P23415 (GLRA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycine receptor subunit alpha-1

Alternative name(s):
Glycine receptor 48 kDa subunit
Glycine receptor strychnine-binding subunit

Gene names

Name:

GLRA1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	457 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
Subunit structure	Pentamer composed of three alpha and two beta subunits. Homopentamers of alpha subunits also form functional receptors. Ref.6
Subcellular location	Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Involvement in disease	Hyperekplexia 1 (HKPX1) [MIM:149400]: A neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9 Ref.10 Ref.11 Ref.12 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18 Ref.19
Miscellaneous	The alpha subunit binds strychnine.
Sequence similarities	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Coding sequence diversity	Alternative splicing
Disease	Disease mutation
Domain	Signal Transmembrane Transmembrane helix
Ligand	Chloride
Molecular function	Chloride channel Ion channel Ligand-gated ion channel Receptor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	acrosome reaction Inferred from electronic annotation. Source: Compara adult walking behavior Inferred from electronic annotation. Source: Compara muscle contraction Inferred from mutant phenotype PubMed 11973623. Source: UniProtKB negative regulation of transmission of nerve impulse Inferred from mutant phenotype PubMed 11973623. Source: UniProtKB neuromuscular process controlling posture Inferred from electronic annotation. Source: Compara neuropeptide signaling pathway Inferred from direct assay Ref.1. Source: UniProtKB positive regulation of acrosome reaction Inferred from mutant phenotype PubMed 11751269. Source: UniProtKB protein heterooligomerization Inferred from electronic annotation. Source: Compara protein homooligomerization Inferred from electronic annotation. Source: Compara regulation of action potential Inferred from electronic annotation. Source: Compara regulation of inhibitory postsynaptic membrane potential Inferred from electronic annotation. Source: Compara regulation of membrane potential Inferred from mutant phenotype PubMed 7920629. Source: MGI regulation of respiratory gaseous exchange by neurological system process Inferred from electronic annotation. Source: Compara righting reflex Inferred from electronic annotation. Source: Compara startle response Inferred from mutant phenotype PubMed 11973623Ref.9. Source: UniProtKB synaptic transmission, glycinergic Inferred from electronic annotation. Source: Compara visual perception Inferred from electronic annotation. Source: Compara
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW chloride channel complex Inferred from electronic annotation. Source: UniProtKB-KW endoplasmic reticulum Inferred from electronic annotation. Source: Compara external side of plasma membrane Inferred from electronic annotation. Source: Compara integral to plasma membrane Inferred from direct assay PubMed 7506679. Source: UniProtKB intracellular membrane-bounded organelle Inferred from direct assay PubMed 7506679. Source: UniProtKB postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	extracellular-glycine-gated chloride channel activity Inferred from direct assay Ref.1PubMed 8137830. Source: UniProtKB glycine binding Inferred from direct assay PubMed 15748848Ref.1. Source: UniProtKB taurine binding Inferred from direct assay PubMed 15748848. Source: UniProtKB transmitter-gated ion channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform a (identifier: P23415-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform b (identifier: P23415-2)

The sequence of this isoform differs from the canonical sequence as follows:
     354-361: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 28

28

Potential

Chain

29 – 457

429

Glycine receptor subunit alpha-1

PRO_0000000412

Regions

Topological domain

29 – 247

219

Extracellular Probable

Transmembrane

248 – 274

27

Helical; Probable

Transmembrane

281 – 298

18

Helical; Probable

Transmembrane

313 – 336

24

Helical; Probable

Topological domain

337 – 428

92

Cytoplasmic Probable

Transmembrane

429 – 446

18

Helical; Probable

Region

225 – 230

6

Strychnine-binding By similarity

Amino acid modifications

Glycosylation

66

1

N-linked (GlcNAc...) Probable

Disulfide bond

166 ↔ 180

Ref.5

Disulfide bond

226 ↔ 237

Ref.5

Natural variations

Alternative sequence

354 – 361

8

Missing in isoform b.

