Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P23347

- B3A2_RAT

UniProt

P23347 - B3A2_RAT

Protein

Anion exchange protein 2

Gene

Slc4a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Nov 1991)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Plasma membrane anion exchange protein of wide distribution.

    GO - Molecular functioni

    1. chloride transmembrane transporter activity Source: Ensembl
    2. inorganic anion exchanger activity Source: InterPro

    Keywords - Biological processi

    Anion exchange, Antiport, Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anion exchange protein 2
    Short name:
    AE 2
    Short name:
    Anion exchanger 2
    Alternative name(s):
    Band 3-related protein 2
    Short name:
    B3RP-2
    Non-erythroid band 3-like protein
    Solute carrier family 4 member 2
    Gene namesi
    Name:Slc4a2
    Synonyms:Ae2, B3rp2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi3711. Slc4a2.

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: MGI
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12341234Anion exchange protein 2PRO_0000079218Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei113 – 1131PhosphoserineBy similarity
    Modified residuei145 – 1451PhosphoserineBy similarity
    Modified residuei171 – 1711PhosphoserineBy similarity
    Modified residuei173 – 1731PhosphoserineBy similarity
    Modified residuei254 – 2541PhosphothreonineBy similarity
    Modified residuei440 – 4401PhosphoserineBy similarity
    Glycosylationi856 – 8561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi866 – 8661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi878 – 8781N-linked (GlcNAc...)Sequence Analysis
    Lipidationi1166 – 11661S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    PTM databases

    PhosphoSiteiP23347.

    Expressioni

    Gene expression databases

    GenevestigatoriP23347.

    Interactioni

    Protein-protein interaction databases

    BioGridi246904. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP23347.
    SMRiP23347. Positions 689-730, 1126-1158.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 704704CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini844 – 89350ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini912 – 92615CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei705 – 72824HelicalSequence AnalysisAdd
    BLAST
    Transmembranei734 – 77138HelicalSequence AnalysisAdd
    BLAST
    Transmembranei791 – 81323HelicalSequence AnalysisAdd
    BLAST
    Transmembranei823 – 84321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei894 – 91118HelicalSequence AnalysisAdd
    BLAST
    Transmembranei927 – 94721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei981 – 100323HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1029 – 105022HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1084 – 112946HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1156 – 119237HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni705 – 1234530Membrane (anion exchange)Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi5 – 317313Pro-richAdd
    BLAST
    Compositional biasi74 – 8815His-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG268067.
    GeneTreeiENSGT00560000076933.
    HOGENOMiHOG000280683.
    HOVERGENiHBG004326.
    InParanoidiP23347.
    KOiK13855.
    OMAiDREMKCL.
    OrthoDBiEOG7TMZR0.
    PhylomeDBiP23347.
    TreeFamiTF313630.

    Family and domain databases

    Gene3Di3.40.1100.10. 1 hit.
    InterProiIPR001717. Anion_exchange.
    IPR002978. Anion_exchange_2.
    IPR018241. Anion_exchange_CS.
    IPR013769. Band3_cytoplasmic_dom.
    IPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    IPR016152. PTrfase/Anion_transptr.
    [Graphical view]
    PANTHERiPTHR11453. PTHR11453. 1 hit.
    PTHR11453:SF14. PTHR11453:SF14. 1 hit.
    PfamiPF07565. Band_3_cyto. 1 hit.
    PF00955. HCO3_cotransp. 1 hit.
    [Graphical view]
    PRINTSiPR00165. ANIONEXCHNGR.
    PR01188. ANIONEXHNGR2.
    PR01231. HCO3TRNSPORT.
    SUPFAMiSSF55804. SSF55804. 2 hits.
    TIGRFAMsiTIGR00834. ae. 1 hit.
    PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
    PS00220. ANION_EXCHANGER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P23347-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSAPRRPAS GADSLHTPEP ESLSPGTPGF PEQEEEDELR TLGVERFEEI     50
    LQEAGSRGGE EPGRSYGEED FEYHRQSSHH IHHPLSTHLP PDARRRKTPQ 100
    GPGRKPRRRP GASPTGETPT IEEGEEDEDE VGEAEGFRAP PQQPSPASSP 150
    SAVQFFLQED EGTDRKAERT SPSPPTQTPH QEAAPRASKG AQTGTLVEEM 200
    VAVASGTAGG DDGGAAGRPL TKAQPGHRSY NLQERRRIGS MTGVEQALLP 250
    RVPTDESEAQ TLATADLDLM KSHRFEDVPG VRRHLVRKNA KGSTQAAREG 300
    REPGPTPRAR PRAPHKPHEV FVELNELQLD KNQEPQWRET ARWIKFEEDV 350
    EEETERWGKP HVASLSFRSL LELRRTLAHG AVLLDLDQQT LPGVAHQVVE 400
    QMVISDQIKA EDRANVLRAL LLKHSHPSDE KEFSFPRNIS AGSLGSLLGH 450
    HHAQGTESDP HVTEPLIGGV PETRLEVDRE RELPPPAPPA GITRSKSKHE 500
    LKLLEKIPEN AEATVVLVGC VEFLSRPTMA FVRLREAVEL DAVLEVPVPV 550
    RFLFLLLGPS SANMDYHEIG RSISTLMSDK QFHEAAYLAD ERDDLLTAIN 600
    AFLDCSVVLP PSEVQGEELL RSVAHFQRQM LKKREEQGRL LPPGAGLEPK 650
    SAQDKALLQM VEVAGAAEDD PLRRTGRPFG GLIRDVRRRY PHYLSDFRDA 700
    LDPQCLAAVI FIYFAALSPA ITFGGLLGEK TQDLIGVSEL IMSTALQGVI 750
    FCLLGAQPLL VIGFSGPLLV FEEAFFSFCK SNQLEYLVGR VWIGFWLVLL 800
    ALLMVALEGS FLVRFVSRFT QEIFAFLISL IFIYETFYKL IKIFQEHPLH 850
    GCSVSNDSEA DSSSNNMTWA ATTLAPDNSS ASGQERPRGQ PNTALLSLVL 900
    MAGTFFIAFF LRKFKNSRFF PGRIRRVIGD FGVPIAILIM VLVDYSIEDT 950
    YTQKLSVPSG FSVTAPDKRG WVINPLGEKT PFPVWMMVAS LLPAVLVFIL 1000
    IFMETQITTL IISKKERMLQ KGSGFHLDLL LIVAMGGICA LFGLPWLAAA 1050
    TVRSVTHANA LTVMSKAVAP GDKPKIQEVK EQRVTGLLVA LLVGLSMVIG 1100
    DLLRQIPLAV LFGIFLYMGV TSLNGIQFYE RLHLLLMPPK HHPDVTYVKK 1150
    VRTMRMHLFT ALQLLCLALL WAVMSTAASL AFPFILILTV PLRMVVLTRI 1200
    FTEREMKCLD ANEAEPVFDE CEGVDEYNEM PMPV 1234
    Length:1,234
    Mass (Da):136,636
    Last modified:November 1, 1991 - v1
    Checksum:iFAB4ED12BB916216
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti206 – 2061G → A no nucleotide entry (PubMed:2371270)Curated
    Sequence conflicti925 – 9262RR → PG no nucleotide entry (PubMed:2371270)Curated
    Sequence conflicti1018 – 10192ML → IV no nucleotide entry (PubMed:2371270)Curated
    Sequence conflicti1156 – 11572MH → ID no nucleotide entry (PubMed:2371270)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05166 mRNA. Translation: AAA40799.1.
    PIRiA34911.
    RefSeqiNP_058744.1. NM_017048.2.
    XP_006235936.1. XM_006235874.1.
    XP_006235937.1. XM_006235875.1.
    XP_006235938.1. XM_006235876.1.
    UniGeneiRn.9860.

