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P23359

- BMP7_MOUSE

UniProt

P23359 - BMP7_MOUSE

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Protein

Bone morphogenetic protein 7

Gene
Bmp7, Bmp-7, Op1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.

GO - Molecular functioni

  1. BMP receptor binding Source: MGI
  2. cytokine activity Source: MGI
  3. heparin binding Source: Ensembl
  4. protein binding Source: MGI

GO - Biological processi

  1. anatomical structure formation involved in morphogenesis Source: MGI
  2. axon guidance Source: MGI
  3. BMP signaling pathway Source: MGI
  4. branching involved in salivary gland morphogenesis Source: MGI
  5. branching morphogenesis of an epithelial tube Source: MGI
  6. camera-type eye morphogenesis Source: MGI
  7. cartilage development Source: UniProtKB-KW
  8. cell development Source: MGI
  9. embryonic camera-type eye morphogenesis Source: MGI
  10. embryonic limb morphogenesis Source: MGI
  11. embryonic pattern specification Source: MGI
  12. embryonic skeletal joint morphogenesis Source: MGI
  13. epithelial cell differentiation Source: MGI
  14. eye development Source: UniProtKB
  15. growth Source: InterPro
  16. kidney development Source: UniProtKB
  17. mesenchymal cell differentiation Source: UniProtKB
  18. mesenchyme development Source: UniProtKB
  19. mesoderm formation Source: MGI
  20. mesonephros development Source: Ensembl
  21. metanephric mesenchymal cell proliferation involved in metanephros development Source: UniProtKB
  22. metanephric mesenchyme morphogenesis Source: UniProtKB
  23. monocyte aggregation Source: Ensembl
  24. negative regulation of cell proliferation Source: MGI
  25. negative regulation of glomerular mesangial cell proliferation Source: UniProtKB
  26. negative regulation of MAP kinase activity Source: UniProtKB
  27. negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis Source: MGI
  28. negative regulation of mitosis Source: UniProtKB
  29. negative regulation of neurogenesis Source: MGI
  30. negative regulation of neuron differentiation Source: MGI
  31. negative regulation of Notch signaling pathway Source: MGI
  32. negative regulation of phosphorylation Source: UniProtKB
  33. negative regulation of prostatic bud formation Source: MGI
  34. negative regulation of transcription, DNA-templated Source: UniProtKB
  35. nephrogenic mesenchyme morphogenesis Source: UniProtKB
  36. neuron projection morphogenesis Source: MGI
  37. odontogenesis of dentin-containing tooth Source: MGI
  38. organ morphogenesis Source: MGI
  39. ossification Source: UniProtKB-KW
  40. pattern specification process Source: MGI
  41. positive regulation of apoptotic process Source: MGI
  42. positive regulation of bone mineralization Source: Ensembl
  43. positive regulation of cell death Source: UniProtKB
  44. positive regulation of cell differentiation Source: MGI
  45. positive regulation of dendrite development Source: Ensembl
  46. positive regulation of heterotypic cell-cell adhesion Source: Ensembl
  47. positive regulation of hyaluranon cable assembly Source: Ensembl
  48. positive regulation of neuron differentiation Source: MGI
  49. positive regulation of osteoblast differentiation Source: Ensembl
  50. positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
  51. positive regulation of peptidyl-threonine phosphorylation Source: Ensembl
  52. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  53. protein localization to nucleus Source: UniProtKB
  54. regulation of branching involved in prostate gland morphogenesis Source: MGI
  55. response to estradiol Source: Ensembl
  56. response to peptide hormone Source: Ensembl
  57. response to vitamin D Source: Ensembl
  58. salivary gland morphogenesis Source: MGI
  59. SMAD protein signal transduction Source: UniProtKB
  60. steroid hormone mediated signaling pathway Source: Ensembl
  61. tube morphogenesis Source: MGI
  62. ureteric bud development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Enzyme and pathway databases

ReactomeiREACT_198998. Molecules associated with elastic fibres.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 7
Short name:
BMP-7
Alternative name(s):
Osteogenic protein 1
Short name:
OP-1
Gene namesi
Name:Bmp7
Synonyms:Bmp-7, Op1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:103302. Bmp7.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular matrix Source: Ensembl
  2. extracellular space Source: MGI
  3. membrane-bounded vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 Reviewed predictionAdd
BLAST
Propeptidei30 – 291262 By similarityPRO_0000033878Add
BLAST
Chaini292 – 430139Bone morphogenetic protein 7PRO_0000033879Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi186 – 1861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi301 – 3011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi320 – 3201N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi329 ↔ 395 By similarity
Disulfide bondi358 ↔ 427 By similarity
Disulfide bondi362 ↔ 429 By similarity
Glycosylationi371 – 3711N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi394 – 394Interchain By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP23359.

