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Protein

Antiviral protein S

Gene
N/A
Organism
Phytolacca americana (American pokeweed) (Phytolacca decandra)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits viral infection of plants, and protein synthesis in vitro.

Catalytic activityi

Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei175By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein synthesis inhibitor, Toxin
Biological processAntiviral defense, Plant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Antiviral protein S (EC:3.2.2.22)
Alternative name(s):
PAP-S
Ribosome-inactivating protein
rRNA N-glycosidase
OrganismiPhytolacca americana (American pokeweed) (Phytolacca decandra)
Taxonomic identifieri3527 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeCaryophyllalesPhytolaccaceaePhytolacca

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002214151 – 261Antiviral protein SAdd BLAST261

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 2581 Publication
Disulfide bondi84 ↔ 1051 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP23339

Structurei

Secondary structure

1261
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 10Combined sources8
Helixi13 – 27Combined sources15
Beta strandi34 – 36Combined sources3
Beta strandi37 – 39Combined sources3
Beta strandi49 – 55Combined sources7
Beta strandi61 – 67Combined sources7
Turni68 – 70Combined sources3
Beta strandi73 – 80Combined sources8
Beta strandi83 – 88Combined sources6
Helixi95 – 104Combined sources10
Beta strandi111 – 113Combined sources3
Beta strandi116 – 118Combined sources3
Helixi122 – 129Combined sources8
Helixi134 – 136Combined sources3
Helixi141 – 151Combined sources11
Helixi159 – 172Combined sources14
Helixi174 – 178Combined sources5
Helixi180 – 188Combined sources9
Beta strandi190 – 192Combined sources3
Helixi198 – 205Combined sources8
Helixi207 – 215Combined sources9
Helixi218 – 220Combined sources3
Beta strandi221 – 229Combined sources9
Beta strandi235 – 240Combined sources6
Helixi241 – 244Combined sources4
Helixi245 – 247Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GIKX-ray1.80A1-261[»]
1J1QX-ray1.80A1-261[»]
1J1RX-ray1.90A1-261[»]
1J1SX-ray2.00A1-261[»]
ProteinModelPortaliP23339
SMRiP23339
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23339

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.420.10, 1 hit
4.10.470.10, 1 hit
InterProiView protein in InterPro
IPR036041 Ribosome-inact_prot_sf
IPR017989 Ribosome_inactivat_1/2
IPR001574 Ribosome_inactivat_prot
IPR017988 Ribosome_inactivat_prot_CS
IPR016138 Ribosome_inactivat_prot_sub1
IPR016139 Ribosome_inactivat_prot_sub2
PfamiView protein in Pfam
PF00161 RIP, 1 hit
PRINTSiPR00396 SHIGARICIN
SUPFAMiSSF56371 SSF56371, 1 hit
PROSITEiView protein in PROSITE
PS00275 SHIGA_RICIN, 1 hit

Sequencei

Sequence statusi: Complete.

P23339-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
INTITFDAGN ATINKYATFM ESLRNEAKDP SLKCYGIPML PNTNSTIKYL
60 70 80 90 100
LVKLQGASLK TITLMLRRNN LYVMGYSDPY DNKCRYHIFN DIKGTEYSDV
110 120 130 140 150
ENTLCPSSNP RVAKPINYNG LYPTLEKKAG VTSRNEVQLG IQILSSDIGK
160 170 180 190 200
ISGQGSFTEK IEAKFLLVAI QMVSEAARFK YIENQVKTNF NRDFSPNDKV
210 220 230 240 250
LDLEENWGKI STAIHNSKNG ALPKPLELKN ADGTKWIVLR VDEIKPDVGL
260
LNYVNGTCQA T
Length:261
Mass (Da):29,200
Last modified:November 1, 1991 - v1
Checksum:iD88B99962FE8399D
GO

Sequence databases

PIRiJE0401

Similar proteinsi

Entry informationi

Entry nameiRIPS_PHYAM
AccessioniPrimary (citable) accession number: P23339
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

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