P23363 (BDNF_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Brain-derived neurotrophic factor
Short name=BDNF

Gene names

Name:

Bdnf

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	249 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS By similarity.
Subunit structure	Monomers and homodimers. Binds to NTRK2/TRKB By similarity.
Subcellular location	Secreted.
Post-translational modification	Converted into mature BDNF by plasmin (PLG) By similarity.
Sequence similarities	Belongs to the NGF-beta family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Growth factor
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	chronic inflammatory response Inferred from expression pattern. Source: RGD cognition Inferred from expression pattern. Source: RGD mitochondrial electron transport, NADH to ubiquinone Inferred from mutant phenotype. Source: RGD negative regulation of striated muscle tissue development Inferred from mutant phenotype. Source: RGD neuron differentiation Traceable author statement. Source: RGD positive regulation of long-term neuronal synaptic plasticity Inferred from mutant phenotype. Source: RGD regulation of excitatory postsynaptic membrane potential Inferred from mutant phenotype. Source: RGD regulation of short-term neuronal synaptic plasticity Inferred from direct assay. Source: RGD response to anesthetic Inferred from expression pattern. Source: RGD response to drug Inferred from expression pattern. Source: RGD response to fluoxetine Inferred from expression pattern. Source: RGD response to hormone stimulus Inferred from expression pattern. Source: RGD response to hyperoxia Inferred from expression pattern. Source: RGD response to hypoxia Inferred from expression pattern. Source: RGD response to vitamin A Inferred from expression pattern. Source: RGD
Cellular component	extracellular region Traceable author statement. Source: Reactome synaptic vesicle Inferred from direct assay. Source: RGD
Molecular function	growth factor activity Traceable author statement. Source: RGD neurotrophin TRKB receptor binding Inferred from direct assay Ref.1. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Propeptide	19 – 130	112			PRO_0000019643
	Chain	131 – 249	119	Brain-derived neurotrophic factor		PRO_0000019644
Sites
	Site	57 – 58	2	Cleavage; by S1P By similarity
Amino acid modifications
	Glycosylation	123	1	N-linked (GlcNAc...) Potential
	Disulfide bond	143 ↔ 210		By similarity
	Disulfide bond	188 ↔ 239		By similarity
	Disulfide bond	198 ↔ 241		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P23363 [UniParc]. Last modified November 1, 1991. Version 1. Checksum: F9CAAA5DEF9A78B7	FASTA	249	28,109
	10 20 30 40 50 60 MTILFLTMVI SYFGCMKAAP MKEANVHGQG NLAYPAVRTH GTLESVNGPR AGSRGLTTTS 70 80 90 100 110 120 LADTFEHVIE ELLDEDQKVR PNEENHKDAD LYTSRVMLSS QVPLEPPLLF LLEEYKNYLD 130 140 150 160 170 180 AANMSMRVRR HSDPARRGEL SVCDSISEWV TAADKKTAVD MSGGTVTVLE KVPVSKGQLK 190 200 210 220 230 240 QYFYETKCNP MGYTKEGCRG IDKRHWNSQC RTTQSYVRAL TMDSKKRIGW RFIRIDTSCV CTLTIKRGR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations." Maisonpierre P.C., le Beau M.M., Espinosa R. III, Ip N.Y., Belluscio L., de la Monte S.M., Squinto S., Furth M.E., Yancopoulos G.D. Genomics 10:558-568(1991) [PubMed: 1889806] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	"A rat brain-derived neurotrophic factor-encoding gene generates multiple transcripts through alternative use of 5' exons and polyadenylation sites." Ohara O., Gahara Y., Teraoka H., Kitamura T. Gene 121:383-386(1992) [PubMed: 1446835] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Neurotrophic factors, their receptors, and the signal transduction pathways they activate." Yancopoulos G.D., Maisonpierre P.C., Ip N.Y., Aldrich T.H., Belluscio L., Boulton T.G., Cobb M.H., Squinto S.P., Furth M.E. Cold Spring Harb. Symp. Quant. Biol. 55:371-379(1990) [PubMed: 1966766] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine." Liu Q.-R., Lu L., Zhu X.-G., Gong J.-P., Shaham Y., Uhl G.R. Brain Res. 1067:1-12(2006) [PubMed: 16376315] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley.
[5]	"Mouse and rat BDNF gene structure and expression revisited." Aid T., Kazantseva A., Piirsoo M., Palm K., Timmusk T. J. Neurosci. Res. 85:525-535(2007) [PubMed: 17149751] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley.
[6]	"Reconstituting BDNF gene to bone marrow mesenchymal stem cells: serving as portals in the therapy of Parkinson's disease." Zhao L.X., Zhang J., Wang D.M., Yu X.J., Yue W., Pei X.T., Xu X.H. Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar. Tissue: Brain.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[8]	"Multiple promoters direct tissue-specific expression of the rat BDNF gene." Timmusk T., Palm K., Metsis M., Reintam T., Palme V., Saarma M., Persson H. Neuron 10:475-489(1993) [PubMed: 8461137] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-249.
[9]	"Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary." Hallboeoek F., Ibanez C.F., Persson H. Neuron 6:845-858(1991) [PubMed: 2025430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 187-229. Strain: Sprague-Dawley. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M61175 mRNA. Translation: AAA16841.1. M61178 Genomic DNA. Translation: AAA63483.1. D10938 Genomic DNA. Translation: BAA01732.1. AY559248 mRNA. Translation: AAS67380.1. AY559249 mRNA. Translation: AAS67381.1. AY559250 mRNA. Translation: AAS67382.1. EF125675 mRNA. Translation: ABM30161.1. EF125676 mRNA. Translation: ABM30162.1. EF125677 mRNA. Translation: ABM30163.1. EF125678 mRNA. Translation: ABM30164.1. EF125679 mRNA. Translation: ABM30165.1. EF125680 mRNA. Translation: ABM30166.1. EF125686 mRNA. Translation: ABM30172.1. EF125687 mRNA. Translation: ABM30173.1. EF125688 mRNA. Translation: ABM30174.1. EF125689 mRNA. Translation: ABM30175.1. EF125690 mRNA. Translation: ABM30176.1. AY176065 mRNA. Translation: AAO17828.1. BC087634 mRNA. Translation: AAH87634.1. X67108 mRNA. Translation: CAA47481.1.
IPI	IPI00210190.
PIR	B40304. B60536.
RefSeq	NP_036645.1. NM_012513.3.
UniGene	Rn.11266.
3D structure databases
ProteinModelPortal	P23363.
SMR	P23363. Positions 138-246.
ModBase	Search...
Proteomic databases
PRIDE	P23363.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	24225.
KEGG	rno:24225.
UCSC	NM_012513. rat.
Organism-specific databases
CTD	627.
RGD	2202. Bdnf.
Phylogenomic databases
eggNOG	maNOG18888.
HOVERGEN	HBG006494.
Enzyme and pathway databases
Reactome	REACT_111984. Signal Transduction.
Gene expression databases
Genevestigator	P23363.
Family and domain databases
InterPro	IPR020430. Brain-der_neurotrophic_factor. IPR020408. Nerve_growth_factor-like. IPR002072. Nerve_growth_factor-rel. IPR019846. Nerve_growth_factor_CS. [Graphical view]
KO	K04355.
PANTHER	PTHR11589. NGF. 1 hit.
Pfam	PF00243. NGF. 1 hit. [Graphical view]
PIRSF	PIRSF001789. NGF. 1 hit.
PRINTS	PR01912. BDNFACTOR. PR00268. NGF.
ProDom	PD002052. Nerve_growth_factor-rel. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00140. NGF. 1 hit. [Graphical view]
PROSITE	PS00248. NGF_1. 1 hit. PS50270. NGF_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	602669.
PMAP-CutDB	P23363.

Entry information

Entry name

BDNF_RAT

Accession

Primary (citable) accession number: P23363
Secondary accession number(s): Q53YL8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	November 1, 1991
Last modified:	November 16, 2011
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program