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Protein

Carbonic anhydrase 6

Gene

CA6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Reversible hydration of carbon dioxide. Its role in saliva is unknown.

Catalytic activityi

H2CO3 = CO2 + H2O.

Cofactori

Zn2+By similarity

Enzyme regulationi

Inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA), saccharin and Foscarnet (phosphonoformate trisodium salt).4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei85Proton acceptorBy similarity1
Metal bindingi111Zinc; catalytic1 Publication1
Metal bindingi113Zinc; catalytic1 Publication1
Metal bindingi138Zinc; catalytic1 Publication1
Active sitei146By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:HS05551-MONOMER.
BRENDAi4.2.1.1. 2681.
ReactomeiR-HSA-1475029. Reversible hydration of carbon dioxide.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase 6 (EC:4.2.1.1)
Alternative name(s):
Carbonate dehydratase VI
Carbonic anhydrase VI
Short name:
CA-VI
Salivary carbonic anhydrase
Secreted carbonic anhydrase
Gene namesi
Name:CA6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:1380. CA6.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi765.
OpenTargetsiENSG00000131686.
PharmGKBiPA25995.

Chemistry databases

ChEMBLiCHEMBL3025.
DrugBankiDB06795. Mafenide.
DB00909. Zonisamide.

Polymorphism and mutation databases

BioMutaiCA6.
DMDMi116241278.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000000424118 – 308Carbonic anhydrase 6Add BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 224Sequence analysis
Glycosylationi67N-linked (GlcNAc...)Sequence analysis1
Glycosylationi256N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP23280.
PeptideAtlasiP23280.
PRIDEiP23280.
TopDownProteomicsiP23280-1. [P23280-1]

Expressioni

Tissue specificityi

Major constituent of saliva.

Gene expression databases

BgeeiENSG00000131686.
CleanExiHS_CA6.
ExpressionAtlasiP23280. baseline and differential.
GenevisibleiP23280. HS.

Organism-specific databases

HPAiHPA028550.
HPA028692.

Interactioni

Protein-protein interaction databases

BioGridi107220. 4 interactors.
STRINGi9606.ENSP00000366662.

Chemistry databases

BindingDBiP23280.

Structurei

Secondary structure

1308
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi35 – 38Combined sources4
Helixi40 – 43Combined sources4
Beta strandi44 – 46Combined sources3
Helixi54 – 56Combined sources3
Beta strandi68 – 70Combined sources3
Beta strandi72 – 82Combined sources11
Beta strandi87 – 90Combined sources4
Beta strandi96 – 98Combined sources3
Beta strandi104 – 114Combined sources11
Beta strandi125 – 128Combined sources4
Beta strandi134 – 143Combined sources10
Beta strandi146 – 148Combined sources3
Helixi149 – 152Combined sources4
Beta strandi159 – 167Combined sources9
Helixi175 – 177Combined sources3
Helixi178 – 183Combined sources6
Helixi184 – 187Combined sources4
Beta strandi193 – 199Combined sources7
Helixi201 – 204Combined sources4
Beta strandi212 – 217Combined sources6
Beta strandi228 – 235Combined sources8
Helixi241 – 249Combined sources9
Beta strandi256 – 258Combined sources3
Beta strandi275 – 277Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FE4X-ray1.90A/B21-290[»]
ProteinModelPortaliP23280.
SMRiP23280.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23280.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 278Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST258

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni220 – 221Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated
Contains 1 alpha-carbonic anhydrase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0382. Eukaryota.
COG3338. LUCA.
GeneTreeiENSGT00760000118915.
HOGENOMiHOG000112637.
HOVERGENiHBG002837.
InParanoidiP23280.
KOiK01672.
OMAiPNQGKGH.
OrthoDBiEOG091G0XFM.
PhylomeDBiP23280.
TreeFamiTF316425.

Family and domain databases

Gene3Di3.10.200.10. 1 hit.
InterProiIPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
IPR018338. Carbonic_anhydrase_a-class_CS.
IPR018428. Carbonic_anhydrase_CA6.
[Graphical view]
PANTHERiPTHR18952. PTHR18952. 1 hit.
PTHR18952:SF110. PTHR18952:SF110. 1 hit.
PfamiPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
SMARTiSM01057. Carb_anhydrase. 1 hit.
[Graphical view]
SUPFAMiSSF51069. SSF51069. 1 hit.
PROSITEiPS00162. ALPHA_CA_1. 1 hit.
PS51144. ALPHA_CA_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P23280-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRALVLLLSL FLLGGQAQHV SDWTYSEGAL DEAHWPQHYP ACGGQRQSPI
60 70 80 90 100
NLQRTKVRYN PSLKGLNMTG YETQAGEFPM VNNGHTVQIS LPSTMRMTVA
110 120 130 140 150
DGTVYIAQQM HFHWGGASSE ISGSEHTVDG IRHVIEIHIV HYNSKYKSYD
160 170 180 190 200
IAQDAPDGLA VLAAFVEVKN YPENTYYSNF ISHLANIKYP GQRTTLTGLD
210 220 230 240 250
VQDMLPRNLQ HYYTYHGSLT TPPCTENVHW FVLADFVKLS RTQVWKLENS
260 270 280 290 300
LLDHRNKTIH NDYRRTQPLN HRVVESNFPN QEYTLGSEFQ FYLHKIEEIL

DYLRRALN
Length:308
Mass (Da):35,367
Last modified:October 17, 2006 - v3
Checksum:i6EBFF15085E7112D
GO
Isoform 2 (identifier: P23280-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     282-308: EYTLGSEFQFYLHKIEEILDYLRRALN → GKGHGGHRGRSQNPRVQPTSTRHPLALGSLEA

Note: No experimental confirmation available.
Show »
Length:313
Mass (Da):35,365
Checksum:i1CF67B5ED1BD9384
GO
Isoform 3 (identifier: P23280-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     27-86: Missing.

Note: No experimental confirmation available.
Show »
Length:248
Mass (Da):28,687
Checksum:i39A6223C958A3029
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103T → I in AAA51892 (PubMed:1899030).Curated1
Sequence conflicti103T → I in BAD89434 (PubMed:16710414).Curated1
Sequence conflicti148S → T in AAA51892 (PubMed:1899030).Curated1
Sequence conflicti148S → T in AAF22565 (Ref. 2) Curated1
Sequence conflicti148S → T in BAD89434 (PubMed:16710414).Curated1
Sequence conflicti270N → K in AAA51892 (PubMed:1899030).Curated1
Sequence conflicti270N → K in AAF22565 (Ref. 2) Curated1
Sequence conflicti270N → K in BAD89434 (PubMed:16710414).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03371237Q → L.Corresponds to variant rs34265054dbSNPEnsembl.1
Natural variantiVAR_02826855T → M.Corresponds to variant rs2274327dbSNPEnsembl.1
Natural variantiVAR_06109358R → W.Corresponds to variant rs58800854dbSNPEnsembl.1
Natural variantiVAR_02826968M → L.Corresponds to variant rs2274328dbSNPEnsembl.1
Natural variantiVAR_02827070G → A.Corresponds to variant rs2274329dbSNPEnsembl.1
Natural variantiVAR_02827190S → G.3 PublicationsCorresponds to variant rs2274333dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04666827 – 86Missing in isoform 3. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_045435282 – 308EYTLG…RRALN → GKGHGGHRGRSQNPRVQPTS TRHPLALGSLEA in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57892 mRNA. Translation: AAA51892.1.
AF128418
, AF128411, AF128412, AF128413, AF128414, AF128415, AF128416, AF128417 Genomic DNA. Translation: AAF22565.1.
AB102863 mRNA. Translation: BAD89397.1.
AB103091 mRNA. Translation: BAD89434.1.
AL139415 Genomic DNA. Translation: CAC42429.1.
CCDSiCCDS30578.1. [P23280-1]
CCDS57970.1. [P23280-2]
CCDS57971.1. [P23280-3]
PIRiA37917. CRHU6.
RefSeqiNP_001206.2. NM_001215.3. [P23280-1]
NP_001257429.1. NM_001270500.1. [P23280-2]
NP_001257430.1. NM_001270501.1. [P23280-3]
UniGeneiHs.100322.

