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P23359 (BMP7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 136. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bone morphogenetic protein 7

Short name=BMP-7
Alternative name(s):
Osteogenic protein 1
Short name=OP-1
Gene names
Name:Bmp7
Synonyms:Bmp-7, Op1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length430 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.

Subunit structure

Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1. Ref.3 Ref.4

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the TGF-beta family.

Ontologies

Keywords
   Biological processChondrogenesis
Differentiation
Osteogenesis
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
Developmental protein
Growth factor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processBMP signaling pathway

Inferred from direct assay Ref.4. Source: MGI

SMAD protein signal transduction

Inferred from sequence or structural similarity. Source: UniProtKB

anatomical structure formation involved in morphogenesis

Inferred from mutant phenotype PubMed 10049573PubMed 16854970PubMed 17878916. Source: MGI

axon guidance

Inferred from direct assay PubMed 12741987. Source: MGI

branching involved in salivary gland morphogenesis

Inferred from mutant phenotype PubMed 11731698. Source: MGI

branching morphogenesis of an epithelial tube

Inferred from direct assay PubMed 15831470. Source: MGI

camera-type eye morphogenesis

Inferred from mutant phenotype PubMed 16154126PubMed 16854970. Source: MGI

cartilage development

Inferred from electronic annotation. Source: UniProtKB-KW

cell development

Inferred from direct assay PubMed 15831470. Source: MGI

embryonic camera-type eye morphogenesis

Inferred from mutant phenotype PubMed 10049573. Source: MGI

embryonic limb morphogenesis

Inferred from mutant phenotype PubMed 9664686. Source: MGI

embryonic pattern specification

Inferred from mutant phenotype PubMed 10049573. Source: MGI

embryonic skeletal joint morphogenesis

Inferred from mutant phenotype PubMed 9664686. Source: MGI

epithelial cell differentiation

Inferred from mutant phenotype PubMed 17878916. Source: MGI

eye development

Inferred from mutant phenotype PubMed 16154126. Source: UniProtKB

growth

Inferred from electronic annotation. Source: InterPro

kidney development

Inferred from mutant phenotype PubMed 16154126. Source: UniProtKB

mesenchymal cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

mesenchyme development

Inferred from mutant phenotype PubMed 9693150. Source: UniProtKB

mesoderm formation

Inferred from genetic interaction Ref.3. Source: MGI

mesonephros development

Inferred from electronic annotation. Source: Ensembl

metanephric mesenchymal cell proliferation involved in metanephros development

Inferred from genetic interaction PubMed 15342483. Source: UniProtKB

metanephric mesenchyme morphogenesis

Inferred from genetic interaction PubMed 15342483. Source: UniProtKB

monocyte aggregation

Inferred from electronic annotation. Source: Ensembl

negative regulation of MAP kinase activity

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of Notch signaling pathway

Inferred from genetic interaction PubMed 16324690. Source: MGI

negative regulation of cell proliferation

Inferred from mutant phenotype PubMed 16854970. Source: MGI

negative regulation of glomerular mesangial cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis

Inferred from mutant phenotype PubMed 9056639. Source: MGI

negative regulation of mitosis

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of neurogenesis

Inferred from direct assay PubMed 17699604. Source: MGI

negative regulation of neuron differentiation

Inferred from mutant phenotype PubMed 16325379. Source: MGI

negative regulation of phosphorylation

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of prostatic bud formation

Inferred from direct assay PubMed 16324690. Source: MGI

negative regulation of transcription, DNA-templated

Inferred from sequence or structural similarity. Source: UniProtKB

nephrogenic mesenchyme morphogenesis

Inferred from genetic interaction PubMed 15342483. Source: UniProtKB

neuron projection morphogenesis

Inferred from mutant phenotype PubMed 16325379. Source: MGI

odontogenesis of dentin-containing tooth

Inferred from direct assay PubMed 15525533. Source: MGI

organ morphogenesis

Inferred from mutant phenotype PubMed 7590254. Source: MGI

ossification

Inferred from electronic annotation. Source: UniProtKB-KW

pattern specification process

Inferred from mutant phenotype PubMed 7590254. Source: MGI

positive regulation of apoptotic process

Inferred from mutant phenotype PubMed 16854970. Source: MGI

positive regulation of bone mineralization

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell death

Inferred from genetic interaction PubMed 15342483. Source: UniProtKB

positive regulation of cell differentiation

Inferred from direct assay PubMed 15525533. Source: MGI

positive regulation of dendrite development

Inferred from electronic annotation. Source: Ensembl

positive regulation of heterotypic cell-cell adhesion

Inferred from electronic annotation. Source: Ensembl

positive regulation of hyaluranon cable assembly

Inferred from electronic annotation. Source: Ensembl

positive regulation of neuron differentiation

Inferred from direct assay PubMed 9786991. Source: MGI

positive regulation of osteoblast differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of pathway-restricted SMAD protein phosphorylation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of peptidyl-threonine phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from genetic interaction PubMed 16801560. Source: MGI

protein localization to nucleus

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of branching involved in prostate gland morphogenesis

