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Protein

Glycogen [starch] synthase isoform 1

Gene

GSY1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. Is believed to regulate the synthesis of glycogen.

Catalytic activityi

UDP-alpha-D-glucose + ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1).

Enzyme regulationi

Allosteric activation by glucose-6-phosphate, and phosphorylation by a cAMP-dependent kinase.

Pathwayi: glycogen biosynthesis

This protein is involved in the pathway glycogen biosynthesis, which is part of Glycan biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycogen biosynthesis and in Glycan biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei20UDP-glucoseBy similarity1

GO - Molecular functioni

  • glycogen (starch) synthase activity Source: SGD

GO - Biological processi

  • glycogen biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Glycogen biosynthesis

Enzyme and pathway databases

BioCyciYEAST:YFR015C-MONOMER.
ReactomeiR-SCE-3322077. Glycogen synthesis.
UniPathwayiUPA00164.

Protein family/group databases

CAZyiGT3. Glycosyltransferase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycogen [starch] synthase isoform 1 (EC:2.4.1.11)
Gene namesi
Name:GSY1
Ordered Locus Names:YFR015C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiFungiDB:YFR015C.
SGDiS000001911. GSY1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001947732 – 708Glycogen [starch] synthase isoform 1Add BLAST707

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei159PhosphoserineSequence analysis1
Modified residuei363PhosphoserineSequence analysis1
Modified residuei560PhosphoserineSequence analysis1
Modified residuei651PhosphoserineCombined sources1
Modified residuei655PhosphoserineCombined sources1
Modified residuei660Phosphoserine; by PKASequence analysis1
Modified residuei662Phosphoserine; by PKASequence analysis1
Modified residuei667PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP23337.
PRIDEiP23337.

PTM databases

iPTMnetiP23337.

Expressioni

Developmental stagei

Activity increases just before cells entry in the stationary phase.

Inductioni

Synthesized in response to growth limitation.

Interactioni

Protein-protein interaction databases

BioGridi31167. 33 interactors.
DIPiDIP-5354N.
IntActiP23337. 12 interactors.
MINTiMINT-483654.

Structurei

3D structure databases

ProteinModelPortaliP23337.
SMRiP23337.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 3 family.Curated

Phylogenomic databases

HOGENOMiHOG000160890.
InParanoidiP23337.
KOiK00693.
OMAiFAMKRHG.
OrthoDBiEOG092C0XGC.

Family and domain databases

InterProiIPR008631. Glycogen_synth.
[Graphical view]
PANTHERiPTHR10176. PTHR10176. 1 hit.
PfamiPF05693. Glycogen_syn. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23337-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARDLQNHLL FEVATEVTNR VGGIYSVLKS KAPVTVAQYG DNYTLLGPLN
60 70 80 90 100
KATYESEVEK LDWEDESIFP EELLPIQKTL MSMREKGVNF VYGNWLIEGA
110 120 130 140 150
PRVILFELDS VRHFLNEWKA DLWSLVGIPS PEHDHETNDA ILLGYVVVWF
160 170 180 190 200
LGEVSKLDSS HAIIGHFHEW LAGVALPLCR KKRIDVVTIF TTHATLLGRY
210 220 230 240 250
LCAAGDVDFY NNLQYFDVDQ EAGKRGIYHR YCIERAAAHT ADVFTTVSQI
260 270 280 290 300
TALEAEHLLK RKPDGILPNG LNVVKFQAVH EFQNLHALKK DKINDFVRGH
310 320 330 340 350
FHGCFDFDLD NTVYFFIAGR YEYKNKGADM FIESLARLNY RLKVSGSKKT
360 370 380 390 400
VVAFLIMPAK TNSFTVEALK SQAIVKSLEN TVNEVTASIG KRIFEHTMRY
410 420 430 440 450
PHNGLESELP TNLDELLKSS EKVLLKKRVL ALRRPYGELP PVVTHNMCDD
460 470 480 490 500
ANDPILNQIR HVRLFNDSSD RVKVIFHPEF LNANNPILGL DYDEFVRGCH
510 520 530 540 550
LGVFPSYYEP WGYTPAECTV MGVPSITTNV SGFGAYMEDL IETDQAKDYG
560 570 580 590 600
IYIVDRRFKS PDESVEQLAD YMEEFVNKTR RQRINQRNRT ERLSDLLDWK
610 620 630 640 650
RMGLEYVKAR QLGLRRAYPE QFKQLVGETI SDANMNTLAG GKKFKIARPL
660 670 680 690 700
SVPGSPKVRS NSTVYMTPGD LGTLQDANNA DDYFNLSTNG AIDNDDDDND

TSAYYEDN
Length:708
Mass (Da):80,510
Last modified:January 23, 2007 - v3
Checksum:i9EF2D3858529E68A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60919 Genomic DNA. Translation: AAA88715.1.
D50617 Genomic DNA. Translation: BAA09254.1.
BK006940 Genomic DNA. Translation: DAA12456.1.
PIRiA38326.
RefSeqiNP_116670.1. NM_001179980.1.

Genome annotation databases

EnsemblFungiiBAA09254; BAA09254; BAA09254.
YFR015C; YFR015C; YFR015C.
GeneIDi850569.
KEGGisce:YFR015C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60919 Genomic DNA. Translation: AAA88715.1.
D50617 Genomic DNA. Translation: BAA09254.1.
BK006940 Genomic DNA. Translation: DAA12456.1.
PIRiA38326.
RefSeqiNP_116670.1. NM_001179980.1.

3D structure databases

ProteinModelPortaliP23337.
SMRiP23337.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31167. 33 interactors.
DIPiDIP-5354N.
IntActiP23337. 12 interactors.
MINTiMINT-483654.

Protein family/group databases

CAZyiGT3. Glycosyltransferase Family 3.

PTM databases

iPTMnetiP23337.

Proteomic databases

MaxQBiP23337.
PRIDEiP23337.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiBAA09254; BAA09254; BAA09254.
YFR015C; YFR015C; YFR015C.
GeneIDi850569.
KEGGisce:YFR015C.

Organism-specific databases

EuPathDBiFungiDB:YFR015C.
SGDiS000001911. GSY1.

Phylogenomic databases

HOGENOMiHOG000160890.
InParanoidiP23337.
KOiK00693.
OMAiFAMKRHG.
OrthoDBiEOG092C0XGC.

Enzyme and pathway databases

UniPathwayiUPA00164.
BioCyciYEAST:YFR015C-MONOMER.
ReactomeiR-SCE-3322077. Glycogen synthesis.

Miscellaneous databases

PROiP23337.

Family and domain databases

InterProiIPR008631. Glycogen_synth.
[Graphical view]
PANTHERiPTHR10176. PTHR10176. 1 hit.
PfamiPF05693. Glycogen_syn. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGYS1_YEAST
AccessioniPrimary (citable) accession number: P23337
Secondary accession number(s): D6VTP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 161 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6300 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.