P23359 (BMP7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bone morphogenetic protein 7
Short name=BMP-7

Alternative name(s):
Osteogenic protein 1
Short name=OP-1

Gene names

Name:	Bmp7
Synonyms:	Bmp-7, Op1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	430 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.
Subunit structure	Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1. Ref.3 Ref.4
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the TGF-beta family.

Ontologies

Keywords
Biological process	Chondrogenesis Differentiation Osteogenesis
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine Developmental protein Growth factor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	BMP signaling pathway Inferred from direct assay Ref.4. Source: MGI SMAD protein signal transduction Inferred from sequence or structural similarity. Source: UniProtKB axon guidance Inferred from direct assay. Source: MGI branching involved in salivary gland morphogenesis Inferred from mutant phenotype. Source: MGI branching morphogenesis of a tube Inferred from direct assay. Source: MGI cartilage development Inferred from electronic annotation. Source: UniProtKB-KW embryonic camera-type eye morphogenesis Inferred from mutant phenotype. Source: MGI embryonic limb morphogenesis Inferred from mutant phenotype. Source: MGI embryonic pattern specification Inferred from mutant phenotype. Source: MGI embryonic skeletal joint morphogenesis Inferred from mutant phenotype. Source: MGI epithelial cell differentiation Inferred from mutant phenotype. Source: MGI growth Inferred from electronic annotation. Source: InterPro mesenchymal cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB mesoderm formation Inferred from genetic interaction Ref.3. Source: MGI metanephric mesenchymal cell proliferation involved in metanephros development Inferred from genetic interaction. Source: UniProtKB metanephric mesenchyme morphogenesis Inferred from genetic interaction. Source: UniProtKB negative regulation of MAP kinase activity Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of Notch signaling pathway Inferred from genetic interaction. Source: MGI negative regulation of glomerular mesangial cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis Inferred from mutant phenotype. Source: MGI negative regulation of mitosis Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of neurogenesis Inferred from direct assay. Source: MGI negative regulation of neuron differentiation Inferred from mutant phenotype. Source: MGI negative regulation of phosphorylation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of prostatic bud formation Inferred from direct assay. Source: MGI negative regulation of transcription, DNA-dependent Inferred from sequence or structural similarity. Source: UniProtKB nephrogenic mesenchyme morphogenesis Inferred from genetic interaction. Source: UniProtKB odontogenesis of dentin-containing tooth Inferred from direct assay. Source: MGI ossification Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of apoptotic process Inferred from mutant phenotype. Source: MGI positive regulation of neuron differentiation Inferred from direct assay. Source: MGI positive regulation of pathway-restricted SMAD protein phosphorylation Inferred from sequence or structural similarity. Source: UniProtKB protein localization to nucleus Inferred from sequence or structural similarity. Source: UniProtKB regulation of branching involved in prostate gland morphogenesis Inferred from mutant phenotype. Source: MGI ureteric bud development Inferred from mutant phenotype. Source: UniProtKB
Cellular component	extracellular space Inferred from direct assay. Source: MGI
Molecular function	cytokine activity Traceable author statement. Source: MGI growth factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	Potential
