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Protein

Antiviral protein S

Gene
N/A
Organism
Phytolacca americana (American pokeweed) (Phytolacca decandra)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits viral infection of plants, and protein synthesis in vitro.

Catalytic activityi

Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei175By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein synthesis inhibitor, Toxin

Keywords - Biological processi

Antiviral defense, Plant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Antiviral protein S (EC:3.2.2.22)
Alternative name(s):
PAP-S
Ribosome-inactivating protein
rRNA N-glycosidase
OrganismiPhytolacca americana (American pokeweed) (Phytolacca decandra)
Taxonomic identifieri3527 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeCaryophyllalesPhytolaccaceaePhytolacca

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002214151 – 261Antiviral protein SAdd BLAST261

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 2581 Publication
Disulfide bondi84 ↔ 1051 Publication

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

1261
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 10Combined sources8
Helixi13 – 27Combined sources15
Beta strandi34 – 36Combined sources3
Beta strandi37 – 39Combined sources3
Beta strandi49 – 55Combined sources7
Beta strandi61 – 67Combined sources7
Turni68 – 70Combined sources3
Beta strandi73 – 80Combined sources8
Beta strandi83 – 88Combined sources6
Helixi95 – 104Combined sources10
Beta strandi111 – 113Combined sources3
Beta strandi116 – 118Combined sources3
Helixi122 – 129Combined sources8
Helixi134 – 136Combined sources3
Helixi141 – 151Combined sources11
Helixi159 – 172Combined sources14
Helixi174 – 178Combined sources5
Helixi180 – 188Combined sources9
Beta strandi190 – 192Combined sources3
Helixi198 – 205Combined sources8
Helixi207 – 215Combined sources9
Helixi218 – 220Combined sources3
Beta strandi221 – 229Combined sources9
Beta strandi235 – 240Combined sources6
Helixi241 – 244Combined sources4
Helixi245 – 247Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GIKX-ray1.80A1-261[»]
1J1QX-ray1.80A1-261[»]
1J1RX-ray1.90A1-261[»]
1J1SX-ray2.00A1-261[»]
ProteinModelPortaliP23339.
SMRiP23339.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23339.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.420.10. 1 hit.
4.10.470.10. 1 hit.
InterProiIPR001574. Ribosome_inactivat_prot.
IPR017988. Ribosome_inactivat_prot_CS.
IPR016138. Ribosome_inactivat_prot_sub1.
IPR016139. Ribosome_inactivat_prot_sub2.
IPR017989. Ribosome_inactivat_prot_subgr.
[Graphical view]
PfamiPF00161. RIP. 1 hit.
[Graphical view]
PRINTSiPR00396. SHIGARICIN.
SUPFAMiSSF56371. SSF56371. 1 hit.
PROSITEiPS00275. SHIGA_RICIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23339-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
INTITFDAGN ATINKYATFM ESLRNEAKDP SLKCYGIPML PNTNSTIKYL
60 70 80 90 100
LVKLQGASLK TITLMLRRNN LYVMGYSDPY DNKCRYHIFN DIKGTEYSDV
110 120 130 140 150
ENTLCPSSNP RVAKPINYNG LYPTLEKKAG VTSRNEVQLG IQILSSDIGK
160 170 180 190 200
ISGQGSFTEK IEAKFLLVAI QMVSEAARFK YIENQVKTNF NRDFSPNDKV
210 220 230 240 250
LDLEENWGKI STAIHNSKNG ALPKPLELKN ADGTKWIVLR VDEIKPDVGL
260
LNYVNGTCQA T
Length:261
Mass (Da):29,200
Last modified:November 1, 1991 - v1
Checksum:iD88B99962FE8399D
GO

Sequence databases

PIRiJE0401.

Cross-referencesi

Sequence databases

PIRiJE0401.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GIKX-ray1.80A1-261[»]
1J1QX-ray1.80A1-261[»]
1J1RX-ray1.90A1-261[»]
1J1SX-ray2.00A1-261[»]
ProteinModelPortaliP23339.
SMRiP23339.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP23339.

Family and domain databases

Gene3Di3.40.420.10. 1 hit.
4.10.470.10. 1 hit.
InterProiIPR001574. Ribosome_inactivat_prot.
IPR017988. Ribosome_inactivat_prot_CS.
IPR016138. Ribosome_inactivat_prot_sub1.
IPR016139. Ribosome_inactivat_prot_sub2.
IPR017989. Ribosome_inactivat_prot_subgr.
[Graphical view]
PfamiPF00161. RIP. 1 hit.
[Graphical view]
PRINTSiPR00396. SHIGARICIN.
SUPFAMiSSF56371. SSF56371. 1 hit.
PROSITEiPS00275. SHIGA_RICIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRIPS_PHYAM
AccessioniPrimary (citable) accession number: P23339
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.