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Protein

Brain-derived neurotrophic factor

Gene

Bdnf

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS (By similarity).By similarity

GO - Molecular functioni

  • growth factor activity Source: RGD
  • neurotrophin TRKB receptor binding Source: RGD

GO - Biological processi

  • activation of MAPKK activity Source: Reactome
  • activation of phospholipase C activity Source: Reactome
  • cellular response to nerve growth factor stimulus Source: RGD
  • cellular response to norepinephrine stimulus Source: RGD
  • cellular response to tumor necrosis factor Source: RGD
  • chronic inflammatory response Source: RGD
  • cognition Source: RGD
  • excitatory postsynaptic potential Source: RGD
  • learning Source: RGD
  • mitochondrial electron transport, NADH to ubiquinone Source: RGD
  • negative regulation of neuron death Source: RGD
  • negative regulation of striated muscle tissue development Source: RGD
  • nervous system development Source: RGD
  • neuron differentiation Source: RGD
  • neuron projection extension Source: RGD
  • neurotrophin TRK receptor signaling pathway Source: Reactome
  • positive regulation of apoptotic process Source: Reactome
  • positive regulation of glucocorticoid receptor signaling pathway Source: MGI
  • positive regulation of long-term neuronal synaptic plasticity Source: RGD
  • positive regulation of peptidyl-serine phosphorylation Source: MGI
  • positive regulation of sequence-specific DNA binding transcription factor activity Source: MGI
  • Ras protein signal transduction Source: Reactome
  • regeneration Source: RGD
  • regulation of axon extension Source: RGD
  • regulation of long-term neuronal synaptic plasticity Source: RGD
  • regulation of short-term neuronal synaptic plasticity Source: RGD
  • response to activity Source: RGD
  • response to anesthetic Source: RGD
  • response to auditory stimulus Source: RGD
  • response to drug Source: RGD
  • response to electrical stimulus Source: RGD
  • response to food Source: RGD
  • response to hormone Source: RGD
  • response to hyperoxia Source: RGD
  • response to hypoxia Source: RGD
  • response to L-glutamate Source: RGD
  • response to light intensity Source: RGD
  • response to light stimulus Source: RGD
  • response to nerve growth factor Source: RGD
  • response to nutrient levels Source: RGD
  • response to potassium ion Source: RGD
  • response to tumor necrosis factor Source: RGD
  • response to vitamin A Source: RGD
  • small GTPase mediated signal transduction Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiR-RNO-167021. PLC-gamma1 signalling.
R-RNO-167044. Signalling to RAS.
R-RNO-170968. Frs2-mediated activation.
R-RNO-170984. ARMS-mediated activation.
R-RNO-177504. Retrograde neurotrophin signalling.
R-RNO-187042. TRKA activation by NGF.
R-RNO-187706. Signalling to p38 via RIT and RIN.
R-RNO-193648. NRAGE signals death through JNK.
R-RNO-198745. Signalling to STAT3.

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-derived neurotrophic factor
Short name:
BDNF
Gene namesi
Name:Bdnf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi2202. Bdnf.

Subcellular locationi

GO - Cellular componenti

  • axon Source: RGD
  • cytoplasm Source: UniProtKB
  • dendrite Source: RGD
  • extracellular region Source: Reactome
  • extracellular space Source: RGD
  • mitochondrial crista Source: RGD
  • neuronal cell body Source: RGD
  • perikaryon Source: RGD
  • perinuclear region of cytoplasm Source: UniProtKB
  • postsynapse Source: GOC
  • synaptic vesicle Source: RGD
  • terminal bouton Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Propeptidei19 – 130112PRO_0000019643Add
BLAST
Chaini131 – 249119Brain-derived neurotrophic factorPRO_0000019644Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence analysis
Disulfide bondi143 ↔ 210By similarity
Disulfide bondi188 ↔ 239By similarity
Disulfide bondi198 ↔ 241By similarity

Post-translational modificationi

Converted into mature BDNF by plasmin (PLG).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei57 – 582Cleavage; by S1PBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP23363.
PRIDEiP23363.

Miscellaneous databases

PMAP-CutDBP23363.

Expressioni

Gene expression databases

ExpressionAtlasiP23363. baseline and differential.
GenevisibleiP23363. RN.

Interactioni

Subunit structurei

Monomers and homodimers. Binds to NTRK2/TRKB (By similarity).By similarity

GO - Molecular functioni

  • growth factor activity Source: RGD
  • neurotrophin TRKB receptor binding Source: RGD

Protein-protein interaction databases

IntActiP23363. 3 interactions.
MINTiMINT-234599.
STRINGi10116.ENSRNOP00000064356.

