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P23299

- KCNE1_MOUSE

UniProt

P23299 - KCNE1_MOUSE

Protein

Potassium voltage-gated channel subfamily E member 1

Gene

Kcne1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr) By similarity.By similarity

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: Ensembl
    2. potassium channel regulator activity Source: Ensembl
    3. voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization Source: Ensembl

    GO - Biological processi

    1. cellular response to acidic pH Source: Ensembl
    2. cellular response to cAMP Source: Ensembl
    3. epithelial cell maturation Source: MGI
    4. heart contraction Source: MGI
    5. male gonad development Source: Ensembl
    6. negative regulation of protein targeting to membrane Source: Ensembl
    7. positive regulation of potassium ion transmembrane transport Source: Ensembl
    8. potassium ion export Source: Ensembl
    9. protein N-linked glycosylation Source: UniProtKB
    10. protein O-linked glycosylation Source: UniProtKB
    11. regulation of delayed rectifier potassium channel activity Source: Ensembl
    12. regulation of heart rate by cardiac conduction Source: MGI
    13. regulation of ventricular cardiac muscle cell membrane repolarization Source: Ensembl

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily E member 1
    Alternative name(s):
    Delayed rectifier potassium channel subunit IsK
    Short name:
    mISK
    IKs producing slow voltage-gated potassium channel subunit beta Mink
    Minimal potassium channel
    Gene namesi
    Name:Kcne1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:96673. Kcne1.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: MGI
    2. cell surface Source: Ensembl
    3. endoplasmic reticulum Source: Ensembl
    4. lysosome Source: Ensembl
    5. voltage-gated potassium channel complex Source: Ensembl
    6. Z disc Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 129129Potassium voltage-gated channel subfamily E member 1PRO_0000144279Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi7 – 71O-linked (GalNAc...)By similarity
    Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis
    Modified residuei102 – 1021Phosphoserine; by PKCBy similarity

    Post-translational modificationi

    Phosphorylation inhibits the potassium current.By similarity
    N-glycosylation at Asn-26 occurs post-translationally, and requires prior cotranslational glycosylation at Asn-5.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiP23299.

    PTM databases

    PhosphoSiteiP23299.

    Expressioni

    Tissue specificityi

    Restrictively localized in the apical membrane portion of epithelial cells.

    Gene expression databases

    BgeeiP23299.
    GenevestigatoriP23299.

    Interactioni

    Subunit structurei

    Associates with KCNQ1/KVLQT1 and KCNH2/HERG.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000052248.

    Structurei

    3D structure databases

    ProteinModelPortaliP23299.
    SMRiP23299. Positions 1-127.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini67 – 12963CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei44 – 6623HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the potassium channel KCNE family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG41824.
    HOGENOMiHOG000113207.
    HOVERGENiHBG052226.
    InParanoidiP23299.
    KOiK04894.
    OMAiIERPAND.
    OrthoDBiEOG7WMCMH.
    PhylomeDBiP23299.
    TreeFamiTF335976.

    Family and domain databases

    InterProiIPR000369. K_chnl_volt-dep_bsu_KCNE.
    IPR005424. K_chnl_volt-dep_bsu_KCNE1.
    [Graphical view]
    PANTHERiPTHR17028. PTHR17028. 1 hit.
    PfamiPF02060. ISK_Channel. 1 hit.
    [Graphical view]
    PRINTSiPR01604. KCNE1CHANNEL.
    PR00168. KCNECHANNEL.

    Sequencei

    Sequence statusi: Complete.

    P23299-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLPNSTTVL PFLARLWQET AEQGGNVSGL ARKSQLRDDS KLEALYILMV    50
    LGFFGFFTLG IMLSYIRSKK LEHSHDPFNV YIESDAWQEK GKAVFQARVL 100
    ESFRACYVIE NQAAVEQPAT HLPELKPLS 129
    Length:129
    Mass (Da):14,578
    Last modified:November 1, 1991 - v1
    Checksum:iE66DF4742300E839
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60457 mRNA. Translation: CAA42990.1.
    AK028907 mRNA. Translation: BAC26189.1.
    CCDSiCCDS28336.1.
    PIRiS17307.
    RefSeqiNP_032450.1. NM_008424.3.
    XP_006523004.1. XM_006522941.1.
    UniGeneiMm.299425.

    Genome annotation databases

    EnsembliENSMUST00000051705; ENSMUSP00000052248; ENSMUSG00000039639.
    ENSMUST00000166707; ENSMUSP00000130866; ENSMUSG00000039639.
    GeneIDi16509.
    KEGGimmu:16509.
    UCSCiuc007zza.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60457 mRNA. Translation: CAA42990.1 .
    AK028907 mRNA. Translation: BAC26189.1 .
    CCDSi CCDS28336.1.
    PIRi S17307.
    RefSeqi NP_032450.1. NM_008424.3.
    XP_006523004.1. XM_006522941.1.
    UniGenei Mm.299425.

    3D structure databases

    ProteinModelPortali P23299.
    SMRi P23299. Positions 1-127.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000052248.

    PTM databases

    PhosphoSitei P23299.

    Proteomic databases

    PRIDEi P23299.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000051705 ; ENSMUSP00000052248 ; ENSMUSG00000039639 .
    ENSMUST00000166707 ; ENSMUSP00000130866 ; ENSMUSG00000039639 .
    GeneIDi 16509.
    KEGGi mmu:16509.
    UCSCi uc007zza.1. mouse.

    Organism-specific databases

    CTDi 3753.
    MGIi MGI:96673. Kcne1.

    Phylogenomic databases

    eggNOGi NOG41824.
    HOGENOMi HOG000113207.
    HOVERGENi HBG052226.
    InParanoidi P23299.
    KOi K04894.
    OMAi IERPAND.
    OrthoDBi EOG7WMCMH.
    PhylomeDBi P23299.
    TreeFami TF335976.

    Miscellaneous databases

    NextBioi 289843.
    PROi P23299.
    SOURCEi Search...

    Gene expression databases

    Bgeei P23299.
    Genevestigatori P23299.

    Family and domain databases

    InterProi IPR000369. K_chnl_volt-dep_bsu_KCNE.
    IPR005424. K_chnl_volt-dep_bsu_KCNE1.
    [Graphical view ]
    PANTHERi PTHR17028. PTHR17028. 1 hit.
    Pfami PF02060. ISK_Channel. 1 hit.
    [Graphical view ]
    PRINTSi PR01604. KCNE1CHANNEL.
    PR00168. KCNECHANNEL.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, expression, pharmacology and regulation of a delayed rectifier K+ channel in mouse heart."
      Honore E., Attali B., Romey G., Heurteaux C., Ricard P., Lesage F., Lazdunski M., Barhanin J.
      EMBO J. 10:2805-2811(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Tissue: Heart.
    2. "ISK, a slowly activating voltage-sensitive K+ channel. Characterization of multiple cDNAs and gene organization in the mouse."
      Lesage F., Attali B., Lazdunski M., Barhanin J.
      FEBS Lett. 301:168-172(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Skin.

    Entry informationi

    Entry nameiKCNE1_MOUSE
    AccessioniPrimary (citable) accession number: P23299
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: November 1, 1991
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3