VSP_021142

Natural variant

272

1

I → N in HKPX1. Ref.13

VAR_000296

Natural variant

278

1

P → T in HKPX1. Ref.19

VAR_010112

Natural variant

280

1

R → H in HKPX1. Ref.18

VAR_010113

Natural variant

294

1

Q → H in HKPX1. Ref.15

VAR_000297

Natural variant

299

1

R → L in HKPX1; decreased potency of glycine to activate the channel. Ref.9 Ref.11 Ref.12

VAR_000298

Natural variant

299

1

R → Q in HKPX1; decreased potency of glycine to activate the channel. Ref.9 Ref.11

VAR_000299

Natural variant

304

1

K → E in HKPX1. Ref.16 Ref.17

VAR_000300

Natural variant

307

1

Y → C in HKPX1. Ref.10 Ref.14

VAR_000301

Natural variant

428

1

R → H in HKPX1. Ref.18

VAR_010114

Experimental info

Sequence conflict

12 – 14

3

WET → SGA in CAA36258. Ref.1

Sequence conflict

33

1

P → T in CAA36258. Ref.1

Secondary structure

1

.

.

.

.

.

.

.

.

.

457

Helix Strand Turn

Details...

Helix

279 – 291

13

Beta strand

294 – 301

8

Helix

305 – 313

9

Helix

315 – 335

21

Sequences

	Sequence		Length	Mass (Da)
	Isoform a [UniParc]. Last modified October 17, 2006. Version 2. Checksum: 5ED80AF62B06A3AA	FASTA	457	52,624
	10 20 30 40 50 60 MYSFNTLRLY LWETIVFFSL AASKEAEAAR SAPKPMSPSD FLDKLMGRTS GYDARIRPNF 70 80 90 100 110 120 KGPPVNVSCN IFINSFGSIA ETTMDYRVNI FLRQQWNDPR LAYNEYPDDS LDLDPSMLDS 130 140 150 160 170 180 IWKPDLFFAN EKGAHFHEIT TDNKLLRISR NGNVLYSIRI TLTLACPMDL KNFPMDVQTC 190 200 210 220 230 240 IMQLESFGYT MNDLIFEWQE QGAVQVADGL TLPQFILKEE KDLRYCTKHY NTGKFTCIEA 250 260 270 280 290 300 RFHLERQMGY YLIQMYIPSL LIVILSWISF WINMDAAPAR VGLGITTVLT MTTQSSGSRA 310 320 330 340 350 360 SLPKVSYVKA IDIWMAVCLL FVFSALLEYA AVNFVSRQHK ELLRFRRKRR HHKSPMLNLF 370 380 390 400 410 420 QEDEAGEGRF NFSAYGMGPA CLQAKDGISV KGANNSNTTN PPPAPSKSPE EMRKLFIQRA 430 440 450 KKIDKISRIG FPMAFLIFNM FYWIIYKIVR REDVHNQ
	Isoform b [UniParc]. Checksum: 8F6EEB28634E2A94	FASTA	449	51,693
	10 20 30 40 50 60 MYSFNTLRLY LWETIVFFSL AASKEAEAAR SAPKPMSPSD FLDKLMGRTS GYDARIRPNF 70 80 90 100 110 120 KGPPVNVSCN IFINSFGSIA ETTMDYRVNI FLRQQWNDPR LAYNEYPDDS LDLDPSMLDS 130 140 150 160 170 180 IWKPDLFFAN EKGAHFHEIT TDNKLLRISR NGNVLYSIRI TLTLACPMDL KNFPMDVQTC 190 200 210 220 230 240 IMQLESFGYT MNDLIFEWQE QGAVQVADGL TLPQFILKEE KDLRYCTKHY NTGKFTCIEA 250 260 270 280 290 300 RFHLERQMGY YLIQMYIPSL LIVILSWISF WINMDAAPAR VGLGITTVLT MTTQSSGSRA 310 320 330 340 350 360 SLPKVSYVKA IDIWMAVCLL FVFSALLEYA AVNFVSRQHK ELLRFRRKRR HHKEDEAGEG 370 380 390 400 410 420 RFNFSAYGMG PACLQAKDGI SVKGANNSNT TNPPPAPSKS PEEMRKLFIQ RAKKIDKISR 430 440 IGFPMAFLIF NMFYWIIYKI VRREDVHNQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes." Grenningloh G., Schmieden V., Schofield P.R., Seeburg P.H., Siddique T., Mohandas T.K., Becker C.-M., Betz H. EMBO J. 9:771-776(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A AND B).
[5]	"Mapping of disulfide bonds within the amino-terminal extracellular domain of the inhibitory glycine receptor." Vogel N., Kluck C.J., Melzer N., Schwarzinger S., Breitinger U., Seeber S., Becker C.M. J. Biol. Chem. 284:36128-36136(2009) [PubMed] [Europe PMC] [Abstract] Cited for: DISULFIDE BONDS.
[6]	"Stoichiometry of the human glycine receptor revealed by direct subunit counting." Durisic N., Godin A.G., Wever C.M., Heyes C.D., Lakadamyali M., Dent J.A. J. Neurosci. 32:12915-12920(2012) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT STOICHIOMETRY.
[7]	"NMR structure and backbone dynamics of the extended second transmembrane domain of the human neuronal glycine receptor alpha1 subunit." Yushmanov V.E., Mandal P.K., Liu Z., Tang P., Xu Y. Biochemistry 42:3989-3995(2003) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 277-304.
