P23315 (TRPE_ACICA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anthranilate synthase component 1
EC=4.1.3.27

Alternative name(s):
Anthranilate synthase component I

Gene names

Name:

trpE

Organism

Acinetobacter calcoaceticus

Taxonomic identifier

471 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter › Acinetobacter calcoaceticus/baumannii complex

Protein attributes

Sequence length	497 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 497	497	Anthranilate synthase component 1		PRO_0000154073

Sequences

	Sequence		Length	Mass (Da)
	P23315 [UniParc]. Last modified November 1, 1991. Version 1. Checksum: E61A713F53A327D4	FASTA	497	55,386
	10 20 30 40 50 60 MTSLTQFEQL KTAGYNTIPV YRQRLADTDT PLSVFARLKD YTQAYLFESV EGGENWARYS 70 80 90 100 110 120 IIGLGESTVF SCNAGQLTIK NAQGNITTQS CADPFQYIRD YQSQFKVPPH ALIPDLPQFT 130 140 150 160 170 180 GGLVGYFGYD AVRYIEPRLS NVPEADPVGL PDIWMMLSKT VIIFDNLKDT LFLIVHANTT 190 200 210 220 230 240 DEEAYQRAQN QLDYLERLLA TPVSLQAKKH KAPHFESLTG KEKFLESVET VKEYIRAGDV 250 260 270 280 290 300 MQVVPGHRMV SDFDGDPLQV YRALRHLNPS PYLFLVQGHT LTDNTPFHIV GSSPEILSRL 310 320 330 340 350 360 EDGIATVRPL AGTRPRGKTK EEDLALEQEL LADEKEIAEH LMLIDLGRND VGRVSKIGKV 370 380 390 400 410 420 QVTDRMVIER YSHVMHIVSN VQGEVRDDID ALDVFKATFP AGTLSGAPKI RAMEIIDEVE 430 440 450 460 470 480 PVKRGIFGGA VGYLGWHGEM DMSIAIRTCV IRENKVYVQA GAGLVADSNP ESEWNETQIK 490 ARAVIKAVEL SSNGLIL

References

[1]	"Identification and nucleotide sequence of the Acinetobacter calcoaceticus encoded trpE gene." Haspel G., Hunger M., Schmucker R., Hillen W. Mol. Gen. Genet. 220:475-477(1990) [PubMed: 2338941] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X51633 Genomic DNA. Translation: CAA35960.1.
PIR	S11891.
3D structure databases
ProteinModelPortal	P23315.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR019999. Anth_synth_I. IPR006805. Anth_synth_I_N. IPR005256. Anth_synth_I_PabB. IPR015890. Chorismate-bd_C. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
SUPFAM	SSF56322. TRPE_1_chor_bd. 1 hit.
TIGRFAMs	TIGR00564. TrpE_most. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_ACICA

Accession

Primary (citable) accession number: P23315

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	November 1, 1991
Last modified:	September 21, 2011
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program