Genome annotation databases

EnsembliENST00000377436; ENSP00000366654; ENSG00000131686. [P23280-2]
ENST00000377442; ENSP00000366661; ENSG00000131686. [P23280-3]
ENST00000377443; ENSP00000366662; ENSG00000131686. [P23280-1]
GeneIDi765.
KEGGihsa:765.
UCSCiuc001apm.5. human. [P23280-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57892 mRNA. Translation: AAA51892.1.
AF128418
, AF128411, AF128412, AF128413, AF128414, AF128415, AF128416, AF128417 Genomic DNA. Translation: AAF22565.1.
AB102863 mRNA. Translation: BAD89397.1.
AB103091 mRNA. Translation: BAD89434.1.
AL139415 Genomic DNA. Translation: CAC42429.1.
CCDSiCCDS30578.1. [P23280-1]
CCDS57970.1. [P23280-2]
CCDS57971.1. [P23280-3]
PIRiA37917. CRHU6.
RefSeqiNP_001206.2. NM_001215.3. [P23280-1]
NP_001257429.1. NM_001270500.1. [P23280-2]
NP_001257430.1. NM_001270501.1. [P23280-3]
UniGeneiHs.100322.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FE4X-ray1.90A/B21-290[»]
ProteinModelPortaliP23280.
SMRiP23280.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107220. 4 interactors.
STRINGi9606.ENSP00000366662.

Chemistry databases

BindingDBiP23280.
ChEMBLiCHEMBL3025.
DrugBankiDB06795. Mafenide.
DB00909. Zonisamide.

Polymorphism and mutation databases

BioMutaiCA6.
DMDMi116241278.

Proteomic databases

PaxDbiP23280.
PeptideAtlasiP23280.
PRIDEiP23280.
TopDownProteomicsiP23280-1. [P23280-1]

Protocols and materials databases

DNASUi765.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377436; ENSP00000366654; ENSG00000131686. [P23280-2]
ENST00000377442; ENSP00000366661; ENSG00000131686. [P23280-3]
ENST00000377443; ENSP00000366662; ENSG00000131686. [P23280-1]
GeneIDi765.
KEGGihsa:765.
UCSCiuc001apm.5. human. [P23280-1]

Organism-specific databases

CTDi765.
DisGeNETi765.
GeneCardsiCA6.
H-InvDBHIX0028508.
HIX0116265.
HGNCiHGNC:1380. CA6.
HPAiHPA028550.
HPA028692.
MIMi114780. gene.
neXtProtiNX_P23280.
OpenTargetsiENSG00000131686.
PharmGKBiPA25995.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0382. Eukaryota.
COG3338. LUCA.
GeneTreeiENSGT00760000118915.
HOGENOMiHOG000112637.
HOVERGENiHBG002837.
InParanoidiP23280.
KOiK01672.
OMAiPNQGKGH.
OrthoDBiEOG091G0XFM.
PhylomeDBiP23280.
TreeFamiTF316425.

Enzyme and pathway databases

BioCyciZFISH:HS05551-MONOMER.
BRENDAi4.2.1.1. 2681.
ReactomeiR-HSA-1475029. Reversible hydration of carbon dioxide.

Miscellaneous databases

EvolutionaryTraceiP23280.
GeneWikiiCarbonic_anhydrase_VI.
GenomeRNAii765.
PROiP23280.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131686.
CleanExiHS_CA6.
ExpressionAtlasiP23280. baseline and differential.
GenevisibleiP23280. HS.

Family and domain databases

Gene3Di3.10.200.10. 1 hit.
InterProiIPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
IPR018338. Carbonic_anhydrase_a-class_CS.
IPR018428. Carbonic_anhydrase_CA6.
[Graphical view]
PANTHERiPTHR18952. PTHR18952. 1 hit.
PTHR18952:SF110. PTHR18952:SF110. 1 hit.
PfamiPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
SMARTiSM01057. Carb_anhydrase. 1 hit.
[Graphical view]
SUPFAMiSSF51069. SSF51069. 1 hit.
PROSITEiPS00162. ALPHA_CA_1. 1 hit.
PS51144. ALPHA_CA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAH6_HUMAN
AccessioniPrimary (citable) accession number: P23280
Secondary accession number(s): E7EMQ1
, Q5FBW3, Q5FC00, Q96QX8, Q9UF03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: October 17, 2006
Last modified: November 2, 2016
This is version 159 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.