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P23378

- GCSP_HUMAN

UniProt

P23378 - GCSP_HUMAN

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Protein
Glycine dehydrogenase (decarboxylating), mitochondrial
Gene
GLDC, GCSP
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH).UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.

Enzyme regulationi

Stimulated by lipoic acid. Inhibited in presence of methylamine By similarity.UniRule annotation

GO - Molecular functioni

  1. electron carrier activity Source: UniProtKB
  2. glycine dehydrogenase (decarboxylating) activity Source: ProtInc
  3. lyase activity Source: InterPro
  4. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:HS00622-MONOMER.
SABIO-RKP23378.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating), mitochondrial (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:GLDC
Synonyms:GCSP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:4313. GLDC.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Involvement in diseasei

Non-ketotic hyperglycinemia (NKH) [MIM:605899]: Autosomal recessive disease characterized by accumulation of a large amount of glycine in body fluid and by severe neurological symptoms.
Note: The disease is caused by mutations affecting the gene represented in this entry.4 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti283 – 2831A → P in NKH. 1 Publication
VAR_016849
Natural varianti515 – 5151R → S in NKH. 1 Publication
Corresponds to variant rs121964976 [ dbSNP | Ensembl ].
VAR_016851
Natural varianti564 – 5641S → I in NKH; common mutation in Finland. 1 Publication
VAR_004979
Natural varianti756 – 7561Missing in NKH. 1 Publication
VAR_009939

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi605899. phenotype.
Orphaneti289863. Atypical glycine encephalopathy.
289860. Infantile glycine encephalopathy.
289857. Neonatal glycine encephalopathy.
PharmGKBiPA28716.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3535Mitochondrion Reviewed prediction
Add
BLAST
Chaini36 – 1020985Glycine dehydrogenase (decarboxylating), mitochondrialUniRule annotation
PRO_0000010740Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei447 – 4471N6-acetyllysine By similarity
Modified residuei514 – 5141N6-acetyllysine By similarity
Modified residuei648 – 6481N6-acetyllysine By similarity
Modified residuei664 – 6641N6-acetyllysine By similarity
Modified residuei754 – 7541N6-(pyridoxal phosphate)lysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP23378.
PaxDbiP23378.
PRIDEiP23378.

PTM databases

PhosphoSiteiP23378.

Expressioni

Gene expression databases

BgeeiP23378.
CleanExiHS_GLDC.
GenevestigatoriP23378.

Organism-specific databases

HPAiHPA002318.

Interactioni

Subunit structurei

Interacts with GCSH By similarity. Homodimer. The glycine cleavage system is composed of four proteins: P (GLDC), T (GCST), L (DLD) and H (GCSH).UniRule annotation

Protein-protein interaction databases

BioGridi108993. 5 interactions.
IntActiP23378. 6 interactions.
MINTiMINT-7554996.
STRINGi9606.ENSP00000370737.

Structurei

3D structure databases

ProteinModelPortaliP23378.
SMRiP23378. Positions 46-1005.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
HOVERGENiHBG005820.
KOiK00281.
OMAiAELMPVS.
OrthoDBiEOG7FJGZQ.
PhylomeDBiP23378.
TreeFamiTF300678.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR001597. ArAA_b-elim_lyase/Thr_aldolase.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF01212. Beta_elim_lyase. 1 hit.
PF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23378-1 [UniParc]FASTAAdd to Basket

« Hide

MQSCARAWGL RLGRGVGGGR RLAGGSGPCW APRSRDSSSG GGDSAAAGAS     50
RLLERLLPRH DDFARRHIGP GDKDQREMLQ TLGLASIDEL IEKTVPANIR 100
LKRPLKMEDP VCENEILATL HAISSKNQIW RSYIGMGYYN CSVPQTILRN 150
LLENSGWITQ YTPYQPEVSQ GRLESLLNYQ TMVCDITGLD MANASLLDEG 200
TAAAEALQLC YRHNKRRKFL VDPRCHPQTI AVVQTRAKYT GVLTELKLPC 250
EMDFSGKDVS GVLFQYPDTE GKVEDFTELV ERAHQSGSLA CCATDLLALC 300
ILRPPGEFGV DIALGSSQRF GVPLGYGGPH AAFFAVRESL VRMMPGRMVG 350
VTRDATGKEV YRLALQTREQ HIRRDKATSN ICTAQALLAN MAAMFAIYHG 400
SHGLEHIARR VHNATLILSE GLKRAGHQLQ HDLFFDTLKI QCGCSVKEVL 450
GRAAQRQINF RLFEDGTLGI SLDETVNEKD LDDLLWIFGC ESSAELVAES 500
MGEECRGIPG SVFKRTSPFL THQVFNSYHS ETNIVRYMKK LENKDISLVH 550
SMIPLGSCTM KLNSSSELAP ITWKEFANIH PFVPLDQAQG YQQLFRELEK 600
DLCELTGYDQ VCFQPNSGAQ GEYAGLATIR AYLNQKGEGH RTVCLIPKSA 650
HGTNPASAHM AGMKIQPVEV DKYGNIDAVH LKAMVDKHKE NLAAIMITYP 700
STNGVFEENI SDVCDLIHQH GGQVYLDGAN MNAQVGICRP GDFGSDVSHL 750
NLHKTFCIPH GGGGPGMGPI GVKKHLAPFL PNHPVISLKR NEDACPVGTV 800
SAAPWGSSSI LPISWAYIKM MGGKGLKQAT ETAILNANYM AKRLETHYRI 850
LFRGARGYVG HEFILDTRPF KKSANIEAVD VAKRLQDYGF HAPTMSWPVA 900
GTLMVEPTES EDKAELDRFC DAMISIRQEI ADIEEGRIDP RVNPLKMSPH 950
SLTCVTSSHW DRPYSREVAA FPLPFVKPEN KFWPTIARID DIYGDQHLVC 1000
TCPPMEVYES PFSEQKRASS 1020
Length:1,020
Mass (Da):112,730
Last modified:May 5, 2009 - v2
Checksum:i8FAEA7D56BEB17B2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti283 – 2831A → P in NKH. 1 Publication
VAR_016849
Natural varianti329 – 3291P → T in one non-ketotic hyperglycinemia patient. 1 Publication
VAR_016850
Natural varianti515 – 5151R → S in NKH. 1 Publication
Corresponds to variant rs121964976 [ dbSNP | Ensembl ].
VAR_016851
Natural varianti564 – 5641S → I in NKH; common mutation in Finland. 1 Publication
VAR_004979
Natural varianti756 – 7561Missing in NKH. 1 Publication
VAR_009939

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti396 – 3961A → R in AAA36463. 1 Publication
Sequence conflicti396 – 3961A → R in BAA14286. 1 Publication
Sequence conflicti441 – 4411Q → H in AAA36478. 1 Publication
Sequence conflicti441 – 4411Q → H in AAA36463. 1 Publication
Sequence conflicti441 – 4411Q → H in BAA14286. 1 Publication
Sequence conflicti608 – 6081Y → H in AAA36478. 1 Publication
Sequence conflicti976 – 9761V → M in AAA36463. 1 Publication
Sequence conflicti976 – 9761V → M in BAA14286. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M63635 mRNA. Translation: AAA36478.1.
M64590 mRNA. Translation: AAA36463.1.
D90239 mRNA. Translation: BAA14286.1.
AK314156 mRNA. Translation: BAG36841.1.
AL353718, AL162411 Genomic DNA. Translation: CAQ07607.1.
AL162411, AL353718 Genomic DNA. Translation: CAQ10367.1.
CH471071 Genomic DNA. Translation: EAW58740.1.
BC111993 mRNA. Translation: AAI11994.1.
BC111995 mRNA. Translation: AAI11996.1.
CCDSiCCDS34987.1.
PIRiJN0124.
RefSeqiNP_000161.2. NM_000170.2.
UniGeneiHs.584238.

Genome annotation databases

EnsembliENST00000321612; ENSP00000370737; ENSG00000178445.
GeneIDi2731.
KEGGihsa:2731.
UCSCiuc003zkc.3. human.

