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P23335 (KITH_SWPVK) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:TK
ORF Names:SWF8
OrganismSwinepox virus (strain Kasza) (SWPV)
Taxonomic identifier10277 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeSuipoxvirus
Virus hostSus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length177 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sequence similarities

Belongs to the thymidine kinase family.

Sequence caution

The sequence AAA47894.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 177177Thymidine kinase
PRO_0000174936

Regions

Nucleotide binding11 – 188ATP By similarity
Region158 – 1625Substrate binding By similarity

Sites

Active site841Proton acceptor Potential
Metal binding1391Zinc By similarity
Metal binding1421Zinc By similarity
Metal binding1711Zinc By similarity
Metal binding1741Zinc By similarity
Binding site1141Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
P23335 [UniParc].

Last modified November 1, 1991. Version 1.
Checksum: 91694E4A1B4CB942

FASTA17720,053
        10         20         30         40         50         60 
MSCGFIHLIL GPMFSGKSTE LIRLVNRYQI ATYNCRVIKY SKDNRYGNDA VYTHDKCYIS 

        70         80         90        100        110        120 
AVSTDSLFDI KDTLDDVDIV GIDEGQFFND IVEFCEYIAN KGKIVIVAAL DGTYERKPFG 

       130        140        150        160        170 
NILNLIPLSE KVTKLNAICM ICHRDASFSK RLSDEKEIEL IGGKEKYLSV CRSCYLT 

« Hide

References

[1]"Isolation and molecular characterization of the swinepox virus thymidine kinase gene."
Feller J.A., Massung R.F., Turner P.C., Gibbs E.P.J., Bockamp E.O., Beloso A., Talavera A., Vinuela E., Moyer R.W.
Virology 183:578-585(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Identification and nucleotide sequence of the thymidine kinase gene of swinepox virus."
Schnitzlein W.M., Tripathy D.N.
Virology 181:727-732(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M64000 Genomic DNA. Translation: AAA47894.1. Different initiation.
M59931 Genomic DNA. Translation: AAA47891.1.
PIRKIVZSW. B37949.

3D structure databases

ProteinModelPortalP23335.
SMRP23335. Positions 4-176.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERPTHR11441. PTHR11441. 1 hit.
PfamPF00265. TK. 1 hit.
[Graphical view]
PIRSFPIRSF035805. TK_cell. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKITH_SWPVK
AccessionPrimary (citable) accession number: P23335
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: February 19, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families