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Protein

Anion exchange protein 3

Gene

Slc4a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plasma membrane anion exchange protein.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Anion exchange, Antiport, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange protein 3
Short name:
AE 3
Short name:
Anion exchanger 3
Alternative name(s):
Band 3-related protein 3
Short name:
B3RP-3
Neuronal band 3-like protein
Solute carrier family 4 member 3
Gene namesi
Name:Slc4a3
Synonyms:Ae3, B3rp3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3712. Slc4a3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 707CytoplasmicAdd BLAST707
Transmembranei708 – 730HelicalSequence analysisAdd BLAST23
Transmembranei736 – 773HelicalSequence analysisAdd BLAST38
Transmembranei793 – 815HelicalSequence analysisAdd BLAST23
Transmembranei825 – 846HelicalSequence analysisAdd BLAST22
Transmembranei888 – 905HelicalSequence analysisAdd BLAST18
Topological domaini906 – 920CytoplasmicSequence analysisAdd BLAST15
Transmembranei921 – 941HelicalSequence analysisAdd BLAST21
Transmembranei975 – 997HelicalSequence analysisAdd BLAST23
Transmembranei1023 – 1044HelicalSequence analysisAdd BLAST22
Transmembranei1078 – 1123HelicalSequence analysisAdd BLAST46
Transmembranei1150 – 1186HelicalSequence analysisAdd BLAST37

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000792221 – 1227Anion exchange protein 3Add BLAST1227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei167PhosphoserineCombined sources1
Modified residuei170PhosphoserineCombined sources1
Modified residuei175PhosphoserineCombined sources1
Modified residuei198PhosphoserineCombined sources1
Modified residuei294Omega-N-methylarginineBy similarity1
Glycosylationi868N-linked (GlcNAc...)Sequence analysis1
Lipidationi1160S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Glycoprotein, Lipoprotein, Methylation, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP23348.
PRIDEiP23348.

PTM databases

iPTMnetiP23348.
PhosphoSitePlusiP23348.

Expressioni

Tissue specificityi

Neuronal.

Interactioni

GO - Molecular functioni

  • enzyme binding Source: RGD

Protein-protein interaction databases

BioGridi246905. 1 interactor.
STRINGi10116.ENSRNOP00000027337.

Structurei

3D structure databases

ProteinModelPortaliP23348.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni708 – 1227Membrane (anion exchange)Add BLAST520

