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P23378

- GCSP_HUMAN

UniProt

P23378 - GCSP_HUMAN

Protein

Glycine dehydrogenase (decarboxylating), mitochondrial

Gene

GLDC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH).

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.

    Cofactori

    Pyridoxal phosphate.

    Enzyme regulationi

    Stimulated by lipoic acid. Inhibited in presence of methylamine By similarity.By similarity

    GO - Molecular functioni

    1. electron carrier activity Source: UniProtKB
    2. glycine dehydrogenase (decarboxylating) activity Source: ProtInc
    3. lyase activity Source: InterPro
    4. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine catabolic process Source: ProtInc

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciMetaCyc:HS00622-MONOMER.
    SABIO-RKP23378.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating), mitochondrial (EC:1.4.4.2)
    Alternative name(s):
    Glycine cleavage system P protein
    Glycine decarboxylase
    Glycine dehydrogenase (aminomethyl-transferring)
    Gene namesi
    Name:GLDC
    Synonyms:GCSP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:4313. GLDC.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Involvement in diseasei

    Non-ketotic hyperglycinemia (NKH) [MIM:605899]: Autosomal recessive disease characterized by accumulation of a large amount of glycine in body fluid and by severe neurological symptoms.4 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti283 – 2831A → P in NKH. 1 Publication
    VAR_016849
    Natural varianti515 – 5151R → S in NKH. 1 Publication
    Corresponds to variant rs121964976 [ dbSNP | Ensembl ].
    VAR_016851
    Natural varianti564 – 5641S → I in NKH; common mutation in Finland. 1 Publication
    VAR_004979
    Natural varianti756 – 7561Missing in NKH. 1 Publication
    VAR_009939

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi605899. phenotype.
    Orphaneti289863. Atypical glycine encephalopathy.
    289860. Infantile glycine encephalopathy.
    289857. Neonatal glycine encephalopathy.
    PharmGKBiPA28716.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3535MitochondrionSequence AnalysisAdd
    BLAST
    Chaini36 – 1020985Glycine dehydrogenase (decarboxylating), mitochondrialPRO_0000010740Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei447 – 4471N6-acetyllysineBy similarity
    Modified residuei514 – 5141N6-acetyllysineBy similarity
    Modified residuei648 – 6481N6-acetyllysineBy similarity
    Modified residuei664 – 6641N6-acetyllysineBy similarity
    Modified residuei754 – 7541N6-(pyridoxal phosphate)lysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP23378.
    PaxDbiP23378.
    PRIDEiP23378.

    PTM databases

    PhosphoSiteiP23378.

    Expressioni

    Gene expression databases

    BgeeiP23378.
    CleanExiHS_GLDC.
    GenevestigatoriP23378.

    Organism-specific databases

    HPAiHPA002318.

    Interactioni

    Subunit structurei

    Interacts with GCSH By similarity. Homodimer. The glycine cleavage system is composed of four proteins: P (GLDC), T (GCST), L (DLD) and H (GCSH).By similarity

    Protein-protein interaction databases

    BioGridi108993. 5 interactions.
    IntActiP23378. 6 interactions.
    MINTiMINT-7554996.
    STRINGi9606.ENSP00000370737.

