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Protein

Anion exchange protein 2

Gene

Slc4a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plasma membrane anion exchange protein of wide distribution.

GO - Molecular functioni

  1. anion transmembrane transporter activity Source: GO_Central
  2. chloride transmembrane transporter activity Source: Ensembl
  3. inorganic anion exchanger activity Source: InterPro

GO - Biological processi

  1. bicarbonate transport Source: GO_Central
  2. chloride transmembrane transport Source: GO_Central
  3. regulation of intracellular pH Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Anion exchange, Antiport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_260612. Bicarbonate transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange protein 2
Short name:
AE 2
Short name:
Anion exchanger 2
Alternative name(s):
Band 3-related protein 2
Short name:
B3RP-2
Non-erythroid band 3-like protein
Solute carrier family 4 member 2
Gene namesi
Name:Slc4a2
Synonyms:Ae2, B3rp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi3711. Slc4a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 704704CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei705 – 72824HelicalSequence AnalysisAdd
BLAST
Transmembranei734 – 77138HelicalSequence AnalysisAdd
BLAST
Transmembranei791 – 81323HelicalSequence AnalysisAdd
BLAST
Transmembranei823 – 84321HelicalSequence AnalysisAdd
BLAST
Topological domaini844 – 89350ExtracellularSequence AnalysisAdd
BLAST
Transmembranei894 – 91118HelicalSequence AnalysisAdd
BLAST
Topological domaini912 – 92615CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei927 – 94721HelicalSequence AnalysisAdd
BLAST
Transmembranei981 – 100323HelicalSequence AnalysisAdd
BLAST
Transmembranei1029 – 105022HelicalSequence AnalysisAdd
BLAST
Transmembranei1084 – 112946HelicalSequence AnalysisAdd
BLAST
Transmembranei1156 – 119237HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: MGI
  2. focal adhesion Source: Ensembl
  3. integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12341234Anion exchange protein 2PRO_0000079218Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei113 – 1131PhosphoserineBy similarity
Modified residuei145 – 1451PhosphoserineBy similarity
Modified residuei171 – 1711PhosphoserineBy similarity
Modified residuei173 – 1731PhosphoserineBy similarity
Modified residuei254 – 2541PhosphothreonineBy similarity
Modified residuei440 – 4401PhosphoserineBy similarity
Glycosylationi856 – 8561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi866 – 8661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi878 – 8781N-linked (GlcNAc...)Sequence Analysis
Lipidationi1166 – 11661S-palmitoyl cysteineBy similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

PTM databases

PhosphoSiteiP23347.

Expressioni

Gene expression databases

ExpressionAtlasiP23347. baseline and differential.
GenevestigatoriP23347.

