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P23418

- CHS1_SOLLC

UniProt

P23418 - CHS1_SOLLC

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Protein
Chalcone synthase 1
Gene
CHS1
Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei164 – 1641 By similarity

GO - Molecular functioni

  1. naringenin-chalcone synthase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. auxin polar transport Source: EnsemblPlants/Gramene
  2. flavonoid biosynthetic process Source: UniProtKB-UniPathway
  3. regulation of anthocyanin biosynthetic process Source: EnsemblPlants/Gramene
  4. response to UV-B Source: EnsemblPlants/Gramene
  5. response to auxin Source: EnsemblPlants/Gramene
  6. response to gravity Source: EnsemblPlants/Gramene
  7. response to jasmonic acid Source: EnsemblPlants/Gramene
  8. response to oxidative stress Source: EnsemblPlants/Gramene
  9. response to wounding Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase 1 (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase 1
Gene namesi
Name:CHS1
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
ProteomesiUP000004994: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: EnsemblPlants/Gramene
  2. nucleus Source: EnsemblPlants/Gramene
  3. plant-type vacuole membrane Source: EnsemblPlants/Gramene
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Chalcone synthase 1
PRO_0000216001Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP23418.
SMRiP23418. Positions 3-388.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00660.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23418-1 [UniParc]FASTAAdd to Basket

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MVTVEEYRKA QRAEGPATIL AIGTSTPSNC VDQSTYPDYY FRITNSEHKT    50
ELKEKFKRMC DKSMIKKRYM HLTEEILKEN PNMCAYMAPS LDARQDIVVV 100
EVPKLGKRGT QKAIKEWGQP KSKITHLVFC TTSGVDMPAC DYQLAKLLPV 150
RPSVKRLMMY QQGCFAGGTV LRLAKDLAEN NKGARVLVVC SEITAVTFRG 200
PSESHLDSLV GQALFGDGAA AIIIGSDPII GVERPLFELV SAAQTLVPDS 250
EGAIDGHLRE VGLTFHLLKD VPGLISKNIE KSLLEAFQPL GISDWNSLFW 300
IAHPGGPAIL DQVELKLGLK PEKLRATREV LSNYGNMSSA CVLFILDEMR 350
KASTKEGLGT TGEGLEWGVL FGFGPGLTVE TVVLHSVAA 389
Length:389
Mass (Da):42,552
Last modified:April 1, 1993 - v2
Checksum:i553DC69E5EA96A8B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55194 mRNA. Translation: CAA38980.1.
PIRiS12223.
RefSeqiNP_001234033.1. NM_001247104.1.
UniGeneiLes.16908.

Genome annotation databases

GeneIDi778294.
KEGGisly:778294.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55194 mRNA. Translation: CAA38980.1 .
PIRi S12223.
RefSeqi NP_001234033.1. NM_001247104.1.
UniGenei Les.16908.

3D structure databases

ProteinModelPortali P23418.
SMRi P23418. Positions 3-388.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 778294.
KEGGi sly:778294.

Phylogenomic databases

KOi K00660.

Enzyme and pathway databases

UniPathwayi UPA00154 .

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000451. PKS_III. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular genetic analysis of chalcone synthase in Lycopersicon esculentum and an anthocyanin-deficient mutant."
    O'Neill S.D., Tong Y., Spoerlein B., Forkmann G., Yoder J.I.
    Mol. Gen. Genet. 224:279-288(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Cotyledon, Hypocotyl and Leaf.

Entry informationi

Entry nameiCHS1_SOLLC
AccessioniPrimary (citable) accession number: P23418
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: April 1, 1993
Last modified: September 3, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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