P23327 (SRCH_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sarcoplasmic reticulum histidine-rich calcium-binding protein

Gene names

Name:	HRC
Synonyms:	HCP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	699 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle.
Subcellular location	Sarcoplasmic reticulum lumen.
Sequence similarities	To rabbit HRC.

Ontologies

Keywords
Cellular component	Sarcoplasmic reticulum
Coding sequence diversity	Polymorphism
Domain	Repeat Signal
Ligand	Calcium
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	calcium ion homeostasis Inferred from electronic annotation. Source: Compara muscle contraction Traceable author statement Ref.1. Source: ProtInc regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Traceable author statement PubMed 17526652. Source: BHF-UCL
Cellular_component	sarcoplasmic reticulum lumen Traceable author statement PubMed 11504710. Source: BHF-UCL sarcoplasmic reticulum membrane Inferred from electronic annotation. Source: Compara
Molecular_function	calcium ion binding Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28
	Chain	29 – 699	671	Sarcoplasmic reticulum histidine-rich calcium-binding protein		PRO_0000022414
Regions
	Repeat	106 – 121	16	2-1
	Repeat	134 – 154	21	2-2
	Repeat	155 – 177	23	2-3
	Repeat	180 – 213	34	1-1
	Repeat	214 – 237	24	2-4
	Repeat	238 – 270	33	1-2
	Repeat	271 – 294	24	2-5
	Repeat	295 – 318	24	1-3
	Repeat	319 – 342	24	2-6
	Repeat	343 – 365	23	1-4
	Region	106 – 365	260	4 X tandem repeats, acidic
	Region	106 – 342	237	6 X approximate tandem repeats
	Region	627 – 673	47	Metal-binding Potential
	Compositional bias	193 – 204	12	Glu-rich (acidic)
	Compositional bias	246 – 261	16	Asp-rich (acidic)
Natural variations
	Natural variant	43	1	S → N. Corresponds to variant rs3745298 [ dbSNP | Ensembl ].		VAR_021931
	Natural variant	96	1	S → A. Corresponds to variant rs3745297 [ dbSNP | Ensembl ].		VAR_005623
	Natural variant	204	1	Missing.		VAR_011622

Sequences

	Sequence		Length	Mass (Da)
	P23327 [UniParc]. Last modified November 1, 1991. Version 1. Checksum: 9922EEDF012C61DD	FASTA	699	80,244
	10 20 30 40 50 60 MGHHRPWLHA SVLWAGVASL LLPPAMTQQL RGDGLGFRNR NNSTGVAGLS EEASAELRHH 70 80 90 100 110 120 LHSPRDHPDE NKDVSTENGH HFWSHPDREK EDEDVSKEYG HLLPGHRSQD HKVGDEGVSG 130 140 150 160 170 180 EEVFAEHGGQ ARGHRGHGSE DTEDSAEHRH HLPSHRSHSH QDEDEDEVVS SEHHHHILRH 190 200 210 220 230 240 GHRGHDGEDD EGEEEEEEEE EEEEASTEYG HQAHRHRGHG SEEDEDVSDG HHHHGPSHRH 250 260 270 280 290 300 QGHEEDDDDD DDDDDDDDDD DVSIEYRHQA HRHQGHGIEE DEDVSDGHHH RDPSHRHRSH 310 320 330 340 350 360 EEDDNDDDDV STEYGHQAHR HQDHRKEEVE AVSGEHHHHV PDHRHQGHRD EEEDEDVSTE 370 380 390 400 410 420 RWHQGPQHVH HGLVDEEEEE EEITVQFGHY VASHQPRGHK SDEEDFQDEY KTEVPHHHHH 430 440 450 460 470 480 RVPREEDEEV SAELGHQAPS HRQSHQDEET GHGQRGSIKE MSHHPPGHTV VKDRSHLRKD 490 500 510 520 530 540 DSEEEKEKEE DPGSHEEDDE SSEQGEKGTH HGSRDQEDEE DEEEGHGLSL NQEEEEEEDK 550 560 570 580 590 600 EEEEEEEDEE RREERAEVGA PLSPDHSEEE EEEEEGLEED EPRFTIIPNP LDRREEAGGA 610 620 630 640 650 660 SSEEESGEDT GPQDAQEYGN YQPGSLCGYC SFCNRCTECE SCHCDEENMG EHCDQCQHCQ 670 680 690 FCYLCPLVCE TVCAPGSYVD YFSSSLYQAL ADMLETPEP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA and genomic cloning of HRC, a human sarcoplasmic reticulum protein, and localization of the gene to human chromosome 19 and mouse chromosome 7." Hofmann S.L., Topham M., Hsieh C.-L., Francke U. Genomics 9:656-669(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS. Tissue: Skeletal muscle.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skeletal muscle.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M60052 mRNA. Translation: AAA88071.1. BC069795 mRNA. Translation: AAH69795.1. BC069802 mRNA. Translation: AAH69802.1. BC094691 mRNA. Translation: AAH94691.1.
IPI	IPI00219226.
PIR	A54660.
RefSeq	NP_002143.1. NM_002152.2.
UniGene	Hs.436885.
3D structure databases
ProteinModelPortal	P23327.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000252825.
PTM databases
PhosphoSite	P23327.
Polymorphism databases
DMDM	134873.
Proteomic databases
PaxDb	P23327.
PRIDE	P23327.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000252825; ENSP00000252825; ENSG00000130528.
GeneID	3270.
KEGG	hsa:3270.
UCSC	uc002pmv.3. human.
Organism-specific databases
CTD	3270.
GeneCards	GC19M049654.
HGNC	HGNC:5178. HRC.
HPA	HPA004833.
MIM	142705. gene.
neXtProt	NX_P23327.
PharmGKB	PA29452.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG328567.
HOVERGEN	HBG016630.
InParanoid	P23327.
OMA	SHRHQGH.
OrthoDB	EOG4XH00G.
PhylomeDB	P23327.
Gene expression databases
ArrayExpress	P23327.
Bgee	P23327.
CleanEx	HS_HRC.
Genevestigator	P23327.
Family and domain databases
InterPro	IPR015666. His-rich_Ca-bd. IPR019552. Hist_rich_Ca-bd. [Graphical view]
PANTHER	PTHR15054. PTHR15054. 1 hit.
Pfam	PF10529. Hist_rich_Ca-bd. 6 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	3270.
NextBio	12991.
SOURCE	Search...

Entry information

Entry name

SRCH_HUMAN

Accession

Primary (citable) accession number: P23327
Secondary accession number(s): Q504Y6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	November 1, 1991
Last modified:	May 1, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.