P23325 (ARPA_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ankyrin repeat protein A

Alternative name(s):
Ankyrin-like regulatory protein

Gene names

Name:	arpA
Synonyms:	arp, yjaC
Ordered Locus Names:	b4017, JW3977

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	728 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Sequence similarities

Contains 5 ANK repeats.

Ontologies

Keywords
Domain	ANK repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 728	728	Ankyrin repeat protein A		PRO_0000067228
Regions
	Repeat	381 – 410	30	ANK 1
	Repeat	429 – 458	30	ANK 2
	Repeat	477 – 506	30	ANK 3
	Repeat	525 – 554	30	ANK 4
	Repeat	573 – 602	30	ANK 5
Experimental info
	Sequence conflict	124	1	N → D in AAA73004. Ref.4
	Sequence conflict	282	1	S → T in AAA73004. Ref.4
	Sequence conflict	701 – 728	28	GFTDN…PHTVR → TQKSISPYRTLNLCLRRYA in AAA73004. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P23325 [UniParc]. Last modified July 19, 2003. Version 3. Checksum: 19EE240C4561B3F0	FASTA	728	82,598
	10 20 30 40 50 60 MITRIPRSSF SANINNTAQT NEHQTLSELF YKELEDKFSG KELATPLLKS FSENCRQNGR 70 80 90 100 110 120 HIFSNKDFVI KFSTSVLQAD KKEITIINKN ENTTLTQTIA PIFEKYLMEI LPQRSDTLDK 130 140 150 160 170 180 QELNLKSDRK EKEFPRIKLN GQCYFPGRPQ NRIVCRHIAA QYINDIYQNV DYKPHQDDYS 190 200 210 220 230 240 SAEKFLTHFN KKCKNQTLAL VSSRPEGRCV AACGDFGLVM KAYFDKMESN GISVMAAILL 250 260 270 280 290 300 VDNHALTVRL RIKNTTEGCT HYVVSVYDPN VTNDKIRIMS ESKENIKHYS LMDFMNVDYS 310 320 330 340 350 360 LLKWSNDHVI NQSVAIIPAL PKEQLLMLKG SVDEITPPLS PATMNLLMAI GQNHQLTQLM 370 380 390 400 410 420 IQLQKMPELH RTEMLTAYNS INLPGLYLAI NYGNADIVET IFNSLSETGY EGLLSKKNLM 430 440 450 460 470 480 HILEAKDKNG FSGLFLAISR KDKNVVTSIL NALPKLAATH HLDNEQVYKF LSAKNRTSSH 490 500 510 520 530 540 VLYHVMANGD ADMLKIVLNA LPLLIRTCHL TKEQVLDLLK AKDFYGCPGL YLAMQNGHSD 550 560 570 580 590 600 IVKVILEALP SLAQEINISA SDIVDLLTAK SLARDTGLFM AMQRGHMNVI NTIFNALPTL 610 620 630 640 650 660 FNTFKFDKKN MKPLLLANNS NEYPGLFSAI QHKQQNVVET VYLALSDHAR LFGFTAEDIM 670 680 690 700 710 720 DFWQHKAPQK YSAFELAFEF GHRVIAELIL NTLNKMAESF GFTDNPRYIA EKNYMEALLK KASPHTVR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes." Blattner F.R., Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L. Nucleic Acids Res. 21:5408-5417(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], SEQUENCE REVISION TO 282. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]	"Primary structure of the intergenic region between aceK and iclR in the Escherichia coli chromosome." Galinier A., Bleicher F., Negre D., Perriere G., Duclos B., Cozzone A.J., Cortay J.-C. Gene 97:149-150(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 108-728.
[5]	"Detecting patterns in protein sequences." Neuwald A.F., Green P. J. Mol. Biol. 239:698-712(1994) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION OF ANKYRIN REPEATS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00006 Genomic DNA. Translation: AAC43111.1. U00096 Genomic DNA. Translation: AAC76987.1. AP009048 Genomic DNA. Translation: BAE78019.1. M63497 Genomic DNA. Translation: AAA73004.1.
PIR	H65208.
RefSeq	NP_418441.1. NC_000913.2. YP_492160.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P23325.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-9159N.
IntAct	P23325. 7 interactions.
STRING	511145.b4017.
Proteomic databases
PaxDb	P23325.
PRIDE	P23325.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000000243; EBESCP00000000243; EBESCG00000000200. EBESCT00000017427; EBESCP00000016718; EBESCG00000016483.
GeneID	12933010. 944933.
KEGG	ecj:Y75_p3904. eco:b4017.
PATRIC	32123563. VBIEscCol129921_4130.
Organism-specific databases
EchoBASE	EB1193.
EcoGene	EG11208. arpA.
Phylogenomic databases
eggNOG	COG0666.
HOGENOM	HOG000009667.
KO	K06867.
OMA	FELGHRV.
ProtClustDB	CLSK880171.
Enzyme and pathway databases
BioCyc	EcoCyc:EG11208-MONOMER. ECOL316407:JW3977-MONOMER.
Gene expression databases
Genevestigator	P23325.
Family and domain databases
Gene3D	1.25.40.20. 1 hit.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR012927. Toxin_15_N. [Graphical view]
Pfam	PF07906. Toxin_15. 1 hit. [Graphical view]
SMART	SM00248. ANK. 6 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. False negative. PS50088. ANK_REPEAT. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARPA_ECOLI

Accession

Primary (citable) accession number: P23325
Secondary accession number(s): P76781, Q2M6T7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	July 19, 2003
Last modified:	May 1, 2013
This is version 100 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program