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P23348

- B3A3_RAT

UniProt

P23348 - B3A3_RAT

Protein

Anion exchange protein 3

Gene

Slc4a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Nov 1991)
      Previous versions | rss
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    Functioni

    Plasma membrane anion exchange protein.

    GO - Molecular functioni

    1. inorganic anion exchanger activity Source: InterPro

    Keywords - Biological processi

    Anion exchange, Antiport, Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anion exchange protein 3
    Short name:
    AE 3
    Short name:
    Anion exchanger 3
    Alternative name(s):
    Band 3-related protein 3
    Short name:
    B3RP-3
    Neuronal band 3-like protein
    Solute carrier family 4 member 3
    Gene namesi
    Name:Slc4a3
    Synonyms:Ae3, B3rp3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3712. Slc4a3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12271227Anion exchange protein 3PRO_0000079222Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi868 – 8681N-linked (GlcNAc...)Sequence Analysis
    Lipidationi1160 – 11601S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP23348.

    PTM databases

    PhosphoSiteiP23348.

    Expressioni

    Tissue specificityi

    Neuronal.

    Gene expression databases

    GenevestigatoriP23348.

    Interactioni

    Protein-protein interaction databases

    BioGridi246905. 1 interaction.
    STRINGi10116.ENSRNOP00000058980.

    Structurei

    3D structure databases

    ProteinModelPortaliP23348.
    SMRiP23348. Positions 691-732.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 707707CytoplasmicAdd
    BLAST
    Topological domaini906 – 92015CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei708 – 73023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei736 – 77338HelicalSequence AnalysisAdd
    BLAST
    Transmembranei793 – 81523HelicalSequence AnalysisAdd
    BLAST
    Transmembranei825 – 84622HelicalSequence AnalysisAdd
    BLAST
    Transmembranei888 – 90518HelicalSequence AnalysisAdd
    BLAST
    Transmembranei921 – 94121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei975 – 99723HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1023 – 104422HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1078 – 112346HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1150 – 118637HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni708 – 1227520Membrane (anion exchange)Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi74 – 8310His-rich
    Compositional biasi135 – 14915Poly-GluAdd
    BLAST
    Compositional biasi155 – 1617Poly-Pro
    Compositional biasi307 – 3126Poly-Lys
    Compositional biasi441 – 4444Poly-Ser
    Compositional biasi1179 – 11824Poly-Leu

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG268067.
    HOGENOMiHOG000280683.
    HOVERGENiHBG004326.
    InParanoidiP23348.
    KOiK13856.
    PhylomeDBiP23348.

