Reviewed, UniProtKB/Swiss-Prot P23373 (VE10_VACCW)

Names and origin

Protein names

Recommended name:
    Probable FAD-linked sulfhydryl oxidase E10
    EC=1.8.3.2

Gene names

ORF Names:

E10R

Organism

Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))

Taxonomic identifier

10254 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Orthopoxvirus

Virus host

Bos taurus (Bovine) [TaxID: 9913]

Protein attributes

Sequence length	95 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation By similarity.
Catalytic activity	4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O.
Cofactor	FAD By similarity.
Sequence similarities	Belongs to the poxviruses E10 family. Contains 1 ERV/ALR sulfhydryl oxidase domain.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	thiol oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 95	95	Probable FAD-linked sulfhydryl oxidase E10		PRO_0000099465
Regions
	Domain	1 – 95	95	ERV/ALR sulfhydryl oxidase
Amino acid modifications
	Disulfide bond	43 ↔ 46		Redox-active Potential

Sequences

	Sequence		Length	Mass (Da)
	P23373-1 [UniParc]. Last modified November 1, 1991. Version 1. Checksum: F4A2FAB4159DFA50	FASTA	95	10,851
	10 20 30 40 50 60 MNPKHWGRAV WTIIFIVLSQ AGLDGNIEAC KRKLYTIVST LPCPACRRHA TIAIEDNNVM 70 80 90 SSDDLNYIYY FFIRLFNNLA SDPKYAIDVT KVNPL

References

[1]	Gershon P.D., Jones E.V., Moss B., Ahn B.-Y. Submitted (JUL-1990) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	M36339 Genomic DNA. Translation: AAB59830.1.
PIR	T30803.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR017905. ERV/ALR_sulphydryl_oxidase. IPR006890. Pox_E10. [Graphical view]
Pfam	PF04805. Pox_E10. 1 hit. [Graphical view]
PIRSF	PIRSF015696. VAC_E10R. 1 hit.
PROSITE	PS51324. ERV_ALR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VE10_VACCW

Accession

Primary (citable) accession number: P23373

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	November 1, 1991
Last modified:	June 16, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)