Structurei

3D structure databases

ProteinModelPortaliP23363.
SMRiP23363. Positions 138-246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IH7X. Eukaryota.
ENOG410XRPH. LUCA.
GeneTreeiENSGT00390000007725.
HOVERGENiHBG006494.
InParanoidiP23363.
KOiK04355.
OMAiRVGWRFI.
OrthoDBiEOG7RBZ8Z.
PhylomeDBiP23363.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR020430. Brain-der_neurotrophic_factor.
IPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01912. BDNFACTOR.
PR00268. NGF.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23363-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTILFLTMVI SYFGCMKAAP MKEANVHGQG NLAYPAVRTH GTLESVNGPR
60 70 80 90 100
AGSRGLTTTS LADTFEHVIE ELLDEDQKVR PNEENHKDAD LYTSRVMLSS
110 120 130 140 150
QVPLEPPLLF LLEEYKNYLD AANMSMRVRR HSDPARRGEL SVCDSISEWV
160 170 180 190 200
TAADKKTAVD MSGGTVTVLE KVPVSKGQLK QYFYETKCNP MGYTKEGCRG
210 220 230 240
IDKRHWNSQC RTTQSYVRAL TMDSKKRIGW RFIRIDTSCV CTLTIKRGR
Length:249
Mass (Da):28,109
Last modified:November 1, 1991 - v1
Checksum:iF9CAAA5DEF9A78B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61175 mRNA. Translation: AAA16841.1.
M61178 Genomic DNA. Translation: AAA63483.1.
D10938 Genomic DNA. Translation: BAA01732.1.
AY559248 mRNA. Translation: AAS67380.1.
AY559249 mRNA. Translation: AAS67381.1.
AY559250 mRNA. Translation: AAS67382.1.
EF125675 mRNA. Translation: ABM30161.1.
EF125676 mRNA. Translation: ABM30162.1.
EF125677 mRNA. Translation: ABM30163.1.
EF125678 mRNA. Translation: ABM30164.1.
EF125679 mRNA. Translation: ABM30165.1.
EF125680 mRNA. Translation: ABM30166.1.
EF125686 mRNA. Translation: ABM30172.1.
EF125687 mRNA. Translation: ABM30173.1.
EF125688 mRNA. Translation: ABM30174.1.
EF125689 mRNA. Translation: ABM30175.1.
EF125690 mRNA. Translation: ABM30176.1.
AY176065 mRNA. Translation: AAO17828.1.
BC087634 mRNA. Translation: AAH87634.1.
X67108 mRNA. Translation: CAA47481.1.
PIRiB60536. B40304.
RefSeqiNP_001257559.1. NM_001270630.1.
NP_001257560.1. NM_001270631.1.
NP_001257561.1. NM_001270632.1.
NP_001257562.1. NM_001270633.1.
NP_001257563.1. NM_001270634.1.
NP_001257564.1. NM_001270635.1.
NP_001257565.1. NM_001270636.1.
NP_001257566.1. NM_001270637.1.
NP_001257567.1. NM_001270638.1.
NP_036645.2. NM_012513.4.
XP_008760300.1. XM_008762078.1.
UniGeneiRn.11266.

Genome annotation databases

EnsembliENSRNOT00000077703; ENSRNOP00000072849; ENSRNOG00000047466.
ENSRNOT00000078543; ENSRNOP00000072315; ENSRNOG00000047466.
ENSRNOT00000080190; ENSRNOP00000073265; ENSRNOG00000047466.
ENSRNOT00000083289; ENSRNOP00000074338; ENSRNOG00000047466.
ENSRNOT00000089233; ENSRNOP00000075479; ENSRNOG00000047466.
ENSRNOT00000090445; ENSRNOP00000073685; ENSRNOG00000047466.
GeneIDi24225.
KEGGirno:24225.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61175 mRNA. Translation: AAA16841.1.
M61178 Genomic DNA. Translation: AAA63483.1.
D10938 Genomic DNA. Translation: BAA01732.1.
AY559248 mRNA. Translation: AAS67380.1.
AY559249 mRNA. Translation: AAS67381.1.
AY559250 mRNA. Translation: AAS67382.1.
EF125675 mRNA. Translation: ABM30161.1.
EF125676 mRNA. Translation: ABM30162.1.
EF125677 mRNA. Translation: ABM30163.1.
EF125678 mRNA. Translation: ABM30164.1.
EF125679 mRNA. Translation: ABM30165.1.
EF125680 mRNA. Translation: ABM30166.1.
EF125686 mRNA. Translation: ABM30172.1.
EF125687 mRNA. Translation: ABM30173.1.
EF125688 mRNA. Translation: ABM30174.1.
EF125689 mRNA. Translation: ABM30175.1.
EF125690 mRNA. Translation: ABM30176.1.
AY176065 mRNA. Translation: AAO17828.1.
BC087634 mRNA. Translation: AAH87634.1.
X67108 mRNA. Translation: CAA47481.1.
PIRiB60536. B40304.
RefSeqiNP_001257559.1. NM_001270630.1.
NP_001257560.1. NM_001270631.1.
NP_001257561.1. NM_001270632.1.
NP_001257562.1. NM_001270633.1.
NP_001257563.1. NM_001270634.1.
NP_001257564.1. NM_001270635.1.
NP_001257565.1. NM_001270636.1.
NP_001257566.1. NM_001270637.1.
NP_001257567.1. NM_001270638.1.
NP_036645.2. NM_012513.4.
XP_008760300.1. XM_008762078.1.
UniGeneiRn.11266.