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi74 – 83His-rich10
Compositional biasi135 – 149Poly-GluAdd BLAST15
Compositional biasi155 – 161Poly-Pro7
Compositional biasi307 – 312Poly-Lys6
Compositional biasi441 – 444Poly-Ser4
Compositional biasi1179 – 1182Poly-Leu4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1172. Eukaryota.
ENOG410XPHD. LUCA.
HOGENOMiHOG000280683.
HOVERGENiHBG004326.
InParanoidiP23348.
KOiK13856.
PhylomeDBiP23348.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002979. Anion_exchange_3.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 2 hits.
PTHR11453:SF15. PTHR11453:SF15. 2 hits.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01189. ANIONEXHNGR3.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23348-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANGVIPPPG GPSPLPQVRV PLEEPPLGPD VEEEDDDLGK TLAVSRFGDL
60 70 80 90 100
ISKTPAWDPE KPSRSYSERD FEFHRHTSHH THHPLSARLP PPHKLRRLPP
110 120 130 140 150
TSARHARRKR KKEKTSAPPS EGTPPIQEEG GAGAEEEEEE EEEEEGESEA
160 170 180 190 200
EPVEPPPPGP PQKAKFSIGS DEDDSPGLSI KAPCAKALPS VGLPSDQSPQ
210 220 230 240 250
RSGSSPSPRA RASRISTEKS RPWSPSASYD LRERLCPGSA LGNPGPEQRV
260 270 280 290 300
PTDEAEAQML GSADLDDMKS HRLEDNPGVR RHLVKKPSRI QGGRGSPSGL
310 320 330 340 350
APILRRKKKK KKLDRRPHEV FVELNELMLD RSQEPHWRET ARWIKFEEDV
360 370 380 390 400
EEETERWGKP HVASLSFRSL LELRRTIAQG AALLDLEQTT LPGIAHLVVE
410 420 430 440 450
TMIVSDQIRP EDRASVLRTL LLKHSHPNDD KDSGFFPRNP SSSSVNSVLG
460 470 480 490 500
NHHPTPSHGP DGAVPTMADD LGEPAPLWPH DPDAKEKPLH MPGGDGHRGK
510 520 530 540 550
SLKLLEKIPE DAEATVVLVG SVPFLEQPAA AFVRLSEAVL LESVLEVPVP
560 570 580 590 600
VRFLFVMLGP SHTSTDYHEL GRSIATLMSD KLFHEAAYQA DDRQDLLGAI
610 620 630 640 650
SEFLDGSIVI PPSEVEGRDL LRSVAAFQRE LLRKRREREQ TKVEMTTRGG
660 670 680 690 700
YVAPGKELSL EMGGSEATSE DDPLQRTGSV FGGLVRDVKR RYPHYPSDLR
710 720 730 740 750
DALHSQCVAA VLFIYFAALS PAITFGGLLG EKTEGLMGVS ELIVSTAVLG
760 770 780 790 800
VLFSLLGAQP LLVVGFSGPL LVFEEAFFKF CRAQDLEYLT GRVWVGLWLV
810 820 830 840 850
VFVLALVAAE GSFLVRYISP FTQEIFAFLI SLIFIYETFH KLYKVFTEHP
860 870 880 890 900
LLPFYPPEEA LEPGLELNSS ALPPTEGPPG PRNQPNTALL SLILMLGTFL
910 920 930 940 950
IAFFLRKFRN SRFLGGKARR VIGDFGIPIS ILVMVLVDYS ITDTYTQKLT
960 970 980 990 1000
VPTGLSVTSP HKRTWFIPPL GSARPFPPWM MVAAAVPALL VLILIFMETQ
1010 1020 1030 1040 1050
ITALIVSQKA RRLLKGSGFH LDLLLIGSLG GLCGLFGLPW LTAATVRSVT
1060 1070 1080 1090 1100
HVNALTVMRT AIAPGDKPQI QEVREQRVTG VLIASLVGLS IVMGAVLRRI
1110 1120 1130 1140 1150
PLAVLFGIFL YMGVTSLSGI QLSQRLLLIF MPAKHHPEQP YVTKVKTWRM
1160 1170 1180 1190 1200
HLFTFIQLGC IALLWVVKST VASLAFPFLL LLTVPLRRCL LPRLFQDREL
1210 1220
QALDSEDAEP NFDEDGQDEY NELHMPV
Length:1,227
Mass (Da):135,407
Last modified:November 1, 1991 - v1
Checksum:i3EB1620EE011730E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05167 mRNA. Translation: AAA40798.1.
PIRiB34911.
RefSeqiNP_058745.1. NM_017049.1.
UniGeneiRn.87739.

Genome annotation databases

GeneIDi24781.
KEGGirno:24781.
UCSCiRGD:3712. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05167 mRNA. Translation: AAA40798.1.
PIRiB34911.
RefSeqiNP_058745.1. NM_017049.1.
UniGeneiRn.87739.

3D structure databases

ProteinModelPortaliP23348.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi246905. 1 interactor.
STRINGi10116.ENSRNOP00000027337.

PTM databases

iPTMnetiP23348.
PhosphoSitePlusiP23348.

Proteomic databases

PaxDbiP23348.
PRIDEiP23348.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24781.
KEGGirno:24781.
UCSCiRGD:3712. rat.

Organism-specific databases

CTDi6508.
RGDi3712. Slc4a3.

Phylogenomic databases

eggNOGiKOG1172. Eukaryota.
ENOG410XPHD. LUCA.
HOGENOMiHOG000280683.
HOVERGENiHBG004326.
InParanoidiP23348.
KOiK13856.
PhylomeDBiP23348.

Miscellaneous databases

PROiP23348.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002979. Anion_exchange_3.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 2 hits.
PTHR11453:SF15. PTHR11453:SF15. 2 hits.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01189. ANIONEXHNGR3.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB3A3_RAT
AccessioniPrimary (citable) accession number: P23348
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.