    Genome annotation databases

    EnsembliENSRNOT00000019666; ENSRNOP00000019666; ENSRNOG00000014347.
    GeneIDi24780.
    KEGGirno:24780.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05166 mRNA. Translation: AAA40799.1 .
    PIRi A34911.
    RefSeqi NP_058744.1. NM_017048.2.
    XP_006235936.1. XM_006235874.1.
    XP_006235937.1. XM_006235875.1.
    XP_006235938.1. XM_006235876.1.
    UniGenei Rn.9860.

    3D structure databases

    ProteinModelPortali P23347.
    SMRi P23347. Positions 689-730, 1126-1158.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 246904. 1 interaction.

    PTM databases

    PhosphoSitei P23347.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000019666 ; ENSRNOP00000019666 ; ENSRNOG00000014347 .
    GeneIDi 24780.
    KEGGi rno:24780.

    Organism-specific databases

    CTDi 6522.
    RGDi 3711. Slc4a2.

    Phylogenomic databases

    eggNOGi NOG268067.
    GeneTreei ENSGT00560000076933.
    HOGENOMi HOG000280683.
    HOVERGENi HBG004326.
    InParanoidi P23347.
    KOi K13855.
    OMAi DREMKCL.
    OrthoDBi EOG7TMZR0.
    PhylomeDBi P23347.
    TreeFami TF313630.

    Miscellaneous databases

    NextBioi 604384.
    PROi P23347.

    Gene expression databases

    Genevestigatori P23347.

    Family and domain databases

    Gene3Di 3.40.1100.10. 1 hit.
    InterProi IPR001717. Anion_exchange.
    IPR002978. Anion_exchange_2.
    IPR018241. Anion_exchange_CS.
    IPR013769. Band3_cytoplasmic_dom.
    IPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    IPR016152. PTrfase/Anion_transptr.
    [Graphical view ]
    PANTHERi PTHR11453. PTHR11453. 1 hit.
    PTHR11453:SF14. PTHR11453:SF14. 1 hit.
    Pfami PF07565. Band_3_cyto. 1 hit.
    PF00955. HCO3_cotransp. 1 hit.
    [Graphical view ]
    PRINTSi PR00165. ANIONEXCHNGR.
    PR01188. ANIONEXHNGR2.
    PR01231. HCO3TRNSPORT.
    SUPFAMi SSF55804. SSF55804. 2 hits.
    TIGRFAMsi TIGR00834. ae. 1 hit.
    PROSITEi PS00219. ANION_EXCHANGER_1. 1 hit.
    PS00220. ANION_EXCHANGER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning and tissue distribution of mRNAs for two proteins that are related to the band 3 Cl-/HCO3-exchanger."
      Kudrycki K.E., Newman P.R., Shull G.E.
      J. Biol. Chem. 265:462-471(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Stomach.
    2. "Functional expression and subcellular localization of an anion exchanger cloned from choroid plexus."
      Lindsey A.E., Schneider K., Simmons D.M., Baron R., Lee B.S., Kopito R.R.
      Proc. Natl. Acad. Sci. U.S.A. 87:5278-5282(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiB3A2_RAT
    AccessioniPrimary (citable) accession number: P23347
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: November 1, 1991
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3