ID   RL7_SYNY3               Reviewed;         128 AA.
AC   P23349;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   27-MAR-2024, entry version 150.
DE   RecName: Full=Large ribosomal subunit protein bL12 {ECO:0000255|HAMAP-Rule:MF_00368};
DE   AltName: Full=50S ribosomal protein L7/L12 {ECO:0000305};
GN   Name=rplL {ECO:0000255|HAMAP-Rule:MF_00368};
GN   Synonyms=rpl12 {ECO:0000255|HAMAP-Rule:MF_00368};
GN   OrderedLocusNames=sll1746;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales; Merismopediaceae;
OC   Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2119815; DOI=10.1016/0167-4781(90)90142-o;
RA   Sibold C., Subramanian A.R.;
RT   "Cloning and characterization of the genes for ribosomal proteins L10 and
RT   L12 from Synechocystis Sp. PCC 6803: comparison of gene clustering pattern
RT   and protein sequence homology between cyanobacteria and chloroplasts.";
RL   Biochim. Biophys. Acta 1050:61-68(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 117-128.
RX   PubMed=7505271; DOI=10.1016/s0021-9258(19)74268-9;
RA   Schmidt J., Bubunenko M., Subramanian A.R.;
RT   "A novel operon organization involving the genes for chorismate synthase
RT   (aromatic biosynthesis pathway) and ribosomal GTPase center proteins (L11,
RT   L1, L10, L12: rplKAJL) in cyanobacterium Synechocystis PCC 6803.";
RL   J. Biol. Chem. 268:27447-27457(1993).
RN   [4]
RP   PROTEIN SEQUENCE OF 2-8.
RX   PubMed=9298645; DOI=10.1002/elps.1150180806;
RA   Sazuka T., Ohara O.;
RT   "Towards a proteome project of cyanobacterium Synechocystis sp. strain
RT   PCC6803: linking 130 protein spots with their respective genes.";
RL   Electrophoresis 18:1252-1258(1997).
CC   -!- FUNCTION: Forms part of the ribosomal stalk which helps the ribosome
CC       interact with GTP-bound translation factors. Is thus essential for
CC       accurate translation. {ECO:0000255|HAMAP-Rule:MF_00368}.
CC   -!- SUBUNIT: Homodimer. Part of the ribosomal stalk of the 50S ribosomal
CC       subunit. Forms a multimeric L10(L12)X complex, where L10 forms an
CC       elongated spine to which 2 to 4 L12 dimers bind in a sequential
CC       fashion. Binds GTP-bound translation factors. {ECO:0000255|HAMAP-
CC       Rule:MF_00368}.
CC   -!- SIMILARITY: Belongs to the bacterial ribosomal protein bL12 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00368}.
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DR   EMBL; X53178; CAA37318.1; -; Genomic_DNA.
DR   EMBL; BA000022; BAA17416.1; -; Genomic_DNA.
DR   EMBL; X67516; CAA47854.1; -; Genomic_DNA.
DR   PIR; S13069; S13069.
DR   AlphaFoldDB; P23349; -.
DR   SMR; P23349; -.
DR   IntAct; P23349; 1.
DR   STRING; 1148.gene:10498279; -.
DR   PaxDb; 1148-1652495; -.
DR   EnsemblBacteria; BAA17416; BAA17416; BAA17416.
DR   KEGG; syn:sll1746; -.
DR   eggNOG; COG0222; Bacteria.
DR   InParanoid; P23349; -.
DR   PhylomeDB; P23349; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR   GO; GO:0006412; P:translation; IBA:GO_Central.
DR   CDD; cd00387; Ribosomal_L7_L12; 1.
DR   Gene3D; 3.30.1390.10; -; 1.
DR   Gene3D; 1.20.5.710; Single helix bin; 1.
DR   HAMAP; MF_00368; Ribosomal_bL12; 1.
DR   InterPro; IPR000206; Ribosomal_bL12.
DR   InterPro; IPR013823; Ribosomal_bL12_C.
DR   InterPro; IPR014719; Ribosomal_bL12_C/ClpS-like.
DR   InterPro; IPR008932; Ribosomal_bL12_oligo.
DR   InterPro; IPR036235; Ribosomal_bL12_oligo_N_sf.
DR   NCBIfam; TIGR00855; L12; 1.
DR   PANTHER; PTHR45987; 39S RIBOSOMAL PROTEIN L12; 1.
DR   PANTHER; PTHR45987:SF4; 39S RIBOSOMAL PROTEIN L12, MITOCHONDRIAL; 1.
DR   Pfam; PF00542; Ribosomal_L12; 1.
DR   Pfam; PF16320; Ribosomal_L12_N; 1.
DR   SUPFAM; SSF54736; ClpS-like; 1.
DR   SUPFAM; SSF48300; Ribosomal protein L7/12, oligomerisation (N-terminal) domain; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Reference proteome; Ribonucleoprotein;
KW   Ribosomal protein.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:9298645"
FT   CHAIN           2..128
FT                   /note="Large ribosomal subunit protein bL12"
FT                   /id="PRO_0000157595"
SQ   SEQUENCE   128 AA;  13259 MW;  FCBF73A205A53946 CRC64;
     MSAATDQILE QLKSLSLLEA SELVKQIEEA FGVSAAAPVG GMVMAAAAAA PAEAAEEKTE
     FDVILEEVPA DKKIAVLKVV RTITGLGLKE AKELVESTPK AIKEATGKDD AEAIKKQIEE
     AGGKAAVK
//