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P23335

- KITH_SWPVK

UniProt

P23335 - KITH_SWPVK

Protein

Thymidine kinase

Gene

TK

Organism
Swinepox virus (strain Kasza) (SWPV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (01 Nov 1991)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei84 – 841Proton acceptorSequence Analysis
    Binding sitei114 – 1141Substrate; via amide nitrogenBy similarity
    Metal bindingi139 – 1391ZincBy similarity
    Metal bindingi142 – 1421ZincBy similarity
    Metal bindingi171 – 1711ZincBy similarity
    Metal bindingi174 – 1741ZincBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 188ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. thymidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinase (EC:2.7.1.21)
    Gene namesi
    Name:TK
    ORF Names:SWF8
    OrganismiSwinepox virus (strain Kasza) (SWPV)
    Taxonomic identifieri10277 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeSuipoxvirus
    Virus hostiSus scrofa (Pig) [TaxID: 9823]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 177177Thymidine kinasePRO_0000174936Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP23335.
    SMRiP23335. Positions 4-176.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni158 – 1625Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the thymidine kinase family.Curated

    Family and domain databases

    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P23335-1 [UniParc]FASTAAdd to Basket

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    MSCGFIHLIL GPMFSGKSTE LIRLVNRYQI ATYNCRVIKY SKDNRYGNDA    50
    VYTHDKCYIS AVSTDSLFDI KDTLDDVDIV GIDEGQFFND IVEFCEYIAN 100
    KGKIVIVAAL DGTYERKPFG NILNLIPLSE KVTKLNAICM ICHRDASFSK 150
    RLSDEKEIEL IGGKEKYLSV CRSCYLT 177
    Length:177
    Mass (Da):20,053
    Last modified:November 1, 1991 - v1
    Checksum:i91694E4A1B4CB942
    GO

    Sequence cautioni

    The sequence AAA47894.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64000 Genomic DNA. Translation: AAA47894.1. Different initiation.
    M59931 Genomic DNA. Translation: AAA47891.1.
    PIRiB37949. KIVZSW.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64000 Genomic DNA. Translation: AAA47894.1 . Different initiation.
    M59931 Genomic DNA. Translation: AAA47891.1 .
    PIRi B37949. KIVZSW.

    3D structure databases

    ProteinModelPortali P23335.
    SMRi P23335. Positions 4-176.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and molecular characterization of the swinepox virus thymidine kinase gene."
      Feller J.A., Massung R.F., Turner P.C., Gibbs E.P.J., Bockamp E.O., Beloso A., Talavera A., Vinuela E., Moyer R.W.
      Virology 183:578-585(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Identification and nucleotide sequence of the thymidine kinase gene of swinepox virus."
      Schnitzlein W.M., Tripathy D.N.
      Virology 181:727-732(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiKITH_SWPVK
    AccessioniPrimary (citable) accession number: P23335
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: November 1, 1991
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3