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P23327

- SRCH_HUMAN

UniProt

P23327 - SRCH_HUMAN

Protein

Sarcoplasmic reticulum histidine-rich calcium-binding protein

Gene

HRC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Nov 1991)
      Previous versions | rss
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    Functioni

    May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle.

    GO - Molecular functioni

    1. ATPase binding Source: BHF-UCL
    2. calcium ion binding Source: BHF-UCL
    3. ion channel binding Source: BHF-UCL
    4. protein binding Source: BHF-UCL

    GO - Biological processi

    1. cytosolic calcium ion homeostasis Source: BHF-UCL
    2. muscle contraction Source: ProtInc
    3. positive regulation of heart contraction Source: BHF-UCL
    4. positive regulation of heart rate Source: BHF-UCL
    5. positive regulation of relaxation of cardiac muscle Source: BHF-UCL
    6. regulation of calcium ion transmembrane transport Source: BHF-UCL
    7. regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: BHF-UCL
    8. regulation of cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
    9. regulation of heart rate Source: BHF-UCL
    10. regulation of peptidyl-serine phosphorylation Source: BHF-UCL
    11. regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: BHF-UCL
    12. regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sarcoplasmic reticulum histidine-rich calcium-binding protein
    Gene namesi
    Name:HRC
    Synonyms:HCP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:5178. HRC.

    Subcellular locationi

    GO - Cellular componenti

    1. sarcoplasmic reticulum lumen Source: BHF-UCL
    2. sarcoplasmic reticulum membrane Source: Ensembl
    3. Z disc Source: BHF-UCL

    Keywords - Cellular componenti

    Sarcoplasmic reticulum

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29452.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Add
    BLAST
    Chaini29 – 699671Sarcoplasmic reticulum histidine-rich calcium-binding proteinPRO_0000022414Add
    BLAST

    Proteomic databases

    MaxQBiP23327.
    PaxDbiP23327.
    PRIDEiP23327.

    PTM databases

    PhosphoSiteiP23327.

    Expressioni

    Gene expression databases

    ArrayExpressiP23327.
    BgeeiP23327.
    CleanExiHS_HRC.
    GenevestigatoriP23327.

    Organism-specific databases

    HPAiHPA004833.

    Interactioni

    Protein-protein interaction databases

    BioGridi109506. 1 interaction.
    STRINGi9606.ENSP00000252825.

    Structurei

    3D structure databases

    ProteinModelPortaliP23327.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati106 – 121162-1Add
    BLAST
    Repeati134 – 154212-2Add
    BLAST
    Repeati155 – 177232-3Add
    BLAST
    Repeati180 – 213341-1Add
    BLAST
    Repeati214 – 237242-4Add
    BLAST
    Repeati238 – 270331-2Add
    BLAST
    Repeati271 – 294242-5Add
    BLAST
    Repeati295 – 318241-3Add
    BLAST
    Repeati319 – 342242-6Add
    BLAST
    Repeati343 – 365231-4Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni106 – 3652604 X tandem repeats, acidicAdd
    BLAST
    Regioni106 – 3422376 X approximate tandem repeatsAdd
    BLAST
    Regioni627 – 67347Metal-bindingSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi193 – 20412Glu-rich (acidic)Add
    BLAST
    Compositional biasi246 – 26116Asp-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Belongs to the HRC family.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG328567.
    HOVERGENiHBG016630.
    InParanoidiP23327.
    OMAiSHRHQGH.
    OrthoDBiEOG7S7SJ1.
    PhylomeDBiP23327.
    TreeFamiTF344276.