	Propeptide	30 – 291	262	By similarity		PRO_0000033878
	Chain	292 – 430	139	Bone morphogenetic protein 7		PRO_0000033879
Amino acid modifications
	Glycosylation	186	1	N-linked (GlcNAc...) Potential
	Glycosylation	301	1	N-linked (GlcNAc...) Potential
	Glycosylation	320	1	N-linked (GlcNAc...) Potential
	Glycosylation	371	1	N-linked (GlcNAc...) Potential
	Disulfide bond	329 ↔ 395		By similarity
	Disulfide bond	358 ↔ 427		By similarity
	Disulfide bond	362 ↔ 429		By similarity
	Disulfide bond	394		Interchain By similarity
Experimental info
	Sequence conflict	167	1	A → R in CAA40222. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P23359 [UniParc]. Last modified January 23, 2002. Version 2. Checksum: 464F36D5D2E54041	FASTA	430	49,199
	10 20 30 40 50 60 MHVRSLRAAA PHSFVALWAP LFLLRSALAD FSLDNEVHSS FIHRRLRSQE RREMQREILS 70 80 90 100 110 120 ILGLPHRPRP HLQGKHNSAP MFMLDLYNAM AVEESGPDGQ GFSYPYKAVF STQGPPLASL 130 140 150 160 170 180 QDSHFLTDAD MVMSFVNLVE HDKEFFHPRY HHREFRFDLS KIPEGEAVTA AEFRIYKDYI 190 200 210 220 230 240 RERFDNETFQ ITVYQVLQEH SGRESDLFLL DSRTIWASEE GWLVFDITAT SNHWVVNPRH 250 260 270 280 290 300 NLGLQLSVET LDGQSINPKL AGLIGRHGPQ NKQPFMVAFF KATEVHLRSI RSTGGKQRSQ 310 320 330 340 350 360 NRSKTPKNQE ALRMASVAEN SSSDQRQACK KHELYVSFRD LGWQDWIIAP EGYAAYYCEG 370 380 390 400 410 420 ECAFPLNSYM NATNHAIVQT LVHFINPDTV PKPCCAPTQL NAISVLYFDD SSNVILKKYR 430 NMVVRACGCH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Murine osteogenic protein (OP-1): high levels of mRNA in kidney." Oezkaynak E., Schnegelsberg P.N.J., Oppermann H. Biochem. Biophys. Res. Commun. 179:116-123(1991) [PubMed: 1715687] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
[3]	"Sirenomelia in Bmp7 and Tsg compound mutant mice: requirement for Bmp signaling in the development of ventral posterior mesoderm." Zakin L., Reversade B., Kuroda H., Lyons K.M., De Robertis E.M. Development 132:2489-2499(2005) [PubMed: 15843411] [Abstract] Cited for: INTERACTION WITH TWSG1.
[4]	"Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot." Laurikkala J., Kassai Y., Pakkasjaervi L., Thesleff I., Itoh N. Dev. Biol. 264:91-105(2003) [PubMed: 14623234] [Abstract] Cited for: INTERACTION WITH SOSTDC1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X56906 mRNA. Translation: CAA40222.1. BC010771 mRNA. Translation: AAH10771.1.
IPI	IPI00315045.
PIR	JQ1184.
RefSeq	NP_031583.2. NM_007557.2.
UniGene	Mm.595.
3D structure databases
ProteinModelPortal	P23359.
SMR	P23359. Positions 319-430.
ModBase	Search...
Protein-protein interaction databases
STRING	P23359.
Proteomic databases
PRIDE	P23359.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000009143; ENSMUSP00000009143; ENSMUSG00000008999.
GeneID	12162.
KEGG	mmu:12162.
Organism-specific databases
CTD	655.
MGI	MGI:103302. Bmp7.
Phylogenomic databases
GeneTree	ENSGT00580000081302.
HOGENOM	HBG717159.
HOVERGEN	HBG004860.
InParanoid	P23359.
OMA	PRPHLHG.
OrthoDB	EOG4GB76H.
PhylomeDB	P23359.
Gene expression databases
ArrayExpress	P23359.
Bgee	P23359.
CleanEx	MM_BMP7.
Genevestigator	P23359.
GermOnline	ENSMUSG00000008999. Mus musculus.
Family and domain databases
InterPro	IPR001839. TGF-b_C. IPR001111. TGF-b_N. IPR015615. TGF-beta-rel. IPR017948. TGFb_CS. [Graphical view]
KO	K04663.
PANTHER	PTHR11848. TGFbeta. 1 hit.
Pfam	PF00019. TGF_beta. 1 hit. PF00688. TGFb_propeptide. 1 hit. [Graphical view]
SMART	SM00204. TGFB. 1 hit. [Graphical view]
PROSITE	PS00250. TGF_BETA_1. 1 hit. PS51362. TGF_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	280515.
SOURCE	Search...

Entry information

Entry name

BMP7_MOUSE

Accession

Primary (citable) accession number: P23359
Secondary accession number(s): Q91XF7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	January 23, 2002
Last modified:	November 16, 2011
This is version 116 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program