Reviewed, UniProtKB/Swiss-Prot P23362 (CCKN_MACFA)

Names and origin

Protein names

Recommended name:
    Cholecystokinin
      Short name=CCK
Cleaved into the following 10 chains:
    1- Recommended name:
            Cholecystokinin-58
                Short name=CCK58
    2- Recommended name:
            Cholecystokinin-58 desnonopeptide
        Alternative name(s):
            (1-49)-CCK58
    3- Recommended name:
            Cholecystokinin-39
                Short name=CCK39
    4- Recommended name:
            Cholecystokinin-33
                Short name=CCK33
    5- Recommended name:
            Cholecystokinin-25
                Short name=CCK25
    6- Recommended name:
            Cholecystokinin-18
                Short name=CCK18
    7- Recommended name:
            Cholecystokinin-12
                Short name=CCK12
    8- Recommended name:
            Cholecystokinin-8
                Short name=CCK8
    9- Recommended name:
            Cholecystokinin-7
                Short name=CCK7
    10- Recommended name:
            Cholecystokinin-5
                Short name=CCK5

Gene names

Name:	CCK
ORF Names:	QccE-12659

Organism

Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	115 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.
Subunit structure	Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain By similarity.
Subcellular location	Secreted.
Post-translational modification	The precursor is cleaved by proteases to produce a number of active cholecystokinins.
Sequence similarities	Belongs to the gastrin/cholecystokinin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone
PTM	Amidation Cleavage on pair of basic residues Sulfation
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hormone activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	By similarity
	Chain	21 – 115	95	Cholecystokinin		PRO_0000010544
	Propeptide	21 – 44	24			PRO_0000010545
	Peptide	46 – 103	58	Cholecystokinin-58 By similarity		PRO_0000010546
	Peptide	46 – 94	49	Cholecystokinin-58 desnonopeptide By similarity		PRO_0000306309
	Peptide	65 – 103	39	Cholecystokinin-39 By similarity		PRO_0000010547
	Peptide	71 – 103	33	Cholecystokinin-33 By similarity		PRO_0000010548
	Peptide	79 – 103	25	Cholecystokinin-25 By similarity		PRO_0000306310
	Peptide	86 – 103	18	Cholecystokinin-18 By similarity		PRO_0000306311
	Peptide	92 – 103	12	Cholecystokinin-12 By similarity		PRO_0000010549
	Peptide	96 – 103	8	Cholecystokinin-8 By similarity		PRO_0000010550
	Peptide	97 – 103	7	Cholecystokinin-7 By similarity		PRO_0000306312
	Peptide	99 – 103	5	Cholecystokinin-5 By similarity		PRO_0000306313
	Propeptide	107 – 115	9			PRO_0000010551
Amino acid modifications
	Modified residue	97	1	Sulfotyrosine By similarity
	Modified residue	103	1	Phenylalanine amide
	Modified residue	111	1	Sulfotyrosine By similarity
	Modified residue	113	1	Sulfotyrosine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P23362-1 [UniParc]. Last modified November 1, 1991. Version 1. Checksum: C151B73646E95019	FASTA	115	12,665
	10 20 30 40 50 60 MNSGVSLCVL MAVLAAGALT QPVPPAEPAG SGLQRAEEAP RRQLRAVQRT DGESRAHLGA 70 80 90 100 110 LLARYIQQAR KAPSGRMSII KNLQNLDPSH RISDRDYMGW MDFGRRSAEE YEYPS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Patterns of cerebral cortex mRNA expression." Bernal J., Godbout M., Hasel K.W., Travis G.H., Sutcliffe J.G. J. Neurosci. Res. 27:153-158(1990) [PubMed: 2174979] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications." International consortium for macaque cDNA sequencing and analysis Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M60458 mRNA. Translation: AAA36837.1. AB169511 mRNA. Translation: BAE01593.1.
PIR	A48318.
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	P23362.
Family and domain databases
InterPro	IPR015499. CCK. IPR001651. Gastrin. IPR013152. Gastrin/cholecystokinin_CS. [Graphical view]
PANTHER	PTHR10786. CCK. 1 hit.
Pfam	PF00918. Gastrin. 1 hit. [Graphical view]
SMART	SM00029. GASTRIN. 1 hit. [Graphical view]
PROSITE	PS00259. GASTRIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCKN_MACFA

Accession

Primary (citable) accession number: P23362
Secondary accession number(s): Q4R5N2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	November 1, 1991
Last modified:	June 16, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)