3D structure databases

ProteinModelPortaliP23363.
SMRiP23363. Positions 138-246.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP23363. 3 interactions.
MINTiMINT-234599.
STRINGi10116.ENSRNOP00000064356.

Proteomic databases

PaxDbiP23363.
PRIDEiP23363.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000077703; ENSRNOP00000072849; ENSRNOG00000047466.
ENSRNOT00000078543; ENSRNOP00000072315; ENSRNOG00000047466.
ENSRNOT00000080190; ENSRNOP00000073265; ENSRNOG00000047466.
ENSRNOT00000083289; ENSRNOP00000074338; ENSRNOG00000047466.
ENSRNOT00000089233; ENSRNOP00000075479; ENSRNOG00000047466.
ENSRNOT00000090445; ENSRNOP00000073685; ENSRNOG00000047466.
GeneIDi24225.
KEGGirno:24225.

Organism-specific databases

CTDi627.
RGDi2202. Bdnf.

Phylogenomic databases

eggNOGiENOG410IH7X. Eukaryota.
ENOG410XRPH. LUCA.
GeneTreeiENSGT00390000007725.
HOVERGENiHBG006494.
InParanoidiP23363.
KOiK04355.
OMAiRVGWRFI.
OrthoDBiEOG7RBZ8Z.
PhylomeDBiP23363.

Enzyme and pathway databases

ReactomeiR-RNO-167021. PLC-gamma1 signalling.
R-RNO-167044. Signalling to RAS.
R-RNO-170968. Frs2-mediated activation.
R-RNO-170984. ARMS-mediated activation.
R-RNO-177504. Retrograde neurotrophin signalling.
R-RNO-187042. TRKA activation by NGF.
R-RNO-187706. Signalling to p38 via RIT and RIN.
R-RNO-193648. NRAGE signals death through JNK.
R-RNO-198745. Signalling to STAT3.

Miscellaneous databases

PMAP-CutDBP23363.
PROiP23363.

Gene expression databases

ExpressionAtlasiP23363. baseline and differential.
GenevisibleiP23363. RN.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR020430. Brain-der_neurotrophic_factor.
IPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01912. BDNFACTOR.
PR00268. NGF.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations."
    Maisonpierre P.C., le Beau M.M., Espinosa R. III, Ip N.Y., Belluscio L., de la Monte S.M., Squinto S., Furth M.E., Yancopoulos G.D.
    Genomics 10:558-568(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "A rat brain-derived neurotrophic factor-encoding gene generates multiple transcripts through alternative use of 5' exons and polyadenylation sites."
    Ohara O., Gahara Y., Teraoka H., Kitamura T.
    Gene 121:383-386(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Neurotrophic factors, their receptors, and the signal transduction pathways they activate."
    Yancopoulos G.D., Maisonpierre P.C., Ip N.Y., Aldrich T.H., Belluscio L., Boulton T.G., Cobb M.H., Squinto S.P., Furth M.E.
    Cold Spring Harb. Symp. Quant. Biol. 55:371-379(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine."
    Liu Q.-R., Lu L., Zhu X.-G., Gong J.-P., Shaham Y., Uhl G.R.
    Brain Res. 1067:1-12(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  5. "Mouse and rat BDNF gene structure and expression revisited."
    Aid T., Kazantseva A., Piirsoo M., Palm K., Timmusk T.
    J. Neurosci. Res. 85:525-535(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  6. "Reconstituting BDNF gene to bone marrow mesenchymal stem cells: serving as portals in the therapy of Parkinson's disease."
    Zhao L.X., Zhang J., Wang D.M., Yu X.J., Yue W., Pei X.T., Xu X.H.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Brain.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  8. "Multiple promoters direct tissue-specific expression of the rat BDNF gene."
    Timmusk T., Palm K., Metsis M., Reintam T., Palme V., Saarma M., Persson H.
    Neuron 10:475-489(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-249.
  9. "Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary."
    Hallboeoek F., Ibanez C.F., Persson H.
    Neuron 6:845-858(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 187-229.
    Strain: Sprague-Dawley.
    Tissue: Liver.

Entry informationi

Entry nameiBDNF_RAT
AccessioniPrimary (citable) accession number: P23363
Secondary accession number(s): Q53YL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: June 8, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.