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P23348

- B3A3_RAT

UniProt

P23348 - B3A3_RAT

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Protein

Anion exchange protein 3

Gene
Slc4a3, Ae3, B3rp3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Plasma membrane anion exchange protein.

GO - Molecular functioni

  1. inorganic anion exchanger activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Anion exchange, Antiport, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange protein 3
Short name:
AE 3
Short name:
Anion exchanger 3
Alternative name(s):
Band 3-related protein 3
Short name:
B3RP-3
Neuronal band 3-like protein
Solute carrier family 4 member 3
Gene namesi
Name:Slc4a3
Synonyms:Ae3, B3rp3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3712. Slc4a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 707707CytoplasmicAdd
BLAST
Transmembranei708 – 73023Helical; Reviewed predictionAdd
BLAST
Transmembranei736 – 77338Helical; Reviewed predictionAdd
BLAST
Transmembranei793 – 81523Helical; Reviewed predictionAdd
BLAST
Transmembranei825 – 84622Helical; Reviewed predictionAdd
BLAST
Transmembranei888 – 90518Helical; Reviewed predictionAdd
BLAST
Topological domaini906 – 92015Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei921 – 94121Helical; Reviewed predictionAdd
BLAST
Transmembranei975 – 99723Helical; Reviewed predictionAdd
BLAST
Transmembranei1023 – 104422Helical; Reviewed predictionAdd
BLAST
Transmembranei1078 – 112346Helical; Reviewed predictionAdd
BLAST
Transmembranei1150 – 118637Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12271227Anion exchange protein 3PRO_0000079222Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi868 – 8681N-linked (GlcNAc...) Reviewed prediction
Lipidationi1160 – 11601S-palmitoyl cysteine By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP23348.

PTM databases

PhosphoSiteiP23348.

Expressioni

Tissue specificityi

Neuronal.

Gene expression databases

GenevestigatoriP23348.

Interactioni

Protein-protein interaction databases

BioGridi246905. 1 interaction.
STRINGi10116.ENSRNOP00000058980.

Structurei

3D structure databases

ProteinModelPortaliP23348.
SMRiP23348. Positions 691-732.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni708 – 1227520Membrane (anion exchange)Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi74 – 8310His-rich
Compositional biasi135 – 14915Poly-GluAdd
BLAST
Compositional biasi155 – 1617Poly-Pro
Compositional biasi307 – 3126Poly-Lys
Compositional biasi441 – 4444Poly-Ser
Compositional biasi1179 – 11824Poly-Leu

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG268067.
HOGENOMiHOG000280683.
HOVERGENiHBG004326.
InParanoidiP23348.
KOiK13856.
PhylomeDBiP23348.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002979. Anion_exchange_3.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PTHR11453:SF15. PTHR11453:SF15. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 2 hits.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01189. ANIONEXHNGR3.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23348-1 [UniParc]FASTAAdd to Basket