Polymorphism databases

DMDMi229462870.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M63635 mRNA. Translation: AAA36478.1 .
M64590 mRNA. Translation: AAA36463.1 .
D90239 mRNA. Translation: BAA14286.1 .
AK314156 mRNA. Translation: BAG36841.1 .
AL353718 , AL162411 Genomic DNA. Translation: CAQ07607.1 .
AL162411 , AL353718 Genomic DNA. Translation: CAQ10367.1 .
CH471071 Genomic DNA. Translation: EAW58740.1 .
BC111993 mRNA. Translation: AAI11994.1 .
BC111995 mRNA. Translation: AAI11996.1 .
CCDSi CCDS34987.1.
PIRi JN0124.
RefSeqi NP_000161.2. NM_000170.2.
UniGenei Hs.584238.

3D structure databases

ProteinModelPortali P23378.
SMRi P23378. Positions 46-1005.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108993. 5 interactions.
IntActi P23378. 6 interactions.
MINTi MINT-7554996.
STRINGi 9606.ENSP00000370737.

Chemistry

DrugBanki DB00145. Glycine.
DB00114. Pyridoxal Phosphate.

PTM databases

PhosphoSitei P23378.

Polymorphism databases

DMDMi 229462870.

Proteomic databases

MaxQBi P23378.
PaxDbi P23378.
PRIDEi P23378.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000321612 ; ENSP00000370737 ; ENSG00000178445 .
GeneIDi 2731.
KEGGi hsa:2731.
UCSCi uc003zkc.3. human.

Organism-specific databases

CTDi 2731.
GeneCardsi GC09M006522.
GeneReviewsi GLDC.
H-InvDB HIX0034882.
HGNCi HGNC:4313. GLDC.
HPAi HPA002318.
MIMi 238300. gene.
605899. phenotype.
neXtProti NX_P23378.
Orphaneti 289863. Atypical glycine encephalopathy.
289860. Infantile glycine encephalopathy.
289857. Neonatal glycine encephalopathy.
PharmGKBi PA28716.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
HOVERGENi HBG005820.
KOi K00281.
OMAi AELMPVS.
OrthoDBi EOG7FJGZQ.
PhylomeDBi P23378.
TreeFami TF300678.

Enzyme and pathway databases

BioCyci MetaCyc:HS00622-MONOMER.
SABIO-RK P23378.

Miscellaneous databases

GeneWikii Glycine_dehydrogenase_(decarboxylating).
GenomeRNAii 2731.
NextBioi 10764.
PROi P23378.
SOURCEi Search...

Gene expression databases

Bgeei P23378.
CleanExi HS_GLDC.
Genevestigatori P23378.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR001597. ArAA_b-elim_lyase/Thr_aldolase.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF01212. Beta_elim_lyase. 1 hit.
PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural and expression analyses of normal and mutant mRNA encoding glycine decarboxylase: three-base deletion in mRNA causes nonketotic hyperglycinemia."
    Kure S., Narisawa K., Tada K.
    Biochem. Biophys. Res. Commun. 174:1176-1182(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT NKH PHE-756 DEL.
  2. "The glycine cleavage system. Molecular cloning of the chicken and human glycine decarboxylase cDNAs and some characteristics involved in the deduced protein structures."
    Kume A., Koyata H., Sakakibara T., Ishiguro Y., Kure S., Hiraga K.
    J. Biol. Chem. 266:3323-3329(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Identification of a common mutation in Finnish patients with nonketotic hyperglycinemia."
    Kure S., Takayanagi M., Narisawa K., Tada K., Leisti J.
    J. Clin. Invest. 90:160-164(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT NKH ILE-564.
  10. "Recurrent mutations in P- and T-proteins of the glycine cleavage complex and a novel T-protein mutation (N145I): a strategy for the molecular investigation of patients with nonketotic hyperglycinemia (NKH)."
    Toone J.R., Applegarth D.A., Coulter-Mackie M.B., James E.R.
    Mol. Genet. Metab. 72:322-325(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT NKH SER-515.
  11. "Nonketotic hyperglycinemia (glycine encephalopathy): laboratory diagnosis."
    Applegarth D.A., Toone J.R.
    Mol. Genet. Metab. 74:139-146(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT NKH PRO-283, VARIANT THR-329.

Entry informationi

Entry nameiGCSP_HUMAN
AccessioniPrimary (citable) accession number: P23378
Secondary accession number(s): Q2M2F8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: May 5, 2009
Last modified: July 9, 2014
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi