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P23348

- B3A3_RAT

UniProt

P23348 - B3A3_RAT

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Protein

Anion exchange protein 3

Gene

Slc4a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Plasma membrane anion exchange protein.

GO - Molecular functioni

  1. inorganic anion exchanger activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Anion exchange, Antiport, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange protein 3
Short name:
AE 3
Short name:
Anion exchanger 3
Alternative name(s):
Band 3-related protein 3
Short name:
B3RP-3
Neuronal band 3-like protein
Solute carrier family 4 member 3
Gene namesi
Name:Slc4a3
Synonyms:Ae3, B3rp3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3712. Slc4a3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12271227Anion exchange protein 3PRO_0000079222Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi868 – 8681N-linked (GlcNAc...)Sequence Analysis
Lipidationi1160 – 11601S-palmitoyl cysteineBy similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP23348.

PTM databases

PhosphoSiteiP23348.

Expressioni

Tissue specificityi

Neuronal.

Gene expression databases

GenevestigatoriP23348.

Interactioni

Protein-protein interaction databases

BioGridi246905. 1 interaction.
STRINGi10116.ENSRNOP00000058980.

Structurei

3D structure databases

ProteinModelPortaliP23348.
SMRiP23348. Positions 691-732.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 707707CytoplasmicAdd
BLAST
Topological domaini906 – 92015CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei708 – 73023HelicalSequence AnalysisAdd
BLAST
Transmembranei736 – 77338HelicalSequence AnalysisAdd
BLAST
Transmembranei793 – 81523HelicalSequence AnalysisAdd
BLAST
Transmembranei825 – 84622HelicalSequence AnalysisAdd
BLAST
Transmembranei888 – 90518HelicalSequence AnalysisAdd
BLAST
Transmembranei921 – 94121HelicalSequence AnalysisAdd
BLAST
Transmembranei975 – 99723HelicalSequence AnalysisAdd
BLAST
Transmembranei1023 – 104422HelicalSequence AnalysisAdd
BLAST
Transmembranei1078 – 112346HelicalSequence AnalysisAdd
BLAST
Transmembranei1150 – 118637HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni708 – 1227520Membrane (anion exchange)Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi74 – 8310His-rich
Compositional biasi135 – 14915Poly-GluAdd
BLAST
Compositional biasi155 – 1617Poly-Pro
Compositional biasi307 – 3126Poly-Lys
Compositional biasi441 – 4444Poly-Ser
Compositional biasi1179 – 11824Poly-Leu

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG268067.
HOGENOMiHOG000280683.
HOVERGENiHBG004326.
InParanoidiP23348.
KOiK13856.
PhylomeDBiP23348.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002979. Anion_exchange_3.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PTHR11453:SF15. PTHR11453:SF15. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 2 hits.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01189. ANIONEXHNGR3.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23348-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANGVIPPPG GPSPLPQVRV PLEEPPLGPD VEEEDDDLGK TLAVSRFGDL
60 70 80 90 100
ISKTPAWDPE KPSRSYSERD FEFHRHTSHH THHPLSARLP PPHKLRRLPP
110 120 130 140 150
TSARHARRKR KKEKTSAPPS EGTPPIQEEG GAGAEEEEEE EEEEEGESEA
160 170 180 190 200
EPVEPPPPGP PQKAKFSIGS DEDDSPGLSI KAPCAKALPS VGLPSDQSPQ
210 220 230 240 250
RSGSSPSPRA RASRISTEKS RPWSPSASYD LRERLCPGSA LGNPGPEQRV
260 270 280 290 300
PTDEAEAQML GSADLDDMKS HRLEDNPGVR RHLVKKPSRI QGGRGSPSGL
310 320 330 340 350
APILRRKKKK KKLDRRPHEV FVELNELMLD RSQEPHWRET ARWIKFEEDV
360 370 380 390 400
EEETERWGKP HVASLSFRSL LELRRTIAQG AALLDLEQTT LPGIAHLVVE
410 420 430 440 450
TMIVSDQIRP EDRASVLRTL LLKHSHPNDD KDSGFFPRNP SSSSVNSVLG
460 470 480 490 500
NHHPTPSHGP DGAVPTMADD LGEPAPLWPH DPDAKEKPLH MPGGDGHRGK
510 520 530 540 550
SLKLLEKIPE DAEATVVLVG SVPFLEQPAA AFVRLSEAVL LESVLEVPVP
560 570 580 590 600
VRFLFVMLGP SHTSTDYHEL GRSIATLMSD KLFHEAAYQA DDRQDLLGAI
610 620 630 640 650
SEFLDGSIVI PPSEVEGRDL LRSVAAFQRE LLRKRREREQ TKVEMTTRGG
660 670 680 690 700
YVAPGKELSL EMGGSEATSE DDPLQRTGSV FGGLVRDVKR RYPHYPSDLR
710 720 730 740 750
DALHSQCVAA VLFIYFAALS PAITFGGLLG EKTEGLMGVS ELIVSTAVLG
760 770 780 790 800
VLFSLLGAQP LLVVGFSGPL LVFEEAFFKF CRAQDLEYLT GRVWVGLWLV
810 820 830 840 850
VFVLALVAAE GSFLVRYISP FTQEIFAFLI SLIFIYETFH KLYKVFTEHP
860 870 880 890 900
LLPFYPPEEA LEPGLELNSS ALPPTEGPPG PRNQPNTALL SLILMLGTFL
910 920 930 940 950
IAFFLRKFRN SRFLGGKARR VIGDFGIPIS ILVMVLVDYS ITDTYTQKLT
960 970 980 990 1000
VPTGLSVTSP HKRTWFIPPL GSARPFPPWM MVAAAVPALL VLILIFMETQ
1010 1020 1030 1040 1050
ITALIVSQKA RRLLKGSGFH LDLLLIGSLG GLCGLFGLPW LTAATVRSVT
1060 1070 1080 1090 1100
HVNALTVMRT AIAPGDKPQI QEVREQRVTG VLIASLVGLS IVMGAVLRRI
1110 1120 1130 1140 1150
PLAVLFGIFL YMGVTSLSGI QLSQRLLLIF MPAKHHPEQP YVTKVKTWRM
1160 1170 1180 1190 1200
HLFTFIQLGC IALLWVVKST VASLAFPFLL LLTVPLRRCL LPRLFQDREL
1210 1220
QALDSEDAEP NFDEDGQDEY NELHMPV
Length:1,227
Mass (Da):135,407
Last modified:November 1, 1991 - v1
Checksum:i3EB1620EE011730E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J05167 mRNA. Translation: AAA40798.1.
PIRiB34911.
RefSeqiNP_058745.1. NM_017049.1.
UniGeneiRn.87739.

Genome annotation databases

GeneIDi24781.
KEGGirno:24781.
UCSCiRGD:3712. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J05167 mRNA. Translation: AAA40798.1 .
PIRi B34911.
RefSeqi NP_058745.1. NM_017049.1.
UniGenei Rn.87739.

3D structure databases

ProteinModelPortali P23348.
SMRi P23348. Positions 691-732.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 246905. 1 interaction.
STRINGi 10116.ENSRNOP00000058980.

PTM databases

PhosphoSitei P23348.

Proteomic databases

PaxDbi P23348.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 24781.
KEGGi rno:24781.
UCSCi RGD:3712. rat.

Organism-specific databases

CTDi 6508.
RGDi 3712. Slc4a3.

Phylogenomic databases

eggNOGi NOG268067.
HOGENOMi HOG000280683.
HOVERGENi HBG004326.
InParanoidi P23348.
KOi K13856.
PhylomeDBi P23348.

Miscellaneous databases

NextBioi 604388.
PROi P23348.

Gene expression databases

Genevestigatori P23348.

Family and domain databases

Gene3Di 3.40.1100.10. 1 hit.
InterProi IPR001717. Anion_exchange.
IPR002979. Anion_exchange_3.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view ]
PANTHERi PTHR11453. PTHR11453. 1 hit.
PTHR11453:SF15. PTHR11453:SF15. 1 hit.
Pfami PF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 2 hits.
[Graphical view ]
PRINTSi PR00165. ANIONEXCHNGR.
PR01189. ANIONEXHNGR3.
PR01231. HCO3TRNSPORT.
SUPFAMi SSF55804. SSF55804. 2 hits.
TIGRFAMsi TIGR00834. ae. 1 hit.
PROSITEi PS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning and tissue distribution of mRNAs for two proteins that are related to the band 3 Cl-/HCO3-exchanger."
    Kudrycki K.E., Newman P.R., Shull G.E.
    J. Biol. Chem. 265:462-471(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiB3A3_RAT
AccessioniPrimary (citable) accession number: P23348
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: October 1, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3