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Protein

Peptidyl-prolyl cis-trans isomerase B

Gene

CPR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Miscellaneous

Present with 339 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Cyclosporin A (CsA) inhibits CYPB.

GO - Molecular functioni

  • peptidyl-prolyl cis-trans isomerase activity Source: SGD

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase

Enzyme and pathway databases

BioCyciYEAST:YHR057C-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase B (EC:5.2.1.8)
Short name:
PPIase B
Alternative name(s):
Cyclophilin B
Cyclophilin-related protein
Rotamase B
Gene namesi
Name:CPR2
Synonyms:CRG, CYP2, SCC2
Ordered Locus Names:YHR057C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR057C
SGDiS000001099 CPR2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002548621 – 205Peptidyl-prolyl cis-trans isomerase BAdd BLAST185

Proteomic databases

MaxQBiP23285
PaxDbiP23285
PRIDEiP23285

Interactioni

Protein-protein interaction databases

BioGridi36489, 83 interactors
DIPiDIP-1280N
IntActiP23285, 3 interactors
MINTiP23285
STRINGi4932.YHR057C

Structurei

3D structure databases

ProteinModelPortaliP23285
SMRiP23285
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 198PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST160

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00760000119072
HOGENOMiHOG000065981
InParanoidiP23285
KOiK01802
OMAiFDIQHGD
OrthoDBiEOG092C5DG5

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PIRSFiPIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23285-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFSGLWCWL LLFLSVNVIA SDVGELIDQD DEVITQKVFF DIEHGEEKVG
60 70 80 90 100
RIVIGLYGKV CPKTAKNFYK LSTTTNSKKG FIGSTFHRVI PNFMVQGGDF
110 120 130 140 150
TDGTGVGGKS IYGDTFPDEN FTLKHDRKGR LSMANRGKDT NGSQFFITTT
160 170 180 190 200
EEASWLDGKH VVFGQVVDGM DVVNYIQHVS RDANDKPLEA VKIAKCGEWT

PELSS
Length:205
Mass (Da):22,769
Last modified:November 1, 1991 - v1
Checksum:i616EAEB434837A6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51497 Genomic DNA Translation: CAA35865.1 Sequence problems.
U00061 Genomic DNA Translation: AAB68386.1
AY558279 Genomic DNA Translation: AAS56605.1
BK006934 Genomic DNA Translation: DAA06750.1
PIRiS12324
RefSeqiNP_011924.1, NM_001179187.1

Genome annotation databases

EnsemblFungiiYHR057C; YHR057C; YHR057C
GeneIDi856454
KEGGisce:YHR057C

Similar proteinsi

Entry informationi

Entry nameiCYPB_YEAST
AccessioniPrimary (citable) accession number: P23285
Secondary accession number(s): D3DL06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: June 20, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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