Inferred from mutant phenotype PubMed 16324690. Source: MGI

response to estradiol

Inferred from electronic annotation. Source: Ensembl

response to peptide hormone

Inferred from electronic annotation. Source: Ensembl

response to vitamin D

Inferred from electronic annotation. Source: Ensembl

salivary gland morphogenesis

Inferred from mutant phenotype PubMed 11731698. Source: MGI

steroid hormone mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

tube morphogenesis

Inferred from direct assay PubMed 15831470. Source: MGI

ureteric bud development

Inferred from mutant phenotype PubMed 9693150. Source: UniProtKB

   Cellular_componentextracellular matrix

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from direct assay PubMed 12741987. Source: MGI

membrane-bounded vesicle

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionBMP receptor binding

Inferred from sequence orthology PubMed 7811286. Source: MGI

cytokine activity

Traceable author statement PubMed 7590254. Source: MGI

heparin binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Propeptide30 – 291262 By similarity
PRO_0000033878
Chain292 – 430139Bone morphogenetic protein 7
PRO_0000033879

Amino acid modifications

Glycosylation1861N-linked (GlcNAc...) Potential
Glycosylation3011N-linked (GlcNAc...) Potential
Glycosylation3201N-linked (GlcNAc...) Potential
Glycosylation3711N-linked (GlcNAc...) Potential
Disulfide bond329 ↔ 395 By similarity
Disulfide bond358 ↔ 427 By similarity
Disulfide bond362 ↔ 429 By similarity
Disulfide bond394Interchain By similarity

Experimental info

Sequence conflict1671A → R in CAA40222. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P23359 [UniParc].

Last modified January 23, 2002. Version 2.
Checksum: 464F36D5D2E54041

FASTA43049,199
        10         20         30         40         50         60 
MHVRSLRAAA PHSFVALWAP LFLLRSALAD FSLDNEVHSS FIHRRLRSQE RREMQREILS 

        70         80         90        100        110        120 
ILGLPHRPRP HLQGKHNSAP MFMLDLYNAM AVEESGPDGQ GFSYPYKAVF STQGPPLASL 

       130        140        150        160        170        180 
QDSHFLTDAD MVMSFVNLVE HDKEFFHPRY HHREFRFDLS KIPEGEAVTA AEFRIYKDYI 

       190        200        210        220        230        240 
RERFDNETFQ ITVYQVLQEH SGRESDLFLL DSRTIWASEE GWLVFDITAT SNHWVVNPRH 

       250        260        270        280        290        300 
NLGLQLSVET LDGQSINPKL AGLIGRHGPQ NKQPFMVAFF KATEVHLRSI RSTGGKQRSQ 

       310        320        330        340        350        360 
NRSKTPKNQE ALRMASVAEN SSSDQRQACK KHELYVSFRD LGWQDWIIAP EGYAAYYCEG 

       370        380        390        400        410        420 
ECAFPLNSYM NATNHAIVQT LVHFINPDTV PKPCCAPTQL NAISVLYFDD SSNVILKKYR 

       430 
NMVVRACGCH 

« Hide

References

« Hide 'large scale' references
[1]"Murine osteogenic protein (OP-1): high levels of mRNA in kidney."
Oezkaynak E., Schnegelsberg P.N.J., Oppermann H.
Biochem. Biophys. Res. Commun. 179:116-123(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.
[3]"Sirenomelia in Bmp7 and Tsg compound mutant mice: requirement for Bmp signaling in the development of ventral posterior mesoderm."
Zakin L., Reversade B., Kuroda H., Lyons K.M., De Robertis E.M.
Development 132:2489-2499(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TWSG1.
[4]"Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot."
Laurikkala J., Kassai Y., Pakkasjaervi L., Thesleff I., Itoh N.
Dev. Biol. 264:91-105(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SOSTDC1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X56906 mRNA. Translation: CAA40222.1.
BC010771 mRNA. Translation: AAH10771.1.
PIRJQ1184.
RefSeqNP_031583.2. NM_007557.3.
UniGeneMm.392150.
Mm.595.

3D structure databases

ProteinModelPortalP23359.
SMRP23359. Positions 190-430.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198367. 3 interactions.

PTM databases

PhosphoSiteP23359.

Proteomic databases

PRIDEP23359.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000009143; ENSMUSP00000009143; ENSMUSG00000008999.
GeneID12162.
KEGGmmu:12162.
UCSCuc008odb.2. mouse.

Organism-specific databases

CTD655.
MGIMGI:103302. Bmp7.

Phylogenomic databases

eggNOGNOG272883.
GeneTreeENSGT00730000110505.
HOGENOMHOG000249476.
HOVERGENHBG004860.
InParanoidP23359.
KOK16621.
OMAGKHNAAP.
OrthoDBEOG7J9VPQ.
PhylomeDBP23359.
TreeFamTF316134.

Gene expression databases

BgeeP23359.
CleanExMM_BMP7.
GenevestigatorP23359.

Family and domain databases

InterProIPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERPTHR11848. PTHR11848. 1 hit.
PfamPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
PROSITEPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio280515.
PROP23359.
SOURCESearch...

Entry information

Entry nameBMP7_MOUSE
AccessionPrimary (citable) accession number: P23359
Secondary accession number(s): Q91XF7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: January 23, 2002
Last modified: April 16, 2014
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot