##gff-version 3 P23378 UniProtKB Transit peptide 1 35 . . . Note=Mitochondrion;Ontology_term=ECO:0000255;evidence=ECO:0000255 P23378 UniProtKB Chain 36 1020 . . . ID=PRO_0000010740;Note=Glycine dehydrogenase (decarboxylating)%2C mitochondrial P23378 UniProtKB Region 21 46 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P23378 UniProtKB Modified residue 447 447 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91W43 P23378 UniProtKB Modified residue 514 514 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91W43 P23378 UniProtKB Modified residue 648 648 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91W43 P23378 UniProtKB Modified residue 664 664 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91W43 P23378 UniProtKB Modified residue 754 754 . . . Note=N6-(pyridoxal phosphate)lysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15505 P23378 UniProtKB Natural variant 146 146 . . . ID=VAR_078776;Note=In NKH%3B loss of glycine catabolic process%3B loss of expression. T->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28244183;Dbxref=dbSNP:rs376578742,PMID:28244183 P23378 UniProtKB Natural variant 173 173 . . . ID=VAR_078777;Note=In NKH%3B loss of glycine catabolic process%3B decreased abundance. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28244183;Dbxref=PMID:28244183 P23378 UniProtKB Natural variant 267 267 . . . ID=VAR_078778;Note=In NKH%3B decreased glycine catabolic process%3B changed localization to the mitochondria%3B also expressed diffusely throughout the cytosol%3B decreased abundance. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28244183;Dbxref=dbSNP:rs1554648117,PMID:28244183 P23378 UniProtKB Natural variant 283 283 . . . ID=VAR_016849;Note=In NKH. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11592811;Dbxref=dbSNP:rs386833589,PMID:11592811 P23378 UniProtKB Natural variant 329 329 . . . ID=VAR_016850;Note=In one non-ketotic hyperglycinemia patient. P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11592811;Dbxref=dbSNP:rs386833593,PMID:11592811 P23378 UniProtKB Natural variant 362 362 . . . ID=VAR_078779;Note=In NKH%3B decreased glycine catabolic process%3B decreased abundance. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28244183;Dbxref=dbSNP:rs10975674,PMID:28244183 P23378 UniProtKB Natural variant 373 373 . . . ID=VAR_078780;Note=In NKH%3B decreased glycine catabolic process%3B decreased abundance. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28244183;Dbxref=dbSNP:rs150171524,PMID:28244183 P23378 UniProtKB Natural variant 376 376 . . . ID=VAR_078781;Note=In NKH%3B decreased glycine catabolic process%3B decreased abundance. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28244183;Dbxref=dbSNP:rs774093619,PMID:28244183 P23378 UniProtKB Natural variant 461 461 . . . ID=VAR_078782;Note=In NKH%3B decreased glycine catabolic process%3B changed localization to the mitochondria%3B also expressed diffusely throughout the cytosol%3B decreased abundance. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28244183;Dbxref=dbSNP:rs761957837,PMID:28244183 P23378 UniProtKB Natural variant 515 515 . . . ID=VAR_016851;Note=In NKH. R->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11286506;Dbxref=dbSNP:rs121964976,PMID:11286506 P23378 UniProtKB Natural variant 548 548 . . . ID=VAR_078783;Note=In NKH%3B decreased GCSP-protein glycine exchange activity%3B no effect on abundance. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28244183;Dbxref=PMID:28244183 P23378 UniProtKB Natural variant 564 564 . . . ID=VAR_004979;Note=In NKH%3B common mutation in Finland. S->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1634607;Dbxref=dbSNP:rs121964974,PMID:1634607 P23378 UniProtKB Natural variant 580 580 . . . ID=VAR_078784;Note=In NKH%3B loss of glycine catabolic process%3B loss of expression. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28244183;Dbxref=PMID:28244183 P23378 UniProtKB Natural variant 581 581 . . . ID=VAR_078785;Note=In NKH%3B loss of glycine catabolic process%3B decreased abundance. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28244183;Dbxref=dbSNP:rs772871471,PMID:28244183 P23378 UniProtKB Natural variant 624 624 . . . ID=VAR_078786;Note=In NKH%3B loss of GCSP-protein glycine exchange activity%3B no effect on abundance. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28244183;Dbxref=PMID:28244183 P23378 UniProtKB Natural variant 756 756 . . . ID=VAR_009939;Note=In NKH. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1996985;Dbxref=PMID:1996985 P23378 UniProtKB Natural variant 763 763 . . . ID=VAR_078787;Note=In NKH%3B loss of GCSP-protein glycine exchange activity%3B no effect on abundance. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28244183;Dbxref=dbSNP:rs1374110692,PMID:28244183 P23378 UniProtKB Natural variant 768 768 . . . ID=VAR_078788;Note=In NKH%3B loss of GCSP-protein glycine exchange activity%3B no effect on abundance. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28244183;Dbxref=PMID:28244183 P23378 UniProtKB Natural variant 790 790 . . . ID=VAR_078789;Note=In NKH%3B decreased glycine catabolic process%3B decreased abundance. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28244183;Dbxref=dbSNP:rs386833556,PMID:28244183 P23378 UniProtKB Natural variant 839 839 . . . ID=VAR_079313;Note=In NKH. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28737873;Dbxref=PMID:28737873 P23378 UniProtKB Natural variant 866 866 . . . ID=VAR_078790;Note=In NKH%3B decreased glycine catabolic process%3B decreased abundance. D->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28244183;Dbxref=PMID:28244183 P23378 UniProtKB Natural variant 905 905 . . . ID=VAR_078791;Note=In NKH%3B decreased GCSP-protein glycine exchange activity%3B no effect on abundance. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28244183;Dbxref=dbSNP:rs188269735,PMID:28244183 P23378 UniProtKB Natural variant 933 933 . . . ID=VAR_078792;Note=In NKH%3B decreased glycine catabolic process%3B decreased abundance. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28244183;Dbxref=dbSNP:rs758029533,PMID:28244183 P23378 UniProtKB Natural variant 994 994 . . . ID=VAR_078793;Note=In NKH%3B loss of glycine catabolic process%3B loss of expression. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28244183;Dbxref=dbSNP:rs1406713104,PMID:28244183 P23378 UniProtKB Sequence conflict 396 396 . . . Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 P23378 UniProtKB Sequence conflict 441 441 . . . Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 P23378 UniProtKB Sequence conflict 608 608 . . . Note=Y->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 P23378 UniProtKB Sequence conflict 976 976 . . . Note=V->M;Ontology_term=ECO:0000305;evidence=ECO:0000305 P23378 UniProtKB Helix 52 56 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 64 67 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 72 81 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 87 94 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 97 99 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 113 124 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 145 150 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Turn 151 153 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 155 158 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 166 168 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 170 187 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Beta strand 190 192 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 199 214 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Beta strand 217 221 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 227 240 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Beta strand 243 246 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 249 251 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Beta strand 259 267 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 277 285 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Beta strand 289 294 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 298 300 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 305 308 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Beta strand 311 316 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Turn 318 321 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 325 327 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Beta strand 332 336 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 338 343 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Beta strand 349 354 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Beta strand 359 363 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 366 368 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 370 373 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 374 376 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 386 424 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Beta strand 428 430 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Beta strand 432 441 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 446 455 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Beta strand 468 471 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 478 487 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 494 500 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 508 510 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 523 526 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 531 543 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Turn 548 550 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Turn 556 558 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 565 568 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 569 572 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 574 577 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 585 587 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 589 606 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Beta strand 609 612 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 618 635 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Beta strand 643 647 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 653 660 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Beta strand 664 668 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Beta strand 674 676 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 678 688 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Turn 689 691 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Beta strand 692 700 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 710 718 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Turn 719 721 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Beta strand 723 727 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 728 733 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Turn 734 737 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 740 742 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Beta strand 746 749 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 752 755 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Turn 761 763 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Beta strand 770 772 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 774 779 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Beta strand 784 786 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Beta strand 791 793 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I34 P23378 UniProtKB Beta strand 801 803 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 808 810 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 811 844 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Turn 845 847 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Beta strand 848 850 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Beta strand 863 866 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 869 874 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 878 887 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Beta strand 893 896 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Beta strand 903 905 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 913 934 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Beta strand 940 943 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 944 947 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 952 956 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 966 970 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 978 980 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Beta strand 985 987 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35 P23378 UniProtKB Helix 991 996 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I35