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Protein

Sarcoplasmic reticulum histidine-rich calcium-binding protein

Gene

HRC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle.

GO - Molecular functioni

  1. ATPase binding Source: BHF-UCL
  2. calcium ion binding Source: BHF-UCL
  3. ion channel binding Source: BHF-UCL

GO - Biological processi

  1. cytosolic calcium ion homeostasis Source: BHF-UCL
  2. muscle contraction Source: ProtInc
  3. positive regulation of heart contraction Source: BHF-UCL
  4. positive regulation of heart rate Source: BHF-UCL
  5. positive regulation of relaxation of cardiac muscle Source: BHF-UCL
  6. regulation of calcium ion transmembrane transport Source: BHF-UCL
  7. regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: BHF-UCL
  8. regulation of cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
  9. regulation of heart rate Source: BHF-UCL
  10. regulation of peptidyl-serine phosphorylation Source: BHF-UCL
  11. regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: BHF-UCL
  12. regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Sarcoplasmic reticulum histidine-rich calcium-binding protein
Gene namesi
Name:HRC
Synonyms:HCP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:5178. HRC.

Subcellular locationi

GO - Cellular componenti

  1. sarcoplasmic reticulum lumen Source: BHF-UCL
  2. sarcoplasmic reticulum membrane Source: Ensembl
  3. Z disc Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Sarcoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29452.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Add
BLAST
Chaini29 – 699671Sarcoplasmic reticulum histidine-rich calcium-binding proteinPRO_0000022414Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei333 – 3331Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP23327.
PaxDbiP23327.
PRIDEiP23327.

PTM databases

PhosphoSiteiP23327.

Expressioni

Gene expression databases

BgeeiP23327.
CleanExiHS_HRC.
ExpressionAtlasiP23327. baseline.
GenevestigatoriP23327.

Organism-specific databases

HPAiHPA004833.

Interactioni

Protein-protein interaction databases

BioGridi109506. 1 interaction.
IntActiP23327. 2 interactions.
STRINGi9606.ENSP00000252825.

Structurei

3D structure databases

ProteinModelPortaliP23327.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati106 – 121162-1Add
BLAST
Repeati134 – 154212-2Add
BLAST
Repeati155 – 177232-3Add
BLAST
Repeati180 – 213341-1Add
BLAST
Repeati214 – 237242-4Add
BLAST
Repeati238 – 270331-2Add
BLAST
Repeati271 – 294242-5Add
BLAST
Repeati295 – 318241-3Add
BLAST
Repeati319 – 342242-6Add
BLAST
Repeati343 – 365231-4Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni106 – 3652604 X tandem repeats, acidicAdd
BLAST
Regioni106 – 3422376 X approximate tandem repeatsAdd
BLAST
Regioni627 – 67347Metal-bindingSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi193 – 20412Glu-rich (acidic)Add
BLAST
Compositional biasi246 – 26116Asp-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the HRC family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG328567.
GeneTreeiENSGT00730000111459.
HOVERGENiHBG016630.
InParanoidiP23327.
OMAiSTEHRHQ.
OrthoDBiEOG7S7SJ1.
PhylomeDBiP23327.
TreeFamiTF344276.