    Structurei

    3D structure databases

    ProteinModelPortaliP23378.
    SMRiP23378. Positions 46-1005.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    HOVERGENiHBG005820.
    KOiK00281.
    OMAiAELMPVS.
    OrthoDBiEOG7FJGZQ.
    PhylomeDBiP23378.
    TreeFamiTF300678.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR001597. ArAA_b-elim_lyase/Thr_aldolase.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF01212. Beta_elim_lyase. 1 hit.
    PF02347. GDC-P. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P23378-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQSCARAWGL RLGRGVGGGR RLAGGSGPCW APRSRDSSSG GGDSAAAGAS     50
    RLLERLLPRH DDFARRHIGP GDKDQREMLQ TLGLASIDEL IEKTVPANIR 100
    LKRPLKMEDP VCENEILATL HAISSKNQIW RSYIGMGYYN CSVPQTILRN 150
    LLENSGWITQ YTPYQPEVSQ GRLESLLNYQ TMVCDITGLD MANASLLDEG 200
    TAAAEALQLC YRHNKRRKFL VDPRCHPQTI AVVQTRAKYT GVLTELKLPC 250
    EMDFSGKDVS GVLFQYPDTE GKVEDFTELV ERAHQSGSLA CCATDLLALC 300
    ILRPPGEFGV DIALGSSQRF GVPLGYGGPH AAFFAVRESL VRMMPGRMVG 350
    VTRDATGKEV YRLALQTREQ HIRRDKATSN ICTAQALLAN MAAMFAIYHG 400
    SHGLEHIARR VHNATLILSE GLKRAGHQLQ HDLFFDTLKI QCGCSVKEVL 450
    GRAAQRQINF RLFEDGTLGI SLDETVNEKD LDDLLWIFGC ESSAELVAES 500
    MGEECRGIPG SVFKRTSPFL THQVFNSYHS ETNIVRYMKK LENKDISLVH 550
    SMIPLGSCTM KLNSSSELAP ITWKEFANIH PFVPLDQAQG YQQLFRELEK 600
    DLCELTGYDQ VCFQPNSGAQ GEYAGLATIR AYLNQKGEGH RTVCLIPKSA 650
    HGTNPASAHM AGMKIQPVEV DKYGNIDAVH LKAMVDKHKE NLAAIMITYP 700
    STNGVFEENI SDVCDLIHQH GGQVYLDGAN MNAQVGICRP GDFGSDVSHL 750
    NLHKTFCIPH GGGGPGMGPI GVKKHLAPFL PNHPVISLKR NEDACPVGTV 800
    SAAPWGSSSI LPISWAYIKM MGGKGLKQAT ETAILNANYM AKRLETHYRI 850
    LFRGARGYVG HEFILDTRPF KKSANIEAVD VAKRLQDYGF HAPTMSWPVA 900
    GTLMVEPTES EDKAELDRFC DAMISIRQEI ADIEEGRIDP RVNPLKMSPH 950
    SLTCVTSSHW DRPYSREVAA FPLPFVKPEN KFWPTIARID DIYGDQHLVC 1000
    TCPPMEVYES PFSEQKRASS 1020
    Length:1,020
    Mass (Da):112,730
    Last modified:May 5, 2009 - v2
    Checksum:i8FAEA7D56BEB17B2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti396 – 3961A → R in AAA36463. (PubMed:1993704)Curated
    Sequence conflicti396 – 3961A → R in BAA14286. (PubMed:1993704)Curated
    Sequence conflicti441 – 4411Q → H in AAA36478. (PubMed:1996985)Curated
    Sequence conflicti441 – 4411Q → H in AAA36463. (PubMed:1993704)Curated
    Sequence conflicti441 – 4411Q → H in BAA14286. (PubMed:1993704)Curated
    Sequence conflicti608 – 6081Y → H in AAA36478. (PubMed:1996985)Curated
    Sequence conflicti976 – 9761V → M in AAA36463. (PubMed:1993704)Curated
    Sequence conflicti976 – 9761V → M in BAA14286. (PubMed:1993704)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti283 – 2831A → P in NKH. 1 Publication
    VAR_016849
    Natural varianti329 – 3291P → T in one non-ketotic hyperglycinemia patient. 1 Publication
    VAR_016850
    Natural varianti515 – 5151R → S in NKH. 1 Publication
    Corresponds to variant rs121964976 [ dbSNP | Ensembl ].
    VAR_016851
    Natural varianti564 – 5641S → I in NKH; common mutation in Finland. 1 Publication
    VAR_004979
    Natural varianti756 – 7561Missing in NKH. 1 Publication
    VAR_009939

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M63635 mRNA. Translation: AAA36478.1.
    M64590 mRNA. Translation: AAA36463.1.
    D90239 mRNA. Translation: BAA14286.1.
    AK314156 mRNA. Translation: BAG36841.1.
    AL353718, AL162411 Genomic DNA. Translation: CAQ07607.1.
    AL162411, AL353718 Genomic DNA. Translation: CAQ10367.1.
    CH471071 Genomic DNA. Translation: EAW58740.1.
    BC111993 mRNA. Translation: AAI11994.1.
    BC111995 mRNA. Translation: AAI11996.1.
    CCDSiCCDS34987.1.
    PIRiJN0124.
    RefSeqiNP_000161.2. NM_000170.2.
    UniGeneiHs.584238.

    Genome annotation databases

    EnsembliENST00000321612; ENSP00000370737; ENSG00000178445.
    GeneIDi2731.
    KEGGihsa:2731.
    UCSCiuc003zkc.3. human.

