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Protein

Chorismate synthase

Gene

aroC

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.UniRule annotation

Catalytic activityi

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate.UniRule annotation

Cofactori

FMNH2UniRule annotationNote: Reduced FMN (FMNH(2)).UniRule annotation

Pathwayi: chorismate biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (aroQ)
  4. Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase (aroK)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei47NADPUniRule annotation1
Binding sitei286FMN; via amide nitrogenUniRule annotation1
Binding sitei327FMNUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi124 – 126FMNUniRule annotation3
Nucleotide bindingi301 – 305FMNUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis
LigandFAD, Flavoprotein, FMN, NADP

Enzyme and pathway databases

UniPathwayiUPA00053; UER00090

Names & Taxonomyi

Protein namesi
Recommended name:
Chorismate synthaseUniRule annotation (EC:4.2.3.5UniRule annotation)
Short name:
CSUniRule annotation
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyaseUniRule annotation
Gene namesi
Name:aroCUniRule annotation
Ordered Locus Names:sll1747
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001406671 – 362Chorismate synthaseAdd BLAST362

Proteomic databases

PaxDbiP23353
PRIDEiP23353

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi1148.SYNGTS_0841

Structurei

3D structure databases

ProteinModelPortaliP23353
SMRiP23353
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chorismate synthase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000060335
InParanoidiP23353
KOiK01736
OMAiMLSINAV
PhylomeDBiP23353

Family and domain databases

CDDicd07304 Chorismate_synthase, 1 hit
Gene3Di3.60.150.10, 1 hit
HAMAPiMF_00300 Chorismate_synth, 1 hit
InterProiView protein in InterPro
IPR000453 Chorismate_synth
IPR035904 Chorismate_synth_AroC_sf
IPR020541 Chorismate_synthase_CS
PANTHERiPTHR21085 PTHR21085, 1 hit
PfamiView protein in Pfam
PF01264 Chorismate_synt, 1 hit
PIRSFiPIRSF001456 Chorismate_synth, 1 hit
SUPFAMiSSF103263 SSF103263, 1 hit
TIGRFAMsiTIGR00033 aroC, 1 hit
PROSITEiView protein in PROSITE
PS00787 CHORISMATE_SYNTHASE_1, 1 hit
PS00788 CHORISMATE_SYNTHASE_2, 1 hit
PS00789 CHORISMATE_SYNTHASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

P23353-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNTFGSLFR ITTFGESHGG GVGVIIDGCP PRLEISPEEI QVDLDRRRPG
60 70 80 90 100
QSKITTPRKE ADQCEILSGV FEGKTLGTPI AILVRNKDAR SQDYNEMAVK
110 120 130 140 150
YRPSHADATY EAKYGIRNWQ GGGRSSARET IGRVAAGAIA KKILAQFNGV
160 170 180 190 200
EIVAYVKSIQ DIEATVDSNT VTLEQVESNI VRCPDEECAE KMIERIDQVL
210 220 230 240 250
RQKDSIGGVV ECAIRNAPKG LGEPVFDKLE ADLAKAMMSL PATKGFEFGS
260 270 280 290 300
GFAGTLLTGS QHNDEYYLDE AGEWRTRTNR SGGVQGGISN GEPIIMRIAF
310 320 330 340 350
KPTATIGQEQ KTVSNIGEET TLAAKGRHDP CVLPRAVPMV EAMAALVLCD
360
HLLRFQAQCK TL
Length:362
Mass (Da):39,288
Last modified:February 1, 1995 - v2
Checksum:i9709B0F409168AB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67516 Genomic DNA Translation: CAA47855.1
BA000022 Genomic DNA Translation: BAA17415.1
X53178 Genomic DNA Translation: CAA37319.1
PIRiA49316

Genome annotation databases

EnsemblBacteriaiBAA17415; BAA17415; BAA17415
KEGGisyn:sll1747

Similar proteinsi

Entry informationi

Entry nameiAROC_SYNY3
AccessioniPrimary (citable) accession number: P23353
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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