Skip Header

Contribute Send feedback
Read comments (?) or add your own

P23362 (CCKN_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 5, 2010. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cholecystokinin
Short name=CCK

Cleaved into the following 10 chains:

  1. Cholecystokinin-58
    Short name=CCK58
  2. Cholecystokinin-58 desnonopeptide
    Alternative name(s):
    (1-49)-CCK58
  3. Cholecystokinin-39
    Short name=CCK39
  4. Cholecystokinin-33
    Short name=CCK33
  5. Cholecystokinin-25
    Short name=CCK25
  6. Cholecystokinin-18
    Short name=CCK18
  7. Cholecystokinin-12
    Short name=CCK12
  8. Cholecystokinin-8
    Short name=CCK8
  9. Cholecystokinin-7
    Short name=CCK7
  10. Cholecystokinin-5
    Short name=CCK5
Gene names
Name:CCK
ORF Names:QccE-12659
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length115 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.

Subunit structure

Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain By similarity.

Subcellular location

Secreted.

Post-translational modification

The precursor is cleaved by proteases to produce a number of active cholecystokinins.

Sequence similarities

Belongs to the gastrin/cholecystokinin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 By similarity
Chain21 – 11595Cholecystokinin
PRO_0000010544
Propeptide21 – 4424
PRO_0000010545
Peptide46 – 10358Cholecystokinin-58 By similarity
PRO_0000010546
Peptide46 – 9449Cholecystokinin-58 desnonopeptide By similarity
PRO_0000306309
Peptide65 – 10339Cholecystokinin-39 By similarity
PRO_0000010547
Peptide71 – 10333Cholecystokinin-33 By similarity
PRO_0000010548
Peptide79 – 10325Cholecystokinin-25 By similarity
PRO_0000306310
Peptide86 – 10318Cholecystokinin-18 By similarity
PRO_0000306311
Peptide92 – 10312Cholecystokinin-12 By similarity
PRO_0000010549
Peptide96 – 1038Cholecystokinin-8 By similarity
PRO_0000010550
Peptide97 – 1037Cholecystokinin-7 By similarity
PRO_0000306312
Peptide99 – 1035Cholecystokinin-5 By similarity
PRO_0000306313
Propeptide107 – 1159
PRO_0000010551

Amino acid modifications

Modified residue971Sulfotyrosine By similarity
Modified residue1031Phenylalanine amide
Modified residue1111Sulfotyrosine By similarity
Modified residue1131Sulfotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
P23362 [UniParc].

Last modified November 1, 1991. Version 1.
Checksum: C151B73646E95019

FASTA11512,665
        10         20         30         40         50         60 
MNSGVSLCVL MAVLAAGALT QPVPPAEPAG SGLQRAEEAP RRQLRAVQRT DGESRAHLGA 

        70         80         90        100        110 
LLARYIQQAR KAPSGRMSII KNLQNLDPSH RISDRDYMGW MDFGRRSAEE YEYPS

« Hide

References

« Hide 'large scale' references
[1]"Patterns of cerebral cortex mRNA expression."
Bernal J., Godbout M., Hasel K.W., Travis G.H., Sutcliffe J.G.
J. Neurosci. Res. 27:153-158(1990) [PubMed: 2174979] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications."
International consortium for macaque cDNA sequencing and analysis
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M60458 mRNA. Translation: AAA36837.1.
AB169511 mRNA. Translation: BAE01593.1.
PIRA48318.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG005806.

Family and domain databases

InterProIPR015499. CCK.
IPR001651. Gastrin.
IPR013152. Gastrin/cholecystokinin_CS.
[Graphical view]
PANTHERPTHR10786. CCK. 1 hit.
PfamPF00918. Gastrin. 1 hit.
[Graphical view]
SMARTSM00029. GASTRIN. 1 hit.
[Graphical view]
PROSITEPS00259. GASTRIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCCKN_MACFA
AccessionPrimary (citable) accession number: P23362
Secondary accession number(s): Q4R5N2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: October 5, 2010
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents