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Protein

Thymidine kinase

Gene

TK

Organism
Swinepox virus (strain Kasza) (SWPV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei84Proton acceptorSequence analysis1
Binding sitei114Substrate; via amide nitrogenBy similarity1
Metal bindingi139ZincBy similarity1
Metal bindingi142ZincBy similarity1
Metal bindingi171ZincBy similarity1
Metal bindingi174ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:TK
ORF Names:SWF8
OrganismiSwinepox virus (strain Kasza) (SWPV)
Taxonomic identifieri10277 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeSuipoxvirus
Virus hostiSus scrofa (Pig) [TaxID: 9823]

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001749361 – 177Thymidine kinaseAdd BLAST177

Proteomic databases

PRIDEiP23335.

Structurei

3D structure databases

ProteinModelPortaliP23335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni158 – 162Substrate bindingBy similarity5

Sequence similaritiesi

Belongs to the thymidine kinase family.Curated

Family and domain databases

InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23335-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCGFIHLIL GPMFSGKSTE LIRLVNRYQI ATYNCRVIKY SKDNRYGNDA
60 70 80 90 100
VYTHDKCYIS AVSTDSLFDI KDTLDDVDIV GIDEGQFFND IVEFCEYIAN
110 120 130 140 150
KGKIVIVAAL DGTYERKPFG NILNLIPLSE KVTKLNAICM ICHRDASFSK
160 170
RLSDEKEIEL IGGKEKYLSV CRSCYLT
Length:177
Mass (Da):20,053
Last modified:November 1, 1991 - v1
Checksum:i91694E4A1B4CB942
GO

Sequence cautioni

The sequence AAA47894 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64000 Genomic DNA. Translation: AAA47894.1. Different initiation.
M59931 Genomic DNA. Translation: AAA47891.1.
PIRiB37949. KIVZSW.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64000 Genomic DNA. Translation: AAA47894.1. Different initiation.
M59931 Genomic DNA. Translation: AAA47891.1.
PIRiB37949. KIVZSW.

3D structure databases

ProteinModelPortaliP23335.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP23335.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKITH_SWPVK
AccessioniPrimary (citable) accession number: P23335
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: October 5, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.