Interactioni

Protein-protein interaction databases

BioGridi246904. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP23347.
SMRiP23347. Positions 689-730, 1126-1158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni705 – 1234530Membrane (anion exchange)Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 317313Pro-richAdd
BLAST
Compositional biasi74 – 8815His-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG268067.
GeneTreeiENSGT00760000119021.
HOGENOMiHOG000280683.
HOVERGENiHBG004326.
InParanoidiP23347.
KOiK13855.
OMAiALQGVIF.
OrthoDBiEOG7TMZR0.
PhylomeDBiP23347.
TreeFamiTF313630.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002978. Anion_exchange_2.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PTHR11453:SF14. PTHR11453:SF14. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01188. ANIONEXHNGR2.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23347-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSAPRRPAS GADSLHTPEP ESLSPGTPGF PEQEEEDELR TLGVERFEEI
60 70 80 90 100
LQEAGSRGGE EPGRSYGEED FEYHRQSSHH IHHPLSTHLP PDARRRKTPQ
110 120 130 140 150
GPGRKPRRRP GASPTGETPT IEEGEEDEDE VGEAEGFRAP PQQPSPASSP
160 170 180 190 200
SAVQFFLQED EGTDRKAERT SPSPPTQTPH QEAAPRASKG AQTGTLVEEM
210 220 230 240 250
VAVASGTAGG DDGGAAGRPL TKAQPGHRSY NLQERRRIGS MTGVEQALLP
260 270 280 290 300
RVPTDESEAQ TLATADLDLM KSHRFEDVPG VRRHLVRKNA KGSTQAAREG
310 320 330 340 350
REPGPTPRAR PRAPHKPHEV FVELNELQLD KNQEPQWRET ARWIKFEEDV
360 370 380 390 400
EEETERWGKP HVASLSFRSL LELRRTLAHG AVLLDLDQQT LPGVAHQVVE
410 420 430 440 450
QMVISDQIKA EDRANVLRAL LLKHSHPSDE KEFSFPRNIS AGSLGSLLGH
460 470 480 490 500
HHAQGTESDP HVTEPLIGGV PETRLEVDRE RELPPPAPPA GITRSKSKHE
510 520 530 540 550
LKLLEKIPEN AEATVVLVGC VEFLSRPTMA FVRLREAVEL DAVLEVPVPV
560 570 580 590 600
RFLFLLLGPS SANMDYHEIG RSISTLMSDK QFHEAAYLAD ERDDLLTAIN
610 620 630 640 650
AFLDCSVVLP PSEVQGEELL RSVAHFQRQM LKKREEQGRL LPPGAGLEPK
660 670 680 690 700
SAQDKALLQM VEVAGAAEDD PLRRTGRPFG GLIRDVRRRY PHYLSDFRDA
710 720 730 740 750
LDPQCLAAVI FIYFAALSPA ITFGGLLGEK TQDLIGVSEL IMSTALQGVI
760 770 780 790 800
FCLLGAQPLL VIGFSGPLLV FEEAFFSFCK SNQLEYLVGR VWIGFWLVLL
810 820 830 840 850
ALLMVALEGS FLVRFVSRFT QEIFAFLISL IFIYETFYKL IKIFQEHPLH
860 870 880 890 900
GCSVSNDSEA DSSSNNMTWA ATTLAPDNSS ASGQERPRGQ PNTALLSLVL
910 920 930 940 950
MAGTFFIAFF LRKFKNSRFF PGRIRRVIGD FGVPIAILIM VLVDYSIEDT
960 970 980 990 1000
YTQKLSVPSG FSVTAPDKRG WVINPLGEKT PFPVWMMVAS LLPAVLVFIL
1010 1020 1030 1040 1050
IFMETQITTL IISKKERMLQ KGSGFHLDLL LIVAMGGICA LFGLPWLAAA
1060 1070 1080 1090 1100
TVRSVTHANA LTVMSKAVAP GDKPKIQEVK EQRVTGLLVA LLVGLSMVIG
1110 1120 1130 1140 1150
DLLRQIPLAV LFGIFLYMGV TSLNGIQFYE RLHLLLMPPK HHPDVTYVKK
1160 1170 1180 1190 1200
VRTMRMHLFT ALQLLCLALL WAVMSTAASL AFPFILILTV PLRMVVLTRI
1210 1220 1230
FTEREMKCLD ANEAEPVFDE CEGVDEYNEM PMPV
Length:1,234
Mass (Da):136,636
Last modified:November 1, 1991 - v1
Checksum:iFAB4ED12BB916216
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti206 – 2061G → A no nucleotide entry (PubMed:2371270).Curated
Sequence conflicti925 – 9262RR → PG no nucleotide entry (PubMed:2371270).Curated
Sequence conflicti1018 – 10192ML → IV no nucleotide entry (PubMed:2371270).Curated
Sequence conflicti1156 – 11572MH → ID no nucleotide entry (PubMed:2371270).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05166 mRNA. Translation: AAA40799.1.
PIRiA34911.
RefSeqiNP_058744.1. NM_017048.2.
XP_006235936.1. XM_006235874.2.
XP_006235937.1. XM_006235875.2.
XP_006235938.1. XM_006235876.2.
UniGeneiRn.9860.

Genome annotation databases

EnsembliENSRNOT00000019666; ENSRNOP00000019666; ENSRNOG00000014347.
GeneIDi24780.
KEGGirno:24780.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05166 mRNA. Translation: AAA40799.1.
PIRiA34911.
RefSeqiNP_058744.1. NM_017048.2.
XP_006235936.1. XM_006235874.2.
XP_006235937.1. XM_006235875.2.
XP_006235938.1. XM_006235876.2.
UniGeneiRn.9860.

3D structure databases

ProteinModelPortaliP23347.
SMRiP23347. Positions 689-730, 1126-1158.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi246904. 1 interaction.

PTM databases

PhosphoSiteiP23347.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019666; ENSRNOP00000019666; ENSRNOG00000014347.
GeneIDi24780.
KEGGirno:24780.

Organism-specific databases

CTDi6522.
RGDi3711. Slc4a2.

Phylogenomic databases

eggNOGiNOG268067.
GeneTreeiENSGT00760000119021.
HOGENOMiHOG000280683.
HOVERGENiHBG004326.
InParanoidiP23347.
KOiK13855.
OMAiALQGVIF.
OrthoDBiEOG7TMZR0.
PhylomeDBiP23347.
TreeFamiTF313630.

Enzyme and pathway databases

ReactomeiREACT_260612. Bicarbonate transporters.

Miscellaneous databases

NextBioi604384.
PROiP23347.

Gene expression databases

ExpressionAtlasiP23347. baseline and differential.
GenevestigatoriP23347.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002978. Anion_exchange_2.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PTHR11453:SF14. PTHR11453:SF14. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01188. ANIONEXHNGR2.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "cDNA cloning and tissue distribution of mRNAs for two proteins that are related to the band 3 Cl-/HCO3-exchanger."
    Kudrycki K.E., Newman P.R., Shull G.E.
    J. Biol. Chem. 265:462-471(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Stomach.
  2. "Functional expression and subcellular localization of an anion exchanger cloned from choroid plexus."
    Lindsey A.E., Schneider K., Simmons D.M., Baron R., Lee B.S., Kopito R.R.
    Proc. Natl. Acad. Sci. U.S.A. 87:5278-5282(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiB3A2_RAT
AccessioniPrimary (citable) accession number: P23347
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: March 4, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.