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Protein

Protein SinI

Gene

sinI

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an antagonist to SinR. SinI prevents SinR from binding to its target sequence on the gene for AprE.

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciBSUB:BSU24600-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SinI
Gene namesi
Name:sinI
Ordered Locus Names:BSU24600
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5757Protein SinIPRO_0000097763Add
BLAST

Proteomic databases

PaxDbiP23308.

Interactioni

Subunit structurei

Heterodimer with SinR.1 Publication

Protein-protein interaction databases

DIPiDIP-6103N.
IntActiP23308. 1 interaction.
MINTiMINT-1540395.
STRINGi224308.Bsubs1_010100013481.

Structurei

Secondary structure

1
57
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi13 – 2412Combined sources
Helixi29 – 3810Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B0NX-ray1.90B1-57[»]
ProteinModelPortaliP23308.
SMRiP23308. Positions 9-39.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23308.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 4039SinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Sin domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000009025.
KOiK06372.
OMAiSSQHIQA.
OrthoDBiEOG6D5G8R.

Family and domain databases

Gene3Di1.10.287.270. 1 hit.
InterProiIPR010981. SinR/SinI_dimer_dom.
[Graphical view]
PfamiPF08671. SinI. 1 hit.
[Graphical view]
SUPFAMiSSF47406. SSF47406. 1 hit.
PROSITEiPS51500. SIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23308-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNAKQEHFE LDQEWVELMV EAKEANISPE EIRKYLLLNK KSAHPGPAAR

SHTVNPF
Length:57
Mass (Da):6,602
Last modified:November 1, 1991 - v1
Checksum:iB72A89E233CD5491
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14112 Genomic DNA. No translation available.
D84432 Genomic DNA. Translation: BAA12543.1.
AL009126 Genomic DNA. Translation: CAB14391.1.
PIRiA25159.
RefSeqiNP_390340.1. NC_000964.3.
WP_003230187.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB14391; CAB14391; BSU24600.
GeneIDi938543.
KEGGibsu:BSU24600.
PATRICi18976754. VBIBacSub10457_2567.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14112 Genomic DNA. No translation available.
D84432 Genomic DNA. Translation: BAA12543.1.
AL009126 Genomic DNA. Translation: CAB14391.1.
PIRiA25159.
RefSeqiNP_390340.1. NC_000964.3.
WP_003230187.1. NZ_JNCM01000036.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B0NX-ray1.90B1-57[»]
ProteinModelPortaliP23308.
SMRiP23308. Positions 9-39.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-6103N.
IntActiP23308. 1 interaction.
MINTiMINT-1540395.
STRINGi224308.Bsubs1_010100013481.

Proteomic databases

PaxDbiP23308.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB14391; CAB14391; BSU24600.
GeneIDi938543.
KEGGibsu:BSU24600.
PATRICi18976754. VBIBacSub10457_2567.

Phylogenomic databases

HOGENOMiHOG000009025.
KOiK06372.
OMAiSSQHIQA.
OrthoDBiEOG6D5G8R.

Enzyme and pathway databases

BioCyciBSUB:BSU24600-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP23308.

Family and domain databases

Gene3Di1.10.287.270. 1 hit.
InterProiIPR010981. SinR/SinI_dimer_dom.
[Graphical view]
PfamiPF08671. SinI. 1 hit.
[Graphical view]
SUPFAMiSSF47406. SSF47406. 1 hit.
PROSITEiPS51500. SIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a cloned Bacillus subtilis gene that inhibits sporulation in multiple copies."
    Gaur N.K., Dubnau E., Smith I.
    J. Bacteriol. 168:860-869(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the Bacillus subtilis genome containing the skin element and many sporulation genes."
    Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M., Kobayashi Y.
    Microbiology 142:3103-3111(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168 / JH642.
  3. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  4. "SinI modulates the activity of SinR, a developmental switch protein of Bacillus subtilis, by protein-protein interaction."
    Bai U., Mandic-Mulec I., Smith I.
    Genes Dev. 7:139-148(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-20, CHARACTERIZATION.
  5. "An evolutionary link between sporulation and prophage induction in the structure of a repressor:anti-repressor complex."
    Lewis R.J., Brannigan J.A., Offen W.A., Smith I., Wilkinson A.J.
    J. Mol. Biol. 283:907-912(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) IN COMPLEX WITH SINR.

Entry informationi

Entry nameiSINI_BACSU
AccessioniPrimary (citable) accession number: P23308
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: May 11, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.