    Family and domain databases

    Gene3Di3.40.1100.10. 1 hit.
    InterProiIPR001717. Anion_exchange.
    IPR002979. Anion_exchange_3.
    IPR018241. Anion_exchange_CS.
    IPR013769. Band3_cytoplasmic_dom.
    IPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    IPR016152. PTrfase/Anion_transptr.
    [Graphical view]
    PANTHERiPTHR11453. PTHR11453. 1 hit.
    PTHR11453:SF15. PTHR11453:SF15. 1 hit.
    PfamiPF07565. Band_3_cyto. 1 hit.
    PF00955. HCO3_cotransp. 2 hits.
    [Graphical view]
    PRINTSiPR00165. ANIONEXCHNGR.
    PR01189. ANIONEXHNGR3.
    PR01231. HCO3TRNSPORT.
    SUPFAMiSSF55804. SSF55804. 2 hits.
    TIGRFAMsiTIGR00834. ae. 1 hit.
    PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
    PS00220. ANION_EXCHANGER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P23348-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANGVIPPPG GPSPLPQVRV PLEEPPLGPD VEEEDDDLGK TLAVSRFGDL     50
    ISKTPAWDPE KPSRSYSERD FEFHRHTSHH THHPLSARLP PPHKLRRLPP 100
    TSARHARRKR KKEKTSAPPS EGTPPIQEEG GAGAEEEEEE EEEEEGESEA 150
    EPVEPPPPGP PQKAKFSIGS DEDDSPGLSI KAPCAKALPS VGLPSDQSPQ 200
    RSGSSPSPRA RASRISTEKS RPWSPSASYD LRERLCPGSA LGNPGPEQRV 250
    PTDEAEAQML GSADLDDMKS HRLEDNPGVR RHLVKKPSRI QGGRGSPSGL 300
    APILRRKKKK KKLDRRPHEV FVELNELMLD RSQEPHWRET ARWIKFEEDV 350
    EEETERWGKP HVASLSFRSL LELRRTIAQG AALLDLEQTT LPGIAHLVVE 400
    TMIVSDQIRP EDRASVLRTL LLKHSHPNDD KDSGFFPRNP SSSSVNSVLG 450
    NHHPTPSHGP DGAVPTMADD LGEPAPLWPH DPDAKEKPLH MPGGDGHRGK 500
    SLKLLEKIPE DAEATVVLVG SVPFLEQPAA AFVRLSEAVL LESVLEVPVP 550
    VRFLFVMLGP SHTSTDYHEL GRSIATLMSD KLFHEAAYQA DDRQDLLGAI 600
    SEFLDGSIVI PPSEVEGRDL LRSVAAFQRE LLRKRREREQ TKVEMTTRGG 650
    YVAPGKELSL EMGGSEATSE DDPLQRTGSV FGGLVRDVKR RYPHYPSDLR 700
    DALHSQCVAA VLFIYFAALS PAITFGGLLG EKTEGLMGVS ELIVSTAVLG 750
    VLFSLLGAQP LLVVGFSGPL LVFEEAFFKF CRAQDLEYLT GRVWVGLWLV 800
    VFVLALVAAE GSFLVRYISP FTQEIFAFLI SLIFIYETFH KLYKVFTEHP 850
    LLPFYPPEEA LEPGLELNSS ALPPTEGPPG PRNQPNTALL SLILMLGTFL 900
    IAFFLRKFRN SRFLGGKARR VIGDFGIPIS ILVMVLVDYS ITDTYTQKLT 950
    VPTGLSVTSP HKRTWFIPPL GSARPFPPWM MVAAAVPALL VLILIFMETQ 1000
    ITALIVSQKA RRLLKGSGFH LDLLLIGSLG GLCGLFGLPW LTAATVRSVT 1050
    HVNALTVMRT AIAPGDKPQI QEVREQRVTG VLIASLVGLS IVMGAVLRRI 1100
    PLAVLFGIFL YMGVTSLSGI QLSQRLLLIF MPAKHHPEQP YVTKVKTWRM 1150
    HLFTFIQLGC IALLWVVKST VASLAFPFLL LLTVPLRRCL LPRLFQDREL 1200
    QALDSEDAEP NFDEDGQDEY NELHMPV 1227
    Length:1,227
    Mass (Da):135,407
    Last modified:November 1, 1991 - v1
    Checksum:i3EB1620EE011730E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05167 mRNA. Translation: AAA40798.1.
    PIRiB34911.
    RefSeqiNP_058745.1. NM_017049.1.
    UniGeneiRn.87739.

    Genome annotation databases

    GeneIDi24781.
    KEGGirno:24781.
    UCSCiRGD:3712. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05167 mRNA. Translation: AAA40798.1 .
    PIRi B34911.
    RefSeqi NP_058745.1. NM_017049.1.
    UniGenei Rn.87739.

    3D structure databases

    ProteinModelPortali P23348.
    SMRi P23348. Positions 691-732.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 246905. 1 interaction.
    STRINGi 10116.ENSRNOP00000058980.

    PTM databases

    PhosphoSitei P23348.

    Proteomic databases

    PaxDbi P23348.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 24781.
    KEGGi rno:24781.
    UCSCi RGD:3712. rat.

    Organism-specific databases

    CTDi 6508.
    RGDi 3712. Slc4a3.

    Phylogenomic databases

    eggNOGi NOG268067.
    HOGENOMi HOG000280683.
    HOVERGENi HBG004326.
    InParanoidi P23348.
    KOi K13856.
    PhylomeDBi P23348.

    Miscellaneous databases

    NextBioi 604388.
    PROi P23348.

    Gene expression databases

    Genevestigatori P23348.

    Family and domain databases

    Gene3Di 3.40.1100.10. 1 hit.
    InterProi IPR001717. Anion_exchange.
    IPR002979. Anion_exchange_3.
    IPR018241. Anion_exchange_CS.
    IPR013769. Band3_cytoplasmic_dom.
    IPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    IPR016152. PTrfase/Anion_transptr.
    [Graphical view ]
    PANTHERi PTHR11453. PTHR11453. 1 hit.
    PTHR11453:SF15. PTHR11453:SF15. 1 hit.
    Pfami PF07565. Band_3_cyto. 1 hit.
    PF00955. HCO3_cotransp. 2 hits.
    [Graphical view ]
    PRINTSi PR00165. ANIONEXCHNGR.
    PR01189. ANIONEXHNGR3.
    PR01231. HCO3TRNSPORT.
    SUPFAMi SSF55804. SSF55804. 2 hits.
    TIGRFAMsi TIGR00834. ae. 1 hit.
    PROSITEi PS00219. ANION_EXCHANGER_1. 1 hit.
    PS00220. ANION_EXCHANGER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning and tissue distribution of mRNAs for two proteins that are related to the band 3 Cl-/HCO3-exchanger."
      Kudrycki K.E., Newman P.R., Shull G.E.
      J. Biol. Chem. 265:462-471(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiB3A3_RAT
    AccessioniPrimary (citable) accession number: P23348
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: November 1, 1991
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3