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P23359

- BMP7_MOUSE

UniProt

P23359 - BMP7_MOUSE

Protein

Bone morphogenetic protein 7

Gene

Bmp7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 2 (23 Jan 2002)
      Previous versions | rss
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    Functioni

    Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.

    GO - Molecular functioni

    1. BMP receptor binding Source: MGI
    2. cytokine activity Source: MGI
    3. heparin binding Source: Ensembl
    4. protein binding Source: MGI

    GO - Biological processi

    1. anatomical structure formation involved in morphogenesis Source: MGI
    2. axon guidance Source: MGI
    3. BMP signaling pathway Source: MGI
    4. branching involved in salivary gland morphogenesis Source: MGI
    5. branching morphogenesis of an epithelial tube Source: MGI
    6. camera-type eye morphogenesis Source: MGI
    7. cartilage development Source: UniProtKB-KW
    8. cell development Source: MGI
    9. embryonic camera-type eye morphogenesis Source: MGI
    10. embryonic limb morphogenesis Source: MGI
    11. embryonic pattern specification Source: MGI
    12. embryonic skeletal joint morphogenesis Source: MGI
    13. epithelial cell differentiation Source: MGI
    14. eye development Source: UniProtKB
    15. growth Source: InterPro
    16. kidney development Source: UniProtKB
    17. mesenchymal cell differentiation Source: UniProtKB
    18. mesenchyme development Source: UniProtKB
    19. mesoderm formation Source: MGI
    20. mesonephros development Source: Ensembl
    21. metanephric mesenchymal cell proliferation involved in metanephros development Source: UniProtKB
    22. metanephric mesenchyme morphogenesis Source: UniProtKB
    23. monocyte aggregation Source: Ensembl
    24. negative regulation of cell proliferation Source: MGI
    25. negative regulation of glomerular mesangial cell proliferation Source: UniProtKB
    26. negative regulation of MAP kinase activity Source: UniProtKB
    27. negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis Source: MGI
    28. negative regulation of mitosis Source: UniProtKB
    29. negative regulation of neurogenesis Source: MGI
    30. negative regulation of neuron differentiation Source: MGI
    31. negative regulation of Notch signaling pathway Source: MGI
    32. negative regulation of phosphorylation Source: UniProtKB
    33. negative regulation of prostatic bud formation Source: MGI
    34. negative regulation of transcription, DNA-templated Source: UniProtKB
    35. nephrogenic mesenchyme morphogenesis Source: UniProtKB
    36. neuron projection morphogenesis Source: MGI
    37. odontogenesis of dentin-containing tooth Source: MGI
    38. organ morphogenesis Source: MGI
    39. ossification Source: UniProtKB-KW
    40. pattern specification process Source: MGI
    41. positive regulation of apoptotic process Source: MGI
    42. positive regulation of bone mineralization Source: Ensembl
    43. positive regulation of cell death Source: UniProtKB
    44. positive regulation of cell differentiation Source: MGI
    45. positive regulation of dendrite development Source: Ensembl
    46. positive regulation of heterotypic cell-cell adhesion Source: Ensembl
    47. positive regulation of hyaluranon cable assembly Source: Ensembl
    48. positive regulation of neuron differentiation Source: MGI
    49. positive regulation of osteoblast differentiation Source: Ensembl
    50. positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
    51. positive regulation of peptidyl-threonine phosphorylation Source: Ensembl
    52. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    53. protein localization to nucleus Source: UniProtKB
    54. regulation of branching involved in prostate gland morphogenesis Source: MGI
    55. response to estradiol Source: Ensembl
    56. response to peptide hormone Source: Ensembl
    57. response to vitamin D Source: Ensembl
    58. salivary gland morphogenesis Source: MGI
    59. SMAD protein signal transduction Source: UniProtKB
    60. steroid hormone mediated signaling pathway Source: Ensembl
    61. tube morphogenesis Source: MGI
    62. ureteric bud development Source: UniProtKB

    Keywords - Molecular functioni

    Cytokine, Developmental protein, Growth factor

    Keywords - Biological processi

    Chondrogenesis, Differentiation, Osteogenesis

    Enzyme and pathway databases

    ReactomeiREACT_198998. Molecules associated with elastic fibres.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bone morphogenetic protein 7
    Short name:
    BMP-7
    Alternative name(s):
    Osteogenic protein 1
    Short name:
    OP-1
    Gene namesi
    Name:Bmp7
    Synonyms:Bmp-7, Op1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:103302. Bmp7.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular matrix Source: Ensembl
    2. extracellular space Source: MGI
    3. membrane-bounded vesicle Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Propeptidei30 – 291262By similarityPRO_0000033878Add
    BLAST
    Chaini292 – 430139Bone morphogenetic protein 7PRO_0000033879Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi301 – 3011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi320 – 3201N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi329 ↔ 395By similarity
    Disulfide bondi358 ↔ 427By similarity
    Disulfide bondi362 ↔ 429By similarity
    Glycosylationi371 – 3711N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi394 – 394InterchainBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP23359.