[8]	"Structure and dynamics of the second and third transmembrane domains of human glycine receptor." Ma D., Liu Z., Li L., Tang P., Xu Y. Biochemistry 44:8790-8800(2005) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 278-337.
[9]	"Mutations in the alpha 1 subunit of the inhibitory glycine receptor cause the dominant neurologic disorder, hyperekplexia." Shiang R., Ryan S.G., Zhu Y.-Z., Hahn A.F., O'Connell P., Wasmuth J.J. Nat. Genet. 5:351-357(1993) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS HKPX1 LEU-299 AND GLN-299.
[10]	"Mutational and haplotype analysis of the aplha1 subunit of the glycine receptor in hyperekplexia patients." Shiang R., Ryan S.G., Zhu Y.-Z., O'Connell P., Wasmuth J.J. Am. J. Hum. Genet. 55:A242-A242(1994) Cited for: VARIANT HKPX1 CYS-307.
[11]	"Decreased agonist affinity and chloride conductance of mutant glycine receptors associated with human hereditary hyperekplexia." Langosch D., Laube B., Runstroem N., Schmieden V., Bormann J., Betz H. EMBO J. 13:4223-4228(1994) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION OF VARIANTS HKPX1 LEU-299 AND GLN-299.
[12]	"An additional family with Startle disease and a G1192A mutation at the alpha 1 subunit of the inhibitory glycine receptor gene." Schorderet D.F., Pescia G., Bernasconi A., Regli F. Hum. Mol. Genet. 3:1201-1201(1994) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT HKPX1 LEU-299.
[13]	"Evidence for recessive as well as dominant forms of startle disease (hyperekplexia) caused by mutations in the alpha 1 subunit of the inhibitory glycine receptor." Rees M.I., Andrew M., Jawad S., Owen M.J. Hum. Mol. Genet. 3:2175-2179(1994) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT HKPX1 ASN-272.
[14]	"Mutational analysis of familial and sporadic hyperekplexia." Shiang R., Ryan S.G., Zhu Y.-Z., Fielder T.J., Allen R.J., Fryer A., Yamashita S., O'Connell P., Wasmuth J.J. Ann. Neurol. 38:85-91(1995) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT HKPX1 CYS-307.
[15]	"A novel mutation (Gln266-->His) in the alpha 1 subunit of the inhibitory glycine-receptor gene (GLRA1) in hereditary hyperekplexia." Milani N., Dalpra L., del Prete A., Zanini R., Larizza L. Am. J. Hum. Genet. 58:420-422(1996) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT HKPX1 HIS-294.
[16]	"Analysis of GLRA1 in hereditary and sporadic hyperekplexia: a novel mutation in a family cosegregating for hyperekplexia and spastic paraparesis." Elmslie F.V., Hutchings S.M., Spencer V., Curtis A., Covanis T., Gardiner R.M., Rees M. J. Med. Genet. 33:435-436(1996) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT HKPX1 GLU-304.
[17]	"Startle disease in an Italian family by mutation (K276E): the alpha-subunit of the inhibiting glycine receptor." Seri M., Bolino A., Galietta L.J.V., Lerone M., Silengo M., Romeo G. Hum. Mutat. 9:185-187(1997) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT HKPX1 GLU-304.
[18]	"Hyperekplexia phenotype due to compound heterozygosity for GLRA1 gene mutations." Vergouwe M.N., Tijssen M.A., Peters A.C., Wielaard R., Frants R.R. Ann. Neurol. 46:634-638(1999) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS HKPX1 HIS-280 AND HIS-428.
[19]	"Novel GLRA1 missense mutation (P250T) in dominant hyperekplexia defines an intracellular determinant of glycine receptor channel gating." Saul B., Kuner T., Sobetzko D., Brune W., Hanefeld F., Meinck H.-M., Becker C.-M. J. Neurosci. 19:869-877(1999) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT HKPX1 THR-278.
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X52009 mRNA. Translation: CAA36258.1.
AK312702 mRNA. Translation: BAG35580.1.
CH471062 Genomic DNA. Translation: EAW61657.1.
BC074980 mRNA. Translation: AAH74980.1.
BC114947 mRNA. Translation: AAI14948.1.

IPI

IPI00011565.
IPI00795343.

PIR

S12382.

RefSeq

NP_000162.2. NM_000171.3.
NP_001139512.1. NM_001146040.1.

UniGene

Hs.121490.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1MOT	NMR	-	A	277-304	[»]
1VRY	NMR	-	A	278-337	[»]

ProteinModelPortal

P23415.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-48768N.

STRING

9606.ENSP00000274576.

Protein family/group databases

TCDB

1.A.9.3.1. neurotransmitter receptor, cys loop, ligand-gated ion channel (LIC) family.

PTM databases

PhosphoSite

P23415.

Polymorphism databases

DMDM

116242495.

Proteomic databases

PaxDb

P23415.

PRIDE

P23415.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000274576; ENSP00000274576; ENSG00000145888.
ENST00000455880; ENSP00000411593; ENSG00000145888.

GeneID

2741.

KEGG

hsa:2741.

UCSC

uc003lur.3. human.
uc003lut.3. human.

Organism-specific databases

CTD

2741.

GeneCards

GC05M151182.

HGNC

HGNC:4326. GLRA1.

HPA

HPA016502.

MIM

138491. gene.
149400. phenotype.

neXtProt

NX_P23415.

Orphanet

3197. Hereditary hyperekplexia.

PharmGKB

PA28727.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG265706.

HOGENOM

HOG000231336.

HOVERGEN

HBG051707.

InParanoid

P23415.

KO

K05193.

OMA

NTANPVP.

OrthoDB

EOG4TF0KF.

Enzyme and pathway databases

Reactome

REACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpress

P23415.

Bgee

P23415.

CleanEx

HS_GLRA1.

Genevestigator

P23415.

GermOnline

ENSG00000145888. Homo sapiens.

Family and domain databases

Gene3D

2.70.170.10. 1 hit.

InterPro

IPR006028. GABAA_rcpt.
IPR008127. Glycine_rcpt_A.
IPR008128. Glycine_rcpt_A1.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]

PANTHER

PTHR18945. PTHR18945. 1 hit.

Pfam

PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 2 hits.
[Graphical view]

PRINTS

PR00253. GABAARECEPTR.
PR01673. GLYRALPHA.
PR01674. GLYRALPHA1.
PR00252. NRIONCHANNEL.

SUPFAM

SSF90112. Neu_channel_TM. 1 hit.
SSF63712. Neur_chan_LBD. 1 hit.

TIGRFAMs

TIGR00860. LIC. 1 hit.

PROSITE

PS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

P23415.

ChEMBL

CHEMBL5845.

DrugBank

DB01189. Desflurane.
DB00228. Enflurane.
DB00898. Ethanol.
DB00145. Glycine.
DB01159. Halothane.
DB00753. Isoflurane.
DB01028. Methoxyflurane.
DB01236. Sevoflurane.

EvolutionaryTrace

P23415.

GenomeRNAi

2741.

NextBio

10804.

SOURCE

Search...

Entry information

Entry name

GLRA1_HUMAN

Accession

Primary (citable) accession number: P23415
Secondary accession number(s): B2R6T3, Q14C77, Q6DJV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	October 17, 2006
Last modified:	May 29, 2013
This is version 149 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.