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Protein

60S ribosomal protein L12

Gene

Rpl12

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds directly to 26S ribosomal RNA.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding

Enzyme and pathway databases

ReactomeiR-RNO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-RNO-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-RNO-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-RNO-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-RNO-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L12
Gene namesi
Name:Rpl12
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1565106. Rpl12.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: RGD

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001044581 – 16560S ribosomal protein L12Add BLAST165

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38PhosphoserineBy similarity1
Cross-linki40Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei54N6-acetyllysineBy similarity1
Modified residuei165PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP23358.
PRIDEiP23358.

PTM databases

iPTMnetiP23358.
PhosphoSitePlusiP23358.

Expressioni

Gene expression databases

BgeeiENSRNOG00000028993.
ExpressionAtlasiP23358. baseline.
GenevisibleiP23358. RN.

Interactioni

Protein-protein interaction databases

BioGridi3430786. 1 interactor.
IntActiP23358. 2 interactors.
MINTiMINT-4571063.
STRINGi10116.ENSRNOP00000041462.

Structurei

3D structure databases

ProteinModelPortaliP23358.
SMRiP23358.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0886. Eukaryota.
COG0080. LUCA.
GeneTreeiENSGT00390000006922.
HOGENOMiHOG000082125.
HOVERGENiHBG007231.
InParanoidiP23358.
KOiK02870.
OMAiGCTIDGR.
OrthoDBiEOG091G0PW6.
PhylomeDBiP23358.
TreeFamiTF300123.

Family and domain databases

CDDicd00349. Ribosomal_L11. 1 hit.
Gene3Di1.10.10.250. 1 hit.
3.30.1550.10. 1 hit.
HAMAPiMF_00736. Ribosomal_L11. 1 hit.
InterProiView protein in InterPro
IPR000911. Ribosomal_L11/L12.
IPR020783. Ribosomal_L11_C.
IPR020785. Ribosomal_L11_CS.
IPR020784. Ribosomal_L11_N.
PANTHERiPTHR11661. PTHR11661. 1 hit.
PfamiView protein in Pfam
PF00298. Ribosomal_L11. 1 hit.
PF03946. Ribosomal_L11_N. 1 hit.
SMARTiView protein in SMART
SM00649. RL11. 1 hit.
SUPFAMiSSF46906. SSF46906. 1 hit.
SSF54747. SSF54747. 1 hit.
PROSITEiView protein in PROSITE
PS00359. RIBOSOMAL_L11. 1 hit.

Sequencei

Sequence statusi: Complete.

P23358-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPKFDPNEI KVVYLRCTGG EVGATSALAP KIGPLGLSPK KVGDDIAKAT
60 70 80 90 100
GDWKGLRITV KLTIQNRQAQ IEVVPSASAL IIKALKEPPR DRKKQKNIKH
110 120 130 140 150
NGNITFDEIV NIARQMRHRS LARELSGTIK EILGTAQSVG CNVDGRHPHD
160
IIDDINSGAV ECPAS
Length:165
Mass (Da):17,846
Last modified:November 1, 1991 - v1
Checksum:i6F1C882B6F2350F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53504 mRNA. Translation: CAA37581.1.
PIRiA36667. R7RT12.
RefSeqiNP_001102668.1. NM_001109198.1.
XP_006227318.1. XM_006227256.3.
XP_006256697.1. XM_006256635.3.
UniGeneiRn.128979.
Rn.203094.
Rn.203151.

Genome annotation databases

EnsembliENSRNOT00000042736; ENSRNOP00000041462; ENSRNOG00000028993.
GeneIDi102555453.
499782.
KEGGirno:102555453.
rno:499782.
UCSCiRGD:1565106. rat.

Similar proteinsi

Entry informationi

Entry nameiRL12_RAT
AccessioniPrimary (citable) accession number: P23358
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: August 30, 2017
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families