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P23327 (SRCH_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sarcoplasmic reticulum histidine-rich calcium-binding protein
Gene names
Name:HRC
Synonyms:HCP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length699 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle.

Subcellular location

Sarcoplasmic reticulum lumen.

Sequence similarities

Belongs to the HRC family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828
Chain29 – 699671Sarcoplasmic reticulum histidine-rich calcium-binding protein
PRO_0000022414

Regions

Repeat106 – 121162-1
Repeat134 – 154212-2
Repeat155 – 177232-3
Repeat180 – 213341-1
Repeat214 – 237242-4
Repeat238 – 270331-2
Repeat271 – 294242-5
Repeat295 – 318241-3
Repeat319 – 342242-6
Repeat343 – 365231-4
Region106 – 3652604 X tandem repeats, acidic
Region106 – 3422376 X approximate tandem repeats
Region627 – 67347Metal-binding Potential
Compositional bias193 – 20412Glu-rich (acidic)
Compositional bias246 – 26116Asp-rich (acidic)

Natural variations

Natural variant431S → N.
Corresponds to variant rs3745298 [ dbSNP | Ensembl ].
VAR_021931
Natural variant961S → A.
Corresponds to variant rs3745297 [ dbSNP | Ensembl ].
VAR_005623
Natural variant2041Missing.
VAR_011622

Sequences

Sequence LengthMass (Da)Tools
P23327 [UniParc].

Last modified November 1, 1991. Version 1.
Checksum: 9922EEDF012C61DD

FASTA69980,244
        10         20         30         40         50         60 
MGHHRPWLHA SVLWAGVASL LLPPAMTQQL RGDGLGFRNR NNSTGVAGLS EEASAELRHH 

        70         80         90        100        110        120 
LHSPRDHPDE NKDVSTENGH HFWSHPDREK EDEDVSKEYG HLLPGHRSQD HKVGDEGVSG 

       130        140        150        160        170        180 
EEVFAEHGGQ ARGHRGHGSE DTEDSAEHRH HLPSHRSHSH QDEDEDEVVS SEHHHHILRH 

       190        200        210        220        230        240 
GHRGHDGEDD EGEEEEEEEE EEEEASTEYG HQAHRHRGHG SEEDEDVSDG HHHHGPSHRH 

       250        260        270        280        290        300 
QGHEEDDDDD DDDDDDDDDD DVSIEYRHQA HRHQGHGIEE DEDVSDGHHH RDPSHRHRSH 

       310        320        330        340        350        360 
EEDDNDDDDV STEYGHQAHR HQDHRKEEVE AVSGEHHHHV PDHRHQGHRD EEEDEDVSTE 

       370        380        390        400        410        420 
RWHQGPQHVH HGLVDEEEEE EEITVQFGHY VASHQPRGHK SDEEDFQDEY KTEVPHHHHH 

       430        440        450        460        470        480 
RVPREEDEEV SAELGHQAPS HRQSHQDEET GHGQRGSIKE MSHHPPGHTV VKDRSHLRKD 

       490        500        510        520        530        540 
DSEEEKEKEE DPGSHEEDDE SSEQGEKGTH HGSRDQEDEE DEEEGHGLSL NQEEEEEEDK 

       550        560        570        580        590        600 
EEEEEEEDEE RREERAEVGA PLSPDHSEEE EEEEEGLEED EPRFTIIPNP LDRREEAGGA 

       610        620        630        640        650        660 
SSEEESGEDT GPQDAQEYGN YQPGSLCGYC SFCNRCTECE SCHCDEENMG EHCDQCQHCQ 

       670        680        690 
FCYLCPLVCE TVCAPGSYVD YFSSSLYQAL ADMLETPEP 

« Hide

References

« Hide 'large scale' references
[1]"cDNA and genomic cloning of HRC, a human sarcoplasmic reticulum protein, and localization of the gene to human chromosome 19 and mouse chromosome 7."
Hofmann S.L., Topham M., Hsieh C.-L., Francke U.
Genomics 9:656-669(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS.
Tissue: Skeletal muscle.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skeletal muscle.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M60052 mRNA. Translation: AAA88071.1.
BC069795 mRNA. Translation: AAH69795.1.
BC069802 mRNA. Translation: AAH69802.1.
BC094691 mRNA. Translation: AAH94691.1.
CCDSCCDS12759.1.
PIRA54660.
RefSeqNP_002143.1. NM_002152.2.
UniGeneHs.436885.

3D structure databases

ProteinModelPortalP23327.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109506. 1 interaction.
STRING9606.ENSP00000252825.

PTM databases

PhosphoSiteP23327.

Polymorphism databases

DMDM134873.

Proteomic databases

MaxQBP23327.
PaxDbP23327.
PRIDEP23327.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000252825; ENSP00000252825; ENSG00000130528.
GeneID3270.
KEGGhsa:3270.
UCSCuc002pmv.3. human.

Organism-specific databases

CTD3270.
GeneCardsGC19M049654.
HGNCHGNC:5178. HRC.
HPAHPA004833.
MIM142705. gene.
neXtProtNX_P23327.
PharmGKBPA29452.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG328567.
HOVERGENHBG016630.
InParanoidP23327.
OMASHRHQGH.
OrthoDBEOG7S7SJ1.
PhylomeDBP23327.
TreeFamTF344276.

Gene expression databases

ArrayExpressP23327.
BgeeP23327.
CleanExHS_HRC.
GenevestigatorP23327.

Family and domain databases

InterProIPR015666. His-rich_Ca-bd.
IPR019552. Hist_rich_Ca-bd.
[Graphical view]
PANTHERPTHR15054. PTHR15054. 1 hit.
PfamPF10529. Hist_rich_Ca-bd. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiHRC_(gene).
GenomeRNAi3270.
NextBio12991.
PROP23327.
SOURCESearch...

Entry information

Entry nameSRCH_HUMAN
AccessionPrimary (citable) accession number: P23327
Secondary accession number(s): Q504Y6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: July 9, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM