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Protein

Casein kinase I homolog 1

Gene

YCK1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei98ATPPROSITE-ProRule annotation1
Active sitei188Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi75 – 83ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: SGD

GO - Biological processi

  • cell morphogenesis Source: SGD
  • endocytosis Source: SGD
  • peptidyl-serine phosphorylation Source: GO_Central
  • protein phosphorylation Source: SGD
  • regulation of cell shape Source: GO_Central
  • response to glucose Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:YHR135C-MONOMER.
BRENDAi2.7.11.1. 984.

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase I homolog 1 (EC:2.7.11.1)
Gene namesi
Name:YCK1
Synonyms:CKI2
Ordered Locus Names:YHR135C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR135C.
SGDiS000001177. YCK1.

Subcellular locationi

  • Cell membrane 1 Publication; Lipid-anchor 1 Publication

GO - Cellular componenti

  • nucleus Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3497.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001928561 – 538Casein kinase I homolog 1Add BLAST538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei522PhosphoserineCombined sources1
Modified residuei523PhosphoserineCombined sources1
Modified residuei527PhosphoserineCombined sources1
Lipidationi537S-palmitoyl cysteineBy similarity1
Lipidationi538S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Palmitoylated by AKR1.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP23291.
PRIDEiP23291.

PTM databases

iPTMnetiP23291.
SwissPalmiP23291.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AKR1P390103EBI-4718,EBI-2421

Protein-protein interaction databases

BioGridi36568. 409 interactors.
DIPiDIP-719N.
IntActiP23291. 15 interactors.
MINTiMINT-392014.

Structurei

3D structure databases

ProteinModelPortaliP23291.
SMRiP23291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 353Protein kinasePROSITE-ProRule annotationAdd BLAST285

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00850000132311.
HOGENOMiHOG000182055.
InParanoidiP23291.
KOiK02218.
OMAiFYFLRGH.
OrthoDBiEOG092C30PR.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23291-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMPIASTTL AVNNLTNING NANFNVQANK QLHHQAVDSP ARSSMTATTA
60 70 80 90 100
ANSNSNSSRD DSTIVGLHYK IGKKIGEGSF GVLFEGTNMI NGVPVAIKFE
110 120 130 140 150
PRKTEAPQLR DEYKTYKILN GTPNIPYAYY FGQEGLHNIL VIDLLGPSLE
160 170 180 190 200
DLFDWCGRKF SVKTVVQVAV QMITLIEDLH AHDLIYRDIK PDNFLIGRPG
210 220 230 240 250
QPDANNIHLI DFGMAKQYRD PKTKQHIPYR EKKSLSGTAR YMSINTHLGR
260 270 280 290 300
EQSRRDDMEA LGHVFFYFLR GHLPWQGLKA PNNKQKYEKI GEKKRSTNVY
310 320 330 340 350
DLAQGLPVQF GRYLEIVRSL SFEECPDYEG YRKLLLSVLD DLGETADGQY
360 370 380 390 400
DWMKLNDGRG WDLNINKKPN LHGYGHPNPP NEKSRKHRNK QLQMQQLQMQ
410 420 430 440 450
QLQQQQQQQQ YAQKTEADMR NSQYKPKLDP TSYEAYQHQT QQKYLQEQQK
460 470 480 490 500
RQQQQKLQEQ QLQEQQLQQQ QQQQQQLRAT GQPPSQPQAQ TQSQQFGARY
510 520 530
QPQQQPSAAL RTPEQHPNDD NSSLAASHKG FFQKLGCC
Length:538
Mass (Da):61,715
Last modified:November 1, 1991 - v1
Checksum:i77344717818C2D17
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti201Q → H in AAU09743 (PubMed:17322287).Curated1
Sequence conflicti367K → E in CAA42897 (PubMed:1627830).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74552 Genomic DNA. Translation: AAA35229.1.
X60327 Genomic DNA. Translation: CAA42897.1.
U10398 Genomic DNA. Translation: AAB68417.1.
Y13625 Genomic DNA. Translation: CAA73948.1.
BK006934 Genomic DNA. Translation: DAA06828.1.
AY723826 Genomic DNA. Translation: AAU09743.1.
PIRiS29521.
RefSeqiNP_012003.1. NM_001179265.1.

Genome annotation databases

EnsemblFungiiYHR135C; YHR135C; YHR135C.
GeneIDi856537.
KEGGisce:YHR135C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74552 Genomic DNA. Translation: AAA35229.1.
X60327 Genomic DNA. Translation: CAA42897.1.
U10398 Genomic DNA. Translation: AAB68417.1.
Y13625 Genomic DNA. Translation: CAA73948.1.
BK006934 Genomic DNA. Translation: DAA06828.1.
AY723826 Genomic DNA. Translation: AAU09743.1.
PIRiS29521.
RefSeqiNP_012003.1. NM_001179265.1.

3D structure databases

ProteinModelPortaliP23291.
SMRiP23291.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36568. 409 interactors.
DIPiDIP-719N.
IntActiP23291. 15 interactors.
MINTiMINT-392014.

Chemistry databases

ChEMBLiCHEMBL3497.

PTM databases

iPTMnetiP23291.
SwissPalmiP23291.

Proteomic databases

MaxQBiP23291.
PRIDEiP23291.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR135C; YHR135C; YHR135C.
GeneIDi856537.
KEGGisce:YHR135C.

Organism-specific databases

EuPathDBiFungiDB:YHR135C.
SGDiS000001177. YCK1.

Phylogenomic databases

GeneTreeiENSGT00850000132311.
HOGENOMiHOG000182055.
InParanoidiP23291.
KOiK02218.
OMAiFYFLRGH.
OrthoDBiEOG092C30PR.

Enzyme and pathway databases

BioCyciYEAST:YHR135C-MONOMER.
BRENDAi2.7.11.1. 984.

Miscellaneous databases

PROiP23291.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKC11_YEAST
AccessioniPrimary (citable) accession number: P23291
Secondary accession number(s): D3DL84, E9P958
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: November 2, 2016
This is version 160 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1630 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.