« Hide

MANGVIPPPG GPSPLPQVRV PLEEPPLGPD VEEEDDDLGK TLAVSRFGDL     50
ISKTPAWDPE KPSRSYSERD FEFHRHTSHH THHPLSARLP PPHKLRRLPP 100
TSARHARRKR KKEKTSAPPS EGTPPIQEEG GAGAEEEEEE EEEEEGESEA 150
EPVEPPPPGP PQKAKFSIGS DEDDSPGLSI KAPCAKALPS VGLPSDQSPQ 200
RSGSSPSPRA RASRISTEKS RPWSPSASYD LRERLCPGSA LGNPGPEQRV 250
PTDEAEAQML GSADLDDMKS HRLEDNPGVR RHLVKKPSRI QGGRGSPSGL 300
APILRRKKKK KKLDRRPHEV FVELNELMLD RSQEPHWRET ARWIKFEEDV 350
EEETERWGKP HVASLSFRSL LELRRTIAQG AALLDLEQTT LPGIAHLVVE 400
TMIVSDQIRP EDRASVLRTL LLKHSHPNDD KDSGFFPRNP SSSSVNSVLG 450
NHHPTPSHGP DGAVPTMADD LGEPAPLWPH DPDAKEKPLH MPGGDGHRGK 500
SLKLLEKIPE DAEATVVLVG SVPFLEQPAA AFVRLSEAVL LESVLEVPVP 550
VRFLFVMLGP SHTSTDYHEL GRSIATLMSD KLFHEAAYQA DDRQDLLGAI 600
SEFLDGSIVI PPSEVEGRDL LRSVAAFQRE LLRKRREREQ TKVEMTTRGG 650
YVAPGKELSL EMGGSEATSE DDPLQRTGSV FGGLVRDVKR RYPHYPSDLR 700
DALHSQCVAA VLFIYFAALS PAITFGGLLG EKTEGLMGVS ELIVSTAVLG 750
VLFSLLGAQP LLVVGFSGPL LVFEEAFFKF CRAQDLEYLT GRVWVGLWLV 800
VFVLALVAAE GSFLVRYISP FTQEIFAFLI SLIFIYETFH KLYKVFTEHP 850
LLPFYPPEEA LEPGLELNSS ALPPTEGPPG PRNQPNTALL SLILMLGTFL 900
IAFFLRKFRN SRFLGGKARR VIGDFGIPIS ILVMVLVDYS ITDTYTQKLT 950
VPTGLSVTSP HKRTWFIPPL GSARPFPPWM MVAAAVPALL VLILIFMETQ 1000
ITALIVSQKA RRLLKGSGFH LDLLLIGSLG GLCGLFGLPW LTAATVRSVT 1050
HVNALTVMRT AIAPGDKPQI QEVREQRVTG VLIASLVGLS IVMGAVLRRI 1100
PLAVLFGIFL YMGVTSLSGI QLSQRLLLIF MPAKHHPEQP YVTKVKTWRM 1150
HLFTFIQLGC IALLWVVKST VASLAFPFLL LLTVPLRRCL LPRLFQDREL 1200
QALDSEDAEP NFDEDGQDEY NELHMPV 1227
Length:1,227
Mass (Da):135,407
Last modified:November 1, 1991 - v1
Checksum:i3EB1620EE011730E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J05167 mRNA. Translation: AAA40798.1.
PIRiB34911.
RefSeqiNP_058745.1. NM_017049.1.
UniGeneiRn.87739.

Genome annotation databases

GeneIDi24781.
KEGGirno:24781.
UCSCiRGD:3712. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J05167 mRNA. Translation: AAA40798.1 .
PIRi B34911.
RefSeqi NP_058745.1. NM_017049.1.
UniGenei Rn.87739.

3D structure databases

ProteinModelPortali P23348.
SMRi P23348. Positions 691-732.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 246905. 1 interaction.
STRINGi 10116.ENSRNOP00000058980.

PTM databases

PhosphoSitei P23348.

Proteomic databases

PaxDbi P23348.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 24781.
KEGGi rno:24781.
UCSCi RGD:3712. rat.

Organism-specific databases

CTDi 6508.
RGDi 3712. Slc4a3.

Phylogenomic databases

eggNOGi NOG268067.
HOGENOMi HOG000280683.
HOVERGENi HBG004326.
InParanoidi P23348.
KOi K13856.
PhylomeDBi P23348.

Miscellaneous databases

NextBioi 604388.
PROi P23348.

Gene expression databases

Genevestigatori P23348.

Family and domain databases

Gene3Di 3.40.1100.10. 1 hit.
InterProi IPR001717. Anion_exchange.
IPR002979. Anion_exchange_3.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view ]
PANTHERi PTHR11453. PTHR11453. 1 hit.
PTHR11453:SF15. PTHR11453:SF15. 1 hit.
Pfami PF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 2 hits.
[Graphical view ]
PRINTSi PR00165. ANIONEXCHNGR.
PR01189. ANIONEXHNGR3.
PR01231. HCO3TRNSPORT.
SUPFAMi SSF55804. SSF55804. 2 hits.
TIGRFAMsi TIGR00834. ae. 1 hit.
PROSITEi PS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning and tissue distribution of mRNAs for two proteins that are related to the band 3 Cl-/HCO3-exchanger."
    Kudrycki K.E., Newman P.R., Shull G.E.
    J. Biol. Chem. 265:462-471(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiB3A3_RAT
AccessioniPrimary (citable) accession number: P23348
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: April 16, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi