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P23348 (B3A3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Anion exchange protein 3

Short name=AE 3
Short name=Anion exchanger 3
Alternative name(s):
Band 3-related protein 3
Short name=B3RP-3
Neuronal band 3-like protein
Solute carrier family 4 member 3
Gene names
Name:Slc4a3
Synonyms:Ae3, B3rp3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length1227 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plasma membrane anion exchange protein.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Neuronal.

Sequence similarities

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12271227Anion exchange protein 3
PRO_0000079222

Regions

Topological domain1 – 707707Cytoplasmic
Transmembrane708 – 73023Helical; Potential
Transmembrane736 – 77338Helical; Potential
Transmembrane793 – 81523Helical; Potential
Transmembrane825 – 84622Helical; Potential
Transmembrane888 – 90518Helical; Potential
Topological domain906 – 92015Cytoplasmic Potential
Transmembrane921 – 94121Helical; Potential
Transmembrane975 – 99723Helical; Potential
Transmembrane1023 – 104422Helical; Potential
Transmembrane1078 – 112346Helical; Potential
Transmembrane1150 – 118637Helical; Potential
Region708 – 1227520Membrane (anion exchange)
Compositional bias74 – 8310His-rich
Compositional bias135 – 14915Poly-Glu
Compositional bias155 – 1617Poly-Pro
Compositional bias307 – 3126Poly-Lys
Compositional bias441 – 4444Poly-Ser
Compositional bias1179 – 11824Poly-Leu

Amino acid modifications

Lipidation11601S-palmitoyl cysteine By similarity
Glycosylation8681N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P23348 [UniParc].

Last modified November 1, 1991. Version 1.
Checksum: 3EB1620EE011730E

FASTA1,227135,407
        10         20         30         40         50         60 
MANGVIPPPG GPSPLPQVRV PLEEPPLGPD VEEEDDDLGK TLAVSRFGDL ISKTPAWDPE 

        70         80         90        100        110        120 
KPSRSYSERD FEFHRHTSHH THHPLSARLP PPHKLRRLPP TSARHARRKR KKEKTSAPPS 

       130        140        150        160        170        180 
EGTPPIQEEG GAGAEEEEEE EEEEEGESEA EPVEPPPPGP PQKAKFSIGS DEDDSPGLSI 

       190        200        210        220        230        240 
KAPCAKALPS VGLPSDQSPQ RSGSSPSPRA RASRISTEKS RPWSPSASYD LRERLCPGSA 

       250        260        270        280        290        300 
LGNPGPEQRV PTDEAEAQML GSADLDDMKS HRLEDNPGVR RHLVKKPSRI QGGRGSPSGL 

       310        320        330        340        350        360 
APILRRKKKK KKLDRRPHEV FVELNELMLD RSQEPHWRET ARWIKFEEDV EEETERWGKP 

       370        380        390        400        410        420 
HVASLSFRSL LELRRTIAQG AALLDLEQTT LPGIAHLVVE TMIVSDQIRP EDRASVLRTL 

       430        440        450        460        470        480 
LLKHSHPNDD KDSGFFPRNP SSSSVNSVLG NHHPTPSHGP DGAVPTMADD LGEPAPLWPH 

       490        500        510        520        530        540 
DPDAKEKPLH MPGGDGHRGK SLKLLEKIPE DAEATVVLVG SVPFLEQPAA AFVRLSEAVL 

       550        560        570        580        590        600 
LESVLEVPVP VRFLFVMLGP SHTSTDYHEL GRSIATLMSD KLFHEAAYQA DDRQDLLGAI 

       610        620        630        640        650        660 
SEFLDGSIVI PPSEVEGRDL LRSVAAFQRE LLRKRREREQ TKVEMTTRGG YVAPGKELSL 

       670        680        690        700        710        720 
EMGGSEATSE DDPLQRTGSV FGGLVRDVKR RYPHYPSDLR DALHSQCVAA VLFIYFAALS 

       730        740        750        760        770        780 
PAITFGGLLG EKTEGLMGVS ELIVSTAVLG VLFSLLGAQP LLVVGFSGPL LVFEEAFFKF 

       790        800        810        820        830        840 
CRAQDLEYLT GRVWVGLWLV VFVLALVAAE GSFLVRYISP FTQEIFAFLI SLIFIYETFH 

       850        860        870        880        890        900 
KLYKVFTEHP LLPFYPPEEA LEPGLELNSS ALPPTEGPPG PRNQPNTALL SLILMLGTFL 

       910        920        930        940        950        960 
IAFFLRKFRN SRFLGGKARR VIGDFGIPIS ILVMVLVDYS ITDTYTQKLT VPTGLSVTSP 

       970        980        990       1000       1010       1020 
HKRTWFIPPL GSARPFPPWM MVAAAVPALL VLILIFMETQ ITALIVSQKA RRLLKGSGFH 

      1030       1040       1050       1060       1070       1080 
LDLLLIGSLG GLCGLFGLPW LTAATVRSVT HVNALTVMRT AIAPGDKPQI QEVREQRVTG 

      1090       1100       1110       1120       1130       1140 
VLIASLVGLS IVMGAVLRRI PLAVLFGIFL YMGVTSLSGI QLSQRLLLIF MPAKHHPEQP 

      1150       1160       1170       1180       1190       1200 
YVTKVKTWRM HLFTFIQLGC IALLWVVKST VASLAFPFLL LLTVPLRRCL LPRLFQDREL 

      1210       1220 
QALDSEDAEP NFDEDGQDEY NELHMPV 

« Hide

References

[1]"cDNA cloning and tissue distribution of mRNAs for two proteins that are related to the band 3 Cl-/HCO3-exchanger."
Kudrycki K.E., Newman P.R., Shull G.E.
J. Biol. Chem. 265:462-471(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J05167 mRNA. Translation: AAA40798.1.
PIRB34911.
RefSeqNP_058745.1. NM_017049.1.
UniGeneRn.87739.

3D structure databases

ProteinModelPortalP23348.
SMRP23348. Positions 691-732.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid246905. 1 interaction.
STRING10116.ENSRNOP00000058980.

PTM databases

PhosphoSiteP23348.

Proteomic databases

PaxDbP23348.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID24781.
KEGGrno:24781.
UCSCRGD:3712. rat.

Organism-specific databases

CTD6508.
RGD3712. Slc4a3.

Phylogenomic databases

eggNOGNOG268067.
HOGENOMHOG000280683.
HOVERGENHBG004326.
InParanoidP23348.
KOK13856.
PhylomeDBP23348.

Gene expression databases

GenevestigatorP23348.

Family and domain databases

Gene3D3.40.1100.10. 1 hit.
InterProIPR001717. Anion_exchange.
IPR002979. Anion_exchange_3.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERPTHR11453. PTHR11453. 1 hit.
PTHR11453:SF15. PTHR11453:SF15. 1 hit.
PfamPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 2 hits.
[Graphical view]
PRINTSPR00165. ANIONEXCHNGR.
PR01189. ANIONEXHNGR3.
PR01231. HCO3TRNSPORT.
SUPFAMSSF55804. SSF55804. 2 hits.
TIGRFAMsTIGR00834. ae. 1 hit.
PROSITEPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio604388.
PROP23348.

Entry information

Entry nameB3A3_RAT
AccessionPrimary (citable) accession number: P23348
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: April 16, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families