelPortalP23418.
SMRP23418. Positions 3-388.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID778294.
KEGGsly:778294.

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHS1_SOLLC
AccessionPrimary (citable) accession number: P23418
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: April 1, 1993
Last modified: March 19, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways