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Protein

Protein S100-A1

Gene

S100A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably acts as a Ca2+ signal transducer (PubMed:22399290). In response to an increase in intracellular Ca2+ levels, binds calcium which triggers a conformational change (PubMed:23351007). This conformational change allows interaction of S1001A with specific target proteins, such as TPR-containing proteins, and the modulation of their activity (PubMed:22399290).2 Publications

Miscellaneous

Able to bind zinc in vitro; the binding sites are different from the calcium binding sites. The physiological relevance of zinc binding is unclear. Physiological concentrations of potassium antagonize the binding of both divalent cations, especially affecting the high-affinity calcium-binding sites.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 331; low affinity1 PublicationAdd BLAST14
Calcium bindingi63 – 742; high affinity1 PublicationAdd BLAST12

GO - Molecular functioni

  • ATPase binding Source: UniProtKB
  • calcium-dependent protein binding Source: Ensembl
  • calcium ion binding Source: ProtInc
  • identical protein binding Source: IntAct
  • protein homodimerization activity Source: UniProtKB
  • S100 protein binding Source: UniProtKB

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-5686938. Regulation of TLR by endogenous ligand.

Protein family/group databases

TCDBi8.A.81.1.1. the s100 calcium-binding protein (s100) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A1
Alternative name(s):
S-100 protein alpha chain
S-100 protein subunit alpha
S100 calcium-binding protein A1
Gene namesi
Name:S100A1
Synonyms:S100A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000160678.11.
HGNCiHGNC:10486. S100A1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi6271.
OpenTargetsiENSG00000160678.
PharmGKBiPA34898.

Chemistry databases

DrugBankiDB00768. Olopatadine.

Polymorphism and mutation databases

BioMutaiS100A1.
DMDMi134136.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001439611 – 94Protein S100-A1Add BLAST94

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei86S-nitrosocysteine1 Publication1

Keywords - PTMi

S-nitrosylation

Proteomic databases

MaxQBiP23297.
PaxDbiP23297.
PeptideAtlasiP23297.
PRIDEiP23297.

PTM databases

iPTMnetiP23297.
PhosphoSitePlusiP23297.

Expressioni

Tissue specificityi

Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain.1 Publication

Gene expression databases

BgeeiENSG00000160678.
CleanExiHS_S100A1.
ExpressionAtlasiP23297. baseline and differential.
GenevisibleiP23297. HS.

Organism-specific databases

HPAiCAB002599.
HPA006462.

Interactioni

Subunit structurei

Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain (PubMed:21296671). Also forms heterodimers with S100P (PubMed:15171681). Interacts with AGER (By similarity). Intreacts with CAPZA1 (By similarity). Interacts with FKBP4 (PubMed:20188096). Interacts with RYR1 and RYR2 (PubMed:18650434). Interacts with CACYBP in a calcium-dependent manner (PubMed:12042313). Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity (PubMed:22399290).By similarity6 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • ATPase binding Source: UniProtKB
  • calcium-dependent protein binding Source: Ensembl
  • identical protein binding Source: IntAct
  • protein homodimerization activity Source: UniProtKB
  • S100 protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112179. 20 interactors.
IntActiP23297. 12 interactors.
MINTiMINT-1543322.
STRINGi9606.ENSP00000292169.

Structurei

Secondary structure

194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 20Combined sources17
Beta strandi22 – 24Combined sources3
Beta strandi26 – 30Combined sources5
Helixi31 – 41Combined sources11
Helixi45 – 48Combined sources4
Helixi52 – 64Combined sources13
Turni65 – 67Combined sources3
Beta strandi68 – 70Combined sources3
Helixi72 – 87Combined sources16
Turni88 – 90Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L0PNMR-A/B1-94[»]
2LHLNMR-A/B2-94[»]
2LLSNMR-A/B2-94[»]
2LLTNMR-A/B2-94[»]
2LLUNMR-A/B2-94[»]
2LP2NMR-A/B2-94[»]
2LP3NMR-A/B2-94[»]
2LUXNMR-A/B2-94[»]
2M3WNMR-A/B2-94[»]
5K89X-ray2.25A/C/H1-94[»]
ProteinModelPortaliP23297.
SMRiP23297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 48EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini50 – 85EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IXZ2. Eukaryota.
ENOG4111987. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP23297.
PhylomeDBiP23297.
TreeFamiTF332727.

Family and domain databases

CDDicd05025. S-100A1. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028486. S100-A1.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
PANTHERiPTHR11639:SF86. PTHR11639:SF86. 1 hit.
PfamiView protein in Pfam
PF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.

Sequencei

Sequence statusi: Complete.

P23297-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSELETAME TLINVFHAHS GKEGDKYKLS KKELKELLQT ELSGFLDAQK
60 70 80 90
DVDAVDKVMK ELDENGDGEV DFQEYVVLVA ALTVACNNFF WENS
Length:94
Mass (Da):10,546
Last modified:January 23, 2007 - v2
Checksum:iAD5E53AF326B25D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58079 mRNA. Translation: CAA41107.1.
AK312152 mRNA. Translation: BAG35086.1.
BT006938 mRNA. Translation: AAP35584.1.
AB451316 mRNA. Translation: BAG70130.1.
AB451446 mRNA. Translation: BAG70260.1.
AL162258 Genomic DNA. No translation available.
CH471121 Genomic DNA. Translation: EAW53302.1.
BC014392 mRNA. Translation: AAH14392.1.
CCDSiCCDS1047.1.
PIRiA44470. BCHUIA.
RefSeqiNP_006262.1. NM_006271.1.
UniGeneiHs.515715.

Genome annotation databases

EnsembliENST00000292169; ENSP00000292169; ENSG00000160678.
GeneIDi6271.
KEGGihsa:6271.
UCSCiuc001fck.1. human.

Similar proteinsi

Entry informationi

Entry nameiS10A1_HUMAN
AccessioniPrimary (citable) accession number: P23297
Secondary accession number(s): B2R5D9, Q5T7Y3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: January 23, 2007
Last modified: September 27, 2017
This is version 171 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families