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Protein

Thymidine kinase

Gene

TK

Organism
Swinepox virus (strain Kasza) (SWPV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei84 – 841Proton acceptorSequence Analysis
Binding sitei114 – 1141Substrate; via amide nitrogenBy similarity
Metal bindingi139 – 1391ZincBy similarity
Metal bindingi142 – 1421ZincBy similarity
Metal bindingi171 – 1711ZincBy similarity
Metal bindingi174 – 1741ZincBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 188ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:TK
ORF Names:SWF8
OrganismiSwinepox virus (strain Kasza) (SWPV)
Taxonomic identifieri10277 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeSuipoxvirus
Virus hostiSus scrofa (Pig) [TaxID: 9823]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 177177Thymidine kinasePRO_0000174936Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP23335.
SMRiP23335. Positions 4-176.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni158 – 1625Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the thymidine kinase family.Curated

Phylogenomic databases

KOiK00857.

Family and domain databases

InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23335-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCGFIHLIL GPMFSGKSTE LIRLVNRYQI ATYNCRVIKY SKDNRYGNDA
60 70 80 90 100
VYTHDKCYIS AVSTDSLFDI KDTLDDVDIV GIDEGQFFND IVEFCEYIAN
110 120 130 140 150
KGKIVIVAAL DGTYERKPFG NILNLIPLSE KVTKLNAICM ICHRDASFSK
160 170
RLSDEKEIEL IGGKEKYLSV CRSCYLT
Length:177
Mass (Da):20,053
Last modified:November 1, 1991 - v1
Checksum:i91694E4A1B4CB942
GO

Sequence cautioni

The sequence AAA47894.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64000 Genomic DNA. Translation: AAA47894.1. Different initiation.
M59931 Genomic DNA. Translation: AAA47891.1.
PIRiB37949. KIVZSW.

Genome annotation databases

KEGGivg:932479.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64000 Genomic DNA. Translation: AAA47894.1. Different initiation.
M59931 Genomic DNA. Translation: AAA47891.1.
PIRiB37949. KIVZSW.

3D structure databases

ProteinModelPortaliP23335.
SMRiP23335. Positions 4-176.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGivg:932479.

Phylogenomic databases

KOiK00857.

Family and domain databases

InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation and molecular characterization of the swinepox virus thymidine kinase gene."
    Feller J.A., Massung R.F., Turner P.C., Gibbs E.P.J., Bockamp E.O., Beloso A., Talavera A., Vinuela E., Moyer R.W.
    Virology 183:578-585(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Identification and nucleotide sequence of the thymidine kinase gene of swinepox virus."
    Schnitzlein W.M., Tripathy D.N.
    Virology 181:727-732(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiKITH_SWPVK
AccessioniPrimary (citable) accession number: P23335
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: July 22, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.