PTM databases

PhosphoSiteiP23359.

Expressioni

Gene expression databases

BgeeiP23359.
CleanExiMM_BMP7.
GenevestigatoriP23359.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1.2 Publications

Protein-protein interaction databases

BioGridi198367. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliP23359.
SMRiP23359. Positions 190-430.

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG272883.
GeneTreeiENSGT00730000110505.
HOGENOMiHOG000249476.
HOVERGENiHBG004860.
InParanoidiP23359.
KOiK16621.
OMAiVVNPQHN.
OrthoDBiEOG7J9VPQ.
PhylomeDBiP23359.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23359-1 [UniParc]FASTAAdd to Basket

« Hide

MHVRSLRAAA PHSFVALWAP LFLLRSALAD FSLDNEVHSS FIHRRLRSQE    50
RREMQREILS ILGLPHRPRP HLQGKHNSAP MFMLDLYNAM AVEESGPDGQ 100
GFSYPYKAVF STQGPPLASL QDSHFLTDAD MVMSFVNLVE HDKEFFHPRY 150
HHREFRFDLS KIPEGEAVTA AEFRIYKDYI RERFDNETFQ ITVYQVLQEH 200
SGRESDLFLL DSRTIWASEE GWLVFDITAT SNHWVVNPRH NLGLQLSVET 250
LDGQSINPKL AGLIGRHGPQ NKQPFMVAFF KATEVHLRSI RSTGGKQRSQ 300
NRSKTPKNQE ALRMASVAEN SSSDQRQACK KHELYVSFRD LGWQDWIIAP 350
EGYAAYYCEG ECAFPLNSYM NATNHAIVQT LVHFINPDTV PKPCCAPTQL 400
NAISVLYFDD SSNVILKKYR NMVVRACGCH 430
Length:430
Mass (Da):49,199
Last modified:January 23, 2002 - v2
Checksum:i464F36D5D2E54041
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti167 – 1671A → R in CAA40222. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56906 mRNA. Translation: CAA40222.1.
BC010771 mRNA. Translation: AAH10771.1.
CCDSiCCDS17136.1.
PIRiJQ1184.
RefSeqiNP_031583.2. NM_007557.3.
UniGeneiMm.392150.
Mm.595.

Genome annotation databases

EnsembliENSMUST00000009143; ENSMUSP00000009143; ENSMUSG00000008999.
GeneIDi12162.
KEGGimmu:12162.
UCSCiuc008odb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56906 mRNA. Translation: CAA40222.1 .
BC010771 mRNA. Translation: AAH10771.1 .
CCDSi CCDS17136.1.
PIRi JQ1184.
RefSeqi NP_031583.2. NM_007557.3.
UniGenei Mm.392150.
Mm.595.

3D structure databases

ProteinModelPortali P23359.
SMRi P23359. Positions 190-430.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198367. 3 interactions.

PTM databases

PhosphoSitei P23359.

Proteomic databases

PRIDEi P23359.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000009143 ; ENSMUSP00000009143 ; ENSMUSG00000008999 .
GeneIDi 12162.
KEGGi mmu:12162.
UCSCi uc008odb.2. mouse.

Organism-specific databases

CTDi 655.
MGIi MGI:103302. Bmp7.

Phylogenomic databases

eggNOGi NOG272883.
GeneTreei ENSGT00730000110505.
HOGENOMi HOG000249476.
HOVERGENi HBG004860.
InParanoidi P23359.
KOi K16621.
OMAi VVNPQHN.
OrthoDBi EOG7J9VPQ.
PhylomeDBi P23359.
TreeFami TF316134.

Enzyme and pathway databases

Reactomei REACT_198998. Molecules associated with elastic fibres.

Miscellaneous databases

NextBioi 280515.
PROi P23359.
SOURCEi Search...

Gene expression databases

Bgeei P23359.
CleanExi MM_BMP7.
Genevestigatori P23359.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Murine osteogenic protein (OP-1): high levels of mRNA in kidney."
    Oezkaynak E., Schnegelsberg P.N.J., Oppermann H.
    Biochem. Biophys. Res. Commun. 179:116-123(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  3. "Sirenomelia in Bmp7 and Tsg compound mutant mice: requirement for Bmp signaling in the development of ventral posterior mesoderm."
    Zakin L., Reversade B., Kuroda H., Lyons K.M., De Robertis E.M.
    Development 132:2489-2499(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TWSG1.
  4. "Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot."
    Laurikkala J., Kassai Y., Pakkasjaervi L., Thesleff I., Itoh N.
    Dev. Biol. 264:91-105(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SOSTDC1.

Entry informationi

Entry nameiBMP7_MOUSE
AccessioniPrimary (citable) accession number: P23359
Secondary accession number(s): Q91XF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: January 23, 2002
Last modified: September 3, 2014
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi