Reviewed, UniProtKB/Swiss-Prot P23359 (BMP7_MOUSE)

Names and origin

Protein names

Recommended name:
    Bone morphogenetic protein 7
      Short name=BMP-7
Alternative name(s):
    Osteogenic protein 1
      Short name=OP-1

Gene names

Name:	Bmp7
Synonyms:	Bmp-7, Op1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	430 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.
Subunit structure	Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1. Ref.3 Ref.4
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the TGF-beta family.

Ontologies

Keywords
Biological process	Chondrogenesis Differentiation Osteogenesis
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine Developmental protein Growth factor
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	BMP signaling pathway Ref.4 Inferred from direct assay. Source: MGI axon guidance Inferred from direct assay. Source: MGI branching morphogenesis of a tube Inferred from direct assay. Source: MGI cartilage development Inferred from electronic annotation. Source: UniProtKB-KW embryonic camera-type eye morphogenesis Inferred from mutant phenotype. Source: MGI embryonic pattern specification Inferred from mutant phenotype. Source: MGI epithelial cell differentiation Inferred from mutant phenotype. Source: MGI growth Inferred from electronic annotation. Source: InterPro kidney development Inferred from mutant phenotype. Source: MGI mesoderm formation Ref.3 Inferred from genetic interaction. Source: MGI negative regulation of cell proliferation Inferred from mutant phenotype. Source: MGI negative regulation of neurogenesis Inferred from direct assay. Source: MGI odontogenesis of dentine-containing tooth Inferred from direct assay. Source: MGI ossification Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of apoptosis Inferred from mutant phenotype. Source: MGI positive regulation of cell differentiation Inferred from direct assay. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from genetic interaction. Source: MGI salivary gland morphogenesis Inferred from mutant phenotype. Source: MGI
Cellular component	extracellular space Inferred from direct assay. Source: MGI
Molecular function	cytokine activity Traceable author statement. Source: MGI growth factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	Potential
	Propeptide	30 – 291	262	By similarity		PRO_0000033878
	Chain	292 – 430	139	Bone morphogenetic protein 7		PRO_0000033879
Amino acid modifications
	Glycosylation	186	1	N-linked (GlcNAc...) Potential
	Glycosylation	301	1	N-linked (GlcNAc...) Potential
	Glycosylation	320	1	N-linked (GlcNAc...) Potential
	Glycosylation	371	1	N-linked (GlcNAc...) Potential
	Disulfide bond	329 ↔ 395		By similarity
	Disulfide bond	358 ↔ 427		By similarity
	Disulfide bond	362 ↔ 429		By similarity
	Disulfide bond	394		Interchain By similarity
Experimental info
	Sequence conflict	167	1	A → R in CAA40222. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P23359-1 [UniParc]. Last modified January 23, 2002. Version 2. Checksum: 464F36D5D2E54041	FASTA	430	49,199
	10 20 30 40 50 60 MHVRSLRAAA PHSFVALWAP LFLLRSALAD FSLDNEVHSS FIHRRLRSQE RREMQREILS 70 80 90 100 110 120 ILGLPHRPRP HLQGKHNSAP MFMLDLYNAM AVEESGPDGQ GFSYPYKAVF STQGPPLASL 130 140 150 160 170 180 QDSHFLTDAD MVMSFVNLVE HDKEFFHPRY HHREFRFDLS KIPEGEAVTA AEFRIYKDYI 190 200 210 220 230 240 RERFDNETFQ ITVYQVLQEH SGRESDLFLL DSRTIWASEE GWLVFDITAT SNHWVVNPRH 250 260 270 280 290 300 NLGLQLSVET LDGQSINPKL AGLIGRHGPQ NKQPFMVAFF KATEVHLRSI RSTGGKQRSQ 310 320 330 340 350 360 NRSKTPKNQE ALRMASVAEN SSSDQRQACK KHELYVSFRD LGWQDWIIAP EGYAAYYCEG 370 380 390 400 410 420 ECAFPLNSYM NATNHAIVQT LVHFINPDTV PKPCCAPTQL NAISVLYFDD SSNVILKKYR 430 NMVVRACGCH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Murine osteogenic protein (OP-1): high levels of mRNA in kidney." Oezkaynak E., Schnegelsberg P.N.J., Oppermann H. Biochem. Biophys. Res. Commun. 179:116-123(1991) [PubMed: 1715687] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
[3]	"Sirenomelia in Bmp7 and Tsg compound mutant mice: requirement for Bmp signaling in the development of ventral posterior mesoderm." Zakin L., Reversade B., Kuroda H., Lyons K.M., De Robertis E.M. Development 132:2489-2499(2005) [PubMed: 15843411] [Abstract] Cited for: INTERACTION WITH TWSG1.
[4]	"Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot." Laurikkala J., Kassai Y., Pakkasjaervi L., Thesleff I., Itoh N. Dev. Biol. 264:91-105(2003) [PubMed: 14623234] [Abstract] Cited for: INTERACTION WITH SOSTDC1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X56906 mRNA. Translation: CAA40222.1. BC010771 mRNA. Translation: AAH10771.1.
IPI	IPI00315045.
PIR	JQ1184.
RefSeq	NP_031583.2.
UniGene	Mm.595
3D structure databases
HSSP	HSSP built from PDB template 1M4U based on UniProtKB P18075.
SMR	P23359. Positions 319-430.
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000008999. Mus musculus. [Contig view]
GeneID	12162.
KEGG	mmu:12162.
Organism-specific databases
MGI	MGI:103302. Bmp7.
Phylogenomic databases
HOGENOM	P23359.
HOVERGEN	P23359.
OMA	P23359. FTTQGPP.
Gene expression databases
ArrayExpress	P23359.
Bgee	P23359.
CleanEx	MM_BMP7.
GermOnline	ENSMUSG00000008999. Mus musculus.
Family and domain databases
InterPro	IPR001839. TGFb. IPR017948. TGFb_CS. IPR001111. TGFb_N. IPR015615. TGFbeta. [Graphical view]
PANTHER	PTHR11848. TGFbeta. 1 hit.
Pfam	PF00019. TGF_beta. 1 hit. PF00688. TGFb_propeptide. 1 hit. [Graphical view]
ProDom	PD000357. TGFb. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00204. TGFB. 1 hit. [Graphical view]
PROSITE	PS00250. TGF_BETA_1. 1 hit. PS51362. TGF_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	280515.
SOURCE	Search...

Entry information

Entry name

BMP7_MOUSE

Accession

Primary (citable) accession number: P23359
Secondary accession number(s): Q91XF7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	January 23, 2002
Last modified:	June 16, 2009
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)