Family and domain databases

InterProiIPR015666. His-rich_Ca-bd.
IPR019552. Hist_rich_Ca-bd.
[Graphical view]
PANTHERiPTHR15054. PTHR15054. 1 hit.
PfamiPF10529. Hist_rich_Ca-bd. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23327-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHHRPWLHA SVLWAGVASL LLPPAMTQQL RGDGLGFRNR NNSTGVAGLS
60 70 80 90 100
EEASAELRHH LHSPRDHPDE NKDVSTENGH HFWSHPDREK EDEDVSKEYG
110 120 130 140 150
HLLPGHRSQD HKVGDEGVSG EEVFAEHGGQ ARGHRGHGSE DTEDSAEHRH
160 170 180 190 200
HLPSHRSHSH QDEDEDEVVS SEHHHHILRH GHRGHDGEDD EGEEEEEEEE
210 220 230 240 250
EEEEASTEYG HQAHRHRGHG SEEDEDVSDG HHHHGPSHRH QGHEEDDDDD
260 270 280 290 300
DDDDDDDDDD DVSIEYRHQA HRHQGHGIEE DEDVSDGHHH RDPSHRHRSH
310 320 330 340 350
EEDDNDDDDV STEYGHQAHR HQDHRKEEVE AVSGEHHHHV PDHRHQGHRD
360 370 380 390 400
EEEDEDVSTE RWHQGPQHVH HGLVDEEEEE EEITVQFGHY VASHQPRGHK
410 420 430 440 450
SDEEDFQDEY KTEVPHHHHH RVPREEDEEV SAELGHQAPS HRQSHQDEET
460 470 480 490 500
GHGQRGSIKE MSHHPPGHTV VKDRSHLRKD DSEEEKEKEE DPGSHEEDDE
510 520 530 540 550
SSEQGEKGTH HGSRDQEDEE DEEEGHGLSL NQEEEEEEDK EEEEEEEDEE
560 570 580 590 600
RREERAEVGA PLSPDHSEEE EEEEEGLEED EPRFTIIPNP LDRREEAGGA
610 620 630 640 650
SSEEESGEDT GPQDAQEYGN YQPGSLCGYC SFCNRCTECE SCHCDEENMG
660 670 680 690
EHCDQCQHCQ FCYLCPLVCE TVCAPGSYVD YFSSSLYQAL ADMLETPEP
Length:699
Mass (Da):80,244
Last modified:November 1, 1991 - v1
Checksum:i9922EEDF012C61DD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti43 – 431S → N.
Corresponds to variant rs3745298 [ dbSNP | Ensembl ].
VAR_021931
Natural varianti96 – 961S → A.
Corresponds to variant rs3745297 [ dbSNP | Ensembl ].
VAR_005623
Natural varianti204 – 2041Missing .
VAR_011622

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60052 mRNA. Translation: AAA88071.1.
BC069795 mRNA. Translation: AAH69795.1.
BC069802 mRNA. Translation: AAH69802.1.
BC094691 mRNA. Translation: AAH94691.1.
CCDSiCCDS12759.1.
PIRiA54660.
RefSeqiNP_002143.1. NM_002152.2.
UniGeneiHs.436885.

Genome annotation databases

EnsembliENST00000252825; ENSP00000252825; ENSG00000130528.
GeneIDi3270.
KEGGihsa:3270.
UCSCiuc002pmv.3. human.

Polymorphism databases

DMDMi134873.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60052 mRNA. Translation: AAA88071.1.
BC069795 mRNA. Translation: AAH69795.1.
BC069802 mRNA. Translation: AAH69802.1.
BC094691 mRNA. Translation: AAH94691.1.
CCDSiCCDS12759.1.
PIRiA54660.
RefSeqiNP_002143.1. NM_002152.2.
UniGeneiHs.436885.

3D structure databases

ProteinModelPortaliP23327.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109506. 1 interaction.
IntActiP23327. 2 interactions.
STRINGi9606.ENSP00000252825.

PTM databases

PhosphoSiteiP23327.

Polymorphism databases

DMDMi134873.

Proteomic databases

MaxQBiP23327.
PaxDbiP23327.
PRIDEiP23327.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252825; ENSP00000252825; ENSG00000130528.
GeneIDi3270.
KEGGihsa:3270.
UCSCiuc002pmv.3. human.

Organism-specific databases

CTDi3270.
GeneCardsiGC19M049654.
HGNCiHGNC:5178. HRC.
HPAiHPA004833.
MIMi142705. gene.
neXtProtiNX_P23327.
PharmGKBiPA29452.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG328567.
GeneTreeiENSGT00730000111459.
HOVERGENiHBG016630.
InParanoidiP23327.
OMAiSTEHRHQ.
OrthoDBiEOG7S7SJ1.
PhylomeDBiP23327.
TreeFamiTF344276.

Miscellaneous databases

ChiTaRSiHRC. human.
GeneWikiiHRC_(gene).
GenomeRNAii3270.
NextBioi12991.
PROiP23327.
SOURCEiSearch...

Gene expression databases

BgeeiP23327.
CleanExiHS_HRC.
ExpressionAtlasiP23327. baseline.
GenevestigatoriP23327.

Family and domain databases

InterProiIPR015666. His-rich_Ca-bd.
IPR019552. Hist_rich_Ca-bd.
[Graphical view]
PANTHERiPTHR15054. PTHR15054. 1 hit.
PfamiPF10529. Hist_rich_Ca-bd. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA and genomic cloning of HRC, a human sarcoplasmic reticulum protein, and localization of the gene to human chromosome 19 and mouse chromosome 7."
    Hofmann S.L., Topham M., Hsieh C.-L., Francke U.
    Genomics 9:656-669(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS.
    Tissue: Skeletal muscle.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skeletal muscle.
  3. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-333, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiSRCH_HUMAN
AccessioniPrimary (citable) accession number: P23327
Secondary accession number(s): Q504Y6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: March 4, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.