    Polymorphism databases

    DMDMi229462870.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M63635 mRNA. Translation: AAA36478.1 .
    M64590 mRNA. Translation: AAA36463.1 .
    D90239 mRNA. Translation: BAA14286.1 .
    AK314156 mRNA. Translation: BAG36841.1 .
    AL353718 , AL162411 Genomic DNA. Translation: CAQ07607.1 .
    AL162411 , AL353718 Genomic DNA. Translation: CAQ10367.1 .
    CH471071 Genomic DNA. Translation: EAW58740.1 .
    BC111993 mRNA. Translation: AAI11994.1 .
    BC111995 mRNA. Translation: AAI11996.1 .
    CCDSi CCDS34987.1.
    PIRi JN0124.
    RefSeqi NP_000161.2. NM_000170.2.
    UniGenei Hs.584238.

    3D structure databases

    ProteinModelPortali P23378.
    SMRi P23378. Positions 46-1005.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108993. 5 interactions.
    IntActi P23378. 6 interactions.
    MINTi MINT-7554996.
    STRINGi 9606.ENSP00000370737.

    Chemistry

    DrugBanki DB00145. Glycine.
    DB00114. Pyridoxal Phosphate.

    PTM databases

    PhosphoSitei P23378.

    Polymorphism databases

    DMDMi 229462870.

    Proteomic databases

    MaxQBi P23378.
    PaxDbi P23378.
    PRIDEi P23378.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000321612 ; ENSP00000370737 ; ENSG00000178445 .
    GeneIDi 2731.
    KEGGi hsa:2731.
    UCSCi uc003zkc.3. human.

    Organism-specific databases

    CTDi 2731.
    GeneCardsi GC09M006522.
    GeneReviewsi GLDC.
    H-InvDB HIX0034882.
    HGNCi HGNC:4313. GLDC.
    HPAi HPA002318.
    MIMi 238300. gene.
    605899. phenotype.
    neXtProti NX_P23378.
    Orphaneti 289863. Atypical glycine encephalopathy.
    289860. Infantile glycine encephalopathy.
    289857. Neonatal glycine encephalopathy.
    PharmGKBi PA28716.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    HOVERGENi HBG005820.
    KOi K00281.
    OMAi AELMPVS.
    OrthoDBi EOG7FJGZQ.
    PhylomeDBi P23378.
    TreeFami TF300678.

    Enzyme and pathway databases

    BioCyci MetaCyc:HS00622-MONOMER.
    SABIO-RK P23378.

    Miscellaneous databases

    GeneWikii Glycine_dehydrogenase_(decarboxylating).
    GenomeRNAii 2731.
    NextBioi 10764.
    PROi P23378.
    SOURCEi Search...

    Gene expression databases

    Bgeei P23378.
    CleanExi HS_GLDC.
    Genevestigatori P23378.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR001597. ArAA_b-elim_lyase/Thr_aldolase.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF01212. Beta_elim_lyase. 1 hit.
    PF02347. GDC-P. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Structural and expression analyses of normal and mutant mRNA encoding glycine decarboxylase: three-base deletion in mRNA causes nonketotic hyperglycinemia."
      Kure S., Narisawa K., Tada K.
      Biochem. Biophys. Res. Commun. 174:1176-1182(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT NKH PHE-756 DEL.
    2. "The glycine cleavage system. Molecular cloning of the chicken and human glycine decarboxylase cDNAs and some characteristics involved in the deduced protein structures."
      Kume A., Koyata H., Sakakibara T., Ishiguro Y., Kure S., Hiraga K.
      J. Biol. Chem. 266:3323-3329(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Identification of a common mutation in Finnish patients with nonketotic hyperglycinemia."
      Kure S., Takayanagi M., Narisawa K., Tada K., Leisti J.
      J. Clin. Invest. 90:160-164(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT NKH ILE-564.
    10. "Recurrent mutations in P- and T-proteins of the glycine cleavage complex and a novel T-protein mutation (N145I): a strategy for the molecular investigation of patients with nonketotic hyperglycinemia (NKH)."
      Toone J.R., Applegarth D.A., Coulter-Mackie M.B., James E.R.
      Mol. Genet. Metab. 72:322-325(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT NKH SER-515.
    11. "Nonketotic hyperglycinemia (glycine encephalopathy): laboratory diagnosis."
      Applegarth D.A., Toone J.R.
      Mol. Genet. Metab. 74:139-146(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT NKH PRO-283, VARIANT THR-329.

    Entry informationi

    Entry nameiGCSP_HUMAN
    AccessioniPrimary (citable) accession number: P23378
    Secondary accession number(s): Q2M2F8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 136 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3