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P23347 (B3A2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Anion exchange protein 2

Short name=AE 2
Short name=Anion exchanger 2
Alternative name(s):
Band 3-related protein 2
Short name=B3RP-2
Non-erythroid band 3-like protein
Solute carrier family 4 member 2
Gene names
Name:Slc4a2
Synonyms:Ae2, B3rp2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length1234 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plasma membrane anion exchange protein of wide distribution.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12341234Anion exchange protein 2
PRO_0000079218

Regions

Topological domain1 – 704704Cytoplasmic Potential
Transmembrane705 – 72824Helical; Potential
Transmembrane734 – 77138Helical; Potential
Transmembrane791 – 81323Helical; Potential
Transmembrane823 – 84321Helical; Potential
Topological domain844 – 89350Extracellular Potential
Transmembrane894 – 91118Helical; Potential
Topological domain912 – 92615Cytoplasmic Potential
Transmembrane927 – 94721Helical; Potential
Transmembrane981 – 100323Helical; Potential
Transmembrane1029 – 105022Helical; Potential
Transmembrane1084 – 112946Helical; Potential
Transmembrane1156 – 119237Helical; Potential
Region705 – 1234530Membrane (anion exchange)
Compositional bias5 – 317313Pro-rich
Compositional bias74 – 8815His-rich

Amino acid modifications

Modified residue1131Phosphoserine By similarity
Modified residue1451Phosphoserine By similarity
Modified residue1711Phosphoserine By similarity
Modified residue1731Phosphoserine By similarity
Modified residue2541Phosphothreonine By similarity
Modified residue4401Phosphoserine By similarity
Lipidation11661S-palmitoyl cysteine By similarity
Glycosylation8561N-linked (GlcNAc...) Potential
Glycosylation8661N-linked (GlcNAc...) Potential
Glycosylation8781N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict2061G → A no nucleotide entry Ref.2
Sequence conflict925 – 9262RR → PG no nucleotide entry Ref.2
Sequence conflict1018 – 10192ML → IV no nucleotide entry Ref.2
Sequence conflict1156 – 11572MH → ID no nucleotide entry Ref.2

Sequences

Sequence LengthMass (Da)Tools
P23347 [UniParc].

Last modified November 1, 1991. Version 1.
Checksum: FAB4ED12BB916216

FASTA1,234136,636
        10         20         30         40         50         60 
MSSAPRRPAS GADSLHTPEP ESLSPGTPGF PEQEEEDELR TLGVERFEEI LQEAGSRGGE 

        70         80         90        100        110        120 
EPGRSYGEED FEYHRQSSHH IHHPLSTHLP PDARRRKTPQ GPGRKPRRRP GASPTGETPT 

       130        140        150        160        170        180 
IEEGEEDEDE VGEAEGFRAP PQQPSPASSP SAVQFFLQED EGTDRKAERT SPSPPTQTPH 

       190        200        210        220        230        240 
QEAAPRASKG AQTGTLVEEM VAVASGTAGG DDGGAAGRPL TKAQPGHRSY NLQERRRIGS 

       250        260        270        280        290        300 
MTGVEQALLP RVPTDESEAQ TLATADLDLM KSHRFEDVPG VRRHLVRKNA KGSTQAAREG 

       310        320        330        340        350        360 
REPGPTPRAR PRAPHKPHEV FVELNELQLD KNQEPQWRET ARWIKFEEDV EEETERWGKP 

       370        380        390        400        410        420 
HVASLSFRSL LELRRTLAHG AVLLDLDQQT LPGVAHQVVE QMVISDQIKA EDRANVLRAL 

       430        440        450        460        470        480 
LLKHSHPSDE KEFSFPRNIS AGSLGSLLGH HHAQGTESDP HVTEPLIGGV PETRLEVDRE 

       490        500        510        520        530        540 
RELPPPAPPA GITRSKSKHE LKLLEKIPEN AEATVVLVGC VEFLSRPTMA FVRLREAVEL 

       550        560        570        580        590        600 
DAVLEVPVPV RFLFLLLGPS SANMDYHEIG RSISTLMSDK QFHEAAYLAD ERDDLLTAIN 

       610        620        630        640        650        660 
AFLDCSVVLP PSEVQGEELL RSVAHFQRQM LKKREEQGRL LPPGAGLEPK SAQDKALLQM 

       670        680        690        700        710        720 
VEVAGAAEDD PLRRTGRPFG GLIRDVRRRY PHYLSDFRDA LDPQCLAAVI FIYFAALSPA 

       730        740        750        760        770        780 
ITFGGLLGEK TQDLIGVSEL IMSTALQGVI FCLLGAQPLL VIGFSGPLLV FEEAFFSFCK 

       790        800        810        820        830        840 
SNQLEYLVGR VWIGFWLVLL ALLMVALEGS FLVRFVSRFT QEIFAFLISL IFIYETFYKL 

       850        860        870        880        890        900 
IKIFQEHPLH GCSVSNDSEA DSSSNNMTWA ATTLAPDNSS ASGQERPRGQ PNTALLSLVL 

       910        920        930        940        950        960 
MAGTFFIAFF LRKFKNSRFF PGRIRRVIGD FGVPIAILIM VLVDYSIEDT YTQKLSVPSG 

       970        980        990       1000       1010       1020 
FSVTAPDKRG WVINPLGEKT PFPVWMMVAS LLPAVLVFIL IFMETQITTL IISKKERMLQ 

      1030       1040       1050       1060       1070       1080 
KGSGFHLDLL LIVAMGGICA LFGLPWLAAA TVRSVTHANA LTVMSKAVAP GDKPKIQEVK 

      1090       1100       1110       1120       1130       1140 
EQRVTGLLVA LLVGLSMVIG DLLRQIPLAV LFGIFLYMGV TSLNGIQFYE RLHLLLMPPK 

      1150       1160       1170       1180       1190       1200 
HHPDVTYVKK VRTMRMHLFT ALQLLCLALL WAVMSTAASL AFPFILILTV PLRMVVLTRI 

      1210       1220       1230 
FTEREMKCLD ANEAEPVFDE CEGVDEYNEM PMPV 

« Hide

References

[1]"cDNA cloning and tissue distribution of mRNAs for two proteins that are related to the band 3 Cl-/HCO3-exchanger."
Kudrycki K.E., Newman P.R., Shull G.E.
J. Biol. Chem. 265:462-471(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Stomach.
[2]"Functional expression and subcellular localization of an anion exchanger cloned from choroid plexus."
Lindsey A.E., Schneider K., Simmons D.M., Baron R., Lee B.S., Kopito R.R.
Proc. Natl. Acad. Sci. U.S.A. 87:5278-5282(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J05166 mRNA. Translation: AAA40799.1.
PIRA34911.
RefSeqNP_058744.1. NM_017048.2.
XP_006235936.1. XM_006235874.1.
XP_006235937.1. XM_006235875.1.
XP_006235938.1. XM_006235876.1.
UniGeneRn.9860.

3D structure databases

ProteinModelPortalP23347.
SMRP23347. Positions 689-730, 1126-1158.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid246904. 1 interaction.

PTM databases

PhosphoSiteP23347.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000019666; ENSRNOP00000019666; ENSRNOG00000014347.
GeneID24780.
KEGGrno:24780.

Organism-specific databases

CTD6522.
RGD3711. Slc4a2.

Phylogenomic databases

eggNOGNOG268067.
GeneTreeENSGT00560000076933.
HOGENOMHOG000280683.
HOVERGENHBG004326.
InParanoidP23347.
KOK13855.
OMAGADSFCT.
OrthoDBEOG7TMZR0.
PhylomeDBP23347.
TreeFamTF313630.

Gene expression databases

GenevestigatorP23347.

Family and domain databases

Gene3D3.40.1100.10. 1 hit.
InterProIPR001717. Anion_exchange.
IPR002978. Anion_exchange_2.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERPTHR11453. PTHR11453. 1 hit.
PTHR11453:SF14. PTHR11453:SF14. 1 hit.
PfamPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSPR00165. ANIONEXCHNGR.
PR01188. ANIONEXHNGR2.
PR01231. HCO3TRNSPORT.
SUPFAMSSF55804. SSF55804. 2 hits.
TIGRFAMsTIGR00834. ae. 1 hit.
PROSITEPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio604384.
PROP23347.

Entry information

Entry nameB3A2_RAT
AccessionPrimary (citable) accession number: P23347
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: April 16, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families