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P23347

- B3A2_RAT

UniProt

P23347 - B3A2_RAT

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Protein

Anion exchange protein 2

Gene
Slc4a2, Ae2, B3rp2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Plasma membrane anion exchange protein of wide distribution.

GO - Molecular functioni

  1. chloride transmembrane transporter activity Source: Ensembl
  2. inorganic anion exchanger activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Anion exchange, Antiport, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange protein 2
Short name:
AE 2
Short name:
Anion exchanger 2
Alternative name(s):
Band 3-related protein 2
Short name:
B3RP-2
Non-erythroid band 3-like protein
Solute carrier family 4 member 2
Gene namesi
Name:Slc4a2
Synonyms:Ae2, B3rp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi3711. Slc4a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 704704Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei705 – 72824Helical; Reviewed predictionAdd
BLAST
Transmembranei734 – 77138Helical; Reviewed predictionAdd
BLAST
Transmembranei791 – 81323Helical; Reviewed predictionAdd
BLAST
Transmembranei823 – 84321Helical; Reviewed predictionAdd
BLAST
Topological domaini844 – 89350Extracellular Reviewed predictionAdd
BLAST
Transmembranei894 – 91118Helical; Reviewed predictionAdd
BLAST
Topological domaini912 – 92615Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei927 – 94721Helical; Reviewed predictionAdd
BLAST
Transmembranei981 – 100323Helical; Reviewed predictionAdd
BLAST
Transmembranei1029 – 105022Helical; Reviewed predictionAdd
BLAST
Transmembranei1084 – 112946Helical; Reviewed predictionAdd
BLAST
Transmembranei1156 – 119237Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12341234Anion exchange protein 2PRO_0000079218Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei113 – 1131Phosphoserine By similarity
Modified residuei145 – 1451Phosphoserine By similarity
Modified residuei171 – 1711Phosphoserine By similarity
Modified residuei173 – 1731Phosphoserine By similarity
Modified residuei254 – 2541Phosphothreonine By similarity
Modified residuei440 – 4401Phosphoserine By similarity
Glycosylationi856 – 8561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi866 – 8661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi878 – 8781N-linked (GlcNAc...) Reviewed prediction
Lipidationi1166 – 11661S-palmitoyl cysteine By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

PTM databases

PhosphoSiteiP23347.

Expressioni

Gene expression databases

GenevestigatoriP23347.

Interactioni

Protein-protein interaction databases

BioGridi246904. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP23347.
SMRiP23347. Positions 689-730, 1126-1158.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni705 – 1234530Membrane (anion exchange)Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 317313Pro-richAdd
BLAST
Compositional biasi74 – 8815His-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG268067.
GeneTreeiENSGT00560000076933.
HOGENOMiHOG000280683.
HOVERGENiHBG004326.
InParanoidiP23347.
KOiK13855.
OMAiDREMKCL.
OrthoDBiEOG7TMZR0.
PhylomeDBiP23347.
TreeFamiTF313630.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002978. Anion_exchange_2.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PTHR11453:SF14. PTHR11453:SF14. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01188. ANIONEXHNGR2.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23347-1 [UniParc]FASTAAdd to Basket

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MSSAPRRPAS GADSLHTPEP ESLSPGTPGF PEQEEEDELR TLGVERFEEI     50
LQEAGSRGGE EPGRSYGEED FEYHRQSSHH IHHPLSTHLP PDARRRKTPQ 100
GPGRKPRRRP GASPTGETPT IEEGEEDEDE VGEAEGFRAP PQQPSPASSP 150
SAVQFFLQED EGTDRKAERT SPSPPTQTPH QEAAPRASKG AQTGTLVEEM 200
VAVASGTAGG DDGGAAGRPL TKAQPGHRSY NLQERRRIGS MTGVEQALLP 250
RVPTDESEAQ TLATADLDLM KSHRFEDVPG VRRHLVRKNA KGSTQAAREG 300
REPGPTPRAR PRAPHKPHEV FVELNELQLD KNQEPQWRET ARWIKFEEDV 350
EEETERWGKP HVASLSFRSL LELRRTLAHG AVLLDLDQQT LPGVAHQVVE 400
QMVISDQIKA EDRANVLRAL LLKHSHPSDE KEFSFPRNIS AGSLGSLLGH 450
HHAQGTESDP HVTEPLIGGV PETRLEVDRE RELPPPAPPA GITRSKSKHE 500
LKLLEKIPEN AEATVVLVGC VEFLSRPTMA FVRLREAVEL DAVLEVPVPV 550
RFLFLLLGPS SANMDYHEIG RSISTLMSDK QFHEAAYLAD ERDDLLTAIN 600
AFLDCSVVLP PSEVQGEELL RSVAHFQRQM LKKREEQGRL LPPGAGLEPK 650
SAQDKALLQM VEVAGAAEDD PLRRTGRPFG GLIRDVRRRY PHYLSDFRDA 700
LDPQCLAAVI FIYFAALSPA ITFGGLLGEK TQDLIGVSEL IMSTALQGVI 750
FCLLGAQPLL VIGFSGPLLV FEEAFFSFCK SNQLEYLVGR VWIGFWLVLL 800
ALLMVALEGS FLVRFVSRFT QEIFAFLISL IFIYETFYKL IKIFQEHPLH 850
GCSVSNDSEA DSSSNNMTWA ATTLAPDNSS ASGQERPRGQ PNTALLSLVL 900
MAGTFFIAFF LRKFKNSRFF PGRIRRVIGD FGVPIAILIM VLVDYSIEDT 950
YTQKLSVPSG FSVTAPDKRG WVINPLGEKT PFPVWMMVAS LLPAVLVFIL 1000
IFMETQITTL IISKKERMLQ KGSGFHLDLL LIVAMGGICA LFGLPWLAAA 1050
TVRSVTHANA LTVMSKAVAP GDKPKIQEVK EQRVTGLLVA LLVGLSMVIG 1100
DLLRQIPLAV LFGIFLYMGV TSLNGIQFYE RLHLLLMPPK HHPDVTYVKK 1150
VRTMRMHLFT ALQLLCLALL WAVMSTAASL AFPFILILTV PLRMVVLTRI 1200
FTEREMKCLD ANEAEPVFDE CEGVDEYNEM PMPV 1234
Length:1,234
Mass (Da):136,636
Last modified:November 1, 1991 - v1
Checksum:iFAB4ED12BB916216
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti206 – 2061G → A no nucleotide entry 1 Publication
Sequence conflicti925 – 9262RR → PG no nucleotide entry 1 Publication
Sequence conflicti1018 – 10192ML → IV no nucleotide entry 1 Publication
Sequence conflicti1156 – 11572MH → ID no nucleotide entry 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J05166 mRNA. Translation: AAA40799.1.
PIRiA34911.
RefSeqiNP_058744.1. NM_017048.2.
XP_006235936.1. XM_006235874.1.
XP_006235937.1. XM_006235875.1.
XP_006235938.1. XM_006235876.1.
UniGeneiRn.9860.

Genome annotation databases

EnsembliENSRNOT00000019666; ENSRNOP00000019666; ENSRNOG00000014347.
GeneIDi24780.
KEGGirno:24780.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J05166 mRNA. Translation: AAA40799.1 .
PIRi A34911.
RefSeqi NP_058744.1. NM_017048.2.
XP_006235936.1. XM_006235874.1.
XP_006235937.1. XM_006235875.1.
XP_006235938.1. XM_006235876.1.
UniGenei Rn.9860.

3D structure databases

ProteinModelPortali P23347.
SMRi P23347. Positions 689-730, 1126-1158.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 246904. 1 interaction.

PTM databases

PhosphoSitei P23347.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000019666 ; ENSRNOP00000019666 ; ENSRNOG00000014347 .
GeneIDi 24780.
KEGGi rno:24780.

Organism-specific databases

CTDi 6522.
RGDi 3711. Slc4a2.

Phylogenomic databases

eggNOGi NOG268067.
GeneTreei ENSGT00560000076933.
HOGENOMi HOG000280683.
HOVERGENi HBG004326.
InParanoidi P23347.
KOi K13855.
OMAi DREMKCL.
OrthoDBi EOG7TMZR0.
PhylomeDBi P23347.
TreeFami TF313630.

Miscellaneous databases

NextBioi 604384.
PROi P23347.

Gene expression databases

Genevestigatori P23347.

Family and domain databases

Gene3Di 3.40.1100.10. 1 hit.
InterProi IPR001717. Anion_exchange.
IPR002978. Anion_exchange_2.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view ]
PANTHERi PTHR11453. PTHR11453. 1 hit.
PTHR11453:SF14. PTHR11453:SF14. 1 hit.
Pfami PF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view ]
PRINTSi PR00165. ANIONEXCHNGR.
PR01188. ANIONEXHNGR2.
PR01231. HCO3TRNSPORT.
SUPFAMi SSF55804. SSF55804. 2 hits.
TIGRFAMsi TIGR00834. ae. 1 hit.
PROSITEi PS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning and tissue distribution of mRNAs for two proteins that are related to the band 3 Cl-/HCO3-exchanger."
    Kudrycki K.E., Newman P.R., Shull G.E.
    J. Biol. Chem. 265:462-471(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Stomach.
  2. "Functional expression and subcellular localization of an anion exchanger cloned from choroid plexus."
    Lindsey A.E., Schneider K., Simmons D.M., Baron R., Lee B.S., Kopito R.R.
    Proc. Natl. Acad. Sci. U.S.A. 87:5278-5282(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiB3A2_RAT
AccessioniPrimary (citable) accession number: P23347
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: May 14, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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