    PTM databases

    PhosphoSiteiP23359.

    Expressioni

    Gene expression databases

    BgeeiP23359.
    CleanExiMM_BMP7.
    GenevestigatoriP23359.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1.2 Publications

    Protein-protein interaction databases

    BioGridi198367. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP23359.
    SMRiP23359. Positions 190-430.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG272883.
    GeneTreeiENSGT00730000110505.
    HOGENOMiHOG000249476.
    HOVERGENiHBG004860.
    InParanoidiP23359.
    KOiK16621.
    OMAiVVNPQHN.
    OrthoDBiEOG7J9VPQ.
    PhylomeDBiP23359.
    TreeFamiTF316134.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P23359-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHVRSLRAAA PHSFVALWAP LFLLRSALAD FSLDNEVHSS FIHRRLRSQE    50
    RREMQREILS ILGLPHRPRP HLQGKHNSAP MFMLDLYNAM AVEESGPDGQ 100
    GFSYPYKAVF STQGPPLASL QDSHFLTDAD MVMSFVNLVE HDKEFFHPRY 150
    HHREFRFDLS KIPEGEAVTA AEFRIYKDYI RERFDNETFQ ITVYQVLQEH 200
    SGRESDLFLL DSRTIWASEE GWLVFDITAT SNHWVVNPRH NLGLQLSVET 250
    LDGQSINPKL AGLIGRHGPQ NKQPFMVAFF KATEVHLRSI RSTGGKQRSQ 300
    NRSKTPKNQE ALRMASVAEN SSSDQRQACK KHELYVSFRD LGWQDWIIAP 350
    EGYAAYYCEG ECAFPLNSYM NATNHAIVQT LVHFINPDTV PKPCCAPTQL 400
    NAISVLYFDD SSNVILKKYR NMVVRACGCH 430
    Length:430
    Mass (Da):49,199
    Last modified:January 23, 2002 - v2
    Checksum:i464F36D5D2E54041
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti167 – 1671A → R in CAA40222. (PubMed:1715687)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56906 mRNA. Translation: CAA40222.1.
    BC010771 mRNA. Translation: AAH10771.1.
    CCDSiCCDS17136.1.
    PIRiJQ1184.
    RefSeqiNP_031583.2. NM_007557.3.
    UniGeneiMm.392150.
    Mm.595.

    Genome annotation databases

    EnsembliENSMUST00000009143; ENSMUSP00000009143; ENSMUSG00000008999.
    GeneIDi12162.
    KEGGimmu:12162.
    UCSCiuc008odb.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56906 mRNA. Translation: CAA40222.1 .
    BC010771 mRNA. Translation: AAH10771.1 .
    CCDSi CCDS17136.1.
    PIRi JQ1184.
    RefSeqi NP_031583.2. NM_007557.3.
    UniGenei Mm.392150.
    Mm.595.

    3D structure databases

    ProteinModelPortali P23359.
    SMRi P23359. Positions 190-430.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198367. 3 interactions.

    PTM databases

    PhosphoSitei P23359.

    Proteomic databases

    PRIDEi P23359.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000009143 ; ENSMUSP00000009143 ; ENSMUSG00000008999 .
    GeneIDi 12162.
    KEGGi mmu:12162.
    UCSCi uc008odb.2. mouse.

    Organism-specific databases

    CTDi 655.
    MGIi MGI:103302. Bmp7.

    Phylogenomic databases

    eggNOGi NOG272883.
    GeneTreei ENSGT00730000110505.
    HOGENOMi HOG000249476.
    HOVERGENi HBG004860.
    InParanoidi P23359.
    KOi K16621.
    OMAi VVNPQHN.
    OrthoDBi EOG7J9VPQ.
    PhylomeDBi P23359.
    TreeFami TF316134.

    Enzyme and pathway databases

    Reactomei REACT_198998. Molecules associated with elastic fibres.

    Miscellaneous databases

    NextBioi 280515.
    PROi P23359.
    SOURCEi Search...

    Gene expression databases

    Bgeei P23359.
    CleanExi MM_BMP7.
    Genevestigatori P23359.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Murine osteogenic protein (OP-1): high levels of mRNA in kidney."
      Oezkaynak E., Schnegelsberg P.N.J., Oppermann H.
      Biochem. Biophys. Res. Commun. 179:116-123(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    3. "Sirenomelia in Bmp7 and Tsg compound mutant mice: requirement for Bmp signaling in the development of ventral posterior mesoderm."
      Zakin L., Reversade B., Kuroda H., Lyons K.M., De Robertis E.M.
      Development 132:2489-2499(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TWSG1.
    4. "Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot."
      Laurikkala J., Kassai Y., Pakkasjaervi L., Thesleff I., Itoh N.
      Dev. Biol. 264:91-105(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SOSTDC1.

    Entry informationi

    Entry nameiBMP7_MOUSE
    AccessioniPrimary (citable) accession number: P23359
    Secondary accession number(s): Q91XF7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: January 23, 2002
    Last modified: October 1, 2014
    This is version 141 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3