    Family and domain databases

    InterProiIPR015666. His-rich_Ca-bd.
    IPR019552. Hist_rich_Ca-bd.
    [Graphical view]
    PANTHERiPTHR15054. PTHR15054. 1 hit.
    PfamiPF10529. Hist_rich_Ca-bd. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P23327-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGHHRPWLHA SVLWAGVASL LLPPAMTQQL RGDGLGFRNR NNSTGVAGLS    50
    EEASAELRHH LHSPRDHPDE NKDVSTENGH HFWSHPDREK EDEDVSKEYG 100
    HLLPGHRSQD HKVGDEGVSG EEVFAEHGGQ ARGHRGHGSE DTEDSAEHRH 150
    HLPSHRSHSH QDEDEDEVVS SEHHHHILRH GHRGHDGEDD EGEEEEEEEE 200
    EEEEASTEYG HQAHRHRGHG SEEDEDVSDG HHHHGPSHRH QGHEEDDDDD 250
    DDDDDDDDDD DVSIEYRHQA HRHQGHGIEE DEDVSDGHHH RDPSHRHRSH 300
    EEDDNDDDDV STEYGHQAHR HQDHRKEEVE AVSGEHHHHV PDHRHQGHRD 350
    EEEDEDVSTE RWHQGPQHVH HGLVDEEEEE EEITVQFGHY VASHQPRGHK 400
    SDEEDFQDEY KTEVPHHHHH RVPREEDEEV SAELGHQAPS HRQSHQDEET 450
    GHGQRGSIKE MSHHPPGHTV VKDRSHLRKD DSEEEKEKEE DPGSHEEDDE 500
    SSEQGEKGTH HGSRDQEDEE DEEEGHGLSL NQEEEEEEDK EEEEEEEDEE 550
    RREERAEVGA PLSPDHSEEE EEEEEGLEED EPRFTIIPNP LDRREEAGGA 600
    SSEEESGEDT GPQDAQEYGN YQPGSLCGYC SFCNRCTECE SCHCDEENMG 650
    EHCDQCQHCQ FCYLCPLVCE TVCAPGSYVD YFSSSLYQAL ADMLETPEP 699
    Length:699
    Mass (Da):80,244
    Last modified:November 1, 1991 - v1
    Checksum:i9922EEDF012C61DD
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti43 – 431S → N.
    Corresponds to variant rs3745298 [ dbSNP | Ensembl ].
    VAR_021931
    Natural varianti96 – 961S → A.
    Corresponds to variant rs3745297 [ dbSNP | Ensembl ].
    VAR_005623
    Natural varianti204 – 2041Missing.
    VAR_011622

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60052 mRNA. Translation: AAA88071.1.
    BC069795 mRNA. Translation: AAH69795.1.
    BC069802 mRNA. Translation: AAH69802.1.
    BC094691 mRNA. Translation: AAH94691.1.
    CCDSiCCDS12759.1.
    PIRiA54660.
    RefSeqiNP_002143.1. NM_002152.2.
    UniGeneiHs.436885.

    Genome annotation databases

    EnsembliENST00000252825; ENSP00000252825; ENSG00000130528.
    GeneIDi3270.
    KEGGihsa:3270.
    UCSCiuc002pmv.3. human.

    Polymorphism databases

    DMDMi134873.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60052 mRNA. Translation: AAA88071.1 .
    BC069795 mRNA. Translation: AAH69795.1 .
    BC069802 mRNA. Translation: AAH69802.1 .
    BC094691 mRNA. Translation: AAH94691.1 .
    CCDSi CCDS12759.1.
    PIRi A54660.
    RefSeqi NP_002143.1. NM_002152.2.
    UniGenei Hs.436885.

    3D structure databases

    ProteinModelPortali P23327.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109506. 1 interaction.
    STRINGi 9606.ENSP00000252825.

    PTM databases

    PhosphoSitei P23327.

    Polymorphism databases

    DMDMi 134873.

    Proteomic databases

    MaxQBi P23327.
    PaxDbi P23327.
    PRIDEi P23327.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000252825 ; ENSP00000252825 ; ENSG00000130528 .
    GeneIDi 3270.
    KEGGi hsa:3270.
    UCSCi uc002pmv.3. human.

    Organism-specific databases

    CTDi 3270.
    GeneCardsi GC19M049654.
    HGNCi HGNC:5178. HRC.
    HPAi HPA004833.
    MIMi 142705. gene.
    neXtProti NX_P23327.
    PharmGKBi PA29452.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG328567.
    HOVERGENi HBG016630.
    InParanoidi P23327.
    OMAi SHRHQGH.
    OrthoDBi EOG7S7SJ1.
    PhylomeDBi P23327.
    TreeFami TF344276.

    Miscellaneous databases

    GeneWikii HRC_(gene).
    GenomeRNAii 3270.
    NextBioi 12991.
    PROi P23327.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P23327.
    Bgeei P23327.
    CleanExi HS_HRC.
    Genevestigatori P23327.

    Family and domain databases

    InterProi IPR015666. His-rich_Ca-bd.
    IPR019552. Hist_rich_Ca-bd.
    [Graphical view ]
    PANTHERi PTHR15054. PTHR15054. 1 hit.
    Pfami PF10529. Hist_rich_Ca-bd. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA and genomic cloning of HRC, a human sarcoplasmic reticulum protein, and localization of the gene to human chromosome 19 and mouse chromosome 7."
      Hofmann S.L., Topham M., Hsieh C.-L., Francke U.
      Genomics 9:656-669(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS.
      Tissue: Skeletal muscle.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skeletal muscle.

    Entry informationi

    Entry nameiSRCH_HUMAN
    AccessioniPrimary (citable) accession number: P23327
    Secondary accession number(s): Q504Y6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: November 1, 1991
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3