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Protein

Peptidyl-prolyl cis-trans isomerase B

Gene

CPR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Cyclosporin A (CsA) inhibits CYPB.

GO - Molecular functioni

  • peptide binding Source: UniProtKB-KW
  • peptidyl-prolyl cis-trans isomerase activity Source: SGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Ligandi

Cyclosporin

Enzyme and pathway databases

BioCyciYEAST:YHR057C-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase B (EC:5.2.1.8)
Short name:
PPIase B
Alternative name(s):
Cyclophilin B
Cyclophilin-related protein
Rotamase B
Gene namesi
Name:CPR2
Synonyms:CRG, CYP2, SCC2
Ordered Locus Names:YHR057C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR057C.
SGDiS000001099. CPR2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 205185Peptidyl-prolyl cis-trans isomerase BPRO_0000025486Add
BLAST

Proteomic databases

MaxQBiP23285.

Interactioni

Protein-protein interaction databases

BioGridi36489. 19 interactions.
DIPiDIP-1280N.
IntActiP23285. 3 interactions.
MINTiMINT-405082.

Structurei

3D structure databases

ProteinModelPortaliP23285.
SMRiP23285. Positions 34-198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 198160PPIase cyclophilin-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00760000119072.
HOGENOMiHOG000065981.
InParanoidiP23285.
KOiK01802.
OMAiCVELPVE.
OrthoDBiEOG757D7G.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23285-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFSGLWCWL LLFLSVNVIA SDVGELIDQD DEVITQKVFF DIEHGEEKVG
60 70 80 90 100
RIVIGLYGKV CPKTAKNFYK LSTTTNSKKG FIGSTFHRVI PNFMVQGGDF
110 120 130 140 150
TDGTGVGGKS IYGDTFPDEN FTLKHDRKGR LSMANRGKDT NGSQFFITTT
160 170 180 190 200
EEASWLDGKH VVFGQVVDGM DVVNYIQHVS RDANDKPLEA VKIAKCGEWT

PELSS
Length:205
Mass (Da):22,769
Last modified:November 1, 1991 - v1
Checksum:i616EAEB434837A6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51497 Genomic DNA. Translation: CAA35865.1. Sequence problems.
U00061 Genomic DNA. Translation: AAB68386.1.
AY558279 Genomic DNA. Translation: AAS56605.1.
BK006934 Genomic DNA. Translation: DAA06750.1.
PIRiS12324.
RefSeqiNP_011924.1. NM_001179187.1.

Genome annotation databases

EnsemblFungiiYHR057C; YHR057C; YHR057C.
GeneIDi856454.
KEGGisce:YHR057C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51497 Genomic DNA. Translation: CAA35865.1. Sequence problems.
U00061 Genomic DNA. Translation: AAB68386.1.
AY558279 Genomic DNA. Translation: AAS56605.1.
BK006934 Genomic DNA. Translation: DAA06750.1.
PIRiS12324.
RefSeqiNP_011924.1. NM_001179187.1.

3D structure databases

ProteinModelPortaliP23285.
SMRiP23285. Positions 34-198.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36489. 19 interactions.
DIPiDIP-1280N.
IntActiP23285. 3 interactions.
MINTiMINT-405082.

Proteomic databases

MaxQBiP23285.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR057C; YHR057C; YHR057C.
GeneIDi856454.
KEGGisce:YHR057C.

Organism-specific databases

EuPathDBiFungiDB:YHR057C.
SGDiS000001099. CPR2.

Phylogenomic databases

GeneTreeiENSGT00760000119072.
HOGENOMiHOG000065981.
InParanoidiP23285.
KOiK01802.
OMAiCVELPVE.
OrthoDBiEOG757D7G.

Enzyme and pathway databases

BioCyciYEAST:YHR057C-MONOMER.

Miscellaneous databases

NextBioi982087.
PROiP23285.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A second cyclophilin-related gene in Saccharomyces cerevisiae."
    Koser P., Sylvester D., Livi G.P., Bergsma D.J.
    Nucleic Acids Res. 18:1643-1643(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "The CYP2 gene of Saccharomyces cerevisiae encodes a cyclosporin A-sensitive peptidyl-prolyl cis-trans isomerase with an N-terminal signal sequence."
    Koser P., Bergsma D.J., Cafferkey R., Eng W.-K., McLaughlin M.M., Ferrara A., Silverman C., Kasyan K., Bossard M.J., Johnson R.K., Porter T.G., Levy M.A., Livi G.P.
    Gene 108:73-80(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCYPB_YEAST
AccessioniPrimary (citable) accession number: P23285
Secondary accession number(s): D3DL06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: May 11, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 339 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.