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P23418

- CHS1_SOLLC

UniProt

P23418 - CHS1_SOLLC

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Protein

Chalcone synthase 1

Gene

CHS1

Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei164 – 1641PROSITE-ProRule annotation

GO - Molecular functioni

  1. naringenin-chalcone synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. flavonoid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase 1 (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase 1
Gene namesi
Name:CHS1
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
ProteomesiUP000004994: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Chalcone synthase 1PRO_0000216001Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP23418.
SMRiP23418. Positions 3-388.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Phylogenomic databases

InParanoidiP23418.
KOiK00660.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23418-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVTVEEYRKA QRAEGPATIL AIGTSTPSNC VDQSTYPDYY FRITNSEHKT
60 70 80 90 100
ELKEKFKRMC DKSMIKKRYM HLTEEILKEN PNMCAYMAPS LDARQDIVVV
110 120 130 140 150
EVPKLGKRGT QKAIKEWGQP KSKITHLVFC TTSGVDMPAC DYQLAKLLPV
160 170 180 190 200
RPSVKRLMMY QQGCFAGGTV LRLAKDLAEN NKGARVLVVC SEITAVTFRG
210 220 230 240 250
PSESHLDSLV GQALFGDGAA AIIIGSDPII GVERPLFELV SAAQTLVPDS
260 270 280 290 300
EGAIDGHLRE VGLTFHLLKD VPGLISKNIE KSLLEAFQPL GISDWNSLFW
310 320 330 340 350
IAHPGGPAIL DQVELKLGLK PEKLRATREV LSNYGNMSSA CVLFILDEMR
360 370 380
KASTKEGLGT TGEGLEWGVL FGFGPGLTVE TVVLHSVAA
Length:389
Mass (Da):42,552
Last modified:April 1, 1993 - v2
Checksum:i553DC69E5EA96A8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55194 mRNA. Translation: CAA38980.1.
PIRiS12223.
RefSeqiNP_001234033.1. NM_001247104.1.
UniGeneiLes.16908.

Genome annotation databases

GeneIDi778294.
KEGGisly:778294.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55194 mRNA. Translation: CAA38980.1 .
PIRi S12223.
RefSeqi NP_001234033.1. NM_001247104.1.
UniGenei Les.16908.

3D structure databases

ProteinModelPortali P23418.
SMRi P23418. Positions 3-388.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 778294.
KEGGi sly:778294.

Phylogenomic databases

InParanoidi P23418.
KOi K00660.

Enzyme and pathway databases

UniPathwayi UPA00154 .

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000451. PKS_III. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular genetic analysis of chalcone synthase in Lycopersicon esculentum and an anthocyanin-deficient mutant."
    O'Neill S.D., Tong Y., Spoerlein B., Forkmann G., Yoder J.I.
    Mol. Gen. Genet. 224:279-288(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Cotyledon, Hypocotyl and Leaf.

Entry informationi

Entry nameiCHS1_SOLLC
AccessioniPrimary (citable) accession number: P23418
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: April 1, 1993
Last modified: October 29, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3