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P23418

- CHS1_SOLLC

UniProt

P23418 - CHS1_SOLLC

Protein

Chalcone synthase 1

Gene

CHS1

Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

    Catalytic activityi

    3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei164 – 1641PROSITE-ProRule annotation

    GO - Molecular functioni

    1. naringenin-chalcone synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. auxin polar transport Source: EnsemblPlants/Gramene
    2. flavonoid biosynthetic process Source: UniProtKB-UniPathway
    3. regulation of anthocyanin biosynthetic process Source: EnsemblPlants/Gramene
    4. response to auxin Source: EnsemblPlants/Gramene
    5. response to gravity Source: EnsemblPlants/Gramene
    6. response to jasmonic acid Source: EnsemblPlants/Gramene
    7. response to oxidative stress Source: EnsemblPlants/Gramene
    8. response to UV-B Source: EnsemblPlants/Gramene
    9. response to wounding Source: EnsemblPlants/Gramene

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Flavonoid biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00154.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chalcone synthase 1 (EC:2.3.1.74)
    Alternative name(s):
    Naringenin-chalcone synthase 1
    Gene namesi
    Name:CHS1
    OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
    Taxonomic identifieri4081 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
    ProteomesiUP000004994: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: EnsemblPlants/Gramene
    2. nucleus Source: EnsemblPlants/Gramene
    3. plant-type vacuole membrane Source: EnsemblPlants/Gramene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 389389Chalcone synthase 1PRO_0000216001Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP23418.
    SMRiP23418. Positions 3-388.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the chalcone/stilbene synthases family.Curated

    Phylogenomic databases

    KOiK00660.

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    InterProiIPR012328. Chalcone/stilbene_synth_C.
    IPR018088. Chalcone/stilbene_synthase_AS.
    IPR001099. Chalcone/stilbene_synthase_N.
    IPR011141. Polyketide_synthase_type-III.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF02797. Chal_sti_synt_C. 1 hit.
    PF00195. Chal_sti_synt_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000451. PKS_III. 1 hit.
    SUPFAMiSSF53901. SSF53901. 2 hits.
    PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P23418-1 [UniParc]FASTAAdd to Basket

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    MVTVEEYRKA QRAEGPATIL AIGTSTPSNC VDQSTYPDYY FRITNSEHKT    50
    ELKEKFKRMC DKSMIKKRYM HLTEEILKEN PNMCAYMAPS LDARQDIVVV 100
    EVPKLGKRGT QKAIKEWGQP KSKITHLVFC TTSGVDMPAC DYQLAKLLPV 150
    RPSVKRLMMY QQGCFAGGTV LRLAKDLAEN NKGARVLVVC SEITAVTFRG 200
    PSESHLDSLV GQALFGDGAA AIIIGSDPII GVERPLFELV SAAQTLVPDS 250
    EGAIDGHLRE VGLTFHLLKD VPGLISKNIE KSLLEAFQPL GISDWNSLFW 300
    IAHPGGPAIL DQVELKLGLK PEKLRATREV LSNYGNMSSA CVLFILDEMR 350
    KASTKEGLGT TGEGLEWGVL FGFGPGLTVE TVVLHSVAA 389
    Length:389
    Mass (Da):42,552
    Last modified:April 1, 1993 - v2
    Checksum:i553DC69E5EA96A8B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55194 mRNA. Translation: CAA38980.1.
    PIRiS12223.
    RefSeqiNP_001234033.1. NM_001247104.1.
    UniGeneiLes.16908.

    Genome annotation databases

    GeneIDi778294.
    KEGGisly:778294.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55194 mRNA. Translation: CAA38980.1 .
    PIRi S12223.
    RefSeqi NP_001234033.1. NM_001247104.1.
    UniGenei Les.16908.

    3D structure databases

    ProteinModelPortali P23418.
    SMRi P23418. Positions 3-388.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 778294.
    KEGGi sly:778294.

    Phylogenomic databases

    KOi K00660.

    Enzyme and pathway databases

    UniPathwayi UPA00154 .

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    InterProi IPR012328. Chalcone/stilbene_synth_C.
    IPR018088. Chalcone/stilbene_synthase_AS.
    IPR001099. Chalcone/stilbene_synthase_N.
    IPR011141. Polyketide_synthase_type-III.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF02797. Chal_sti_synt_C. 1 hit.
    PF00195. Chal_sti_synt_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000451. PKS_III. 1 hit.
    SUPFAMi SSF53901. SSF53901. 2 hits.
    PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular genetic analysis of chalcone synthase in Lycopersicon esculentum and an anthocyanin-deficient mutant."
      O'Neill S.D., Tong Y., Spoerlein B., Forkmann G., Yoder J.I.
      Mol. Gen. Genet. 224:279-288(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Cotyledon, Hypocotyl and Leaf.

    Entry informationi

    Entry nameiCHS1_SOLLC
    AccessioniPrimary (citable) accession number: P23418
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3